This document discusses rebranding hemp as Canterpene for use as a health supplement. It notes that hemp currently has negative associations with marijuana in many consumers' minds. The document outlines how rapeseed was similarly rebranded as canola to be marketed for human consumption. It then proposes rebranding hemp extracts as Canterpene and patenting a proprietary hempseed formulation under that name. The document argues that cannabinoids in hemp may help treat diseases of aging by reducing oxidative stress and inflammation. It reviews evidence that CBD in particular may benefit conditions like arthritis, Parkinson's, Alzheimer's, and more. Finally, it asserts that without an effective commercialization strategy, promising science will

1. REBRANDING HEMP
FOR THE
NEUTRACEUTICAL
MARKET
CANTERPENE AS A
HEALTHSPAN EXTENSION
SUPPLEMENT

2. Lifespan Pharma Inc.
Morris Johnson,
CTO, Founder
Terry Grossman,
M.D., Medical
Director
Silas Kanning,
Co-founder

3. REBRANDING HEMP AS
CANTERPENE MAKES SENSE
FOR THE NATURAL HEALTH
PRODUCT/ DSHEA FOOD
SUPPLEMENT MARKETS

4. 35 YEARS AGO RAPESEED
EXPERIENCED THE SAME
PROBLEMS AFFECTING HEMP
TODAY
Growers needed to rebrand something that was
associated with a machine oil regarded as too
toxic for humans to consume
Low Erucic Acid Rapeseed (LEAR)?
“CANadian source of OLeic Acid” became
CANOLA
It was promoted as a safe, nutritious, multi-
purpose human and animal food ingredient

5. Hemp is undergoing a similar identity crisisHemp is undergoing a similar identity crisis iin then the
minds of many todayminds of many today

6. When you Google “hemp” you get a largeWhen you Google “hemp” you get a large
number of “POT” hitsnumber of “POT” hits
 Purveyors of recreational and medicinalPurveyors of recreational and medicinal
marijuana use “hemp” indiscriminately whenmarijuana use “hemp” indiscriminately when
speaking about marijuanaspeaking about marijuana

7. SOME CANADIAN HEMPSOME CANADIAN HEMP
PRODUCTS ASSOCIATE HEMP WITHPRODUCTS ASSOCIATE HEMP WITH
MARIJUANAMARIJUANA

8. ASSOCIATING HEMP
WITH MARIJUANA IS
CREATING CONSUMER
CONFUSION
• Solutions:
• Litigate?
• Regulate?
• Educate?
• Ignore?

9. AFTER MUCH CONSIDERATION WEAFTER MUCH CONSIDERATION WE
CONCLUDED NONE OF THE ABOVECONCLUDED NONE OF THE ABOVE
SOLUTIONS ARE PRACTICAL OR COSTSOLUTIONS ARE PRACTICAL OR COST
EFFECTIVEEFFECTIVE
Some hemp manufacturersSome hemp manufacturers
want to capitalize on the sciencewant to capitalize on the science
which has popularized thewhich has popularized the
term “Medical Marijuana”term “Medical Marijuana”
The best solution:The best solution:
REBRANDINGREBRANDING

10. REBRAND CANADIAN HEMP ASREBRAND CANADIAN HEMP AS
CANTERPENECANTERPENE
We link Canadian Hemp
with the message
“Extend Health-span
and Life-span naturally
with cannabis chemistry

11. WE HAVE PATENTEDWE HAVE PATENTED
CANTERPENE AS ACANTERPENE AS A
PROPRIETARY FORMULATIONPROPRIETARY FORMULATION
OF MILLED HEMPSEEDOF MILLED HEMPSEED

12. AGING CAN BE BRUTAL

13. IT IS POSSIBLE TO
GROW OLDER WITHOUT
AGING AT ANY AGE
60 yrs old 80 yrs old

14. ANTIAGING IS AN
ENORMOUS MARKET
76 million baby boomers in the US
6 million “boomies” in Canada
Boomers now 48 – 64 and have begun to
experience the “aging process” firsthand
This generation has redefined each stage of
their lives and is currently redefining aging

15. BOOMERS
REGARD
AGING IS A
DISEASE …

16. … THAT AFFECTS EVERYONE

17. … AND IS 100
PERCENT FATAL

18. THIS IS THE NEW VIEW OF
AGING
Bob
Delmonteque,
age 84

19. THE TWO PILLARS OF
HEALTH
Prevention Early
Detection

20. CANTERPENE CAN HELP
AS A PREVENTIVE
ANTIAGING STRATEGY
Science has linked numerous CannabisScience has linked numerous Cannabis
compounds found in Canterpene withcompounds found in Canterpene with
beneficial effects on the diseases resultingbeneficial effects on the diseases resulting
from “normal” agingfrom “normal” aging
Canterpene captures much that otherCanterpene captures much that other
conventional hemp supplements haveconventional hemp supplements have
ignoredignored

21. Can Canterpene work as a lifespanCan Canterpene work as a lifespan
enhancement tool?enhancement tool?

22. THE
MEDICAL
BENEFITS
CANTERPENE

23. NUMEROUS BIOCHEMICAL BENEFITS
OF CANNABINOIDS IN HEMP

24. SOME DISEASES/CONDITIONS
ASSOCIATED WITH AGING
Oxidative stress
Arthritis
Central nervous system degeneration
Parkinson’s
Alzheimer’s
Cannabidiol (CBD) the major cannabinoid in
hemp has been shown to be of benefit in each of
these and many other conditions

25. OXIDATIVE STRESS
CBD treatmentsignificantly reduced oxidative stress;
decreased the levelsof tumor necrosis factor, vascular
endothelial growth factor,and intercellular adhesion
molecule-1; and prevented retinalcell death and vascular
hyperpermeability in the diabetic retina.Consistent with
these effects, CBD treatment also significantlyinhibited p38
MAP kinase in the diabetic retina. These resultsdemonstrate
that CBD treatment reduces neurotoxicity, inflammation,and
BRB breakdown in diabetic animals.
EL Remessey AB et al. Neuroprotective and blood-retinal
barrier-preserving effects of cannabidiol in experimental
diabetes. Am J Pathol. 2006 Jan;168(1):235-44.

26. ARTHRITIS
These potentially anti-inflammatory properties of CBD,
together with the lack of psychotropic effect and low toxicity
prompted us to test the potential of CBD as a therapeutic
agent in collagen-induced arthritis (CIA).
RESULTS: “We report that CBD has a beneficial therapeutic
action on established CIA.”
Malfait AM et al. The nonpsychoactive cannabis constituent
cannabidiol is an oral anti-arthritic therapeutic in murine
collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000
Aug 15;97(17):9561-6.

27. PARKINSON’S DISEASE
Evidence suggests that cannabinoids may prove useful in
Parkinson's disease by inhibiting the excitotoxic
neurotransmitter glutamate and counteracting oxidative damage
to dopaminergic neurons
Croxford JL. Therapeutic potential of cannabinoids in CNS
disease. CNS Drugs. 2003;17(3):179-202.
It seems that cannabinoids could delay or even stop progressive
degeneration of brain dopaminergic systems, a process for
which there is presently no prevention. In combination with
currently used drugs, cannabinoids might represent,
qualitatively, a new approach to the treatment of PD, making it
more effective.
Sevcik J, Masek K Potential role of cannabinoids in Parkinson's
disease DRUG AGING 16 (6): 391-395 JUN 2000

28. ALZHEIMER’S DISEASE
Memory loss, the first and primary symptom of Alzheimer’s
disease, can be slowed down significantly in mice by
cannabidiol.
In a study at the Cajal Institute in Madrid, Spain, mice were
injected with a molecule found in the brain of humans suffering
from Alzheimer’s disease, and then treated for one week with
cannabidiol.
Those mice injected with cannabidiol successfully performed
the task within 25-30 seconds, compared to control mice, who
took almost double the amount of time, 45-50 seconds, to
complete the task.
See also: Iuvone T, Esposito G, Esposito R, et al.
Neuroprotective effect of cannabidiol, a non-psychoactive
component from Cannabis sativa, on beta-amyloid-induced
toxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004

29. CANTERPENE
AS AN
ANTIAGING
STRATEGY
GOOD SCIENCE WITHOUT A METHOD TOGOOD SCIENCE WITHOUT A METHOD TO
COMMERCIALIZE IT WILL NOT BENEFITCOMMERCIALIZE IT WILL NOT BENEFIT
ANYONEANYONE

30. Morris/Greg/Leah/Erin Rod Fisher Steve Burnside