Dr. Cady reviews the science and the facts of weight gain, weight loss, and the new genomically focused weight loss program from Pharmanex: TR90. In this program, Dr. Cady relentlessly dissects the errors of the "low fat" way to eat, targets high glycemic eating and protein deficient diets as the main culprits in our society's weight gain, and proposes a common-sense and rational way to eat to achieve any of the following goals: (a) not gain any more weight, (b) maintain your current weight, (c ) lose weight. The genomic science behind the technology used by Pharmanex to develop TR-90 is reviewed. TR90 is the only genomically focused, nutritionally sound weight management available for sale today. The genomic science behind this product is established. Multiple scientific papers (one of which is referenced in this presentation) unequivocally show that what you eat in your diet alters gene expression. As of the release of this slide deck on 4/19/2014, the three month TR90 system will only be available for sale in the US for one day on April 23rd at 11 a.m. CST. It is estimated that the entire manufactured run available for the US will sell out in 60 - 90 minutes. It will not be available for sale in this country for six months after this date. Please contact the office at Cady Wellness Institute if you are interested in securing a three month supply. (812) 429-0772.

1. Louis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness InstituteLouis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness Institute
Adjunct Clinical Lecturer – Indiana University School of Medicine
Department of Psychiatry
Wellness Medicine & Functional Neuropsychiatry – Evansville, Indiana
TR 90: A Revolutionary Genomic Based
Weight Loss Approach

2. Focus of this review
• What most people do not know about
why they are (a) gaining weight and (b)
can’t lose weight.
• How does this eating and insulin thing
work?
• Why calorie restriction and typical diets
don’t work.
• Is the problem “all in your glands”?
• “What is TR 90?”

3. Calorie restriction
• The foundational principle of the “yo-yo diet”
• The FAILURE of calorie restriction only
– Starve yourself
– Lose fat and muscle
– Go off diet
– Put on all the weight, and then some, because
of loss of muscle
– Repeat ad infinitum. And get bigger and
heavier.

4. Techniques of (net) calorie reduction
part I: cut calories
• Using diet books, weighing portions, counting
calories, increasing activity
• Join Weight Watchers.
• Diet pills & supplements
• Fen-Phen disaster – heart valve abnormalities
• Stimulant problems –
– Stresses adrenals
– Potential for adverse cardiac events
• Lap band (surgical complications), muscle with fat
loss, toxins

6. WEIGHT STATS
ADULTS 70%
OVERWEIGHT
CHILDREN 20% OBESE
OBESITY IS A KILLER

7. UP TO 40% OF THE WEIGHT LOSS IN TYPICAL
DIETS IS MUSCLE LOSS

9. M
us
cl
e
M
us
cl
e
Metab
olic
Burn
Metab
olic
Burn
LEAN MUSCLE = METABOLIC ENGINE
• Traditional calorie
restricted diet
• Lose lean muscle
as well as fat
• Protein heavy,
calorie
restricted
• Maintain more
lean muscle
Metabolic burn = rate at which body
Mu
scl
e
Mus
cle
Metabo
lic
Burn
Metab
olic
Burn

10. Glycemic index
• A measure of how fast a
carbohydrate triggers a rise in
circulating blood sugar.
• The higher the number, the greater
the blood sugar response.

11. Selenium, the Thyroid, and You
• “T3” is the ACTIVE
form of thyroid
• Conversion of T4
to T3 is selenium
dependent
• LP & LP Nano
have 200% of
RDA of selenium
Se+


12. The Old FDA Food pyramid – R.I.P 2005

14. June 1, 2011

16. “Pyramid Power”
USDA Food PyramidZone Food Pyramid
Vegetables
Fruits
Low-fat Protein
Monounsaturated Fat
Grains and Starches
(Use in Moderation)

17. How to lose it?

18. FAT LOSS SECRET #1
Source: http://win.niddk.nih.gov/statistics/index.htm#overweight

19. FAT LOSS SECRET #2
Source: http://win.niddk.nih.gov/statistics/index.htm#overweight

20. FAT LOSS SECRET #3
Source: http://win.niddk.nih.gov/statistics/index.htm#overweight

21. The top weight loss secret from Tim Ferris
“Consume 30
grams of protein
within one hour
of waking up.”

22. ageLOC – a novel mechanism to target
and reset “youth gene clusters”
Old Gene
Expression
Young Gene
Expression
TARGET
Old Gene
Expression
RESET
1
Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research
Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets
Conference Center, Les Diablerets, Switzerland.

23. “Youth Gene Clusters” – bogus
or bonanza?
Comparative genomics of fungal allergens
and epitopes show widespread distribution of
closely related allergen and epitope
orthologues. Bower P, et al, BMC
Genomics. 2006; 7:251.
Yeast species
SPECIFIC genes

24. Prostate Cancer – more
relevant?
Changes in prostate gene expression in
men undergoing an intensive nutrition
and lifestyle intervention. Ornish, Dean
et al. Proc Natl Acad Sci USA
2008 June 17; 105(24):8369-8374
Pre-invention gene
expression
Post-intervention gene
expression
TRANSLATION: What you eat
talks to your genes and
CHANGES THEIR
EXPRESSION.

25. Comparison of Genetic Profiles of
Adipose Tissue in Identical Twins
Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.
Same DNA
Different Expression of Genes
Normal Weight Twin Overweight Twin
Compared to their normal weight twin, overweight twins exhibited down
regulation of gene expression pathways related to:
• Fat Regulation (storage versus utilization)
• Muscle Protein Synthesis

26. Ghrelin
Leptin
Insulin
References:
Gene Expression relates to the Appetite Control
Center of the Brain
• Appetite Control
• Eating Behavior
• Regulation of energy intake
1. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520.
2. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755.
3. De Silva, et al. Cell Metab. 2011;14:700-706.
4. Malik S, et al. Cell Metab. 2008;7:400-409.
5. Farooqi IS, et al. Science. 2007;317:1355
6. Suzuki K, et al. Experimental Diabetes Research. 2012:1-19.
7. Viquerie N, et al. Diabetologia. 2005;48(1):123-131.
8. Mager et al. European Journal of Endocrinology. 2008;158:
9. Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.

27. Carbohydrates
(260g)
Proteins
(90g)
Fats
(67g)
Normal Calorie Diet – 2000 kcal
FatBurning
Foods
FatStoring
Foods
FatStoring
Foods
Carbohydrates
(260 g)
Proteins
(90 g)
Fats
(67 g)

28. Carbohydrates
(260g)
Proteins
(90g)
Fats
(67g)
Typical Reduced Calorie Diet – 2000 kcal
FatBurning
Foods
FatStoring
Foods
FatStoring
Foods
Carbohydrates
(180 g)
– 1200 kcal
Fats
(33 g)
Proteins
(45 g)

29. Carbohydrates
(260g)
Proteins
(90g)
Fats
(67g)
FatBurning
Foods
FatStoring
Foods
FatStoring
Foods
Carbohydrates
(120 g)
Fats
(40 g)
Muscle Retention Eating Plan – 1200 kcal
Proteins
(90 g)

30. Eating Most of Your Protein with Only One Meal of the
Day Limits Duration of Metabolic Burn
FATSTORINGFATSTORINGFATBURNINGFATBURNING
Time in Metabolic Burn Zone = Only 3 hours/day
Adapted from:
1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.
2.Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
ZONES

31. Eating Protein with Each Meal
Accelerates Metabolic BurnFATSTORINGFATSTORINGFATBURNINGFATBURNING
Adapted from:
1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.
2.Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
Time in Metabolic Burn Zone = 9 hours/day
ZONES

32. The TR90 Eating Plan Based on:
Protein Science & Nutrition Science
• Supports metabolically-active
lean muscle and inhibits fat
storage1
Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
• An eating plan designed to
complement the supplements.

33. Breakfast Snack Lunch Snack Dinner
At least 30 Grams of Protein
Trim Shake
Egg Omelet
Vegetable of color (peppers,
onions, zucchini, spinach,
broccoli, tomatoes, salsa)
Berries on the side
Yogurt
Cottage Cheese
At least 30 Grams of Protein
Trim Shake
Chicken
Fish
Pork
Shrimp
Tofu
Cottage Cheese
Color Food (see guide)
Sweet Potato
At least 30 Grams of Protein
Chicken
Fish
Pork
Tofu
Shrimp
Vegetable of color (peppers,
zucchini, spinach, salsa)
Sweet Potato
Yogurt
Cottage Cheese
Nuts (1 oz)
Melon
Berries
Apple
Pear
Carrots
Celery
Cucumber
Vegetables
Greek Yogurt
Yogurt
Cottage Cheese
Nuts (1 oz)
Melon
Berries
Apple
Pear
Carrots
Celery
Cucumber
Vegetables
Greek Yogurt
Non-Shake
Healthy Meal
30-60 grams protein
+
1 Grain
1 Fruit
1 Vegetable
15+ Grams
protein from TR90
Shake
+
(15-45 grams protein
from non-shake
protein sources) --- previous eating plan, TR 90, Oct 2013 ---

34. HOW MANY GRAMS?

36. H - 36
Benefits of low-glycemic eating

37. 78 pounds gone forever!78 pounds gone forever!
TINA CLARK

38. DENNY PRETZ

39. October 5th
, 2013

40. TR 90 – a look back
October 28, 2013 January 28, 2014
Jan 29, 2014

41. Withings WS-50 Smart Body Analyzer

42. (Start weight: 168.5 lbs – Oct 28th
)
10 lbs of total weight
loss = 6% body weight

43. (43.1 lbs – Oct 28th
)
7.7lbs of fat loss
10 lbs of total loss
= 77% of weight
loss was FAT loss

44. Pre-TR90 172 -169
Start June 28th
-Oct 28th
4 months, 3 lbs= ¾ lb/mo
Oct 28th
-Jan 28th
3 mo’s, ll lbs = 3.7 lbs / mo =
5 X the wt. loss rate
TR90 – (done
imperfectly) -169-158
Post TR90
158 to 155
Jan 28th
–April 17th
2.75 mo’s, 3lbs
= 1.1 lbs/mo
“What happens after I
finish 3 months of TR-90?”

45. “When you change
the way you look at
things, the things
that you look at
change.”
-John Assaraf

51. Key down-home principles
• Jump start your genes.
• Eliminate the junk. Pitch it. If you don’t have it, you can’t
eat it.
• Develop a taste for [low glycemic] fruit.
• Ostrich jerky (GNC) or balance protein/carb bars
• 30 grams of protein in the a.m. within ½ - 1 hour of
awakening
• Eat real food
• Minimize eating out.
• NO FAST FOOD!! NO FAST FOOD!!
• Axiom: If you’re full of the good stuff, you won’t crave the
bad stuff.

52. Personal collection
Louis B. Cady,
M.D.

53. The Question: What Will You Do
About It?