Diese Präsentation wurde erfolgreich gemeldet.
Die SlideShare-Präsentation wird heruntergeladen. ×

Volatile Anesthesia History.pptx

Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Anzeige
Wird geladen in …3
×

Hier ansehen

1 von 35 Anzeige

Volatile Anesthesia History.pptx

Herunterladen, um offline zu lesen

When and where the history of volatile anesthesia started and what was the story ?
Whom was the triggering for discovering the effect of volatile anesthesia on human being ?
How the volatile anesthesia developed year by year till reach the best and the most safe volatile anesthetic ?
What were the complications of old volatile anesthetics ?

When and where the history of volatile anesthesia started and what was the story ?
Whom was the triggering for discovering the effect of volatile anesthesia on human being ?
How the volatile anesthesia developed year by year till reach the best and the most safe volatile anesthetic ?
What were the complications of old volatile anesthetics ?

Anzeige
Anzeige

Weitere Verwandte Inhalte

Aktuellste (20)

Anzeige

Volatile Anesthesia History.pptx

  1. 1. Inhalational Anesthetics History Mahmood Hasan Taha HD/ Anesthesia Zakho General H. Aug/2022
  2. 2. Old Agent Release/ use New Agent Release/ use Ether 1846 Halothane 1956 Chloroform 1847-1848 Enflurane 1966 Cyclopropane 1936 Isoflurane 1979 Sevoflurane 1990 Desflurane 1992
  3. 3. History • In 1845 Horace Well, attempted unsuccessfully to demonstrate the analgesic properties of Nitrous Oxide. • T.G Morton American dentist (1819-1868). With his former teacher, Boston chemist, Charles Jackson, The tow discussed the use of Ether (C2H5)2O.
  4. 4. • On September 30, 1846, Morton did first painless tooth extraction using Ether. • On October 16,1846, a demonstration of Ether at the operating room of Massachusetts General Hospital MGH.
  5. 5. Morton made the first successful surgery: • Removing a tumour from the neck. • Patient : Mr Edward Gilbert Abbott • Surgeon Dr. John Collins Warren, in the same theatre where Wells had failed nearly tow years earlier using nitrous oxide.
  6. 6. • The entire medical community had been shocked when the patient wasn't screaming. • This theatre came to be known as the: Ether Dome. • The 16th of October being the Ether Day which nowadays known as: Anesthesia Day.
  7. 7. Ether Dome/MGH/Boston
  8. 8. • So, Ether was first brought to public attention by …….?
  9. 9. Charles T. Jackson William T.G Morton
  10. 10. Unfortunately for Morton; other doctors tried to claim that they discovered it before him, like chemist Dr.Charles T. Jackson, and Dr. Crawford Long, who claimed to have use it four or five years earlier, but never showed it to the public.
  11. 11. Crawford Long
  12. 12. Replica of Morton Inhaler (Morton Etherizer)
  13. 13. Early Inhaler for Ether
  14. 14. Advanced Etherizer
  15. 15. Chloroform (CHCl3) First produced in 1831. Simultaneously in the USA by Samuel Guthrie and in France by Eugene soubeiran.
  16. 16. Samuel Guthrie Eugene Soubeiran USA France
  17. 17. Dr. James Young Simpson The first narcosis with Chloroform was performed by Dr. James Young Simpson on himself on November 4, 1847.
  18. 18. • The first fatality was a15 years old girl called: Hnnah Greener, who died on January 28, 1848, after receiving a Chloroform for the removal of toenail. • The question remain of whether the complications were solely due to respiratory disturbance or whether Chloroform had a specific effect on the heart ?!
  19. 19. Hnnah Greener, receiving a Chloroform for the removal of toenail, January 28, 1848
  20. 20. • Between 1864 and 1910 numerous commissions in U.K studied Chloroform, but failed to come to any clear conclusions. It was only in 1911 that A.G Levy proved in experiments with animals that Chloroform can cause ventricular fibrillation.
  21. 21. • Between about 1865 and 1920, Chloroform was used in 80 to 95% of all narcosis performed in U.K and German speaking countries.
  22. 22. Chloroform inhaler devised in 1850 by John Snow
  23. 23. Levy- type regulating Chloroform Inhaler England 1919
  24. 24. Murphy type Chloroform inhaler
  25. 25. • In 1934, Hans Franz Edmund Killian, gathered all the statistics compiled until then and found the chances of suffering fatal complications under Ether were between 1:14000 and 1:28000, were as under Chloroform the chance were between 1:3000 and 1:6000
  26. 26. Hans F. E.Killian
  27. 27. • The rise of gas anesthesia using Nitrous, improved equipment for administering anesthesia and the discovery of Hexobarbital, an IV anesthetic in 1932 led to the gradual decline of Chloroform narcosis. • In 1947 Ralph M. Waters attempted to reactivate Chloroforom, but failed. The story of clinical use of Chloroform ended 1976.
  28. 28. Dr. Ralph M. Waters
  29. 29. Cyclopropane C3H6 • Discovered in 1881 by August Freund (a German chemist). • Its anesthetic properties discovered in 1929 by Henderson and Lucas. • Industerial production: 1936. • Introduced into clinical use by the American anesthetist Ralph M. Waters who used a closed system with carbon dioxide absorption to conserve this costly agent.
  30. 30. Physical properties: • Relatively potent. • Colorless. • Highly flammable. • Sweet petrol smell. • Nonirritating to mucous membrane and does not depress respiration. • Applied by cylinders and flow meters were colored orange.
  31. 31. Cyclopropane cylinder and flow rate
  32. 32. Cyclopropane cylinders, orange colored
  33. 33. • MAC is 17.5%. • Blood/gas partition coefficient is 0.55. • Induction and emergence from cyclopropane anesthesia are usually rapid and smooth. • Cyclopropane shock: prolonged anesthesia sudden decrease in blood pressure, cardiac dysrhythmia.
  34. 34. • Shock, as well as its high cost and its explosive nature, it was latterly used only for the induction of anesthesia. • Its clinical use ended since the mid 1980s.

×