Cramer's Rule can be used to solve systems of linear equations. For a 3x3 system, it involves calculating the determinants of the coefficient matrix (D) and matrices where one column is replaced by the constants vector (Dx, Dy, Dz). The solutions are then given by x=Dx/D, y=Dy/D, z=Dz/D. As an example, Cramer's Rule is used to solve the 3x3 system 2x-y+3z=-3, -x-y+3z=-6, -2y-z=-2, finding the solutions to be x=1, y=2, z=-1.