1. “TARGETED EPIGENETIC THERAPIES:
THE NEXT FRONTIER?” AND “ADN
TECHNOLOGY AND EVOLUTION
OF THE CENTRAL DOGMA”
Juliana Caro Palacio
Medicine Student
Molecular Biology
III Semester
UPB

2. FOLDING

3. FOLDING

4. INTRODUCTION
Replication
DNA
Transcription
RNA
Translation
PROTEIN
Expression
PHENOTYPE

5. NEW #1
TARGETED EPIGENETIC
THERAPIES: THE NEXT
FRONTIER?
(JANUARY 2014)

6. TARGETED EPIGENETIC THERAPIES: THE NEXT
FRONTIER? (JANUARY 2014)
Epigenetic
therapies
• Clinical success
• Improve patient
outcomes
Epigenome
• System that
alters the
structure of
DNA
• Regulating
gene activity
without
changing the
nucleotide
sequence.
Epigenetic
effectors
• Enzymes EZH2
and UTX
• Regulate
multiple
transcription
factors

7. TARGETED EPIGENETIC THERAPIES: THE NEXT
FRONTIER? (JANUARY 2014)
Epigenetic
Therapies targeted at
specific epigenetic
regulators
Progression
and tumor
formation

8. TARGETED EPIGENETIC THERAPIES: THE NEXT
FRONTIER? (JANUARY 2014)
Associated with
approximately
half of the
ovarian clear-cell
cancers tested
Epigenetic
regulatory
Tumor
suppressor
Gen ARID1A

9. PERSONAL OBSERATION
I think today is very
necessary implement
epigenetics, due to large
number of abnormalities
discovered and the
variety of cancers where
this technique may be
useful for better
approaches, diagnoses
and therapies.

10. NEW #2
ADN TECHNOLOGY AND
EVOLUTION OF THE
CENTRAL DOGMA
(JANUARY 2014)

11. ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL
DOGMA
(JANUARY 2014)
Central
Dogma
• Artificial
evolution
DNA sequences
captured digitally
• Reconstruction
of genomic
In silico
models
• Predict and
influence the
phenotype

12. ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL
DOGMA
(JANUARY 2014)
Reintroduction
of megafauna
Biodiversity
preservation
Extension
of the
Central
Dogma
Release of
extinct
pathogens
Synthetic
biology

13. ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL
DOGMA
(JANUARY 2014)
Recording and
storage of
DNA sequence
data obtained
by sequencing
Replication and
dissemination of
data by file
sharing across
the internet
Evolution
of the
Central
Dogma
Expression of
synthetic DNA
through to RNA
transcription and
protein translation
Use of
information for
de
novo chemical
synthesis of
DNA

14. PERSONAL OBSERATION
I think these scientific advances are very important for
the evolution of molecular biology if used with
therapeutic actions, because they facilitate access to
information and help control many diseases and
abnormalities presented during development.

15. MEDICAL UTILITY

16. MEDICAL UTILITY
Allow quick access at any time
and place at libraries genes,
obtaining detailed information on
mutations, expression and
development of genes, looking
for improvement and
reconstruction of the genome

17. MEDICAL UTILITY
Apply the epigenetic in order to prevent the expression
of more than one gene at time, through manipulation of
chromosomes and the transcription machinery, thereby
reducing mutations, diseases and clinical morbidity.

18. MEDICAL UTILITY
Facilitate the creation of
synthetic genetic material
for the correction and
construction of new
biochemical pathways,
thereby improving the
quality of life, therapies and
treatments.

19. BIBLIOGRAPHY

Martínez Sánchez, Lina María. Biología Molecular. 7
Edición. Medellín. UPB. Facultad de Medicina 2012. Pp
74-77

“Targeted Epigenetic Therapies: The Next Frontier?”.
Pub-Med. (online magazine). January 2014. Avaliable
at:
http://jnci.oxfordjournals.org/content/102/24/1824.long

“DNA technology and evolution of the Central Dogma”.
ScienceDirect. (online magazine). January 2014.
Avaliable at:
http://www.sciencedirect.com.consultaremota.upb.edu.c
o/science/article/pii/S0169534713002498

20. THANKS !!
“Isn't he strongest species that survives, nor the
most intelligent, but the one that responds to
change”. Charles Darwin