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and Chronic Stress Alter Brain Function
Course # 830
Contact Hours: 5 Hours
Authors: Meredith Patterson, RN, BSN, CRRN
Shelda L. Hudson, RN, BSN, PHN
Course Material valid through 05/2016

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The Brain on Stress

Page 1
Table of Contents
About The Author ........................................3
........................................3
...............................3
Introduction ..................................................3
....................3
...............................4
...............................4
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..............................9

E

xtraordinary efforts have been made by the authors, the editor and the publisher of the National Center of
Continuing Education, Inc. courses to ensure dosage recommendations and treatments are precise and agree
with the highest standards of practice. However, as a result of accumulating clinical experience and continuing laboratory studies, dosage schedules and/or treatment recommendations are often altered or discontinued. In all cases the advice of a physician should be sought and followed concerning initiating or discontinuing
all medications or treatments. The planner(s), author(s) and/or editor(s) of each course have attested to no conflict
of interest nor bias on the subject. The National Center of Continuing Education, Inc. does not accept commercial
support on any course nor do they endorse any products that may be mentioned in the course. Any off-label use for
medications mentioned in a course is identified as such.
No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by
any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the
publisher.

Page 2

The Brain on Stress
About the Author

Stress

Meredith Patterson, RN, BSN, CRRN

Concepts

Introduction

Purpose and Goals

the care of the patient

Instructional

alarm reaction

The Brain on Stress

Page 3
In the resistance stage

World
exhaustive stage

and tear.

Historical Stress

Acute stress

Episodic acute stress

(See Figure 1)

Page 4

The Brain on Stress
Holmes-Rahe Social Readjustment Rating Scale
1.
2.
3.
4.
5.
6.
7.
9.
10.
11.
12.
14.
15.

17.
18.
19.

20.
21.
22.
23.

Life Event
Life Event

Mean Value
Mean Value

Death of spouse......................................... 100
Divorce ........................................................ 73
Marital separation from mate ................... 65
Detention in jail or other institution ......... 63
Death of a close family member................. 63
Major personal injury or illness................. 53
Marriage ..................................................... 50
..................................... 47
Marital reconciliation with mate ............... 45
Retirement from work ................................ 45
Major change in health or behavior
of a family member ...................................... 44
Pregnancy ................................................... 40
....................................... 39
Gaining a new family member through
birth, adoption, older child moving in ....... 39
Major business readjustment (merger,
bankruptcy)................................................. 39
................ 38
Death of a close friend ................................ 37
Changing to a different line of work.......... 36
Major change in the number of arguments
with spouse (regarding child-rearing,
personal habits) .......................................... 35
Taking out a mortgage or loan for a major
purchase (e.g., home, business, etc.) ......... 31
Foreclosure on a mortgage or a loan ......... 30
Major change in responsibilities at work
(promotion, demotion, lateral transfer)..... 29
Son or daughter leaving home
(marriage, college) ...................................... 29

around the corner and tend to predict

24. Trouble with in-laws .................................. 29
25. Outstanding personal achievement........... 28
26. Spouse beginning or ceasing work outside
the home...................................................... 26
27. Beginning or ceasing formal schooling ...... 26
28. Major change in living conditions ............. 25
29. Revision of personal habits
(dress, manners) ......................................... 24
30. Trouble with the boss ................................. 23
31. Major change in working hours
or conditions................................................ 20
32. Change in residence ................................... 20
33. Changing to a new school........................... 20
34. Major change in type and/or amount
of recreation ................................................ 19
35. Major change in church activities ............ 19
36. Major change in social activities
(dancing, movies) ....................................... 18
37. Taking out a mortgage or loan for a lesser
purchase (car, TV, freezer) ......................... 17
38. Major change in sleeping habits ................ 16
39. Major change in number of family get
togethers .................................................... 15
40. Major change in eating habits .................. 15
41. Vacation ...................................................... 13
42. Christmas ................................................... 12
disturbing the peace) .................................. 11
TOTALS ......................................................... 1466
Adapted From: Holmes, T. H., and Rahe, R. H. (1967). The Social
Readjustment Rating Scale. Journal of Psychosomatic Research,
11, 213-218.

Figure 1

Post-traumatic stress disorder (PTSD)

Chronic stress

The Brain on Stress

Page 5
Decision-Making

Stress Triggers: A

Work Stressors
Other Stress Factors

Awfulizing

The Feedback Loop
How the Brain and the

Some ways to avoid “Awfulizing”

Social Stressors
Disease Stressors

Page 6

The Brain on Stress
Blood pressure

Respiration--

Slowing of digestion

Increased Release of Red Blood Cells

The conversion of glycogen to glucose

The brain releases endogenous
opiates--

The Brain on Stress

Stress and Disease

The Brain on Stress

Page 7
Learning

Page 8

The Brain on Stress
The Emotional Life of Your Brain

a Relaxation Response

Exercise and Stress
Can Meditation Help?

The Brain on Stress

Page 9
with Sleep
Get Your ZZZZ’s

Spark: The Revolutionary
New Science of Exercise and the Brain,

Page 10

The Brain on Stress
Stage 1
Stage 2

L-Theanine
regular. Stages 3 and 4

5-HTP

ing, caffeine, alcohol, and tobacco. Caf

Nutrition and the
Brain

The Brain on Stress

Page 11
Ashwagandha

Out Thinking the Stress

blood urea nitrogen and lactic acid in

Melatonin

Exercise

Venting to Others

Incognito,

Page 12

The Brain on Stress
Nurses
in life

Helping the Stressed
Patient
Start with a Thorough
or pain

Skin

General

Diarrhea

The Brain on Stress

Page 13
Exploring Stress
Issues and Dispelling

Stress is the same for everyone: Stress
is different for everyone

Benson, H. 1976. Steps to Elicit
the Relaxation Response.
From The Relaxation Response. HarperTorch, p162163.

or out of control, or experience

Birdsall T., 5-Hydroxytroptophan: a clinically-effective serotonin precursor. Altern Med
Rev. 1998 Aug.:3(4)271-80.
Bremner, J. Douglas, Does Stress
Damage the Brain?, WH Norton
and Co., 2002, p73-76)

Stress is always bad. According to

Stress is everywhere so nothing can
be done about it

Bremner, J. Douglas “Stressing the Hippocampus: Why it
Matters”,
,
January 8. 2008,
Carter, S. Why Sleep Should be
on the Top of Your To-Do List,
Psychology Today, May 27,
2011.

The most popular ways of treating
stress are the best ones

CNN.com/2009-03-20, Economy
and Finances Survey, September 6, 2011

If I don’t have symptoms, I don’t
have stress.

Davidson, Richard J., The
Emotional Life of Your Brain,
March 2012, p150-152; 204205.

Only major symptoms of stress require attention.

Devi, G. A Calm Brain: Unlocking Your Natural Relaxation
System, Penguin Group, 2012,
p45-47.

Working with
Patients to Help
Manage Stress
Where to Start?

Dimpfel W. Kler A. Krisel E. Lahnfeld R. Keplinger-Dimpfel I.
Source density analysis of the
human EEG after ingestion of
a drink containing decaffeinated extract of green tea enriched
with L-theanine and theogallin. Nutr Neurosci . 2007 JunAug.; 10(3-4); 169-80)
Doidge, N. “ The Brain that
Changes Itself, Penguin
Books, 2007, p.241
Eagleman, D. Incognito: the
Secret Lives of the Brain, 2011,
Pantheon Books, pg. 145.

Page 14

The Brain on Stress
Gutkenchtl., J, Strobel A, et
al. Tryptophan hydroxylase-2
personality traits and disorders related to emotional
dysregulation, Int J Neuropsychopharmacol 2007 June:
10(3) 309-20)
Heese T. Jensinson, J.Love
C, et al. anxiolytic effects of
L-theanine when combined
with midazolam in the male
Sprague-Dawley rat. AANA J.,
2009 Dec.;77(6); 445-9.
Hippocampus Functions, October
12, 2012, Medical News.Net
www.news-medical.net/health/
Hippocampus-Functions.aspx)
Holmes, Thomas H and Rahe,
Richard H., “The Social
Readjustment Rating Scale”,
Journal of Psychosomatic
Research, Volume 11, Issue 2,
August 1967, pages 213-218,
1967, Elsevier Science Inc.
Kaplan, J., Manuck, S., Clarkson,
T., Lusso, F. & Taub, D.(1982).
Social status, environment and
atherosclerosis in cynomolgus
monkeys. Arteriosclerosis 2,
359-368.
Keane & Davidson. Clinician-Administered PTSD Scale (CAPS)
- National Center for PTSDwww.ptsd.va.gov/professional/
pages/assessments/caps.asp
Kennedy D., Wake G, Savelev
S. et al. Modulation of mood
and cognitive performance
following acute administration of single doses of Melissa
human CNS nicotinic and
muscarinic receptor binding
properties. Neuropsychoparmacology. 2003 Oct; 28(10);
1871-81.

Kirby,E., Friedman, A., Covarrubias, D., Ying, C. Sun,
W.,Goosens, K., Sapolsky, R.
Kaufer, D. Basolateral amygdala
regulation of adult hippocampal
neurogenesis and fear-related
activation of newborn neurons
(June 14, 2011 AOP Molecular
Psychiatry)
Kimura K. Ozeki M. Juneja L.,
Ohira H. Theanine reduces
psychological and physiological
stress responses. Biol Psychol.
2007 Jan; 74 (1); 39-45).

NIH Publication No.06-3440-c
Brain Basics: Understanding
Sleep www.ninds.nih.gov/disorMay 21, 2007
Peck, J., etal. Cognitive effects of
exogenous melatonin administration in elderly persons:
a pilot study. Am J Geriatri
Psychiatry, 2004:12: 432-436.
Ratey, J.,M.D. Spark: The
Revolutionary New Science of
Exercise and the Brain, Little,
Brown and Company, 2008,
pg. 91; 123-124

Medina, J.“Brain Rules” , Pear
Press, 2008, pp 178-180.
Miu A, Heilman R, Miclea M.
Reduced heart rate variability and vagal tone in anxiety;
trate versus state , and the
effects of autogenic training
Autunom Neruosci: Basic Clin.
2009; 145; 99-103)
Mohan, A, Sharma, R, Bijlani, M
“Effect of Meditation on StressInduced Changes in Cognitive
Functions, The Journal of Alternative and Complementary
Medicine, Vol 17, No. 3, 200, pp.
207-212.
Nader, K., Kriegler, J., Blake,
D, Pynoos, R.S., Newman,
E., & Weathers, F.W. (1996).
Clinician Administered PTSD
Scale, Child and Adolescent
Version. White River Junction,
VT: National Center for PTSD
Nader, K. Assessing traumatic
experiences in children and
adolescents: Self-reports of
DSM-PTSD Criteria B-D
symptoms. In J. Wilson & T.
Keane (Eds.), Assessing psychological trauma and PTSD,
2nd ed. (pp. 513-537). New
York: Guilford Press. (2004).

Sandler, M., Clow, A., Watkins,
P. J. and Fibiol, V. G. Tribulin — an endocoid marker for
anxiety in man. (1988), Stress
Med., 4: 215–219. doi: 10.1002/
smi.2460040406
Sapolski, Robert Why Don’t
Zebras Get Ulcers, Henry Holt
and Company, 2004, pg. 16.
Science Daily, More Years to Life
and Life to Years Through
Increased Motivation for
an Active Life, Nov 3, 2011.
www.sciencedaily.com/releases/2011/11/111101171042.htm)
Singh et al, Afr J Tradit Complement Altern Med. (2011) 8
(S): 208-213. An Overview on
Ashwagandha, a Rasayana
Rejuvenator of Ayurveda).
Stankus, Tony, The Amygdala’s
Role In Learning, Memory,
Social Intelligence, Criminal
Behavior, Mood Disorders And
Especially The Retention of
Traumatic Memories In Adult
PTSD, FSLA, Sept. 9, 2009.
Stress in America, American Psychological Association, 2011 report www.apa.
org/news/press/releases/
stress/2011/impact.asp

National Sleep Foundation, 2007,
Sleep in America Poll, http://
www.sleepfoundation.org/sites/
ings%20-%20FINAL.pdf

The Brain on Stress

Page 15

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Brain on Stress

  • 1. and Chronic Stress Alter Brain Function Course # 830 Contact Hours: 5 Hours Authors: Meredith Patterson, RN, BSN, CRRN Shelda L. Hudson, RN, BSN, PHN Course Material valid through 05/2016 Copyright © 2013 W.S. Keefer All rights reserved Published by the National Center of Continuing Education, Inc., Lakeway, Texas. Printed in the United States of America. We are proud to be a BBB Accredor exceed the Better Business Bu- E L S © Enhanced Learning & Skills... No Exams, Just Learning! Testing Mandatory For Florida & Electrologists Only Visit www.bbb.org A NATIONAL EPIDEMIC WE ALL KNOW . . . . . . that U.S. Copyright Law grants to the copyright owner the exclusive right to duplicate copyrighted, printed and recorded materials. Piracy involves the illegal duplication of copyrighted materials. YOU MAY NOT KNOW . . . . . . that every time you use or make an illegal copy of cassettes or printed material in any form or by any method you may be subject to litigation. involved in illegal duplication. . . . that the penalty for criminal violation is up to tough new law. (Title 17, U.S. Code, Section 506, and Title 18, U.S. Code Section 2319). . . . that civil or criminal litigation may be costly and embarrassing to any organization or individual. We request you contact us immediately regarding illegal duplication of these copyrighted, printed materials. The National Center of Continuing Education will pay a substantial reward for information leading to the conviction of any individual or institution making any unauthorized duplication of material copyrighted by W.S. Keefer or The National Center of Continuing Education. The Brain on Stress Page 1
  • 2. Table of Contents About The Author ........................................3 ........................................3 ...............................3 Introduction ..................................................3 ....................3 ...............................4 ...............................4 .............................................4 ............................................5 ........6 ...............................6 ......................................6 .....................................6 .......................................6 ..................................6 ...................................6 ..........6 .....................................6 ..............6 ........................................7 ......................................7 ............7 ..........8 .......................8 ...........................................9 ............................9 ......................................................... ...................................................... ....................................................... ............................................. .......................................... ..................................................... ......................................... ............................................... ............................................ .............................................. ........................................... .................................................. ................................. ................................... .............................. .............................. ........................................................ .......................... .............................................. ..................................................... .................................................... ..............................9 E xtraordinary efforts have been made by the authors, the editor and the publisher of the National Center of Continuing Education, Inc. courses to ensure dosage recommendations and treatments are precise and agree with the highest standards of practice. However, as a result of accumulating clinical experience and continuing laboratory studies, dosage schedules and/or treatment recommendations are often altered or discontinued. In all cases the advice of a physician should be sought and followed concerning initiating or discontinuing all medications or treatments. The planner(s), author(s) and/or editor(s) of each course have attested to no conflict of interest nor bias on the subject. The National Center of Continuing Education, Inc. does not accept commercial support on any course nor do they endorse any products that may be mentioned in the course. Any off-label use for medications mentioned in a course is identified as such. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher. Page 2 The Brain on Stress
  • 3. About the Author Stress Meredith Patterson, RN, BSN, CRRN Concepts Introduction Purpose and Goals the care of the patient Instructional alarm reaction The Brain on Stress Page 3
  • 4. In the resistance stage World exhaustive stage and tear. Historical Stress Acute stress Episodic acute stress (See Figure 1) Page 4 The Brain on Stress
  • 5. Holmes-Rahe Social Readjustment Rating Scale 1. 2. 3. 4. 5. 6. 7. 9. 10. 11. 12. 14. 15. 17. 18. 19. 20. 21. 22. 23. Life Event Life Event Mean Value Mean Value Death of spouse......................................... 100 Divorce ........................................................ 73 Marital separation from mate ................... 65 Detention in jail or other institution ......... 63 Death of a close family member................. 63 Major personal injury or illness................. 53 Marriage ..................................................... 50 ..................................... 47 Marital reconciliation with mate ............... 45 Retirement from work ................................ 45 Major change in health or behavior of a family member ...................................... 44 Pregnancy ................................................... 40 ....................................... 39 Gaining a new family member through birth, adoption, older child moving in ....... 39 Major business readjustment (merger, bankruptcy)................................................. 39 ................ 38 Death of a close friend ................................ 37 Changing to a different line of work.......... 36 Major change in the number of arguments with spouse (regarding child-rearing, personal habits) .......................................... 35 Taking out a mortgage or loan for a major purchase (e.g., home, business, etc.) ......... 31 Foreclosure on a mortgage or a loan ......... 30 Major change in responsibilities at work (promotion, demotion, lateral transfer)..... 29 Son or daughter leaving home (marriage, college) ...................................... 29 around the corner and tend to predict 24. Trouble with in-laws .................................. 29 25. Outstanding personal achievement........... 28 26. Spouse beginning or ceasing work outside the home...................................................... 26 27. Beginning or ceasing formal schooling ...... 26 28. Major change in living conditions ............. 25 29. Revision of personal habits (dress, manners) ......................................... 24 30. Trouble with the boss ................................. 23 31. Major change in working hours or conditions................................................ 20 32. Change in residence ................................... 20 33. Changing to a new school........................... 20 34. Major change in type and/or amount of recreation ................................................ 19 35. Major change in church activities ............ 19 36. Major change in social activities (dancing, movies) ....................................... 18 37. Taking out a mortgage or loan for a lesser purchase (car, TV, freezer) ......................... 17 38. Major change in sleeping habits ................ 16 39. Major change in number of family get togethers .................................................... 15 40. Major change in eating habits .................. 15 41. Vacation ...................................................... 13 42. Christmas ................................................... 12 disturbing the peace) .................................. 11 TOTALS ......................................................... 1466 Adapted From: Holmes, T. H., and Rahe, R. H. (1967). The Social Readjustment Rating Scale. Journal of Psychosomatic Research, 11, 213-218. Figure 1 Post-traumatic stress disorder (PTSD) Chronic stress The Brain on Stress Page 5
  • 6. Decision-Making Stress Triggers: A Work Stressors Other Stress Factors Awfulizing The Feedback Loop How the Brain and the Some ways to avoid “Awfulizing” Social Stressors Disease Stressors Page 6 The Brain on Stress
  • 7. Blood pressure Respiration-- Slowing of digestion Increased Release of Red Blood Cells The conversion of glycogen to glucose The brain releases endogenous opiates-- The Brain on Stress Stress and Disease The Brain on Stress Page 7
  • 9. The Emotional Life of Your Brain a Relaxation Response Exercise and Stress Can Meditation Help? The Brain on Stress Page 9
  • 10. with Sleep Get Your ZZZZ’s Spark: The Revolutionary New Science of Exercise and the Brain, Page 10 The Brain on Stress
  • 11. Stage 1 Stage 2 L-Theanine regular. Stages 3 and 4 5-HTP ing, caffeine, alcohol, and tobacco. Caf Nutrition and the Brain The Brain on Stress Page 11
  • 12. Ashwagandha Out Thinking the Stress blood urea nitrogen and lactic acid in Melatonin Exercise Venting to Others Incognito, Page 12 The Brain on Stress
  • 13. Nurses in life Helping the Stressed Patient Start with a Thorough or pain Skin General Diarrhea The Brain on Stress Page 13
  • 14. Exploring Stress Issues and Dispelling Stress is the same for everyone: Stress is different for everyone Benson, H. 1976. Steps to Elicit the Relaxation Response. From The Relaxation Response. HarperTorch, p162163. or out of control, or experience Birdsall T., 5-Hydroxytroptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug.:3(4)271-80. Bremner, J. Douglas, Does Stress Damage the Brain?, WH Norton and Co., 2002, p73-76) Stress is always bad. According to Stress is everywhere so nothing can be done about it Bremner, J. Douglas “Stressing the Hippocampus: Why it Matters”, , January 8. 2008, Carter, S. Why Sleep Should be on the Top of Your To-Do List, Psychology Today, May 27, 2011. The most popular ways of treating stress are the best ones CNN.com/2009-03-20, Economy and Finances Survey, September 6, 2011 If I don’t have symptoms, I don’t have stress. Davidson, Richard J., The Emotional Life of Your Brain, March 2012, p150-152; 204205. Only major symptoms of stress require attention. Devi, G. A Calm Brain: Unlocking Your Natural Relaxation System, Penguin Group, 2012, p45-47. Working with Patients to Help Manage Stress Where to Start? Dimpfel W. Kler A. Krisel E. Lahnfeld R. Keplinger-Dimpfel I. Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin. Nutr Neurosci . 2007 JunAug.; 10(3-4); 169-80) Doidge, N. “ The Brain that Changes Itself, Penguin Books, 2007, p.241 Eagleman, D. Incognito: the Secret Lives of the Brain, 2011, Pantheon Books, pg. 145. Page 14 The Brain on Stress
  • 15. Gutkenchtl., J, Strobel A, et al. Tryptophan hydroxylase-2 personality traits and disorders related to emotional dysregulation, Int J Neuropsychopharmacol 2007 June: 10(3) 309-20) Heese T. Jensinson, J.Love C, et al. anxiolytic effects of L-theanine when combined with midazolam in the male Sprague-Dawley rat. AANA J., 2009 Dec.;77(6); 445-9. Hippocampus Functions, October 12, 2012, Medical News.Net www.news-medical.net/health/ Hippocampus-Functions.aspx) Holmes, Thomas H and Rahe, Richard H., “The Social Readjustment Rating Scale”, Journal of Psychosomatic Research, Volume 11, Issue 2, August 1967, pages 213-218, 1967, Elsevier Science Inc. Kaplan, J., Manuck, S., Clarkson, T., Lusso, F. & Taub, D.(1982). Social status, environment and atherosclerosis in cynomolgus monkeys. Arteriosclerosis 2, 359-368. Keane & Davidson. Clinician-Administered PTSD Scale (CAPS) - National Center for PTSDwww.ptsd.va.gov/professional/ pages/assessments/caps.asp Kennedy D., Wake G, Savelev S. et al. Modulation of mood and cognitive performance following acute administration of single doses of Melissa human CNS nicotinic and muscarinic receptor binding properties. Neuropsychoparmacology. 2003 Oct; 28(10); 1871-81. Kirby,E., Friedman, A., Covarrubias, D., Ying, C. Sun, W.,Goosens, K., Sapolsky, R. Kaufer, D. Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons (June 14, 2011 AOP Molecular Psychiatry) Kimura K. Ozeki M. Juneja L., Ohira H. Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan; 74 (1); 39-45). NIH Publication No.06-3440-c Brain Basics: Understanding Sleep www.ninds.nih.gov/disorMay 21, 2007 Peck, J., etal. Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study. Am J Geriatri Psychiatry, 2004:12: 432-436. Ratey, J.,M.D. Spark: The Revolutionary New Science of Exercise and the Brain, Little, Brown and Company, 2008, pg. 91; 123-124 Medina, J.“Brain Rules” , Pear Press, 2008, pp 178-180. Miu A, Heilman R, Miclea M. Reduced heart rate variability and vagal tone in anxiety; trate versus state , and the effects of autogenic training Autunom Neruosci: Basic Clin. 2009; 145; 99-103) Mohan, A, Sharma, R, Bijlani, M “Effect of Meditation on StressInduced Changes in Cognitive Functions, The Journal of Alternative and Complementary Medicine, Vol 17, No. 3, 200, pp. 207-212. Nader, K., Kriegler, J., Blake, D, Pynoos, R.S., Newman, E., & Weathers, F.W. (1996). Clinician Administered PTSD Scale, Child and Adolescent Version. White River Junction, VT: National Center for PTSD Nader, K. Assessing traumatic experiences in children and adolescents: Self-reports of DSM-PTSD Criteria B-D symptoms. In J. Wilson & T. Keane (Eds.), Assessing psychological trauma and PTSD, 2nd ed. (pp. 513-537). New York: Guilford Press. (2004). Sandler, M., Clow, A., Watkins, P. J. and Fibiol, V. G. Tribulin — an endocoid marker for anxiety in man. (1988), Stress Med., 4: 215–219. doi: 10.1002/ smi.2460040406 Sapolski, Robert Why Don’t Zebras Get Ulcers, Henry Holt and Company, 2004, pg. 16. Science Daily, More Years to Life and Life to Years Through Increased Motivation for an Active Life, Nov 3, 2011. www.sciencedaily.com/releases/2011/11/111101171042.htm) Singh et al, Afr J Tradit Complement Altern Med. (2011) 8 (S): 208-213. An Overview on Ashwagandha, a Rasayana Rejuvenator of Ayurveda). Stankus, Tony, The Amygdala’s Role In Learning, Memory, Social Intelligence, Criminal Behavior, Mood Disorders And Especially The Retention of Traumatic Memories In Adult PTSD, FSLA, Sept. 9, 2009. Stress in America, American Psychological Association, 2011 report www.apa. org/news/press/releases/ stress/2011/impact.asp National Sleep Foundation, 2007, Sleep in America Poll, http:// www.sleepfoundation.org/sites/ ings%20-%20FINAL.pdf The Brain on Stress Page 15