Bioinformatics & Gene Discovery, Technical University of Denmark, Lyngby, Denmark, June 8, 2007

1. Literature Mining and Systems Biology Lars Juhl Jensen EMBL

2. Why?

34. [ expression_repression_active Btk regulates the IL-2 gene ] [ dephosphorylation_nominal Dephosphorylation of Syk and Btk mediated by SHP-1 ] [ phosphorylation_nominal phosphorylation of Shc by the hematopoietic cell-specific tyrosine kinase Syk ] [ phosphorylation_nominal the phosphorylation of the adapter protein SHC by the Src-related kinase Lyn ] [ phosphorylation_active Lyn also participates in [ phosphorylation the tyrosine phosphorylation and activation of syk ]] [ phosphorylation_active Lyn , [ negation but not Jak2 ] phosphorylated CrkL ] [ phosphorylation_active Lyn , [ negation but not Jak2 ] phosphorylated CrkL ] [ phosphorylation_active Lyn also participates in [ phosphorylation the tyrosine phosphorylation and activation of syk ]] [ phosphorylation_nominal the phosphorylation of the adapter protein SHC by the Src-related kinase Lyn ] [ phosphorylation_nominal phosphorylation of Shc by the hematopoietic cell-specific tyrosine kinase Syk ] [ dephosphorylation_nominal Dephosphorylation of Syk and Btk mediated by SHP-1 ] [ expression_repression_active IL-10 also decreased [ expression mRNA expression of IL-2 and IL18 cytokine receptors] [ expression_repression_active IL-10 also decreased [ expression mRNA expression of IL-2 and IL18 cytokine receptors ] [ expression_activation_passive [ expression IL-13 expression] induced by IL-2 + IL-18 ] [ expression_activation_passive [ expression IL-13 expression ] induced by IL-2 + IL-18 ] [ expression_repression_active Btk regulates the IL-2 gene ]

40. Time

41. Buzzwords

43. Transcriptional networks 32 79 83 3592 Regulates Regulated P < 9  10 -9

44. Signaling pathways 11 27 44 3704 Phosphorylates Phosphorylated P < 2  10 -7

51. RCCs

53. G2D

63. Exercises Lars Juhl Jensen EMBL