Weitere ähnliche Inhalte Ähnlich wie Cancer & santé publique interview du professeur agnès buzyn. (20) Kürzlich hochgeladen (20) Cancer & santé publique interview du professeur agnès buzyn.1. !
!"#$!%&#'() CliSP – Bulletin 20, Avril 2013
!"#
!
$%# &'(&#)*'&#+(,%-.%/%$.# (/)*(0'1%#
+2$&#'$%#2-.(3(.1#+%#,%-4%,-4%#56$7
+2/%$.2*%8#
92,# 2(**%',&:# ;<2(# )2,.(-()1# =# +(5517
,%$.%&# ($&.2$-%&# &-(%$.(5(0'%&:# $67
.2//%$.# =# *<>?@@>9@:# =# *<A?@:# =#
*<>BC# 6'# =# +%&# &6-(1.1&# &232$.%&#
+%# /2# &)1-(2*(.1:# .%**%# *2# &6-(1.1#
5,2$D2(&%#+%#E,%55%#+%#/6%**%#%.#+%#
.41,2)(%#-%**'*2(,%#)2,#%F%/)*%8#
G%&#/(&&(6$&# 0'%# ;<2(# 2&&'/1%&# 2'#
&%($#+<1.2H*(&&%/%$.&#)'H*(-&#/<6$.#
2/%$1%# =# 236(,# '$%# 3(&(6$# )*'&#
*2,E%#0'<2')2,232$.#+%#-%#0'<%&.# *2#
&2$.1# )'H*(0'%# %.# +%# -%# 0'%# +6(.#
I.,%# *%# &%,3(-%# )'H*(-# +2$&# *%# +67
/2($%#+%#*2#&2$.18#A**%&#/<6$.#2'&&(#
)%,/(&# +<2-0'1,(,# '$%# %F)1,(%$-%#
+2$&#*2#E%&.(6$#+'#,(&0'%#%$#&2$.18##
J*# /%# &%/H*%# -%)%$+2$.# $1-%&7
&2(,%#+%#E2,+%,#'$%#%F)1,(%$-%#+%#
.%,,2($#%.#;<2(#+6$-#&6'42(.1#)6',7
&'(3,%# /6$# 2-.(3(.1# +%# &6($&# %.#
+<%$&%(E$%/%$.:#/I/%# &(# ;<K# 2-7
-6,+%# '$%# )2,.# H(%$#/6($+,%# +%#
/6$# .%/)&# +%)'(&# LM!!# N'$%#
-6$&'*.2.(6$#)2,#&%/2($%#%$#),17
&%$-%# +<'$# %F.%,$%:# %.# 0'%*0'%&#
-6',&O8##
P%..%# %F)1,(%$-%# -*($(0'%# %&.# ($7
+(&)%$&2H*%# =# *2# ,12*(&2.(6$# +%&#
/(&&(6$&# +6$.# ;<2(# *2# -42,E%# =#
*<JQP2#0'(#%&.#=# *<($.%,52-%#+'#)'7
H*(-:# +%&# /2*2+%&:# +%&# ),65%&7
&(6$$%*&#%.#+%#*<2+/($(&.,2.(6$8##
)
*+) ,) -./0) 1230) 4560783923) 83)
:;&<"=>) 4./5?/.7) 32) @.AA392)
=B.75) C=72) :3) @D.7E)83) @3223)=@27F
B726)G)
>9# 7# R%# ),1&(+%# *%# P6$&%(*#
+<>+/($(&.,2.(6$#+%# *<J$&.(.'.#Q27
.(6$2*#+'#-2$-%,#+%)'(&#/2(#LM!!8#
R<%$# 1.2(&# /%/H,%# +%)'(&# LMMS:#
;<K# 232(&# 1.1# 1*'%# 3(-%7),1&(+%$.%#
%$#6-.6H,%#LM!M8##
P%#-46(F#%&.#'$%#&'(.%#*6E(0'%#0'(#
/%# )%,/%.# +%# 52(,%# -6$3%,E%,#
*+) F)H./B3IFB./0) B./0))456039F
235)=/E)79235930)0;7:)B./0)4:=J2)G)
>B# 7# >$-(%$$%# ($.%,$%# +%&# 4T)(7
.2'F# +%# 92,(&:# 2$-(%$$%# P4%5# +%#
-*($(0'%72&&(&.2$.%:# ;%# &'(&#),65%&7
&%',# +<41/2.6*6E(%# =# *<4T)(.2*#
Q%-U%,7A$52$.&7C2*2+%&#N>97V9O8##
R<2(#1.1#E'(+1%#+2$&#-%#-46(F#)2,#*%#
&6'3%$(,# +<'$%# -2/2,2+%# +%#
-*2&&%#2..%($.%#+<'$%# *%'-1/(%:#%.#
-%..%# /2*2+(%# %&.# +%3%$'%#
*<2,-41.K)%#+'#/2*#2H&6*'8# R%#/<K#
&'(&# +6$-# ($.1,%&&1%# =# .,23%,&# *2#
/1+%-($%#%.#*2#,%-4%,-4%8#
WX&#*%#+1H'.#+%#/6$#-*($(-2.:#/6$#
2-.(3(.1#&<%&.#)2,.2E1%#%$.,%#*2#-*(7
$(0'%# %.# *2# ,%-4%,-4%# 56$+2/%$7
.2*%8# ># *<4T)(.2*# Q%-U%,:# ;<2(# 1.1#
,%&)6$&2H*%#+%#*<'$(.1#+%#&6($&#($7
.%$&(5&# +'# &%,3(-%# +<41/2.6*6E(%#
2+'*.%#0'(#),%$+#%$#-42,E%#*%&#)27
.(%$.&# 2..%($.&# +%# *%'-1/(%&# 2(7
E'Y&:# *%&# 2**6E,%55%&# %.#
*<6,E2$(&2.(6$# +%# *<2-.(3(.1# +%#
.,2$&)*2$.2.(6$8##
C6$# 2-.(3(.1# +%# ,%-4%,-4%# &<%&.#
%&&%$.(%**%/%$.# +1,6'*1%# +2$&# *%#
+1)2,.%/%$.# +<(//'$6*6E(%# +%#
*ZJ$&.(.'.# P6-4($:# 6[# ;<2(# %$&'(.%#
1.1# ,%&)6$&2H*%# +<'$%# 10'()%# JQ7
@AC#)%$+2$.#]#2$&8##
W%)'(&#/2#$6/($2.(6$# =# *2#),1&(7
+%$-%# +<'$# 1.2H*(&&%/%$.# )'H*(-#
%$#LMM^:#*<J$&.(.'.#+%#2+(6),6.%-7
.(6$#%.# &',%.1#$'-*12(,%# NJ@QO:# ;%#
"=9@35)K)(=926)H/L:7?/3)
&9235B73M)8/)H5.C3003/5)!N9O0)+$PQ<))
!"#$%&'()'*&'*+,-($)%).)*/0)%1(0+*&.*20(3'"*
!"14'$$'."*&,5#60)1+17%'8*59:%)0+*/'3;'"!
<*=0* +.))'* 31()"'* +'$* 30(3'"$*
31($)%).'* &1(3* .(* '(>'.* 60>'."*
:1."* +0* 6#&'3%('8* &0($* )1.)'$*
$'$* 316:1$0()'$8* 0.* :"'6%'"*
"0(7* &'$?.'++'$8* +0* $0()#* :.@
A+%?.'*')*+0*6#&'3%('*$13%0+'B*C*
>B!
&90272/2)<=27.9=:)8/)"=9@35)&<"=)
"L:#23%$'%#>$+,1#C6,(_%.#SL"!`#
B6'*6E$%#B(**2$-6',.#P%+%F##
a1*8#b#``#NMO!#]!#!M#"M#MM#
2. !
!"#$!%&#'() CliSP – Bulletin 20, Avril 2013
!c# !
NdJ9O:# *<JQP2# ,2&&%/H*%# *%&# 2-7
.%',&# -*1&# +%# *2# -2$-1,6*6E(%#b#
*<e.2.:#*%&#E,2$+%&&6-(2.(6$&#+'#
-42/)# +%# *2# -2$-1,6*6E(%:# *%&#
-2(&&%&# +<2&&',2$-%# /2*2+(%:# *%&#
6,E2$(&/%&# +%# ,%-4%,-4%# %.# *%&#
51+1,2.(6$.&)(.2*(X,%&8###
a6'&# 6$.# )6',# 2/H(.(6$# -6/7
/'$%# +%# +(/($'%,# *2# &',3%$'%#
+%&# -2$-%,&# 13(.2H*%&:# +%# ,1+'(,%#
*2# /6,.2*(.1# )2,# -2$-%,:#
+<2/1*(6,%,# *2# 0'2*(.1# +%# 3(%# +%&#
)%,&6$$%&# 2..%($.%&# )%$+2$.# %.#
2),X&#*2#/2*2+(%#%.#+%#,1+'(,%#*%&#
($1E2*(.1&#+%#&2$.18##
G<JQP2# 2))6,.%# '$%# 3(&(6$# ($.17
E,1%# +%# *<%$&%/H*%# +%&# +(/%$7
&(6$&# N&2$(.2(,%:# &-(%$.(5(0'%:# &67
-(2*%:# 1-6$6/(0'%O# %.# +%&#
-42/)&# +<($.%,3%$.(6$# N),13%$7
.(6$:#+1)(&.2E%:#&6($&:# ,%-4%,-4%O#
*(1'F#)2.46*6E(%&#-2$-1,%'&%&8##
J*#2#)6',#2/H(.(6$#+%#;6'%,#'$#,T*%#
+<2--1*1,2.%',#+%#),6E,X'# &%,7
3(-%# +%&# )%,&6$$%&# /2*2+%&:# +%#
*%',&#),6-4%&:#+%&#'&2E%,&#+'#&K&7
+%'F#)2&&(6$�'(#/<6$.# .6';6',&#
2$(/1%:# *2#/1+%-($%# %.#/2# )2&7
&(6$# -(.6K%$$%:# -Z%&.7=7+(,%# *%#
)6(+�'%#;<2..2-4%#=#*2#$6.(6$#+%#
&%,3(-%#)'H*(-8##
A.,%# $6//1%# =# *2# ),1&(+%$-%# +%#
*<JQP2#%&.# *2#/(&&(6$# *2#)*'&#H%**%#
0'<6$# 2(.# )'#/%# -6$5(%,:# %**%#/%#
)%,/%.# +%# )6,.%,# 2'# $(3%2'# $27
.(6$2*# +%&# 32*%',&# %.# +%&# 2/H(7
.(6$&# .%**%&# 0'%# *2# -6/)1.%$-%#
),65%&&(6$$%**%:# *<1E2*(.1# +<2--X&#
2'F# &6($&# +%# 0'2*(.1:#
*<2--6/)2E$%/%$.# %.# *2#),(&%# %$#
-42,E%# +%&# )2.(%$.&# +2$&# +%&#
-6$+(.(6$&#*%&#)*''/2($%&#)6&7
&(H*%f#
C2#/(&&(6$# -6$&(&.%# =# 2&&',%,# *2#
5($# +%# *2#/(&%# %$#g'3,%# +'# 9*2$#
-2$-%,#LMMS7LM!`#%.#=#)2,.(-()%,#=#
*2# ,1+2-.(6$# +'# `X/%# 9*2$# -2$-%,:#
2$$6$-1# )2,# *%# 9,1&(+%$.# +%# *2#
1)'H*(0'%# *%# ]# +1-%/H,%# +%,7
$(%,8# J*# ,%&.%# H%2'-6')# =# 52(,%#
)6',# *%&# )2.(%$.&# %.# *%&# ),65%&7
&(6$$%*&# +%# .%,,2($:# /2(&# 2'&&(#
)6',# *'..%,# -6$.,%# *%&# ($1E2*(.1&#
52-%# 2'F# -2$-%,&# %.# /%..,%# %$#
)*2-%#+%-.(6$&#+%#),13%$.(6$8#
)
*+) F)R/3:) :739) 392532393IFB./0)
=B3@):=)(=926)4/L:7?/3)K):=)A6F
83@793) 0.@7=:3)G) R/3) 07N97C7392F
3::30)4./5)B./0)G)
>B# 7# R<2(# 3,2(/%$.# +1-6'3%,.#
-%..%# &)1-(2*(.1# %$# 2,,(32$.# =#
*<JQP28##
Q6'&# 236$&# +2$&# *<J$&.(.'.# +%#
$6/H,%'F# /1+%-($&# +%# &2$.1#
)'H*(0'%# 0'(# 56$.# '$# .,232(*# ,%7
/2,0'2H*%# %.# 0'(# /<6$.# H%2'7
-6')#2)),(&8#G<JQP2#%&.# ,%+%3%$'#
'$#*(%'#+<2--'%(*#%.#+%#&.2E%#)6',#
*%&# ($.%,$%&# +%# &2$.1# )'H*(0'%# =#
/2#+%/2$+%:#+%)'(&#'$#2$8##
R%#/%#&'(&#+6$-#%$#0'%*0'%#&6,.%#
h#,16,(%$.1%#i# 3%,&# *2# &2$.1# )'7
H*(0'%:# /I/%# &(# *<41/2.6*6E(%#
,%&.%,2# .6';6',&# *<'$%# +%# /%&#
)2&&(6$&8#
)
*+) F)H./B3IFB./0)9./0)456039F
235) :;&<"=>) 030) .LS3@27C0>) 0.9)
C.9@27.993A392T)
>B# 7#GZJ$&.(.'.#$2.(6$2*#+'#-2$-%,#
NJQP2O# %&.# *<2E%$-%# &2$(.2(,%# %.#
&-(%$.(5(0'%# +%# *<e.2.# -42,E1%# +%#
-66,+6$$%,# *%&# 2-.(6$&# +%# *'..%#
-6$.,%#*%#-2$-%,8#P,11#)2,#*2#*6(#+%#
&2$.1#)'H*(0'%#+'#S#26j.#LMM]:# (*#
%&.#)*2-1#&6'&#*2#.'.%**%#-6$;6($.%#
+'#C($(&.X,%#+%&#>552(,%&#&6-(2*%&#
%.#+%# *2#@2$.1#%.#+'#C($(&.X,%#+%#
*ZA$&%(E$%/%$.#@')1,(%',#%.#+%#*2#
%-4%,-4%8#
P6$&.(.'1# &6'&# *2# 56,/%# +<'$#
E,6')%/%$.# +<($.1,I.# )'H*(-#
3. !
!"#$!%&#'()
!
CliSP – Bulletin 20, Avril 2013
!
H2*# )2,# -2$-%,# %&.# %$# H2(&&%:# *%#
$6/H,%# +%# -2&# +%# -2$-%,&# -6$.(7
$'%# +<2'E/%$.%,:# 23%-# )*'&# +%#
`c"#MMM#$6'3%2'F#-2&#%&.(/1&#%$#
LM!L8##
G%&# ($1E2*(.1&# &6-(2*%&# 52-%# =# *2#
/2*2+(%# &%# &6$.#1E2*%/%$.# -,%'7
&1%&# +2$&# *%&# +%,$(X,%&# +1-%$7
$(%&:# .2$.# &',# *%# )*2$# +%#
*<($-(+%$-%#0'%#+%#*2#/6,.2*(.18##
A$5($:#*2#),13%$.(6$:#0'(#%&.#($&'57
5(&2//%$.# %$&%(E$1%# 2'# -6',&#
+%.'+%&#+%#/1+%-($%#%.#($&'57
5(&2//%$.# 32*6,(&1%# +2$&#
*<2-.(3(.1#),65%&&(6$$%**%:#)6',,2(.#
,1+'(,%#+%#`M#=#]Ml#*%#$6/H,%#+%#
-2$-%,&#%$#?,2$-%8##
G2#*'..%#-6$.,%#*%&#-2$-%,&#-6$&.(7
.'%#+6$-#'$#%$;%'#/2;%',#)6',#*2#
/1+%-($%:# +2$&# .6'.%&# &%&# -6/7
)6&2$.%&:# 2'# ),%/(%,# ,2$E# +%&7
0'%**%&:# *2# &2$.1# )'H*(0'%# %.# *2#
/1+%-($%#&6-(2*%8#
#
*+) F)R/3:) 5U:3) 27392) 03:.9) B./0)
:;&<"=)8=90)@3223)8V9=A7?/3)G)
>B# 7# A$# /2.(X,%# +%# &2$.1# )'7
H*(0'%:# *<JQP2# 2# )*'&(%',&# ),(6,(7
.1&8##
J*#&<2E(.#.6'.#+<2H6,+#+<1-*2(,%,#*%&#
-6$$2(&&2$-%&# ,%*2.(3%&# 2'F# 52-7
.%',&#+%# ,(&0'%#+%&#-2$-%,&#%.#+%#
5236,(&%,# *<2+6).(6$# +%# -6/)6,7
.%/%$.&# +%# $2.',%# =# ,1+'(,%# *%&#
-2$-%,
(.2H*%&8##
G<JQP2#-6$.,(H'%#1E2*%/%$.#=#+17
5($(,# *%&# &.,2.1E(%&# +%# +1)(&.2E%#
%$#56$-.(6$#+%&#$(3%2'F#+%#,(&0'%#
+%&# )%,&6$$%&# 52-%# 2'F# -2$-%,&:#
%.# =# 6).(/(&%,# *<6,E2$(&2.(6$# +%#
-%&#+1)(&.2E%&8##
.X/%# &2$(.2(,%#%.# &6-(2*:#+%&#),67
5%&&(6$$%*&# +%# &2$.1:# +%&# -4%,7
-4%',&:# +%&# %F)%,.&:# %.# +%&# +1-(7
+%',&8#
P6$-,X.%/%$.:##*<JQP2#
7#-66,+6$$%#*%-.(6$&#+%#*'..%#
-6$.,%#*%#-2$-%,#m#
7# ($(.(%# %.# &6'.(%$.# +%&# ),6;%.&#
+%# ,%-4%,-4%# %.# *<($$632.(6$#
/1+(-2*%:# .%-4$6*6E(0'%# %.# 6,7
E2$(&2.(6$$%**%#m#
7#2E(.# &',# *<6,E2$(&2.(6$#+%&#+17
)(&.2E%&:# +%&# &6($&# %.# +%# *2# ,%7
-4%,-4%#m#
7# ),6+'(.# +%&# %F)%,.(&%&# &6'&#
56,/%#+%#,%-6//2$+2.(6$&#$27
.(6$2*%&:# +%# ,151,%$.(%*&:# +%#
,2))6,.&#%.#+<23(&#m##
7#),6+'(.:#2$2*K&%#%.#132*'%#+%&#
+6$$1%&#+2$&# .6'&# *%&# +67
/2($%&#+%#*2#-2$-1,6*6E(%#m#
7# 5236,(&%# *<2)),6),(2.(6$# +%&#
-6$$2(&&2$-%&# %.# +%&# H6$$%&#
),2.(0'%&#)2,# *%&# +(551,%$.&# )'7
H*(-&8##
#
G<JQP2# )(*6.%# 1E2*%/%$.# c`# +%&#
!!^#2-.(6$&#+'#9*2$#-2$-%,#%.#%&.#
,%&)6$&2H*%#+'#&'(3(#+%#*2#/(&%#%$#
g'3,%#+%#`M#/%&',%&#+%#-%#9*2$8#
Q6.,%# H'+E%.# 2$$'%*# %&.#
+<%$3(,6$# !MM# /(**(6$&# +<%',6&8##
G2# /6(.(1# +%# -%# H'+E%.# %&.# 2*7
*6'1%# 2'# 5($2$-%/%$.# +%# *2# ,%7
-4%,-4%# %.# *<2'.,%#/6(.(1# %&.# +17
+(1%:#$6.2//%$.:#2'F#2-.(6$&#+%#
&6($&:# =# *2# &2$.1# )'H*(0'%# %.# =#
*<($56,/2.(6$#+%&#)'H*(-&8##
G<JQP2#%&.#6,E2$(&1#%$#0'2.,%#%$7
.(.1&# 6)1,2.(6$$%**%&#b# %-4%,-4%#
<*=,-/20*0::1")'* .('* D%$%1(* %(@
)#7"#'* &'* +,'($'6A+'* &'$* &%@
6'($%1($* E$0(%)0%"'8* $3%'()%@
4%?.'8* $13%0+'8* #31(16%?.'F* ')*
&'$* 3G06:$* &,%()'"D'()%1(*
E:"#D'()%1(8* &#:%$)07'8* $1%($8*
"'3G'"3G'F* +%#$* 0.H* :0)G1+17%'$*
30(3#"'.$'$B**
-+* 0* :1."* 06A%)%1(* &'* >1.'"* .(*
!"#$%&'())*#*!(+$,!%&$%-!./!01*
0.* $'"D%3'* &'$* :'"$1(('$* 60@
+0&'$8* &'* +'."$* :"13G'$8* &'$*
.$07'"$*&.*$I$)J6'*$0(%)0%"'*')*
$13%0+8* &'$* :"14'$$%1(('+$* &'*
$0()#8* &'$* 3G'"3G'."$8* &'$* 'H@
:'")$8*')*&'$*%&'."$BC*
>B!
%.# ($$632.(6$:# @2$.1# )'H*(0'%# %.#
&6($&:#%-6//2$+2.(6$&# %.#0'27
*(.1# +%# *<%F)%,.(&%:## P6//'$(-27
.(6$#%.#($56,/2.(6$8##
#
*+) F) R/3:) 53N=58) 4.523IFB./0)
0/5) :=) (=926) 4/L:7?/3) =@2/3::3>)
32)030)4.239273::30)6B.:/27.90)39)
A=27O53)83)@=9@65.:.N73)G)
>B# 7#G2# &2$.1#)'H*(0'%# .(%$.#'$%#
)2,.# %&&%$.(%**%# +2$&# *2# *'..%#
-6$.,%#*%&#-2$-%,&#%$#?,2$-%8##
G%&# )2.46*6E(%&# -2$-1,%'&%&#
&6$.:#+%)'(&#'$%#+(_2($%#+<2$$1%&#
/2($.%$2$.:#*2#),%/(X,%#-2'&%#+%#
/6,.2*(.1# +2$&# $6.,%# )2K&8# P2,#
/I/%#&(#*%#.2'F#+%#/6,.2*(.1#E*67
! !k#
4. !
!"#$!%&#'() CliSP – Bulletin 20, Avril 2013
<*M)"'*(166#'*N* +0* :"#$%&'(3'* &'* +,-/20* '$)* +0* 6%$$%1(* +0* :+.$* A'++'*
?.,1(*0%)*:.*6'*31(4%'"8* '++'*6'*:'"6')*&'*:1")'"*0.*(%D'0.*(0)%1(0+*
&'$*D0+'."$*')*&'$*06A%)%1($*)'++'$*?.'*+0*316:#)'(3'*:"14'$$%1(('++'8*
+,#70+%)#*&,033J$*0.H*$1%($*&'*?.0+%)#8*+,03316:07('6'()*')*+0*:"%$'*'(*
3G0"7'*&'$*:0)%'()$*&0($*&'$*31(&%)%1($*+'$*:+.$*G.60%('$*:1$$%A+'O*C*
!^# !
1E2*%/%$.# ,%)%$&1%# 25($# +%# ,17
)6$+,%# =# *<2'E/%$.2.(6$# +%# *2#
),132*%$-%# +%# *2# /2*2+(%# N)2,#
2'E/%$.2.(6$#+%#*<($-(+%$-%#%.#*2#
),6*6$E2.(6$# +%# *2# &',3(%O:# +'#
3(%(**(&&%/%$.#+%# *2#)6)'*2.(6$#%.#
+%# *2# -6/)*%F(.1# -,6(&&2$.%# +%&#
),(&%&# %$# -42,E%# %$# 56$-.(6$# +%&#
-2$-%,&:# =#/%..,%# %$# ,%E2,+# +%&#
),6H*X/%&# +%# +1/6E,2)4(%# /17
+(-2*%8#
A$5($:#*<42,/6$(&2.(6$#+%#*2#0'2*(7
.1# %.# +%# *<2--X&# 2'F# &6($&# &',# *%#
.%,,(.6(,%# ,%&.%:# )2,# &6'-(#
+<10'(.1#m#=#I.,%#.,232(**1%8#
#
*+) F)R/3:0) @.9037:0) 8.993573IF
B./0) =/E) 79235930) 860753/E) 83)
25=B=7::35)8=90)@3)8.A=793)G)
>B# 7# Q6'&# 236$&# H%&6($# +%# ,%7
E2,+&# $6'3%2'F# )6',# I.,%# ($3%$7
.(5&8##
G%# )2,-6',&# +(3%,&(5(1# +%&# ($7
.%,$%&#+%#@2$.1#)'H*(0'%:#&',.6'.#
&(# -%# )2,-6',&# %&.# 2&&6,.(# +<'$%#
%F)1,(%$-%# ($.%,$2.(6$2*%:# %$,(7
-4(.# -%,.2($%/%$.# *2# ,15*%F(6$#
+2$&# *%&# +(551,%$.&# -42/)&# +%# *2#
*'..%#-6$.,%#*%&#-2$-%,&8##
P<%&.#*2#,2(&6$#)6',#*20'%**%#-%..%#
-6/)1.%$-%#%&.#)2,.(-'*(X,%/%$.#
,%-4%,-41%#=#*<JQP28#
#
!"1:1$*"'3.'%++%$*:0"*K#+1&%'*L'"(0.HB*
W2$&#*%#+6/2($%#+%&#&6($&:#*<JQP2#
2# )6',# /(&&(6$&# +<2/1*(6,%,# *2#
-66,+($2.(6$# +%# *2# ),(&%# %$#
-42,E%#+%&#)%,&6$$%&#/2*2+%&#%.#
*2# 5*'(+(.1#+%&#)2,-6',&:#%.#+%#E27
,2$.(,#*<1E2*(.1#+<2--X&#=#'$%#),(&%#
%$# -42,E%# +%# 0'2*(.1# =# .,23%,&#
.6'.#*%#.%,,(.6(,%8##
A$5($:# *<JQP2# 2# )6',# 5($2*(.1# +%#
.,2+'(,%# 2'# )*'&# 3(.%# *%&# +1-6'7
3%,.%&# 56$+2/%$.2*%&# +%# *2# ,%7
-4%,-4%#%$#232$-1%'#H1$15(-%#
+%#*2#)6)'*2.(6$#%.#+%&#)%,&6$$%&#
/2*2+%&:# +2$&# *%# +6/2($%# +%&#
6'.(*&# +(2E$6&.(0'%&:# +%&# .,2(.%7
/%$.&#)%,&6$$2*(&1&#%.#+%#*2#0'27
*(.1#+%#3(%#$6.2//%$.8#
#
*+) F) H./B3IFB./0) 9./0) 4=5:35)
8/)H:=9)@=9@35)39)@./50)G)
>B# 7# G%# +%'F(X/%# 9*2$# -2$-%,#
&<2-4X3%,2#=#*2#5($#+%#-%..%#2$$1%:#
56,.# +%# 3,2(%&# 232$-1%&# +2$&# *%&#
+6/2($%&# +%# *2# &.,'-.',2.(6$# +%#
*2# ,%-4%,-4%# %.# +%# *<6,E2$(&2.(6$#
+%&#&6($&#$6.2//%$.8##
W%# E,2$+&# ),6E,X&# ,%&.%$.# =# 2-7
-6/)*(,:# %$# /2.(X,%# +%# *'..%#
-6$.,%#*%&#($1E2*(.14-%#=#*2#/27
*2+(%:# 6'# )6',# 2/1*(6,%,# *2# -66,7
+($2.(6$#+%&#&6($&#%$.,%#*2#3(**%#%.#
*<4T)(.2*# %.# ,%$56,-%,# *2# )*2-%# +'#
>B!
/1+%-($#.,2(.2$.#+2$&#*%#)2,-6',&#
+%#&6($&#+%&#)2.(%$.&8##
P%# &%,6$.# +%&# ),(6,(.1&# +'# ),67
-42($#9*2$#-2$-%,:#+6$.# *2#),1)27
,2.(6$#%&.#2-.'%**%/%$.# -66,+6$7
$1%# )2,# R%2$792'*# n%,$2$.:# ),67
5%&&%',#+<41/2.6*6E(%#=#*2#@2*)I7
.,(X,%8#
#
*+)F)'230FB./0)0=270C=723)83)@30)
453A7350)A.70) 4=0060) W) :;&<"=)G)
R/3:0) 0.92) 03:.9) B./0) :30)
N5=980)39S3/E)83)83A=79)G)
>B#7#R%#.,6'3%#-%..%#/(&&(6$#)2&7
&(6$$2$.%#%.:#=#*2#56(&:#%**%#(/)6&%#
'$%#E,2$+%#4'/(*(.18##
P<%&.#'$#.,232(*#+%#*6$E'%#42*%($%#
+%# 52(,%# -42$E%,# *%&# ),2.(0'%&# %.#
+%# -66,+6$$%,# *%&# +(551,%$.&# 2-7
.%',&#+%# *2# *'..%# -6$.,%# *%# -2$-%,#
3%,&#+%H;%-.(5&# -6//'$&:#25($#
+%# ,1)6$+,%# 2'F# 2..%$.%&# ;'&.(7
5(1%&#+%#$6&#-6$-(.6K%$&8#
G%&# %$;%'F# &6$.#/'*.()*%&#/2(&# (*#
%&.# -*2(,# 0'%# *%# -42/)# +%# *2# ),17
3%$.(6$# +6(.# I.,%#/(%'F# %F)*6(.1#
%.# 32# $1-%&&(.%,# '$%# E,2$+%# )17
+2E6E(%# 3(&7=73(&# +%&# ),65%&&(6$7
$%*&#+%# &2$.1#%.#+'#E,2$+#)'H*(-:#
0'(#$<K#%&.#)2&#.,X&#,1-%).(58#
G<6,E2$(&2.(6$#+%&#&6($&#+6(.#I.,%#