1. Manuela Colorado Builes
Medicine Student
UPB
2012

6. • Only 5% of people with diabetes have this
form of the disease.
• Type 1 diabetes is usually diagnosed in
children and young adults, and was previously
known as juvenile diabetes. In type 1
diabetes, the body does not produce insulin.

7. • IHOP (Islet Homeostasis Protein), is located in Inhibited glucagon
the islets of the pancreas, next to cells that
secret insulin and glucagon. IHoP lost it’s expression
Insulin decrease
Glucagon increase
Deaths of cells that produce insuline

8. If IHoP isn’t found, the pancreas
IHoP creates balance goes into a critical state
between glucagon and insulin
initiating the process of type I
• The high IHop was diabetes.
present in health
people.
• The IHop
didn’t express in people
with diabetes.

9. I Think that this investigation is very
important, because help to find a
treatment to type 1 diabetes in the future,
but it’s essential investigate more about
this disease at the molecular level to
reduce its morbidity and mortality in the
world.

11. • Electron transfer is one of the most important
classes of chemical reactions, because The chains
of this process, provide energy in a gradient
concentration of H, and electrical to make ATP in
+
the membrane transport protein.
• The study was carried out in
the cytochrome photolyase protein family.

12. • Even if the family protein share the
same cascade of amino acids
and structural similarities, the electrons
did not have the same behavior.
• In the cyanobacterial cryptochrome the
electrons have different paths although
had to cover a larger distance.
Known (top) and newly discovered (bottom) charge
transfer path. (Credit: Image courtesy of Albert-
Ludwigs-Universität Freiburg).

13. • The aminoacids are very important to
the transfer of electrons.
• The orientation of the aminoacids has a
stronger influence on electron-transfer
efficiency.

14. • This investigation is very important,
because the transfer of electrons, is a
chemical reaction very important at
level molecular.
• I think that this issue receives little
attention in research, so it is necessary
to stimulate this kind of investigation.

16. • The investigation is very important in
our area because it allows new medical
treatments and advances for the
health.
• The best way to gain new knowledge is
involved in research projects, either as
a medical student or doctor.

17. Scientific investigation
Research of solutions to problems
• Find a cure
• New and better treatment
• Find improvement in the quality of life.

18. • In these case the investigations are
very important in the area of
medicine and the molecular
biology, because one of them found a
treatment to a incurable disease, like
type 1 diabetes, and the other
research to get better forms and
materials for the production and
distribution of energy.

19. • Martínez Sánchez, LM. Vargas Grisales N, Toro Montoya AE, Pamplona Sierra AP, Quevedo
Orrego E. Biología Molecular. 6 Ed. Medellín. UPB: Fac. de Medicina; 2011.
• VOET D, VOET, JG. Bioquímica. 3 ed. Buenos Aires. Medica Panamericana; 2006. p. 591-
592.
• MINSAL, S. Guía Clínica Diabetes Mellitus Tipo 1. 1. Ed. Ministerio De Salud. 2005. 7-8 p.