1. Gigantism
Table 4
Kevin Knox, Kaley
Miller, Hailey Ray, Ashley
Spaulding

2. Symptoms
• Pretty big people (usually two
standard deviations above
normal height should be)
• Delayed puberty
• Double vision or difficulty
with side vision

3. • Headaches
• Increased sweating
• Irregular periods (females)
• Large hands and feet with
large fingers and toes

4. • Release of breast milk
• Thickening of facial
features
• Weakness
• Bulging forehead

5. Causes
• ***Excess of growth
hormone ***(Acromegaly)
• Most commonly:
Noncancerous(adenoma)
tumor of the pituitary gland
• Carney complex

6. Possible solutions
• Medications that
reduce growth
hormone release
such as somatostain
analogs
• Dopamine aganoists
but they are the
least effective

7. Radiation
therapy can be
used to bring the
growth hormone
level back to
normal but it
take 5 to 10 years
to take full effect
and often effects
other pituitary
hormones

8. • Removal of tumor on pituitary through
endonasal surgery (through nose)

9. Exams and Tests
• CT or MRI scans
• Failure to suppress serum growth hormone
(GH) levels after an oral glucose challenge
(maximum 75g)
• High prolactin levels
• Increased insulin growth factor-I (IGF-I) levels

10. Miscellaneous
• Female to male ratio of 1:2 (twice as common in
males)
• Commonly occurs with Acromegaly
• App