NanoSynergy® developed technology to accelerate fluids faster than the speed of sound to 1500 ft/sec for 3-5 nanoseconds to create extreme shear and impact forces necessary for molecular dispersion without excessive heat or breaking chemical bonds. “The combination of applied nanotechnology with any compound, molecule, mixture or fluid to deliver an end product of smaller particle size to yield greater bioavailability and efficacy.”  Features for Manufacturers Enhances existing products & formulations by creating stable NanoSyzed™ solutions, emulsions, dispersions Reduce amount of raw materials and increase the absorption of nutrients into the body by stable biophysical “digestion” of agglomerates Competitive marketing edge with efficient integration with existing processing to create superior, stable, and patentable products Benefits for Consumer No water or large tablets (40% of Americans experience difficulty) Exceptional product performance – faster acting (e.g. B12 Spray vs Shot) Prevent wasting of money on useless aggregated products Our particle size analysis of 100’s of leading nutraceutical products shows that nearly the entire industry could benefit from the patented technology developed by NanoSynergy Worldwide, Inc. The lead technology platform, NanoSynergy®, is already proven as a commercially viable system that works effectively for a variety of water soluble and insoluble nutraceutical compounds. Our patented technology can be incorporated into common dosage forms for substantial improvements in product performance. NanoSynergy® has the potential to dramatically improve the marketability of a vast range of products that have issues with solubility, stability, bioavailability, and efficacy.

1. NanoSynergy®
Worldwide
“Setting the Standard in Nanotechnology”
Strategic Technology OverviewStrategic Technology Overview
Russell Van de Casteele,Russell Van de Casteele,
InventorInventor

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“All forms of technology, including
information technology and biotechnology,
will become passé with the advent of
nanoscience. It is a precursor to the next
wave of pervasive technology.”
Robert Curl Jr.
Nobel Laureate

3. NanoSynergy Worldwide has been acknowledged for its’
technology
through:
 The Smithsonian Institute
 The Hubert Humphrey Institute of Public Affairs
 The Woodrow Wilson Institute of Nanotechnology
 The National Nanotechnology Initiative (NNI)
 Food and Drug Administration (FDA)
 New York Times, LA Times, Palm Beach Post, Nutraceutical World, Nutritional
Outlook, Drug Store News, Bloomberg Businessweek, Nanotechnology Now, and
many other publications & journals globally.
NanoSynergy Worldwide has been featured in:
 Hugh Downs National Medical Report
 28 minute infomercial
 Home Shopping Group 60 second commercial
 Genimation Marketing Report

5.  Hubert Humphrey Institute of Public Affairs analysed all
212 claims of nano in the NY Times article ...
 Only 13 products in all categories ... out of 212 products
named were rated as “nano”
 Spray For Life's Vitamin B-12 was the only health product
that actually was rated as “nano”

6. Recommended Dietary Allowance (RDA) the amounts of selected nutrients considered adequate
to meet the nutrient needs of healthy people. These recommendations are set on the basis of
studies
taken from healthy people involving the various states of nutrient depletion.
Electron Micrograph
NanoSynergy conducted Particle Size Studies on 100’s of Market Leaders
- Tablets, Capsules, Sprays, Liquids, Gel Capsules, Beverages
- Vitamins, Herbal Extracts, Minerals, Nutrients, “Nano”
Too Hard
Too Large

7. Conclusion: Numerous commonly prescribed medications in their undissolved,
undigested state are visible on plain x-ray films, as are mineral supplements, which
have high radiodensities. At times, the appearance of these medications and
supplements may be confused with organic pathologic conditions.
MAYO CLINIC PROC. 1998;73:516-519

8. Biophysical Digestion
How Does the Body Mechanically Breakdown Particles? Chewing
Digestive enzymes only breakdown biopolymers, not aggregates.
NanoSynergy®
uses biophysics to digest aggregates into
molecular dispersions, solutions, and emulsions that are
optimized for cellular absorption and biological activity.
Biomechanics of Teeth

9. Nano Micron
Dehydration and Compaction
NanoSynergy®
Hydration and Molecular Dispersion
<1nm

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NanoSynergy®
developed
technology to accelerate
fluids faster than the
speed of sound to 1500
ft/sec for 3-5 nanoseconds
to create extreme shear
and impact forces
necessary for molecular
dispersion without
excessive heat or
breaking chemical bonds.

11. Niacinamide Liquid Emulsion StudyNiacinamide Liquid Emulsion Study
Particle Size 15.1 microns
Before processing
100x each dash is 10 µm
Particle Size 0.087 microns
87 nanometers (175x smaller)
After processing
100x each dash is 10 µm
NanoSynergyNanoSynergy®®
Trade Secrets

12. NanoSynergyNanoSynergy®®
RestoringRestoring
NatureNature

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Approved Processing Patent:
A Method of Delivery of a Biological Active Agent For
Humans And Animals
(U.S. Patent Number 6,861,066 March 1, 2005)

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“The combination of applied nanotechnology with any
compound, molecule, mixture or fluid to deliver
an end product of smaller particle size to
yield greater bioavailability and efficacy.”
~1000x
~1000x

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 Fast and efficient flow rates
 Meets all standards for sanitary and sterile
manufacturing requirements
 Utilizes cold processing technology platform
 Breaks apart aggregates, but does not break covalent
chemical bonds
 Customizes particle size of various compounds at the Nano
and Micro scale levels

16. NanoSynergy®
Sprays
Text
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NanoSynergy®
sprays are water based with natural stabilizers to maximize
cellular bioavailability. In contrast, dry nanoparticles aggregate during
hydration.
New Products – Vitamin C+ Zinc, Spray For Life Sports™ - Energy, Alert-Focus,
Breakfast For The Brain - Neurological Health.
Spray for Life®

17. NANO
CHARGED
Boost energy, metabolism, mood, and strength along with supporting proper
nervous system functioning. Also improves concentration, mental clarity, and
cognitive function while strengthening our immune system. A new product to
our Spray For Life® Family
B 5000

18. 2nm
human hair dust mite
mosquitobacteria
virus
cell receptor
human cell
insulin
DNA
<1nm

20. Spray for Life®
Nano-B12 (0.8nM)
Text
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450 times larger
2,700 times larger 80,000 times larger
Competitor A
Competitor B Competitor C

22. “Nano” Competitors 100 to 100,000 times Larger than NanoSynergy®
Products
<1nm

24. Nano-Diffuse “patent pending” by Iovate Health Sciences and MuscleTech

25. Particle Size = 5 to 100 Microns
5,000 to 100,000 times larger than Spray For Life Nano B-12
Mislabeled Product – Not possible to be 2,003mg/ml
<1nm

26. 200nM
Filter
Only Spray for Life®
B-12 was small enough to pass through the 200nM filter.

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28. Each micron sized droplet contains
thousands of nanoparticles. The
micron size NanoMist®
droplets will
not be transported to the lungs.

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“In my 30 years of evaluating manual red blood
cells, I've never seen such rapid and positive change
in my patients, not only in test results, but
symptoms. Normally using a typical sublingual
tablet or injection of vitamin B-12, it would take
much longer to correct.”
Ellie Cullen, RN
Your Future Health, Tampa, FL

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Abnormalities of size and shape of the red blood cells in a patient
with pernicious anemia induced by vitamin B-12 deficiency.
Results within 30 days of treatment using Spray For Life® Nano B-
12

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33. Nature's Answer
Sedimentation Comparisons
What Would You Buy if You Knew What was Inside?
Spray
For Life®
Comp A Comp B Comp C

35. Sedimentation Comparisons
What Would You Buy if You Knew What was Inside?
SFL Comp A Comp B Comp C
Spray for Life® Vitamin D3 blows away the competition!
Leading store brand Vitamin D3 tablets as shown above are completely insoluble
in simulated gastric fluid. One spray of our Spray for Life® Nano Vitamin D3 is
equal to one tablet (1000IU), if it completely dissolved.
SFL Vit D3 Comp A Comp B
Note areas of
insolubility/creaming

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Features for Manufacturers

Enhances existing products & formulations by creating stable NanoSyzed™
solutions, emulsions, dispersions

Reduce amount of raw materials and increase the absorption of nutrients into
the body by stable biophysical “digestion” of agglomerates

Competitive marketing edge with efficient integration with existing processing
to create superior, stable, and patentable products
Benefits for Consumer

No water or large tablets (40% of Americans experience difficulty)

Exceptional product performance – faster acting (e.g. B12 Spray vs Shot)

Prevent wasting of money on useless aggregated products

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Market Opportunities for Premier Products
Nutraceuticals
Sports Nutrition
Personal Care
Branded Functional Ingredients
Functional Beverages
Pet Nutrition
Over the Counter (OTC)
Pharmaceutical
Biologicals
Veterinary Medicine
Agriculture

38. Nano Liquid Compatible Delivery Methods
Sprays and Droppers (oral, eye, nasal)
Liquid and Gel Caps
Functional Beverages and Foods
Dissolving Mouth Strips
Transdermal Patches
Creams, Toothpaste, Mouthwash
Gummy and Confections
Hydroponics

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NanoSynergy®
Worldwide, Inc. is a life science
pioneer that develops and markets science-based
formulations that utilize our proprietary trade
secrets and patented nano-processing platform.
Through strategic partnerships we license technology
to create effective and patentable health and
wellness products for diverse therapeutic areas.

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R&D Begins
Product
Concepts
Feasibility
Study
Product
Development Production
Marketing and Revenue
From Idea to Revenue in 3 to 9 months

41. 25 cents $3/day

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Our particle size analysis of 100’s of leading nutraceutical products shows that
nearly the entire industry could benefit from the patented technology
developed by NanoSynergy Worldwide, Inc.
The lead technology platform, NanoSynergy®
, is already proven as a
commercially viable system that works effectively for a variety of water soluble
and insoluble nutraceutical compounds.
Our patented technology can be incorporated into common dosage forms for
substantial improvements in product performance.
NanoSynergy®
has the potential to dramatically improve the marketability
of a vast range of products that have issues with solubility, stability,
bioavailability, and efficacy.

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NanoSynergy Worldwide, Inc.
Toll Free: 877-NSW-NANO (676-6266)
Fax: 888-248-3960
Websites:
www.nanosynergyww.com
www.sprayforlife.com
www.sprayforlife.org
Contact:
Russell Van de Casteele, Inventor
Email: russ@nanosynergyww.com