newer drug delivery systems

Newer drug delivery systems
Dr. Manjeeta Gupta
Department of Pharmacology
MIMER Medical College
Friday, July 8, 2016 1
MIMER Medical College Talegaon
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Newer drug delivery systems
ACKNOWLEDGEMENTS
- Principal
- Members Staff Research Society
- Faculty members & PG students
(Pharmacology)
- Scientists & researches whose work was a source of
inspiration & information for this presentation
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Friday, July 8, 2016
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New drug or New
delivery??

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Oral drug delivery
systems

Osmotic drug delivery
system
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Nifedipine
Chlorpheniramine
(Salt)
Before After

Hydrodynamic drug delivery
system
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Valrelease tablet-Diazepam
Liquid formulation
↓
Collapsible drug
container
↓
Absorbent layer
↓ (Water)
Hydrodynamic pressure
↓
Release of drug

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Gastroretentive drug delivery
system
Absorptive
window
Acyclovir
Bisphosphonates
Captopril
Furosemide
Metformin
Gabapentin
Levodopa
Baclofenac
Ciprofloxacin

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Undertrial -
Hepatitis B,
Norwalk virus for
diarhoea,
Rabies,
Corona virus for
gastroenteritis

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Transdermal drug delivery system

Transdermal therapeutic system
Drug
Reservoir
Contact Adhesive
Drug release
membrane
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Diclofenac Pain relief (Pain in terminal
stages of malignancies and
other pains)
Fentanyl, buprenorphine
(Opioids)
Lidocaine Herpes Zoster (Pain relief)
Scopolamine Motion sickness
Nicotine patch Smoking cessation
Clonidine (Catapres) Hypertension
Nitroglycerine Angina
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Vitamin B12 Anaemia (Avoiding multiple
injections / Daily oral treatment)
Methylphenidate
(Daytrana)
ADHD (2006)
Rivastigmine (Exelon) Alzheimer disease (2007)
5-hydroxytryptophan
(2014) Depressive disorder
Selegiline (2006)
(Emsam)
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Pellet Implant
Estradiol &
Testosterone
Implants

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Use of ultrasonic waves (1-3 MHz) for enhancement of migration
of drug molecule through skin
Hydrocortisone in arthritis
Sonophoresis

Intranasal drug delivery system
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Vortical flow principle
Rotational motion +
Particles also move in
directions opposite to
each other
Forceful, deeper,
wider penetration
Better bioavailability

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Mucosal
automizatio
n device
Nitroglycerine
Progesterone
Estradiol
Testosterone
Naloxone
Oxytocin
Desmopressin
Dihydro-ergotamine
Calcitonin

Microprocessor-controlled vibrating mesh
Nebulizer (Amikacin for pneumonia – local action)
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Intraperitoneal Nebulizer
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Ropivacaine ---- Pain control after
laparoscopic cholecystectomy
A double-blind,
randomized, placebo-controlled
trial
http://bja.oxfordjournals.org,
September 11, 2014

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Microneedle drug
delivery system

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Influenza vaccine
Hepatitis B vaccine
Lidocaine
Parathormone
Desmopressin
Vitamin B

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-Bare metal stent coated with drug-polymer matrix
-Local, controlled delivery
- Prevents re-stenosis
Sirolimus - eluting coronary stent – (CYPHER)
Paclitaxel - eluting coronary stent – (TAXUS )
Drug Eluting Stents

Sutures
Sutures impregnated with antimicrobial agent
• Polyglactin 910 (absorbable suture material coated
with antiseptic agent Triclosan)
• Monofilament sutures: Monocryl & PDS (for both
gram positive & gram negative organisms)
• Under clinical trial
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Ophthalmology
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Lacrisert
-Treatment of dry eye keratitis
- Drug : Hydro-propyl cellulose
Retisert
-Treatment of chronic
infectious uveitis
- Drug : Fluocinolone acetonide

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Drug : Gancyclovir
Drug : Latanoprost

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Insulin Pen Insulin jet

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Insulin pump

Inhaled Insulin
• Approved (Jan.2006)
• Short-actinginsulin
• Tocontrolpost-prandialhyperglycemia
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Oral Insulin: a long awaited dream.. !!
Phase 2 & 3 clinical trials
IN-105 (Biocon India)
NN-1952 (Novo nordisk)
ORMD-0801(Oramed)
Pharmfilm (MonoSol, Midatech) - transbuccal
Oral-lyn (Generex) - buccal spray
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Patient- Controlled Analgesia
Programmable device
For pain relief
Terminal stages of
malignancies
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Doxorubicin (Doxil)
– Kaposi’s sarcoma
Amphotericin B –
Serious Systemic
fungal infections
Paclitaxel (Abraxane)
– Metastatic breast
Ca (2005),
Non small cell lung
Ca (2012)
Advanced pancreatic
Ca (2013)

Concept of
Nanomedicine
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NANO

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Medical application of nanotechnology
Nano-sized (1-100 nanometers) particles
Diagnosis, prevention & treatment of diseases
To gain complete understanding of complex patho-
physiology of disease

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Gold nanoparticles
-Generation of free radicals
- Killing of cancer cells

Carbon nanotubules
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Enhanced solubility
Efficient tumour
targeting/drug delivery

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Nano-Erythrosomes
Carry proteins, enzymes & macromolecules
Liver tumours, parasitic & enzymatic diseases

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Genetic transfer system
Under Phase 3 trial
for Adenovirus &
HIV

Imagine…….
• An injectable microfilm goes into the body
• Releases a drug layer by layer
• Over a period of ………. long time
• Long ? How much long ??
• 1 week? 1 month? 6 months ??? STILL LONGER…
• More than a year
• Give anti-TB drug only once, and Will it be done?
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Future will be unimaginably different ??
• Biodegradable nanoscale film - Targeted Controlled delivery
• Pain medications - Release the drug for more than 14 months
• Professor Paula Hammond
• Koch Institute for Integrative Cancer Research at –
• Massachusetts Institute of Technology – Cambridge- USA
• http://pub.mims.com/India/topic/medical-tribune-in/new-te
. accessed 26 Sept 2014
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newer drug delivery systems

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