Hosame Gcc09 Retreat 15min 100209

RING-EXPANDED NUCLEOSIDES (RENS) AS ANTITUMOR AGENTS ,[object Object],[object Object],[object Object],U M B C

It All Started with the Observed Antiviral Activity of RENS! ,[object Object],U M B C ,[object Object],[object Object]

RENs are also Potent Inhibitors of HIV Replication U M B C

What Is The Mechanism of HIV Inhibition by RENS? ,[object Object],[object Object],[object Object],[object Object],U M B C

RENs NZ-46 & NZ-51 Both Inhibit Human RNA Helicase DDX3 U M B C

DDX3 Belongs to the Family of Human RNA Helicases (HRHs) ,[object Object],[object Object],[object Object],[object Object],U M B C

Relationship Between DDX3 and Cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],U M B C

DDX3 Levels in Patient Samples

Molecular Structiure of Human RNA Helicase DDX3 U M B C ,[object Object],[object Object],[object Object],[object Object]

Molecular Modeling: Energy-Minimized Structure of DDX3 Complexed with NZ-51 U M B C

A Close-Up View (5 Å Radius from Ligand) of DDX3:NZ-51 Complex U M B C

Effect of NZ51 on Normal Immortalized Breast Cell Lines U M B C

Effect of NZ51 on Breast Cancer Cell Lines U M B C

NZ51 Induces Cell Death Under Hypoxic Condition U M B C

NZ51 Decreases Tumor Growth in vivo U M B C

Effect of NZ51 on Normal Immortalized Lung Cell Line and Lung Cancer Cell Lines U M B C

Effect of NZ51 on Leukemia Cell Lines U M B C

ACKNOWLEDGMENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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