19. Non-Langerhans cell histiocytosis in KD Figure 3:The dermis reveals infiltration of histiocytes and multinucleate giant cells mixed with some lymphocytes (hematoxylin and eosin stain, 100X). Touton giant cells are also present (upper right corner, 400X). Figure 4: On immunohistochemical study, the histiocytes are diffuse positive for CD68 (A), but negative for S100 (B) and CD1a (C). Kuo et al. BMJ Case Reports 2009 [doi:10.1136/bcr.11.2008.1227]
49. High-Throughput Customized SNP Profiling DNA extraction by kit (1~2 mg DNA) DNA of cord (3~5 ml cord blood ) Hybridization by Illumina array chip (250 ng DNA) DNA QC by PicoGreen (Invitrogen) Analysis (BeadStudio) Combination and calculation (UVA, MVA, MDR) Illumina array chip
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54. P = 9.71*10 -7 PDE2A interact with CYFIP2 in the susceptibility of KD
55. High risk group had lower TGFβ in KD patients P = 0.007 No significant difference in other cytokines studied: IFNγ, IL-2, IL-4, IL-5, IL-6 and IL-10 Plasma TGF-beta1 levels (pg/ml) Low risk group High risk group N=32 N=88 Mann-Whitney U test
56. High risk group didn’t have correlation with CAL and IVIG resistance P=0.42 P=0.86 CAL IVIG resistance
61. P = 3.36*10 -6 IL2RA interact with LOC100133214 in CAL formation of KD
62. KD patients carry high risk group genotypes had higher inflammatory cytokines IL-2, P = 0.008 IFNγ, P = 0.03 IL-6, P = 0.01 Low risk group High risk group Low risk group High risk group Low risk group High risk group Plasma IL-2 levels (pg/ml) Plasma IFNγ levels (pg/ml) Plasma IL-6 levels (pg/ml) N=120, 38 in high risk group 82 in low risk group Mann-Whitney U test
KS is the most common cause of acquired heart disease now. The clinical picture of patient with KD is Conjuctivitis, strawberry tongue, skin rash, induration and desquamation KD was first described in 1967 by Dr. Kawasaki in japan