1. lispro = Eli Lilly ---- Humalog
åíäåßîåéò
aspart = Novo Nordisk ---- NovoLog/NovoRapid
ìç êêñéóç éíóïõëßíçò
glulisine = Sanofi-Aventis ---- Apidra áíôßóôáóç óôçí éíóïõëßíç
üëïé ìå ÓÄ É
ÓÄ ÉÉ : as theirbeta cell function declines
NPH = Eli Lilly ---- Humulin N, Novolin N,Novolin NPH, NPH Lletin II, over time
and isophane insulin
óå êÜèå ô ï / çëéêßá :
glargine = Sanofi-Aventis ---- Lantus
o áíåî ãçôç á ÿëåéá âÜñïõò
detemir = Novo Nordisk ---- Levemir o a short history with severe symptoms
ÍPL = neutral protamine lispro o êåôïíïõñßá
NPH, NPL, DETEMIR, GLARGINE : 1 ÷2 / 24ùñï ãéá êÜëõøç óôéò åñéüäïõò Diabetic ketoacidosis = ÓÄ É
íçóôåßáò êáé ñïò á ïôñï ç áôéêç ò ãëõêïíåïã íåóçò
åîáßñåóç some patients with type 2
diabetes, especially in the Afro-Caribbean
populations (so-called "Flatbush
regular, lispro, aspart, glulisine : ñïãåõìáôéê ÷ïñ ãçóç diabetes]
conventional insulin therapy = intensive insulin therapy = Insulin is absorbed :
regular and NPH insulin, mixed ÷1, ÷2 ì óçò ìáêñÜò äñáóçò o fastest from the abdominal wall,
together in the o slowest from the leg and buttock, and
same syringe and given in fixed + ôá÷åßáò ñéí á ü ôá ãå ìáôá
amounts before breakfast and dinner o at an intermediate rate from the arm
at any of these sites, the rapidity of insulin
absorption
Premeal regular or rapid-acting insulin should be rapidly absorbed, and injection into
the abdominal wall may therefore be preferable. varies inversely with subcutaneous fat
thickness
On the other hand, slower absorption from the leg or buttock may be desirable with the
pre-evening meal dose of intermediate-acting insulin to ensure a duration of action that
lastsí through the night.