Campbell6e lecture ch6

Chapter Six The Behavior of Proteins: Enzymes

Enzyme Catalysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Enzyme Catalysis (Cont’d) ,[object Object],[object Object],[object Object],[object Object]

Enzyme Catalysis (Cont’d) ,[object Object]

Temperature dependence of catalysis ,[object Object],[object Object],[object Object]

Enzyme Kinetics ,[object Object],[object Object],[object Object],[object Object]

Enzyme Kinetics (Cont’d) ,[object Object],[object Object],[object Object],[object Object],[object Object]

How Enzymes bind to Substrate ,[object Object],[object Object],[object Object]

Binding Models ,[object Object],[object Object],[object Object]

2 Modes of E-S Complex Formation

An Example of Enzyme Catalysis ,[object Object],[object Object],[object Object]

An Example of Enzyme Catalysis (Cont’d)

Non-Allosteric Enzyme Behavior ,[object Object]

ATCase: An Example of Allosteric Behavior ,[object Object],[object Object]

Michaelis-Menten Kinetics ,[object Object]

Michaelis-Menten Model ,[object Object],[object Object],[object Object]

Michaelis-Menten Model (Cont’d) ,[object Object],[object Object],[object Object]

Michaelis-Menten Model (Cont’d) ,[object Object],[object Object]

Michaelis-Menten Model (Cont’d) ,[object Object]

Linearizing The Michaelis-Menten Equation ,[object Object],[object Object],[object Object]

Lineweaver-Burk Plot ,[object Object],[object Object],[object Object]

Lineweaver-Burk Plot (Cont’d) ,[object Object],[object Object]

Turnover Numbers ,[object Object],[object Object]

Enzyme Inhibition ,[object Object],[object Object],[object Object],[object Object],[object Object]

Competitive Inhibition ,[object Object],[object Object]

Competitive Inhibition ,[object Object]

A Lineweaver-Burke Plot for Competitive Inhibition

Noncompetitive Inhibition (Cont’d) ,[object Object],[object Object]

Noncompetitive Inhibition (Cont’d)

A Lineweaver-Burke Plot for Noncompetitive Inhibition ,[object Object],[object Object]

A Lineweaver-Burke Plot for Noncompetitive Inhibition (Cont’d)

Other Types of Inhibition ,[object Object],[object Object]

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