On our way to redesign healthcare, we will learn to combine different layers of our biological code (now in reading but soon in writing mode), data from visible and invisible sensors, and the connected Internet of Bodies/Things. These guardian angels will open up unseen opportunities for the way we deal with ourselves in health and disease. With DNA soon becoming the new software, combining biology, electronics, attractive design & smart communication will provide the tools to (bio)hack our lives. Appropriate use of different (nano)technologies will convert us into health consumers, with our doctors as (virtual) coaches. This will move us away from current curative healthcare to precise, preventive and even augmented healthcare. But smart technologies and the data they generate, are just a tool. When not trusted by the established care provider, when not integrated and available in a personal data platform, healthcare will only be pseudo modernized. The real magic happens when these tools allow you to engage and change behaviour. But even in a rapidly automating world, we can’t automate such change. Or can we?

1. Redesigning healthcare,
biohacking our lives
Prof. Dr. Koen Kas
@kaskoen
IMEC ITF2014
June 5, 2014

2. The Chinese paid their doctor to remain healthy
As soon as they got sick, they no longer had to pay

3. Redesigning healthcare like reinventing the wheel
WaterWheel, Cynthia Koenig
Bill Gates was a hacker
Unix Hacks ended up being MS DOS

4. While the term “hacker” has had inappropriately negative connotation, “hacking” simply
means challenging seemingly entrenched problems by testing innovative concepts
and ideas through the rapid building and testing of inchoate and low-cost prototypes.
Though, “hacking” has its origins in software development, this approach is now
being applied to tackle a range of social issues from education, climate to
governance. And soon from healthcare.
Technology alone cannot necessarily deliver change. However, well-designed, user-
informed digital tools can influence individual behaviour and disrupt traditional
cultural norms by making information more accessible, systems more transparent,
and ultimately by giving a voice to more people.
“Biohacking" is a techno-progressive cultural and intellectual movement which
advocates for open access to genetic information and defends the potential of truly
democratic technological development. It can also refer to managing one's own
biology using a combination of medical, nutritional and electronic techniques.
Wikipedia

5. Current healthcare system has expired
100 € spend on
healthcare,
1 € goes to
prevention
90 € to last 2
years of our lives

6. An aging agenda
ALARMclock, fig
Calico

7. Chronic disease epidemics
INTERFERE today
Odra Noel
Projected rise
chronic diseases
2003-2023

8. “Doctors pour drugs of which they know little,
to cure diseases of which they know less,
into patients of whom they know nothing”
“There is nothing wrong with his heart,
hence it should be the liver”
Moliere,
French author (1622-1673)

9. a chronic patient
looks after himself
Biomarkers
Internet of bodies / things
(In)visible sensors
Guardian angels to the rescue

10. Age of genomic medicine: predisposed ? - No problem
First Warning systems
3.000.000.000 commodity

11. Personal genomics’ Napster moment ?
De-risk conception

12. Personalised medicine litigation
Why we need on the spot tumor detection - liquid biopsies
Wagle et al.
J. Clin Oncol, 2011

13. INanoBioGenapsys
The era of Personal genome analysers
Medic

14. Age of self monitoring: Wearables - Dermals - Insideables
Quantifying smartphones, watches, tricorders, … stickies

15. Higi
The quantified citizen / patient: get your stats, easy entry
Healthspot
Self-service sexual health express clinic, SoHo, London
Be Well Point
MD Revolution

16. The dash
Empowerment of citizen - local @home, sports club, car
June bracelet CarePredict
Hapifork
Lumo
Qardio

17. The smartphone (/watch/glass/lens) physician
AliveCor ECG
iExamine,
Welch Allyn
iBGStar Blood Glucose Meter Qardio
Sensimed
Cardiosleeve, Rijuven
BasisVital Connect

18. Sensors in clothing
First Warning systems Athos
Reebok
OM Signal
LifeVest
LECHAL

19. Mobisante
Baby, baby
Bellabeat
Sproutling
Owlet
3D Babies

20. MC10
Temporary tattoos - Stick-on skin circuits
Rogers & Huang, Northwestern

21. FDA approved colonoscopy
(powering) Submarines, stickies & cyborgs
Implantable piezoelectric nanoribbon

22. Gerijoy pet therapy
Communication pending dehydration
Son et al., Nature Nanotech 2014
Vittel

23. Dawn of "personal logging“ era
Samsung/IMEC Simband / SAMI
To succeed, hardware needs software to make it sing
Apple

24. The cloud gets a brain
A trusted 1st or 2nd opinion
Doctors prescribing Apps
WellDoc

25. Social, connected & transparent healthcare
Digital epidemiology & growing patient awareness
D
Kinsa

26. Telehealth by image, facial, voice recognition
PEEK

27. RealView Imaging
VirtualWare
New imaging modalities - Virtual exercising
DevMotion

28. Sitting is the new smoking …
Walkstation, Steelcase Moscow trainstation
Paofit

29. Moves (Facebook)
Argus
Healthcare becomes
attractive, fun, engaging

30. RaceYourself
Motivational games –
Digital meets physical

31. Flappy Bird
->Tappy Fit
FitBit
If my doctor prescribes a stepcounter –
or a walk in the park

32. Automating behavior: IFTTT & virtual coaches
BaseHealth OptimizeMe

33. Betting on therapy adherence
Proteus Digital Health
GlowCaps (Vitality)
Mango Health

34. From measuring brainwaves to electroceuticals
Emotiv EPOC FOC.US

35. Gaming fear & anxiety away - Communicating your mood
Sensoree
Neurowear

36. Training brain patterns of empathy using brain imaging
J. Moll, PlosOne, 2014
Affective brain-computer interfaces

37. Bionic ear: cohlear implant delivers gene therapy
Shepherd & Wise, Univ. Melbourne
Osteoid Medical Cast
Ultrasound bone fracture healing

38. Argus II, Second Sight
Human computer interfaces
Titan arm DekaEkso bionic suit

39. DNA is the new software/memory: 1 g DNA = 700 terabytes
Rothemund, Nature, 2006

40. Using CAD software, building 3D DNA structures & easily
synthesizing them,…
Based on TED talk Ido Bachelet, Nano-Center
Bar Ilan University, Israel (May 17, 2013)
Project Cyborg, Autodesk

41. … to DNA nanorobots (OFF state) … to ON state
Shells loaded with cargo (drug
molecules, proteins,…) Ido Bachelet

42. Nanobots behave like groups of animals
Ido Bachelet

43. Merging bio & digital: nanobots controlable via internet
i.e. via my doctors smartphoneIdo Bachelet

44. BITalino
DIY & Biohacker (maker) spaces
Glowing Plant
e-Health Sensor Shield

45. Biohacking allows return to the original roots of healthcare *
* Modified from a quote by R. Bethencourt, Berkeley BioLabs
Some self-funded amateurs
“I think the biggest
innovations of the
21st century will be
at the intersection
of biology and
technology. A new
era is beginning.”

46. 4 DIMENSiOn AL redesigned future of healthcare
DI gital
M obile
EN gaging
S ocial
integrated Omics-based
quantified
A ttractive
L ocal
Predictive, Personalised/Precise, Participatory, Preventive
Not about being
sick, but about
you staying well
& healthy
La Sienta Sudios

47. Contact
Prof. Dr. Koen Kas
E koen.kas@inbioveritas.com
W http://inbioveritas.com/
L be.linkedin.com/in/koenkas
T @kaskoen
S koenkas