This document summarizes a presentation on quantum neuroscience given by Melanie Swan. It discusses how quantum effects may be relevant to neuroscience, outlines various research topics within quantum neuroscience like imaging and protein folding, and describes mathematical approaches like wavefunctions and topological data analysis that are being applied. It also provides background on the levels of organization in the brain from the nervous system down to ion channels, and reviews the current status of the connectome and motor neuron mapping projects in different organisms. Finally, it discusses modeling of neural signaling across scales using techniques like partial differential equations.
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Quantum Information Science and Quantum Neuroscience.ppt
1. American Physical Society
University of New Mexico, 15 Oct 2022
Slides: http://slideshare.net/LaBlogga
Melanie Swan, PhD
Research Associate
University College London
Quantum Information
Neuroscience and Neural Signaling
“…the laws of physics present no barrier to reducing
the size of computers until bits are the size of atoms,
and quantum behavior holds dominant sway”
- Feynman, Foundations of Physics, 1985, p. 530
2. 15 Oct 2022
Quantum Neuroscience 1
Quantum Technologies Research Program
2015 2019 2020
Blockchain Blockchain
Economics
Quantum
Computing
Quantum
Computing
for the Brain
2022
Image: Thomasian, 2021, Nat
Rev Endocrinol. 18:81-95, p. 12
3. 15 Oct 2022
Quantum Neuroscience
Quantum Information
2
Domain Properties Top Five Properties: Quantum Matter and Quantum Computing Definition
Quantum
Matter
Symmetry Looking the same from different points of view (e.g. a face, cube, laws of physics);
symmetry breaking is phase transition
Topology Geometric structure preserved under deformation (bending, stretching, twisting, and
crumpling, but not cutting or gluing); doughnut and coffee cup both have a hole
Quantum
Computing
Superposition An unobserved particle exists in all possible states simultaneously, but once measured,
collapses to just one state (superpositioned data modeling of all possible states)
Entanglement Particles connected such that their states are related, even when separated by distance
(a “tails-up/tails-down” relationship; one particle in one state, other in the other)
Interference Waves reinforcing or canceling each other out (cohering or decohering)
Source: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Matter Overview. J. 5(2):232-254.
Quantum Information: the
information (physical properties)
of the state of a quantum system
Quantum Information: the
information (physical properties)
of the state of a quantum system
Nobel Prize
2022
Nobel Prize 1998
Nobel Prize 2016
2022
“groundbreaking experiments
using entangled quantum
states, where two particles
behave like a single unit even
when they are separated.
Their results have cleared the
way for new technology based
upon quantum information”
Cat
4. 15 Oct 2022
Quantum Neuroscience
What is Quantum?
3
QCD: Quantum Chromodynamics
Subatomic particles
Matter particles: fermions (quarks)
Force particles: bosons (gluons)
Scale Entities Physical Theory
1 1 x101 m Meter Humans Newtonian mechanics
2 1 x10-9 m Nanometer Atoms Quantum mechanics
(nanotechnology)
3 1 x10-12 m Picometer Ions, photons Optics, photonics
4 1 x10-15 m Femtometer Subatomic particles QCD/gauge theories
5 1 x10-35 m Planck scale Planck length Planck scale
Atoms Quantum objects:
atoms, ions,
photons
“Quantum” = anything at the scale of
atomic and subatomic particles (10-9 to 10-15)
Theme: ability to study and manipulate
physical reality at smaller scales
Study phenomena (e.g. neurons) in the native
3D structure of physical reality
5. 15 Oct 2022
Quantum Neuroscience
Quantum Science Fields
4
Source: Swan, M., dos Santos, R.P. & Witte, F. (2020). Quantum Computing: Physics, Blockchains, and Deep Learning Smart
Networks. London: World Scientific.
Quantum Biology
Quantum Neuroscience
Quantum Machine
Learning
€
$
¥
€
Quantum methods complement classical methods to study field-specific problems
Quantum
Cryptography
Quantum Space
Science Quantum Finance
Foundational
Tools
Advanced
Applications
Quantum
Chemistry
6. 15 Oct 2022
Quantum Neuroscience
Quantum Studies in the Academy
5
Digital
Humanities
Arts
Sciences
Quantum
Humanities
computational astronomy,
computational biology
Digital Humanities (literature & painting
analysis, computational philosophy1)
Quantum Humanities
quantum chemistry, quantum finance,
quantum biology, quantum ecology
Apply quantum methods to study field-specific problems e.g. quantum machine learning
Apply data science methods to study field-specific problems e.g. machine learning
Data science institutes now including quantum
What are Digital Humanities / Quantum Humanities?
1. Apply digital/quantum methods to research questions
2. Find digital/quantum examples in field subject matter
(e.g. quantum mechanical formulations in Shakespeare)
3. Open new investigations per digital/quantum conceptualizations
Sources: Miranda, E.R. (2022). Quantum Computing in the Arts and Humanities. London: Springer. Barzen, J. & Leymann, F.
(2020). Quantum Humanities: A First Use Case for Quantum Machine Learning in Media Science. Digitale Welt. 4:102-103.
1Example of computational philosophy: investigate formal axiomatic metaphysics with an automated reasoning environment
Big Data Science
Vermeer imaging (1665-2018)
Textual
analysis
7. 15 Oct 2022
Quantum Neuroscience
3d lattices: group theory not number theory (factoring)
NIST quantum-safe cryptography (Jul 2022) (“Y2k of crypto”)
Based on the difficulty of lattice problems (finding the shortest vector
to an arbitrary point); learning-with-errors and functions over lattices
Quantum key distribution via quantum teleportation (Bell pair
creation, quantum networks with heralded entanglement)
Space: hyperbolic Bloch theorem & hyperbolic space
Flat, negative, positive curvature space
Time: Floquet methods, discrete time crystals
Discrete time-crystalline order (Maskara-Lukin)
Entanglement generation in optical networks
Standard quantum algorithms
VQE, VAE, QAOA, RKHS, quantum amplitude
estimation; QML, QNN, Born machine, quantum walk
6
Quantum Toolkit
VQE: variational quantum eigensolver; VAE: variational autoencoder; QAOA: quantum approximate optimization algorithm;
RKHS (reproducing kernel Hilbert space); QML: quantum machine learning; QNN: quantum neural network
Sources: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Information Science. IEEE Internet Computing. Special Journal
Issue: Quantum and Post-Moore’s Law Computing. January/February 2022. Maskara et al. (2021). arXiv:2102.13160v1.
Hyperbolic band theory
Time-crystalline Eigenstate order
8. 15 Oct 2022
Quantum Neuroscience
Quantum (neuro)biology: application of quantum methods
to investigate problems in (neuro)biology and the possible
role of quantum effects
Brute physical processes & higher-order cognition, memory, attention
Quantum consciousness hypothesis (microtubules)
Research topics
Traditional (~2010)
Avian magneto-navigation,
photosynthesis, energy transfer
Contemporary (Empirical vs Theoretical)
Imaging (EEG, fMRI, etc.)
Protein folding
Genomics
Collective behavior: neural signaling, swarmalator
7
Quantum Biology
Swarmalator: animal aggregations that self-coordinate in time and space
Human data: imaging (brain wave activity); Model organism data: behaving (task-driven spatiotemporal signaling data)
Source: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Neurobiology. Quantum Reports. 4(1):107-127.
Imaging In-cell Targeting
Connectome Parcellation
9. 15 Oct 2022
Quantum Neuroscience 8
Methods
Quantum Neuroscience
Swarmalator: animal aggregations that self-coordinate in time and space (e.g. crickets, fish, birds)
Source: Swan, M. dos Santos, R.P., Lebedev, M.A. and Witte, F. (2022). Quantum Computing for the Brain. London: World
Scientific.
Research Topic Mathematical Physics Approaches
1 Imaging (EEG, fMRI,
MEG, etc.)
Wavefunctions: Fourier transform, Fourier slice theorem & Radon transform; QML (VQE); quantum
tomography image reconstruction (electrical and chemical (Calcium) wave forms)
2 Protein folding Lowest-energy configuration (Hamiltonian), spin glass, quantum spin liquid, Chern-Simons
Ground-state excited-state energy functions, total system energy
Qubit Hamiltonians, VQE
3 Genomics Lowest-energy knotting compaction, Chern-Simons (topological invariance)
Quantum optimization algorithms (Azure); optics; QAOA; AdS/CFT, BH, chaos, TN, MERA, RG
Quantum amplitude estimation: technique used to estimate the properties of random distributions
Collective Behavior
4 Neural Signaling Single-neuron: Hodgkin-Huxley (1963), integrate-and-fire, theta neuron
Local ensemble: FitzHugh-Nagumo, Hindmarsh-Rose, Morris-Lecor
Neural field theory: Jansen-Rit, Wilson-Cowan, Floquet, Kuramoto oscillators, Fokker-Planck equations
Neuroscience Physics: AdS/CFT, Chern-Simons, gauge theory, bifurcation & bistability
5 Swarmalator Swarmalator: phytoplankton (diffusion); krill (Brownian motion, Kuramoto oscillator); whale (clustering)
Recurrent theme: topology (e.g. Chern-Simons)
Solvable QFT curvature min-max = event (fold, mutation, signal)
Quantum topological materials approach entails
Topology: Chern-Simons, knotting, compaction
Topological data analysis: find the (n-dimensional connecting) Betti
numbers of a simplicial complex (Schmidhuber & Lloyd, 2022)
10. 15 Oct 2022
Quantum Neuroscience
Levels of Organization in the Brain
9
Complex behavior spanning nine orders of
magnitude scale tiers
Level Size (decimal) Size (m) Size (m)
1 Nervous system 1 > 1 m 100
2 Subsystem 0.1 10 cm 10-1
3 Neural network 0.01 1 cm 10-2
4 Microcircuit 0.001 1 nm 10-3
5 Neuron 0.000 1 100 μm 10-4
6 Dendritic arbor 0.000 01 10 μm 10-5
7 Synapse 0.000 001 1 μm 10-6
8 Signaling pathway 0.000 000 001 1 nm 10-9
9 Ion channel 0.000 000 000 001 1 pm 10-12
Sources: Sterratt, D., Graham, B., Gillies, A., & Willshaw, D. (2011). Principles of Computational Modelling in Neuroscience.
Cambridge: Cambridge University Press. Ch. 9:226-66. Sejnowski, T.J. (2020). The unreasonable effectiveness of deep
learning in artificial intelligence. Proc Natl Acad Sci. 117(48):30033-38.
Human brain
86 billion neurons, 242 trillion synapses
~10,000 incoming signals to each neuron
Not large numbers in the big data era
11. 15 Oct 2022
Quantum Neuroscience 10
Structure: Connectome Project Status
Fruit Fly completed in 2018
Worm to mouse:
10-million-fold increase in
brain volume
Brain volume: cubic microns
(represented by 1 cm distance)
Quantum computing technology-driven inflection point
needed (as with human genome sequencing in 2001)
1 zettabyte storage capacity per human connectome required
vs 59 zettabytes of total data generated worldwide in 2020
Sources: Abbott, L.F., Bock, D.D., Callaway, E.M. et al. (2020). The Mind of a Mouse. Cell. 182(6):1372-76. Lichtman, J.W., Pfister,
H. & Shavit, N. (2014). The big data challenges of connectomics. Nat Neurosci. 17(11):1448-54. Reinsel, D. (2020). IDC Report:
Worldwide Global DataSphere Forecast, 2020-2024: The COVID-19 Data Bump and the Future of Data Growth (Doc US44797920).
Neurons Synapses Ratio Volume Complete
Worm 302 7,500 25 5 x 104 1992
Fly 100,000 10,000,000 100 5 x 107 2018
Mouse 71,000,000 100,000,000,000 1,408 5 x 1011 NA
Human 86,000,000,000 242,000,000,000,000 2,814 5 x 1014 NA
Connectome: map of synaptic connections
between neurons (wiring diagram), but
structure does not equal function
12. 15 Oct 2022
Quantum Neuroscience
Function: Motor Neuron Mapping Project Status
Multiscalar Neuroscience
11
Source: Cook, S.J. et al. (2019). Whole-animal connectomes of both Caenorhabditis elegans sexes. Nature. (571):63-89.
C. elegans motor neuron mapping (completed 2019)
302 neurons and 7500 synapses (25:1)
Human: 86 bn neurons 242 tn synapses (2800:1)
Functional map of neuronal connections
13. 15 Oct 2022
Quantum Neuroscience
Neural Signaling
Image Credit: Okinawa Institute of Science and Technology
NEURON: Standard computational neuroscience modeling software
Scale Number Size Size (m) NEURON Microscopy
1 Neuron 86 bn 100 μm 10-4 ODE Electron
2 Synapse 242 tn 1 μm 10-6 ODE Electron/Light field
3 Signaling pathway unknown 1 nm 10-9 PDE Light sheet
4 Ion channel unknown 1 pm 10-12 PDE Light sheet
Electrical-Chemical Signaling
Math: PDE (Partial Differential
Equation: multiple unknowns)
Electrical Signaling (Axon)
Math: ODE (Ordinary Differential
Equation: one unknown)
1. Synaptic Integration:
Aggregating thousands of
incoming spikes from
dendrites and other
neurons
2. Electrical-Chemical
Signaling:
Incorporating neuron-glia
interactions at the
molecular scale
12
Implicated in neuropathologies of Alzheimer’s, Parkinson’s, stroke, cancer
Synaptic Integration
Math: PDE (Partial Differential
Equation: multiple unknowns)
14. 15 Oct 2022
Quantum Neuroscience
Neural Signaling Modeling
Example problem: integrate EEG and fMRI data
Different time, space, and dynamics regimes
Epileptic seizure: chaotic dynamics (straightforward)
Resting state: instability-bifurcation dynamics (system
organizing parameter interrupted by countersignal)
Challenging problem: collective behavior
Neural field theories, neural gauge theories
13
Scale Models
1 Single neuron Hodgkin-Huxley, integrate-and-fire, theta neurons
2 Local ensemble FitzHugh-Nagumo, Hindmarsh-Rose, Morris-Lecor
Linear Fokker-Planck equation (FPE) (uncorrelated behavior)
Nonlinear FPE, Fractional FPE (correlated behavior)
3 Population group
(neural mass)
Neural mass models (Jansen-Rit), mean-field (Wilson-Cowan), tractography,
oscillation, network models
4 Whole brain
(neural field theories)
(neural gauge theories)
Neural field models, Kuramoto oscillators, multistability-bifurcation, directed
percolation random graph phase transition, graph-based oscillation, Floquet
theory, Hopf bifurcation, beyond-Turing instability
Sources: Breakspear (2017). Papadopoulos, L., Lynn, C.W., Battaglia, D. & Bassett, D.S. (2020). Relations between large-scale
brain connectivity and effects of regional stimulation depend on collective dynamical state. PLoS Comput Biol. 16(9). Coombes, S.
(2005). Waves, bumps, and patterns in neural field theories. Biol Cybern. 93(2):91-108.
15. 15 Oct 2022
Quantum Neuroscience
Neural Dynamics: Complex Statistics
14
Collective behavior of the brain generates
unrecognized statistical distributions
Neural ensemble: normal distribution (FPE) and
power law distribution (nonlinear FPE, fractional FPE)
Neural mass: Wilson-Cowan, Jansen-Rit, Floquet, ODE
Neural field theory: wavefunction, oscillation, bifurcation, PDE
FPE: Fokker-Planck equation: partial differential equation describing the time evolution of the probability density function of particle
velocity under the influence of drag forces; equivalent to the convection-diffusion equation in Brownian motion
Source: Breakspear, M. (2017). Dynamic models of large-scale brain activity. Nat Neurosci. 20:340-52.
Approach Description Statistical Distribution Neural Dynamics
1 Neural ensemble
models
Small groups of neurons,
uncorrelated states
Normal (Gaussian) Linear Fokker-Planck
equation (FPE)
2 Small groups of neurons,
correlated states
Non-Gaussian but known
(e.g. power law)
Nonlinear FPE, Fractional
FPE
3 Neural mass models Large-scale populations of
interacting neurons
Unrecognized Wilson-Cowan, Jansen-Rit,
Floquet model, Glass
networks, ODE
4 Neural field models
(whole brain)
Entire cortex as a continuous
sheet
Unrecognized Wavefunction, PDE,
Oscillation analysis
16. 15 Oct 2022
Quantum Neuroscience
Biological System of the Neuron
Neuronal Spike Integration
Electrical
Axonal spikes
Dendritic NMDA spikes
Chemical
Dendritic sodium spikes
Dendritic calcium spikes
15
EPSP: excitatory postsynaptic potential (contrast with IPSP: inhibitory postsynaptic potential)
Sources: Williams, S.R. & Atkinson, S.E. (2008). Dendritic Synaptic Integration in Central Neurons. Curr. Biol. 18(22). R1045-R1047.
Poirazi et al. (2022). The impact of Hodgkin–Huxley models on dendritic research. J Physiol. 0.0:1–12.
(a)
(b)
(c)
(a) Dendritic spine receives EPSP
(b) Local spiking activity along dendrite
(c) Aggregate dendritic spikes at axon
Dendritic sodium, NMDA,
calcium spikes (Poirazi)
17. 15 Oct 2022
Quantum Neuroscience
Glutamate (excitatory) and GABA (inhibitory)
Post-synaptic density (PSD) proteins
16
Sources: Sheng, M. & Kim, E. (2011). The Postsynaptic Organization of Synapses. Cold Spring Harb Perspect Biol. 3(a005678):1-
20. Image: presynaptic terminal – post-synaptic density: Shine, J.M., Muller, E.J., Munn, B. et al. (2021). Computational models link
cellular mechanisms of neuromodulation to large-scale neural dynamics. Nat Neuro. 24(6):765-776.
Glutamate (Excitatory) Receptor GABA (Inhibitory) Receptor
Major proteins at Glutaminergic and GABAergic synapses
18. 15 Oct 2022
Quantum Neuroscience
A physical system with a bulk volume can be described
by a boundary theory in one fewer dimensions
A gravity theory (bulk volume) is equivalent to a gauge theory
or a quantum field theory (boundary surface)
AdS5/CFT4 (5d bulk gravity)=(4d Yang-Mills supersymmetry QFT)
AdS/CFT mathematics
Metric (ds=), Operators (O=), Action (S=), Hamiltonian (H=)
AdS/CFT Correspondence (Anti-de Sitter Space/Conformal Field Theory)
17
Sources: Maldacena, J. (1998). The large N limit of superconformal field theories and supergravity. Adv Theor Math Phys.
2:231-52. Harlow, D. (2017). TASI Lectures on the Emergence of Bulk Physics in AdS/CFT. Physics at the Fundamental
Frontier. arXiv:1802.01040.
AdS/CFT Escher Circle Limits Error correction tiling
Implications for
Quantum gravity theories
Black hole information paradox
Quantum error correction
(information scrambling)
Entropy-based short/long-range
(UV–IR) correlations (bulk structure)
Complexity conjecture (two-sided
wormhole, thermofield double)
19. 15 Oct 2022
Quantum Neuroscience
AdS/SYK (Sachdev-Yi-Kitaev) model
Solvable model of strongly interacting fermions
AdS/SYK: black holes and unconventional materials have
similar properties related to mass, temperature, and charge
SYK Hamiltonian (HSYK) finds wavefunctions for 2 or 4 fermions
Or up to 42 in a black-hole-on-a-superconducting-chip formulation
AdS/CFT Duality: Solve in either Direction
18
Sources: Sachdev, S. (2010). Strange metals and the AdS/CFT correspondence. J Stat Mech. 1011(P11022).. Pikulin, D.I. &
Franz, M. (2017). Black hole on a chip: Proposal for a physical realization of the Sachdev-Ye-Kitaev model in a solid-state
system. Physical Review X. 7(031006):1-16.
Direction Domain Known Unknown
1 Boundary-to-bulk Theoretical physics Standard quantum
field theory (boundary)
Quantum gravity (bulk)
2 Bulk-to-boundary
(AdS/SYK)
Condensed matter,
superconducting
Classical gravity (bulk) Unconventional materials
quantum field theory (boundary)
Ψ : Wavefunction
HSYK : SYK Hamiltonian
(Operator to describe evolution
and energy of system)
Bethe-Salpeter equation
20. 15 Oct 2022
Quantum Neuroscience
Problem: non-local correlations driving behavior
Each domain with own spatiotemporal and dynamics regime
Each tier is the boundary for another bulk
AdS/Brain: Multiscalar Correspondence
19
Neuron
Network
AdS/Brain Multi-tier Holographic Correspondence
Synapse
Molecule
Tier Scale Signal AdS/Brain
1 Network 10-2 Local field potential Boundary
2 Neuron 10-4 Action potential Bulk Boundary
3 Synapse 10-6 Dendritic spike Bulk Boundary
4 Molecule 10-10 Ion docking Bulk
Source: Swan, M. dos Santos, R.P., Lebedev, M.A. and Witte, F. (2022). Quantum Computing for the Brain. London: World
Scientific.
21. 15 Oct 2022
Quantum Neuroscience
AdS/Brain bMERA
MERA models
Renormalized entanglement (correlation) across system tiers
20
MERA cMERA dMERA bMERA
Continuous
spacetime MERA
Deep MERA tensor
network on NISQ devices
Multiscalar neural
field theory
Multiscalar entanglement
renormalization network
Vidal, 2007 Nozaki et al., 2012 Kim & Swingle, 2017 Swan et al., 2022
bMERA (brainMERA)
Renormalize system entanglement (correlation) to obtain
neural signaling action across multiple scale layers
Source: Swan, M. dos Santos, R.P., Lebedev, M.A. and Witte, F. (2022). Quantum Computing for the Brain. London: World
Scientific.
MERA tensor network:
alternating layers of
isometries (triangles)
and disentanglers
(squares) (Vidal, 2007)
22. 15 Oct 2022
Quantum Neuroscience
Analogy to food-web ecosystem multiscalar model
AdS/Brain: Multiscalar Correspondence
21
Neuron
Network
AdS/Brain
Synapse
Molecule
Tier Scale Neural Signaling
Event
Swarmalator
Model
Food-web
Ecosystem Event
Math Approach
1 Network 10-2 Local field potential Whale Predation Distribution
2 Neuron 10-4 Action potential Krill Swarm Lagrangian
3 Synapse 10-6 Dendritic spike Phytoplankton Availability Diffusion
4 Molecule 10-10 Ion docking Light gradient Incidence angle Advection
Source: Swan, M. dos Santos, R.P., Lebedev, M.A. and Witte, F. (2022). Quantum Computing for the Brain. London: World
Scientific.
Krill
Whale
AdS/Krill
Phytoplankton
Light gradient
23. 15 Oct 2022
Quantum Neuroscience
Quantum Krill: 4-Tier Ecosystem Model
B. Enhanced
A. Basic
Optical analysis of light
spectrum gradient (Heggerud)
Swarmalator
hydrodynamic: O’Keeffe
(Kuramoto oscillator),
Ghosh (ring), Murphy (jet)
Lotka-Volterra predator-
prey model spiking
neuronal network
excitatory-inhibitory
model (Lagzi)
Statistical distribution (Miller)
2d Lagrangian (Hofmann)
Mathematics Diffusion (Heggerud)
Statistical analysis: 11 krill
swarm characteristics
analyzed in relation to
whale presence-absence
using Boosted regression
trees (BRTs) via a logit
(quantile function) (to
achieve local regularization
and prevent overfitting by
optimizing the number of
trees, learning rate, and
tree complexity
Quantum circuits
Random tensor network
QML: RKHS, QNN,
Quantum walk
VQE, VAE, QAOA, Quantum
amplitude estimation
Example of multiscalar system: light-phytoplankton-krill-whale
similar to neural signaling ion-synapse-neuron-network
Two species non-local
reaction-diffusion-advection
model to consider niche
differentiation via absorption
spectra separation. (rate of
change of) density of
phytoplankton species as
diffusion minus buoyancy
plus absorbed photons
minus death rate
Spatial light attenuation
through vertical water column
Ice
2d spatial Lagrangian
model based on four
random forces acting on
krill individuals:
displacement, response
to food gradients,
nearest neighbor
interaction (attraction or
repulsion), and
predation
VQE: variational quantum eigensolver; VAE: variational autoencoder; QAOA: quantum approximate optimization algorithm;
RKHS (reproducing kernel Hilbert space) (quantum kernel learning), QNN: quantum neural network
Krill swarm density (%) = forces acting on krill whale predation (death rate)
phytoplankton density –
+
light gradient +
24. 15 Oct 2022
Quantum Neuroscience
Conclusion
23
Topological quantum materials: important advance
Chern-Simons, knot theory, Wilson loops (nonlocal
observables) represented as knots (generalize to the Jones
polynomial (a knot invariant)); solve with path integrals
Application to neural modeling
Three-dimensional lattices; multiscalar
Quantum circuit-ready
Topological additions to standard quantum toolkit
3d lattices: group theory not number theory (factoring)
(NIST), hyperbolic space, Floquet discrete time crystals,
quantum algorithms (VQE, VAE, QAOA, quantum amplitude
estimation, RKHS), QML, QNN, Born machine, quantum walk
Image: Shine, J.M., Muller, E.J., Munn, B. et al. (2021). Computational models link cellular mechanisms of neuromodulation to large-
scale neural dynamics. Nat Neuro. 24(6):765-776. Breakspear laboratory.
25. 15 Oct 2022
Quantum Neuroscience
Risks and Limitations
24
Quantum domain is hard to understand
Complex, non-intuitive, alienating
Quantum computing
Early stage and non-starter without technical
advance in error correction (Preskill 2021)
Substantial worldwide investment in
quantum initiatives
Needed for next-generation quantum internet
networks, quantum cryptography
Ability to coordinate next-tier of even larger and
more complex projects
Heidegger, The Question
Concerning Technology
+
-
Source: Preskill, J. (2021). Quantum computing 40 years later. arXiv:2106.10522.
26. American Physical Society
University of New Mexico, 15 Oct 2022
Slides: http://slideshare.net/LaBlogga
Melanie Swan, PhD
Research Associate
University College London
Quantum Information
Neuroscience and Neural Signaling
“…the laws of physics present no barrier to reducing
the size of computers until bits are the size of atoms,
and quantum behavior holds dominant sway”
- Feynman, Foundations of Physics, 1985, p. 530
Thank you!
Questions?
27. 15 Oct 2022
Quantum Neuroscience
Signal Synchrony
Synchrony as a bulk property of the brain
Synaptic signals arrive simultaneously but
travel different distances, so speeds must vary
Seamless coordination of diverse signals
Evidence: axon propagation speeds
Electrophysiological data recorded at multiple
spatial scales
Microscale current sources (produced by local
field potentials at membrane surfaces) modeled
in a macro-columnar structure, integrating
properties related to
Magnitude, distribution, synchrony
26
Source: Nunez, P.L., Srinivasan, R. & Fields, R.D. (2015). EEG functional connectivity, axon delays and white matter disease. Clin
Neurophysiol. 126(1):110-20.
28. 15 Oct 2022
Quantum Neuroscience
Bifurcation
Bifurcation: split; qualitative change in
system output per change in input parameter
Fixed points, periodic orbits, chaotic attractors
Bifurcation diagram
Traditional model for studying neural signaling
Cell membrane voltage changes from at-rest to
oscillatory as a result of a bifurcation
Epilepsy, Parkinson’s disease: threshold-based
oscillatory behavior
Ex: Hopf bifurcation: system critical point (resting-to-
firing state) at which a periodic orbit appears or
disappears due to a local change in stability
27
Source: Ermentraut, B. & Terman, D.H. (2010). Mathematical Foundations of Neuroscience. London: Springer.
www.math.pitt.edu/~bard/xpp/xpp.html
Neural bifurcation modeling
software: XPP-Aut
Traditional model of
(electrical) neuron
Bifurcation (Lagzi 2019)
Stable periodic orbit
interrupted by
negative saddle value
Toroidal limit cycle model
29. 15 Oct 2022
Quantum Neuroscience
Bifurcation: Human Neural States
Critical bistability: brain’s operating at critical phase
transition between disorder and excessive order
Bistability: two stable points within a system
Human brain activity exhibits
Scale-free avalanche dynamics and power-law long-range
temporal correlations (LRTCs) across the nervous system
Bistability and LRTCs positively correlated in study data
Resting state: moderate levels of bistability
Epilepsy: excessive bistability
28
MEG (magnetoencephalography); SEEG (stereo-EEG)
Source: Wang, S.H., Arnulfo, G., Myrov, V. et al. (2022). Critical-like bistable dynamics in the resting-state human brain. bioRxiv
preprint doi: https://doi.org/10.1101/2022.01.09.475554. Breakspear laboratory.
MEG and SEEG cortical
parcellation data correlation with
bistability index (BiS) estimates
30. 15 Oct 2022
Quantum Neuroscience
Bifurcation: Lotka-Volterra Model
Bifurcation math is advancing (neural signaling)
Theoretical model of collective neural dynamics
Mean-field methods
Wilson-Cowan equations: “up-states” and “down-states”
as dynamic neuronal network states reported in striatum
Bifurcation + Lotka-Volterra predator-prey equations
Result: Lotka-Volterra equations provide a meaningful population-level
description of the collective behavior of spiking neuronal interaction
(via Jacobian matrix eigenvalues)
Result: alternative low-dimensional firing rate equation for populations
of interacting spiking neurons with block-random connections
29
Source: Lagzi, F., Atay, F.A. & Rotter, S. (2019). Bifurcation analysis of the dynamics of interacting subnetworks of a spiking
network. Sci Rep. 9:11397.
dx/dt = αx – βxy
dy/dt = δxy – γxy
x: number of prey
y: number of predator
dx/dt; dy/dt: growth rate of population
α, β, δ, γ: parameters of species interaction
Lotka-Volterra predator-prey equations
Firing rate
trajectories in a 3d
state space
corresponding to
spiking network limit
cycles that bifurcate
from a starting
parameter change
31. 15 Oct 2022
Quantum Neuroscience
Bifurcation and Topology
Bifurcation and topological equivalence
Bifurcations of piecewise smooth flows
Define topological equivalence for piecewise smooth
systems based on orbits (not segments)
Map boundaries to boundaries based on switching
(stronger topological equivalence) and sliding (weaker
topological equivalence)
30
Source: Colombo, A., di Bernardo, M., Hogan, S.J. & Jeffrey, M.R. (2012). Bifurcations of piecewise smooth flows: Perspectives,
methodologies and open problems. Physica D.
Dynamics in a piecewise
smooth system
Local analysis of a limit
cycle at a discontinuity
Near a tangency, two regions
with different orbit topologies
Non-deterministic chaos
32. 15 Oct 2022
Quantum Neuroscience
Quantum Bifurcation
Build node and network model from brain atlas data
Canonical Wilson-Cowan neural mass models
31
Source: Coombes, S., Lai, Y.M., Sayli, M. & Thul, R. (2018). Networks of piecewise linear neural mass models. Eur. J. Appl. Math.
29(5):869–90.
Heaviside Wilson-Cowan
ring network (blue circles:
brain network eigenvalues)
Phase plane for a Wilson-Cowan node with a
Heaviside ring rate with stable periodic orbit (blue)
and unstable periodic sliding orbit (dashed magenta)
Replace s-shaped activation with
piecewise (interval-based) function and
Heaviside (nonlinear activation) function
Supersede usual ODEs by defining orbits
and stability as a Floquet (periodic)
network parameterized by matrix
eigenvalues and Glass networks
(biochemical periodic-aperiodic switching)
Result: new ways to study continuous-
discontinuous, linear-nonlinear behavior
in neural spacetime networks
Key message: ability to model more sophisticated
scenarios (e.g. linear and non-linear, continuous
and discrete, smooth and non-smooth)
33. 15 Oct 2022
Quantum Neuroscience
Neural Operators
Neural ODE: NN architecture whose weights are
smooth functions of continuous depth
Input evolved to output with a trainable differential equation,
instead of mapping discrete layers (Chen 2018)
Neural PDE: NN architecture that uses neural
operators to map between infinite-dimensional spaces
Fourier neural operator solves all instances of
PDE family in multiple spatial discretizations
Parameterizing the integral kernel directly in
Fourier space) (Li 2021)
Neural RG: NN renormalization group
Learns the exact holographic mapping between
bulk and boundary partition functions (Hu 2019)
32
Sources: Chen et al. (2018). Neural Ordinary Differential Equations. Adv Neural Info Proc Sys. Red Hook, NY: Curran Associates
Inc. Pp. 6571-83. Li et al. (2021). Fourier neural operator for parametric partial differential equations. arXiv:2010.08895v3. Hu et al.
(2019). Machine Learning Holographic Mapping by Neural Network Renormalization Group. Phys Rev Res. 2(023369).
34. 15 Oct 2022
Quantum Neuroscience
Practical Application
Brain Atlas Annotation and Deep Learning
Machine learning smooths individual variation to
produce standard reference brain atlas
Multiscalar neuron detection
Deep neural network
Whole-brain image processing
Detect neurons labeled with genetic markers in a range
of imaging planes and modalities at cellular scale
33
Source: Iqbal, A., Khan, R. & Karayannis, T. (2019). Developing a brain atlas through deep learning. Nat. Mach. Intell. 1:277-87.
35. 15 Oct 2022
Quantum Neuroscience
Brain Genomics: Cortical Structure
Genome-wide association meta-
analysis of brain fMRI (n = 51,665)
Measurement of cortical surface area
and thickness from MRI
Identification of genomic locations of
genetic variants that influence global
and regional cortical structure
Implicated in cognitive function,
Parkinson’s disease, insomnia,
depression, neuroticism, and
attention deficit hyperactivity
disorder
34
fMRI: functional magnetic resonance imaging. Source: Grasby, K.L., Jahanshad, N., Painter, J.N. et al. (2020). The genetic
architecture of the human cerebral cortex. Science. 367(6484). Posthuma Laboratory.
36. 15 Oct 2022
Quantum Neuroscience
Alzheimer’s Disease
35
Source: Arboleda-Velasquez J.F., Lopera, F. O’Hare, M. et al. (2019). Resistance to autosomal dominant Alzheimer’s in an APOE3-
Christchurch homozygote: a case report. Nat Med. 25(11):1680-83.
Patient case:
Left: Subject with protective Christchurch APOE3R136S
mutation (rs121918393) A not C: heavy Aβ plaque burden
(top), but limited tau tangles (bottom), and no early onset
Alzheimer’s disease
Right: Control case with Paisa mutation Presenilin 1
(rs63750231): low Aβ plaque burden (top), substantial tau
tangles (bottom), and early-onset Alzheimer’s
Implication: CRISPR-based genetic cut-paste study
Plaques (top red): No
Early-onset Alzheimer’s
Tangles (bottom red):
Early-onset Alzheimer’s
Contra indicating
plaques and
tangles
37. 15 Oct 2022
Quantum Neuroscience
Alzheimer’s Disease Proteome
Cluster analysis of protein changes
1,532 proteins changed more than 20% in Alzheimer’s disease
Upregulation: immune response and cellular signaling pathways
Downregulation: synaptic function pathways including long term
potentiation, glutamate signaling, and calcium signaling
36
“Omics” Field Focus Definition Completion
1 Genome Genes All genetic material of an organism Human, 2001
2 Connectome Neurons All neural connections in the brain Fruit fly, 2018
3 Synaptome Synapses All synapses in the brain and their proteins Mouse, 2020
Hotspot Clustering Analysis
Sources: Hesse et al. (2019). Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the
APOE genotype. Acta Neuropath. Comm. 7(214). Minehart et al. (2021). Developmental Connectomics of Targeted Microcircuits.
Front Synaptic Neuroscience. 12(615059).
39. 15 Oct 2022
Quantum Neuroscience
Chern-Simons theory
Chern-Simons theory: solvable 3d
topological field theory (quantum field theory)
Wilson loops (nonlocal observables) represented as
knots (generalize to the Jones polynomial (an
important knot invariant))
If coarse-grained Wilson loops go to one: sufficient
condition certification of topological order (Maskara-Lukin)
Solve with path integrals
Provide a physical interpretation of the invariants
Give an account of the Hilbert space structure
Example of the AdS/CFT correspondence
Chern-Simons theory = AdS3
Chern-Simons theory on a 3-manifold is equivalent to
a 2D CFT on a Riemann surface (AdS3/CFT2)
38
Sources: Grabovsky, S. (2022). Chern-Simons Theory in a Knotshell. Witten, E. (1989). Quantum Field Theory and the Jones
Polynomial. Commun. Math. Phys. 121:351-399. IMAGE: van Raamsdonk, M. (2015). Gravity and Entanglement.
http://pirsa.org/15020086.
40. 15 Oct 2022
Quantum Neuroscience
Chern-Simons Genomics
39
QFT: quantum field theory
Source: Capozziello, S., Pincak, R., Kanjamapornkul, K. & Saridakis, E.N. (2018). The Chern-Simons current in systems of DNA-
RNA transcriptions. Annalen der Physik. 530(4): 1700271.
Chern-Simons (topological invariance)
Easy-to-assess min-max curvature formulation
Interpretation: DNA mutation, folded protein
QFT w Wilson loop observables solved as knots
Chern-Simons current (superfluid hydrodynamics)
Dynamical system evolution in a complex plane
Change seen as loops in the space (Wilson loops:
measurable quantum mechanical observables)
Sheaf cohomology (Grothendieck topology)
Algebraic topology: geometric structure as subsets of
open sets on a space (covering sieves; sheaf of rings)
Wide bio application: DNA, RNA, protein folding
Cancer, drug development, disease prevention
Access non-coding regions via
retrotransposon entanglement
state of the loop space in the
Hopf fibration (3d model of 4d)
41. 15 Oct 2022
Quantum Neuroscience
Chern-Simons Genomics
40
Source: Capozziello, S., Pincak, R., Kanjamapornkul, K. & Saridakis, E.N. (2018). The Chern-Simons current in systems of DNA-
RNA transcriptions. Annalen der Physik. 530(4): 1700271.
Problem: predict virus-host
genetic evolution
Traditional method: Bayesian probability
New method: high-d mathematical physics
Problem-solving intuition
DNA is chiral
Employ right/left-handed symmetry models
Genetic code is 4d: spatial-temporal
movement of bases
Suggests wavefunction (particle physics)
System evolution in a complex plane
Tensor networks: solvable models
Classical and quantum computing-ready
Virus docks with host cell
Wilson loop evolution of
Cd4 gene and V3 loop as
twistor exchange
42. 15 Oct 2022
Quantum Neuroscience
Chern-Simons Genomics
41
Transposon: sequence that can be transposed
Source: Capozziello, S., Pincak, R., Kanjamapornkul, K. & Saridakis, E.N. (2018). The Chern-Simons current in systems of DNA-
RNA transcriptions. Annalen der Physik. 530(4): 1700271.
Virus-host genetic evolution
Virus docks with host, inserts or
deletes code swatches into the host
genome, host responds
Model host response
Loops introduced to DNA environment
superspace (complex space)
DNA code represented as fields
(energy-based state transition)
Energy states of the coding and non-
coding fields (DNA as field)
Focus of sheaf cohomology
(Grothendieck topology) model
Field-based viral
replication cycle (8 states)
Chern-Simons current and
Wilson loop over DNA (red dot:
knot model of DNA projection)
43. 15 Oct 2022
Quantum Neuroscience
Chern-Simons Genomics
42
Source: Capozziello, S., Pincak, R., Kanjamapornkul, K. & Saridakis, E.N. (2018). The Chern-Simons current in systems of DNA-
RNA transcriptions. Annalen der Physik. 530(4): 1700271.
Result: predict time series code
evolution
Chern-Simons current (superfluid)
transition states
Unoriented knot, twistor states
Knot: high-d polynomial
Twistor: mapping of 4d space to 4d+
complex space
Output: time series data (DNA code)
Plotted with Chern-Simons algebra in a
complex plane
Entanglement states modeled by Hopf
fibration (3d model of 4d) over the loop
space in the spinor field of time series DNA
Hopf fibration with S3 group
action on genetic code space
45. 15 Oct 2022
Quantum Neuroscience 44
Quantum Chemistry (= Molecular QM)
Quantum Chemistry: branch of physical chemistry
applying quantum mechanics to chemical systems
Solve classically-intractable chemistry problems
High temperature superconductivity, solid-state/condensed matter
physics, transition metal catalysis, new compound discovery
Biochemical reactions, molecular dynamics, protein folding
Short-term Objectives
Computational solutions to Schrödinger equation (approximate)
Increase size of molecules that can be studied
Sources: Krenn et al. (2020).Self-referencing embedded strings (SELFIES): A 100% robust molecular string representation. Machine
.Learning: Sci. Tech. 1(4):045024; Kmiecik et al. (2020). Coarse-Grained Protein Models and their Applications. Chem. Rev.
116:7898−7936.
46. 15 Oct 2022
Quantum Neuroscience
Quantum Chemistry
New Materials Found for Electric Batteries
Unsupervised machine learning
method identifies new battery
materials for electric vehicles
Four candidates out of 300
VAE (variational autoencoder to
compress, analyze, re-encode
high-dimensional data) used to
rank chemical combinations
Quaternary phase fields containing two
anions (e.g. lithium solid electrolytes)
Discovery of Li3.3SnS3.3Cl0.7
45
Source: Vasylenko, A., Gamon, J., Duff, B.D. et al. (2021). Element selection for crystalline inorganic solid discovery guided by
unsupervised machine learning of experimentally explored chemistry. Nature Communications. 12:5561.
Ranking of Synthetic Exploration
Probe structure of Li3SnS3Cl predicted
coupled anion and cation order
VAE Analyzes High-Dimensional Data
47. 15 Oct 2022
Quantum Neuroscience
Digital Fabrication Methods
Autonomous Robotic Nanofabrication
Use single molecules to
produce supramolecular
structures
Control single molecules with
the machine learning agent-
based manipulation of scanning
probe microscope actuators
Use reinforcement learning (goal-
directed updating) to remove
molecules autonomously from the
structure with a scanning probe
microscope
46
Source: Leinen, P., Esders, M., Schutt, K.T. et al. (2020). Autonomous robotic nanofabrication with reinforcement learning. Sci. Adv.
6:eabb6987.
Subtractive manufacturing with machine
learning: molecules bind to the scanning
microscope tip; bond formation and breaking
increases or decreases the tunneling
current; new molecules are retained in the
monolayer by a network of hydrogen bonds
48. 15 Oct 2022
Quantum Neuroscience
Atomically-Precise Manufacturing
Single atoms positioned to create macroscopic objects
Applications: molecular electronics, nanomedicine, integrated
circuits, thin films, etch masks, renewable energy materials
47
STM: scanning tunneling microscope; SPM: scanning probe microscope
Source: Randall, J.N. (2021). ZyVector: STM Control System for Atomically Precise Lithography. Zyvex Labs.
https://www.zyvexlabs.com/apm/products/zyvector
Atomically-Precise Writing (Deposition) with an STM
1. Outline the structure of the design
2. Specify crystal lattice vector layout
3. Write (deposit) atoms with the STM tip
4. Finalize atomically-precise pattern
ZyVector: STM Control System
for Atomically Precise
Lithography (Zyvex Labs)
49. 15 Oct 2022
Quantum Neuroscience
Molecular Electronics: Quantum Circuit Design
Molecular circuits for quantum computing, construct
One-qubit gates using one-electron scattering in molecules
Two-qubit controlled-phase gates using electron-electron
scattering along metallic leads
48
Source: Jensen, P.W.K., Kristensen, L.B., Lavigne, C. & Aspuru-Guzik, A. (2022). Toward Quantum Computing with Molecular
Electronics. Journal of Chemical Theory and Computation.
Electron transmission magnitude as
a function of incoming kinetic
energy for molecular hydrogen in
the 6-31G basis attached between
one input and two output leads
Electron transmission through molecular hydrogen in
STO-3G basis (the planes intersecting through the
two orbitals indicate the integration limits)
50. 15 Oct 2022
Quantum Neuroscience
Quantum Chemistry
System Setup: Quantum Algorithms
Qubit Hamiltonians
Quantum algorithm: express Hamiltonian as qubit operator
Retain fermionic exchange symmetries
Describe fermionic states in terms of qubit states
Perform transformations using fermionic-to-qubit mappings (e.g.
Jordan-Wigner transformation)
Excitation gates as Givens rotations
Main tool: Variational Quantum Eigensolver (VQE)
Algorithm to compute approximate system energies
Optimize the parameters of a
quantum circuit with respect to
the expectation value of a
molecular Hamiltonian
(minimizing a cost function)
49
Source: Arrazola, J.M., Jahangiri, S., Delgado, A. et al. (2021). Differentiable quantum computational chemistry with PennyLane.
arXiv:2111.09967v2
51. 15 Oct 2022
Quantum Neuroscience
Quantum Chemistry
Ground and Excited-state Energies
Ground state energy (GSE)
Compute Hamiltonian expectation values
Convert the system Hamiltonian to a sparse matrix
Use the vector representation of the state to compute the expectation value
using matrix vector multiplication
Calculate expectation values by performing single-qubit rotations
Pauli expressions are tensor products of local qubit operators
Manage complexity by grouping Pauli expressions into sets of mutually-
commuting operators (calculate EV from the same measurement statistics)
Excited state energy (ESE)
Compute excited-state energies: add penalty terms to cost function
The lowest-energy eigenstate of the penalized system is the first
excited state of the original system
Iterate to find k-th excited state by adjusting penalty parameters
50
Source: Arrazola, J.M., Jahangiri, S., Delgado, A. et al. (2021). Differentiable quantum computational chemistry with PennyLane.
arXiv:2111.09967v2
GSE: Minimize cost function C(θ) = 〈Ψ(θ)|H |Ψ(θ)〉
Exp Value 〈H〉 = 〈 Ψ | H | Ψ 〉
ESE: Minimize cost function C(1)(θ) = 〈Ψ(θ)|H(1) |Ψ(θ)〉
Exp Value H(1) = H + β |Ψ0 > <Ψ0|
Qubit Rotation
52. 15 Oct 2022
Quantum Neuroscience
Quantum Chemistry
Total System Energy
Study total energy gradients with energy
derivatives
Nuclear forces and geometry optimization
Force experienced each nuclei is given by the
gradient of the total energy with respect to the
nuclear coordinates (Hellman-Feynman
theorem)
Vibrational normal modes and frequencies in
the harmonic approximation
Compute Hessians and vibrational modes
with expressions for higher-order energy
derivatives
51
Sources: Arrazola, J.M., Jahangiri, S., Delgado, A. et al. (2021). Differentiable quantum computational chemistry with PennyLane.
arXiv:2111.09967v2; McArdle, S., Endo, S., Aspuru-Guzik, A. et al. (2020). Quantum computational chemistry. Reviews of Modern
Physics. 92(1):015003.
Fermion to qubit mapping
for Lithium Hydride (LiH)
54. 15 Oct 2022
Quantum Neuroscience
Krill Swarm: 4-tier Food-web Ecosystem
Largest known animal aggregation
30,000 individuals per square meter
Global impact
Aggregate biomass: 500 million tons worldwide
Food source for whales, seals, penguins, squid, fish, birds
Distribution: dispersed patches to dense swarms (Southern Ocean)
Remove 39 mn tons carbon from the surface ocean each year (Belcher 2020)
Krill morphology and activity
Zooplankton invertebrates weighing 2 grams (0.07 oz), ~5 cm long
Eat phytoplankton (microscopic suspended plants) and under-ice algae
Spend the day at depth, rise to ocean surface at night (traveling hundreds of meters)
10-year lifespan if avoiding predation
Can survive up to 200 days without food (body shrinks but not eyes)
Reproduction: lay 10,000 eggs at a time, several times per Jan-Mar spawning season
Eggs laid near surface, sink over a 10-day period before hatching
53
Source: BAS British Antarctic Survey: Tarling et al. (2018). Varying depth and swarm dimensions of open-ocean Antarctic krill
Euphausia superba Dana, 1850 (Euphausiacea) over diel cycles. Journal of Crustacean Biology. 38(6):716–727. Belcher-Tarling
(2020). Why krill swarms are important to the global climate. Frontiers for Young Minds. 8(518995):1–8.
Krill swarm
55. 15 Oct 2022
Quantum Neuroscience
Quantum Krill Ecosystem Model
B. Enhanced
A. Basic
Optical analysis of light
spectrum gradient (Heggerud)
Swarmalator
hydrodynamic: O’Keeffe
(Kuramoto oscillator),
Ghosh (ring), Murphy (jet)
Lotka-Volterra predator-
prey model spiking
neuronal network
excitatory-inhibitory
model (Lagzi)
Statistical distribution (Miller)
2d Lagrangian (Hofmann)
Mathematics Diffusion (Heggerud)
Statistical analysis: 11 krill
swarm characteristics
analyzed in relation to
whale presence-absence
using Boosted regression
trees (BRTs) via a logit
(quantile function) (to
achieve local regularization
and prevent overfitting by
optimizing the number of
trees, learning rate, and
tree complexity
Quantum circuits
Random tensor network
QML: RKHS, QNN,
Quantum walk
VQE, VAE, QAOA, Quantum
amplitude estimation
Example of multiscalar system: phytoplankton-
krill-whale parallel to synapse-neuron-network
Two species non-local
reaction-diffusion-advection
model to consider niche
differentiation via absorption
spectra separation. (rate of
change of) density of
phytoplankton species as
diffusion minus buoyancy
plus absorbed photons
minus death rate
Spatial light attenuation
through vertical water column
Ice
2d spatial Lagrangian
model based on four
random forces acting on
krill individuals:
displacement, response
to food gradients,
nearest neighbor
interaction (attraction or
repulsion), and
predation
VQE: variational quantum eigensolver; VAE: variational autoencoder ; QAOA i: quantum approximate optimization algorithm; QAOA
ii: quantum alternating operator ansatz (guess); RKHS (reproducing kernel Hilbert space) (quantum kernel learning), QNN: quantum
neural network
Krill swarm density (%) = forces acting on krill whale predation (death rate)
phytoplankton density –
+
56. 15 Oct 2022
Quantum Neuroscience 55
Ice
Phytoplankton
Whales
Krill swarm
Krill distribution
Whale distribution
Phytoplankton distribution
Multiscalar System: 4-tier Food-web Ecosystem
Southern Ocean: Phytoplankton – Krill Swarm – Whale
Primary factors: light, nutrients
Secondary factors: temperature
Primary factors: daylight (solar elevation,
radiation), proximity to Antarctic continental slope
Secondary factors: current velocities & gradients
Primary factors: foraging availability,
distance to neighbors
Secondary factors: predation, light,
physiological stimuli, reproduction
HSO = f (P1, K1, W1,
s,
)
∂s
∂P1
∂s
∂K1
∂s
∂W1
, ,
f (P, K, W, s) + g (P, K, W, s) + h (P, K, W, s) = i (P, K, W, s)
∂s
∂W
∂s
∂K
∂s
∂P
Mathematical Model by Ecosystem Tier
Phytoplankton: Reaction-diffusion-advection per light
spectrum differentiation, coupled plankton-oxygen dynamics,
fluid dynamics and Brownian motion (Heggerud, 2021)
Krill swarm: Lagrangian (Brownian motion, spatial distribution)
(Hofmann, 2004); hydrodynamic signal per drafting within
front neighbor propulsion jet (Murphy, 2019); Kuramoto
oscillator for time and space synchrony (O’Keeffe, 2022)
Krill-whale relation: hotspot clustering, statistical field theory
(Miller, 2019)
Light Spectrum Differentiation
57. 15 Oct 2022
Quantum Neuroscience
Phytoplankton: Diffusion (Heggerud)
56
∂tu1 = D1∂xu1 – α1∂xu1 + [g1 (γ1 (x,t)) – d1(x)]u1
∂tu2 = D2∂xu2 – α2∂xu2 + [g2 (γ2 (x,t)) – d2(x)]u2
D1, D2 > 0 Turbulence diffusion coefficients
Sinking/buoyancy coefficients (constants)
α1, α2 ϵ ℝ
γ1 (x,t) Number of absorbed photons
Death rate of the species at depth x and maximum L
d1(x) ϵ C [0,L]
γ1 (x,t) = a1(λ) k1(λ) I(λ, x)dλ
ʃ
u1 (x, t)
x Vertical depth in the water column
Density of phytoplankton species1,2 (depth x, time t)
(rate of change of) Density of Phytoplankton species =
Diffusion – Buoyancy + (Absorbed Photons – Death Rate)
D1u1 = D2u2
Source: Heggerud, C.M., Lam, K.-Y. & Wang, H. (2021). Niche differentiation in the light spectrum promotes coexistence of
phytoplankton species: a spatial modelling approach. arXiv:2109.02634v1.
Absorption spectra
k1(λ)
Action spectrum (proportion of absorbed photons used for photosynthesis)
a1(λ)
I(λ, x)dλ Incident light spectrum (wavelength intensity) of sunlight entering water column (Lambert-Beer’s Law)
Growth rate of species as a function of absorbed photons
g1 (γ1 (x,t))
Ice
2
2
No outcompeting species in the basic model
Enhanced model: attenuation of light through
the vertical water column, spatially explicit
diffusivity of phytoplankton and potential for
system buoyancy regulation (advection)
58. 15 Oct 2022
Quantum Neuroscience
Krill: 2d Lagrangian (Forces) (Hofmann)
57
*Enhanced model: additional variable (equation not included)
Source: Hofmann, E.E., Haskell, A.G.E., Klinck, J.M. & Lascara, C.M. (2004). Lagrangian modelling studies of Antarctic krill
(Euphausia superba) swarm formation. ICES Journal of Marine Science. 61:617e631.
____
β
D
dXi =
dt
X, Y Two horizontal spatial dimensions
dYi
dt
=
____ Krill swarm formation factors:
D: Random displacement
F: Response to food gradients
N: Nearest neighbor interaction
attraction-repulsion
P: Predation
Vf (food,t) Foraging speed
Direction coefficient
local
P = P0(1-e-γρ )
ρ swarm density*
ρlocal < ρtarget
ρlocal < ρrepulsive
ρtarget < ρlocal < ρrepulsive
Diffusion motion
F Foraging motion
N Neighbor-induced motion
α Foraging angle
mFA Minimum turning angle
λFR Increased turning due to food
γ Predation rate constant
P Predation rate
λ Random turning modifier*
Lagrangian model to simulate Antarctic krill swarm formation
κ Neighbor response coefficient
ζ
δ Turning potential*
Sensing distance*
Turning threshold*
Ψ
59. 15 Oct 2022
Quantum Neuroscience
Order, Disorder, Chaos
Order (arrangement), disorder (confusion), chaos
(self-organization: confusion gives way to order)
Flocking: 3D orientation vis-à-vis 5-10 neighbors
Swarmalators: self-synchronization in time and space
Krill self-position in propulsion jet of nearest front neighbor (draft) as
a hydrodynamic communication channel that structures the school
(via metachronal stimulation of individual krill pleopods (~fins))
58
Source: Murphy et al. (2019). The Three-Dimensional Spatial Structure of Antarctic Krill Schools in the Laboratory. Scientific
Reports. 9(381):1-12.
Krill swarm: 30,000 individuals per square meter
Flocking: 3D orientation vis-a-vis 5-10 nearest neighbors
Black holes, quasi-
particles, quantum
spin liquids,
schooling, flocking,
swarming
Hydrodynamic jet orientation
vis-à-vis nearest neighbor
61. 15 Oct 2022
Quantum Neuroscience
Topological Quantum Materials
2016 Nobel Prize
Theoretical discoveries of topological phase transitions and
topological phases of matter (materials, condensed matter physics)
Topological quantum materials: novel matter phases at zero-temperature
described by topology (global invariants) vs symmetry breaking (local)
60
Source: Schine, N.A., Chalupnik, M., Can, T. & Gromov, A. (2019). Measuring Electromagnetic and Gravitational Responses of
Photonic Landau Levels. Nature. 565(7738).
Semimetals and
quantum spin liquids
Symmetry (classical materials)
Looks the same from
different points of view
Phase transition due to
local symmetry breaking
Topology (quantum materials)
Global properties preserved
despite local deformation
Bending, stretching, twisting
Phase transition not
described by Landau
symmetry
breaking
62. 15 Oct 2022
Quantum Neuroscience
Topological Quantum Materials
61
Source: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Matter Overview. J. 5(2):232-254.
Short-range protected materials
Local topology/symmetry protection, entanglement not relevant
Topological insulators
Superconductors
Semimetals
Long-range entangled materials
Entanglement as central non-local ordering parameter to
describe interactions and correlations, symmetry not relevant
Fractional quantum Hall states
Quantum spin liquids
Entanglement entropy
Quantum Matter: novel matter
phases at zero-temperature
63. 15 Oct 2022
Quantum Neuroscience 62
Source: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Matter Overview. J. 5(2):232-254.
Bulk wavefunctions lead to surface states
Energy band theory (allowed energy tiers)
Classification: insulator, semiconductor, semimetal, metal
Floquet engineering: band reshaping
Topological insulators
Materials with a conducting surface and an insulating interior
Symmetry-protected surface states (time-reversal, particle-hole, chiral symmetry)
Superconductors
Materials that conduct electricity without resistance (heat)
Semimetals
Materials with tunable surface states due to overlapping region
between conduction and valence bands
Adjust material thickness, defects (doping), state degeneracy
Short-range Protected Materials
64. 15 Oct 2022
Quantum Neuroscience
Semimetals
Dirac semimetals
Arc-like surface states: complex bulk-
boundary relation between surface
Fermi arcs and bulk Dirac points
Require time-reversal and crystal
lattice (rotation or reflection) symmetry
Weyl semimetals
Arc-like surface states: 1d Fermi arcs
from bulk 3d Weyl points
Require translation symmetry
Nodal-line semimetals
Energy band-touching manifolds at 1d
nodal lines or rings in the bulk
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Dirac/Weyl and Nodal-line Semimetals
Source: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Matter Overview. J. 5(2):232-254.
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Topological Quantum Materials
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Source: Swan, M., dos Santos, R.P. & Witte, F. (2022). Quantum Matter Overview. J. 5(2):232-254.
Short-range protected materials
Local topology/symmetry protection, entanglement not relevant
Topological insulators
Superconductors
Semimetals
Long-range entangled materials
Entanglement as central non-local ordering parameter to
describe interactions and correlations, symmetry not relevant
Fractional quantum Hall states
Quantum spin liquids
Entanglement entropy
Quantum Matter: novel matter
phases at zero-temperature
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Fractional Quantum Hall Effect
1998 Nobel prize:
The discovery of a new form of
quantum fluid with fractionally charged excitations
Hall effect: voltage difference by applying a magnetic
field to a current of electrons in a thin conducting strip
The Lorentz force perpendicular to the current causes a
build-up of charge on the edge of the strip that induces a
voltage across the width of the strip (Edwin Hall 1879)
Fractional quantum Hall effect: quantized
plateaus at fractional values of charge
Gives rise to quasiparticles (collective states)
in which electrons bind magnetic flux lines to
make new quasiparticles that have a fractional
charge and obey anyonic statistics
65
Source: Liu, C.-X., Zhang, S.-C. & Qi, X.-L. (2015). The quantum anomalous Hall effect: Theory and experiment. Ann. Rev. Cond.
Matt. Phys. 7:301–321.
Fractional Quantum Hall Effect (FQHE)
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Quantum Spin Liquid and Magnetics
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Spin `“glass” by analogy to window glass with irregular atomic bond structure vs uniform crystal lattice bonds
Source: Carleo, G. & Troyer, M. (2017). Solving the Quantum Many-Body Problem with Artificial Neural Networks. Science.
355(6325):602-26.
Classical Quantum
Ferromagnet
Magnetic spins aligned in the
same direction (ordered)
Antiferromagnet
Magnetic spins aligned in
opposite directions (ordered)
Spin glass
Magnetic spins not aligned in
a regular pattern (disordered)
Quantum spin glass
Spin glass phase transition at
zero-temperature per quantum
(not thermal) fluctuations
Ising model
Statistical mechanical model
of phase transition studying
ferromagnetism as lattice-
based spins
Ising (basic)
Heisenberg (extensive)
Spin Glass ->
Quantum Spin Liquid
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Quantum Spin Liquid (QSL)
Quantum spin liquid: novel phase in
condensed matter physics in which strong
quantum fluctuations prevent long-range
magnetic order from being established
Electron spins do not form an ordered pattern but
remain liquid-like even at absolute zero temperature
Exotic properties
Long-range entanglement
Fractional (anyon) excitations
Topological order
Use: quantum communication and computation
Matter phase of quantum spins interacting in magnetic
materials, manipulable quasi-disordered ground state
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Quantum spin liquid:
electron spins (blue
arrows) show no long-
range ordering even at
low temperatures
Source: Wen, J., Yu, S.-L., Li, S. et al. (2019). Experimental identification of quantum spin liquids. npj Quantum Materials.
4:12.
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Quantum Spin Liquids
Natural and Synthesized
Herbertsmithite
Mineral with quantum spin liquid
magnetic properties
Magnetic particles with constantly
fluctuating scattered orientations
on a regular kagome (triangle-
hexagon) lattice
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Made in the Lab
Kitaev honeycomb (2015)
Superconducting circuit (2021)
Optical atom array (2021)
2021 result
Engineering the topological
order known as the toric code
Archetypical 2d lattice model
that exhibits the exotic
properties of topologically
ordered states
Proposed for quantum error
correction
Sources: Satzinger et al. (2021). Realizing topologically ordered states on a quantum processor. Science. 374(6572):1237–1241.
Semeghini et al. (2021). Probing topological spin liquids on a programmable quantum simulator. Science. 374(6572):1242–1247.
ZnCu3(OH)6Cl2
Zinc, Copper, Oxygen, Hydrogen, Chlorine
Chile, Arizona, Iran, Greece
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Topological Entanglement Entropy
Topology-based measure of entanglement entropy
Problem: the phases on each side of a quantum critical point
have different topological order
Need a non-local parameter to distinguish phases
Use long-range entanglement entropy
Computation methods
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Entanglement: Quantum property
of correlated physical attributes
among particles (position,
momentum, spin, polarization)
Entropy: number of possible
system microarrangements
Entanglement Entropy: measure of
quantum correlations in a many-
body system
Source: Kitaev, A. & Preskill, J. (2006). Topological entanglement entropy. Phys Rev Lett. 96(110404).
1. Take the logarithm of the total quantum
dimension of the quasiparticle
excitations of the many-body state
2. Compare the von Neumann entropy
between a spatial block and the rest of
the system
Using tripartite information (information
measure of two time, one space dimensions)
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Multiscalar renormalization scheme (tensor networks)
Flow from boundary surface (UV) to bulk (IR) and back up to
boundary to discover hidden correlations in both
AdS/MERA
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MERA: Multiscale Entanglement Renormalization Ansatz (guess)
Source: Vidal, G. (2007). Entanglement renormalization. Phys Rev Lett. 99(220405).
Boundary
Bulk
Boundary
Vidal, 2007
Swingle, 2012
McMahon, 2020
Vidal, 2007
Renormalization: physical system viewed at different scales
Tensor network: mathematical tool for the efficient representation
of quantum states (high-dimensional data in the form of tensors);
tensor networks factor a high-order tensor (a tensor with a large
number of indices) into a set of low-order tensors whose indices
can be summed (contracted) in the form of a network