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Revise Family Case Presentation Final
1. Department of Family & Community Medicine Perpetual Succour Hospital “ LIFE IS SO SWEET IN DIABETES” DR. LIZA D. MARIPOSQUE 2 ND Year FAMED Resident AUG. 13, 2009 FAMILY CASE PRESENTATION
32. Diagnostic Criteria for Impaired Glucose Tolerance and Diabetes Mellitus From Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1999;20(Suppl 1): S5. 2-hr plasma glucose during the OGTT ≥200 mg/dL or <200 mg/dL (11.1 mmol/L) Fasting plasma glucose ≥126 mg/dL (7.0 mmol/L) 2-hr plasma glucose during the OGTT but ≤140 mg/dL or Symptoms [*] of DM plus random plasma glucose ≥200 mg/dL (11.1 mmol/L) Fasting glucose 110–125 mg/dL (6.1–7.0 mmol/L) DIABETES MELLITUS (DM) IMPAIRED GLUCOSE TOLERANCE (IGT) Symptoms include polyuria, polydipsia, and unexplained weight loss with glucosuria and ketonuria. OGTT, oral glucose tolerance test. *
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34. Treatment Goals for Adults with Diabetes a <1.7 mmol/L (<150 mg/dL) Triglycerides >1.1 mmol/L (>40 mg/dL) g High-density lipoprotein <2.6 mmol/L (<100 mg/dL) Low-density lipoprotein Lipids f <130/80 e Blood pressure <10.0 mmol/L (<180 mg/dL) d Peak postprandial capillary plasma glucose 5.0–7.2 mmol/L (90–130 mg/dL) Preprandial capillary plasma glucose <7.0 c A1C Glycemic control b Goal Index
35. Glucose-Lowering Therapies for Type 2 Diabetes Reduce dose with renal Does not cause hypoglycemia Sitagliptin Prolong endogenous GLP-1 action Dipeptidyl peptidase IV inhibitors Renal/liver disease GI flatulence, liver function tests Reduce postprandial glycemia Acarbose, Miglitol Glucose absorption a –Glucosidase inhibitors Serum creatinine >1.5 mg/dL (men) >1.4 mg/dL (women), CHF, acidosis Lactic acidosis, diarrhea, nausea Weight loss Metformin Hepatic glucose production, weight loss, glucose, utilization, insulin resistance Biguanides Oral C.I. or Relative C.I. Disadvantages Advantages Examples MOA
36. C.I. DISADVANTAGES ADVANTAGES MOA CHF, liver disease Peripheral edema, CHF, weight gain, fractures, macular edema; rosiglitazone may increase risk of MI Lower insulin requirements Insulin resistance, glucose utilization Thiazolidinediones Renal or liver disease Hypoglycemia Short onset of action, lowers PPG Insulin secretion Insulin secretagogues—nonsulfonylureas Renal or liver disease Hypoglycemia, weight gain Lower FBS Insulin secretion Insulin secretagogues— sulfonylureas
37. Agents that also slow GI motility Injection, nausea, risk of hypoglycemia with insulin Reduce PPG, weight loss Slow gastric emptying, Glucagon Amylin agonist - Pramlintide Renal disease, agents that also slow GI motility Injection, nausea, risk of hypoglycemia with insulin secretagogues Weight loss Insulin, Glucagon, slow gastric emptying GLP-1 agonist Injection, weight gain, hypoglycemia Known safety profile Glucose utilization and other anabolic actions Insulin C.I. DISADVANTAGES ADVANTAGES MOA Parenteral
38. Nutritional Recommendations for Adults with Diabetes Nonnutrient sweeteners Fiber-containing foods may reduce postprandial glucose excursions Other components 10–35% of total caloric intake (high-protein diets are not recommended) Protein Sucrose-containing foods may be consumed with adjustments in insulin dose Amount and type of carbohydrate important b 45–65% of total caloric intake (low-carbohydrate diets are not recommended) Carbohydrate Minimal trans fat consumption Two or more servings of fish/week provide @ -3 polyunsaturated fatty acids <200 mg/day of dietary cholesterol Saturated fat < 7% of total calories 20–35% of total caloric intake Fat
45. Smilkstein’s Cycle of Family Function STREESFUL LIFE EVENTS: Pneumonia & poorly controlled sugar CRISIS: Inadequate family income EXTRA-FAMILIAL RESOURCES: Free medicines Financial Assistance from the Capitol & Brgy. Lahug Help from co-workers work ADAPTATION FAMILY IN EQUILIBRIUM DISEQUILIBRIUM
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47. FAMILY APGAR Bernadette: Index Patient APGAR SCORE: 9 (Highly Functional) RESOLVE: I am satisfied with the way my family and I share time together AFFECTION: I am satisfied with the way my family expresses affection and responds to my emotion such as anger, sorrow and love GROWTH: I am satisfied that my family accepts and supports my wishes to take on new activities or directions PARTNERSHIP: I am satisfied with the way my family talks on things with me and shares problems with me. ADAPTATION: I am satisfied that I can turn to my family for help when something is troubling me. Hardly Ever (0) Some of the Time (1) Almost always (2)
48. FAMILY APGAR Edgardo: Husband APGAR SCORE: 9 (Highly Functional) RESOLVE: I am satisfied with the way my family and I share time together AFFECTION: I am satisfied with the way my family expresses affection and responds to my emotion such as anger, sorrow and love GROWTH: I am satisfied that my family accepts and supports my wishes to take on new activities or directions PARTNERSHIP: I am satisfied with the way my family talks on things with me and shares problems with me. ADAPTATION: I am satisfied that I can turn to my family for help when something is troubling me. Hardly Ever (0) Some of the Time (1) Almost always (2)
49. The family attends mass every Sunday in St. Therese Parish Church. They are aware of religious events in the local community They have embraced Filipino values and apply these in their everyday life (i.e. respecting elders). The family participates in social activities such as family reunions & fiesta celebrations. They also have Good relationships with their neighbors, friends and co-workers. No known enemies. Resource They do not participate in any religious organization. Religious Cultural Social Weakness SCREEM
50. When medical problems arises, the family can easily access their private physician to seek consultation Edgardo and Editha are highschool graduates hence, making them capable of solving problems rationally and they able to send their children to college. Edgardo is working as “Brgy. Tanod” and Editha as a Brgy Health Worker. The monthly income of both is enough to provide the basic necessities of the family. Resource Weakness SCREEM Blood sugar of Editha is poorly controlled and she had difficulty to comply laboratory work-up. Medical Educational Financial problem arises only if they will support the expenses of their grandchildren and if someone will get sick. Economic
D is for Diet I is for Insulin, human or pig it doesn't matter A is forAmbulance to take you to hospital when you not feeling well B is for Bruises for after you have blood taken from you E is for Eating wronly which we shouldn't but we do T is for Treats that are very hard to find E is for Energy which diabetes need a lot of S is for Sweets which we shouldn't have CC: Claire Page
During the Martial Law in year 1977, Bernadette known to many as “Editha” , 20 years old at that time, a high school student at UV, Cebu City when she met her husband Edgardo. Edgardo a 19 year old, a conductor of a pasengers jeep called “VICTOR” got attracted to Editha her regular passenger. At first, they went out together as “Barkada”. Few months after, when the driver of the jeepney died, since the wake was just in front of editha’ s house they got the chance to see each other more often. They become more closer and love blossomed with each other. A year after, Edgardo and Editha decided to live together. A year later,she gave birth to Clinton in 1979. In 1982, Raquel was born and in 1984, then came Rosanna, thru C/S at Cebu Maternity Hospital and then she consented to had bilateral tubal ligation. From then on… as years have passed, the sexy body of Editha was gone. She loves to eat chocolate, all sorts of sweets, drinks cola almost every after a meal.. Fourteen years later… she was diagnosed with Hypertension, she was compliant with her medications. Ten years later, because of uncontrolled, overly sweet diet, Editha was diagnosed with Diabetes Mellitus. 4 yrs after, her dilemma started when she stopped her exercise and diet plans hence she cannot refuse the call of sweet foods everyday. D is for Diet I is for Insulin, human or pig it doesn't matter A is for Ambulance to take you to hospital when you not feeling well B is for Bruises for after you have blood taken from you E is for Eating wrongly which we shouldn't but we do T is for Treats that are very hard to find E is for Energy which diabetes need a lot of S is for Sweets which we shouldn't have CC: Claire Page
Diabetes Mellitus: Introduction Diabetes mellitus (DM) refers to a group of common, chronic metabolic disorders that share the phenotype of hyperglycemia as a cardinal biochemical feature. The worldwide prevalence of DM has risen dramatically over the past two decades, from an estimated 30 million cases in 1985 to 177 million in 2000. Based on current trends, >360 million individuals will have diabetes by the year 2030. While in Asia & Australia, in year 2000- 82.7M number of people who had Diabetes and it will increase in year 2030 to 190.5M. The projected prevalence of DM in persons 35-64 years is 3-5%. Diabetes was the fifth leading cause of death worldwide and was responsible for almost 3 million deaths annually (1.7–5.2% of deaths worldwide). In the United States, DM is the leading cause of end-stage renal disease (ESRD), nontraumatic lower extremity amputations, and adult blindness. It also predisposes to cardiovascular diseases. With an increasing incidence worldwide, DM will be a leading cause of morbidity and mortality for the foreseeable future. That is why FBS screening is important hence, early detection of DM lead us to prevention of complications.
Several distinct types of DM exist and are caused by a complex interaction of genetics and environmental factors. Depending on the etiology of the DM, factors contributing to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. The metabolic dysregulation associated with DM causes secondary pathophysiologic changes in multiple organ systems that impose a tremendous burden on the individual with diabetes and on the health care system.
Two features of the current classification of DM diverge from previous classifications. First, the terms insulin-dependent diabetes mellitus (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) are obsolete. Since many individuals with type 2 DM eventually require insulin treatment for control of glycemia. A second difference is that age is not a criterion in the classification system. Although type 1 DM most commonly develops before the age of 30, an autoimmune beta cell destructive process can develop at any age. It is estimated that between 5 and 10% of individuals who develop DM after age 30 have type 1 DM. Type 2 DM is characterized by impaired insulin secretion, insulin resistance, excessive hepatic glucose production, and abnormal fat metabolism. Obesity, particularly visceral or central (as evidenced by the hip-waist ratio), is very common in type 2 DM. In the early stages of the disorder, glucose tolerance remains near-normal, despite insulin resistance, because the pancreatic beta cells compensate by increasing insulin output (Fig. 338-7). As insulin resistance and compensatory hyperinsulinemia progress, the pancreatic islets in certain individuals are unable to sustain the hyperinsulinemic state. IGT, characterized by elevations in postprandial glucose, then develops. A further decline in insulin secretion and an increase in hepatic glucose production lead to overt diabetes with fasting hyperglycemia. Ultimately, beta cell failure may ensue.
Type 2 DM is preceded by a period of abnormal glucose homeostasis classified as impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). The National Diabetes Data Group and World Health Organization have issued diagnostic criteria for DM. Individuals with IFG and/or IGT, recently designated pre-diabetes by the American Diabetes Association (ADA), are at substantial risk for developing type 2 DM (25–40% risk over the next 5 years) and have an increased risk of cardiovascular disease.
a As recommended by the ADA; Goals should be developed for each patient (see text). Goals may be different for certain patient populations. b A1C is primary goal. c While the ADA recommends an A1C < 7.0% in general, in the individual patient it recommends an &quot;. . . A1C as close to normal (<6.0%) as possible without significant hypoglycemia. . . .&quot; Normal range for A1C—4.0–6.0 (DCCT-based assay). d One-two hours after beginning of a meal. e In patients with reduced GFR and macroalbuminuria, the goal is <125/75. f In decreasing order of priority. g For women, some suggest a goal that is 0.25 mmol/L (10 mg/dL) higher. Source: Adapted from American Diabetes Association, 2007.
L: Raquel 26 y.o. ff by her daughter Athena Grace, 9y.o studying at USP-Elem. School (Asthmatic) Rosanna 24y.o- daughter ff Editha is Dannica Rachelle 5 y.o studying at USP Elem. School. Clinton 30y.o, beside him is his daughter Wenona Lyn 10 y.o studying at Lahug Elem. School.
Husband: Edgardo, 50 years old. Brgy. Tanod at Brgy. Lahug, Cebu City Known HPN, poor compliant of Neobloc Diet & Exercise
changes in lifestyle (diet and exercise for 30 min/day five times/week) in individuals with IGT prevented or delayed the development of type 2 DM by 58%.