SDL Use Case

1. ©2015 Cambridge Semantics Inc. All rights reserved.
Clinical Trial Site Intelligence (CTSI)
An Anzo Smart Data Lake™ Solution

2. ©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case
Clinical Trial Site Intelligence (CTSI)

3. ©2015 Cambridge Semantics Inc. All rights reserved.
Cambridge Semantics
Cambridge Semantics is the creator of the Anzo Smart Data Lake ™ (ASDL)
Based on semantic web technology, the ASDL provides an end-to-end graph-based
data integration, discovery, management, and analytics technology platform.
Cambridge Semantics delivers Smart Data solutions for Life Science companies
including R&D Intelligence, Scientific Affairs, Clinical Data Integration, clinical site
selection, and much, much more…
• Founded in 2007 by senior members of IBM’s Advanced Internet Technology Group
• The Anzo software suite is built on World Wide Web Consortium (W3C) open data standards and
13+ years of R&D
• The award-winning Anzo software suite is our 3rd generation implementation of semantic web
technologies

4. ©2015 Cambridge Semantics Inc. All rights reserved.
Cambridge Semantics
Cambridge Semantics is the creator of the Anzo Smart Data Lake ™ (ASDL)
Based on semantic web technology, the ASDL provides an end-to-end graph-based
data integration, discovery, management, and analytics technology platform.
Cambridge Semantics delivers Smart Data solutions for Life Science companies
including R&D Intelligence, Scientific Affairs, Clinical Data Integration, clinical site
selection, and much, much more…
• Founded in 2007 by senior members of IBM’s Advanced Internet Technology Group
• The Anzo software suite is built on World Wide Web Consortium (W3C) open data standards and
13+ years of R&D
• The award-winning Anzo software suite is our 3rd generation implementation of semantic web
technologies

5. ©2015 Cambridge Semantics Inc. All rights reserved.
What is SMART Data?
RELATE
‘LIKE’ DATA
(contextualize)
EXPLORATORY
ANALYTICS
(graph-ware)
LINKED
DATA
(diverse sources)
LINKED DATA
- Structured
(Relational DB,
Excel, …)
- Semi-structured
(XML, HTML, …)
- Unstructured
(PDF, Word,
email, …)
- Industry standard
data structures
(RDF)
EXPLORATORY ANALYTICS
- Immediately query ALL the data in the graph DB
- Simple self-service analytics with familiar Excel-like functions
- Industry standard query structures (SPARQL)
RELATE ‘LIKE’ DATA
- Associate related
concepts in a
flexible &
extensible graph DB
- Understand the
data in a human-
readable ontology
- Immediately
operationalize the
data in a machine-
readable graph DB
- Industry standard
data modeling
(OWL)

6. ©2015 Cambridge Semantics Inc. All rights reserved.
On Tuesday,
Drugs123 Inc.
announced phase
1 development of
their newest sleep
aid therapeutic,
Narcoleptol.
On Tuesday,
Drugs123 Inc.
announced phase
1 development of
their newest sleep
aid therapeutic,
Narcoleptol.
Smart Data - Linked & Contextualized Data with Semantics
Company Website Mkt Cap
Bio Corp biocorp.com $2.2B
Drugs123 drugs123.com $930M
… … …
Competitive Company Database
Company
Drugs123
930,000,000
name
market
cap
drugs123.com
website
Web news
Drug
Development
1
development
stage
activity
Drug
developing
Insomnia
indication
Narcoleptol
brand
name
Intelligence Review System
Note
about
3/7/2012
Initial safety
signals are …
when
note

7. ©2015 Cambridge Semantics Inc. All rights reserved.
Standards-based Smart Data
Semantic web technology built with World Wide Web Consortium (W3C)
standards
 Scale & diversity of data on the web
 Ever-changing environments
Semantic web enables Smart Data by providing:
 RDF (Resource Description Framework) - A flexible and logical graph-based data model
that can consider data from any source
=> reduced development time and cost
 OWL (Web Ontology Language) - An human understandable conceptual model of entities
and relationships designed for business analysts and knowledge workers
=> improved application quality, iterative / investigative approach
 SPARQL – A complete, high-performance query language standard for accessing RDF data
where IT-intensive skills are not needed to access the underlying data structures
=> reduced development time and cost
W3C Open Standards – A backbone for industry-specific standards
 Benefit from industry standards e.g. CDISC, MedDRA, SNOMED, OpenPhacts …
=> improved data quality & interoperability

8. ©2015 Cambridge Semantics Inc. All rights reserved.
Exploratory Analytics (Graph-aware)

9. ©2015 Cambridge Semantics Inc. All rights reserved.
The Anzo Smart Data Platform™
An agile, end-to-end,
platform for tackling diverse
information challenges
Link and contextualize
information for search,
analytics, visualization and
collaboration

10. ©2015 Cambridge Semantics Inc. All rights reserved.
The Anzo Smart Data Lake™
Data Source
Ingestion
Link &
Contextualize
Discovery
Analytics
Insight
Realization
Structured Unstructured
. . .
. . .
Anzo Smart Data
Integration (ASDI)
Anzo Smart Data
Lake (ASDL) Server
Anzo Graph Query
Engine (AGQE)
Anzo on the
Web (AotW)
Company’s
Information Fabric
Semi-
structured

11. ©2015 Cambridge Semantics Inc. All rights reserved.
Anzo Smart
Data Lake™
Server
The Anzo Smart Data Lake™
Anzo Smart
Data Integration
Server
Anzo Discovery
and Analytics
Server
…..
Data Discovery
and Analytics
Anzo Discovery
and Analytics
Server
Anzo Smart
Data Lake™
Server
Anzo Graph
Query Engine….
Graph Storage
and Cataloging
Integration -
Ingestion and
Linking
Anzo Smart
Data Integration
Server
Anzo Smart
Data Integration
Server
Existing
Hadoop
Data Lake
Enterprise
Data
Sources

12. ©2015 Cambridge Semantics Inc. All rights reserved.
Engineering
Demonstration
Anzo Smart Data Lake™ is “Big Data” Analytics
Early Adopters
0
20
40
60
80
100
120
ActiveRDFTriples(Billions)
Driving
Insights from
“Big Data”
Analytics

13. ©2015 Cambridge Semantics Inc. All rights reserved.
Sample Life Sciences Use Cases
• Clinical Data Standards Management - Manage the development integration of clinical
metadata standards at multiple levels
• PV & Safety Data Management - Automated tagging of safety Case Report Forms (CRF)
with customized curation workflow & text mining and contextual search
• R&D Competitive Intelligence – Explore the competitive landscape for Therapeutic Area,
Indication, Target, Company, Compound, & Partners
• Clinical Trial Data Integration and Discovery - Create a semantic data lake for clinical
trials within one or more Therapeutic Areas for analytics & decision support
• Real World Evidence (RWE) Driven Clinical Trials - Create a semantic data lake across
clinical and healthcare EMR RWE for data analytics & decision support
• Clinical Trial Site Selection and Optimization - Clinical trial site selection, Key Opinion
Leader (KOL) search & review, & trial site startup planning
• Scientific Affairs/Medical Science Liaisons - Track Key Opinion Leaders (KOL) in
literature and clinical trials & analyze feedback from medical professionals and patients
• Information Landscape - Track and monitor data stewardship and usage through the
organization to drive more efficient usage.
• Taxonomy Management - Blend taxonomies from different sources including versioning,
de-duplication, & matching

14. ©2015 Cambridge Semantics Inc. All rights reserved.
Sample Life Sciences Use Cases
• Clinical Data Standards Management - Manage the development integration of clinical
metadata standards at multiple levels
• PV & Safety Data Management - Automated tagging of safety Case Report Forms (CRF)
with customized curation workflow & text mining and contextual search
• R&D Competitive Intelligence – Explore the competitive landscape for Therapeutic Area,
Indication, Target, Company, Compound, & Partners
• Clinical Trial Data Integration and Discovery - Create a semantic data lake for clinical
trials within one or more Therapeutic Areas for analytics & decision support
• Real World Evidence (RWE) Driven Clinical Trials - Create a semantic data lake across
clinical and healthcare EMR RWE for data analytics & decision support
• Clinical Trial Site Selection and Optimization - Clinical trial site selection, Key Opinion
Leader (KOL) search & review, & trial site startup planning
• Scientific Affairs/Medical Science Liaisons - Track Key Opinion Leaders (KOL) in
literature and clinical trials & analyze feedback from medical professionals and patients
• Information Landscape - Track and monitor data stewardship and usage through the
organization to drive more efficient usage.
• Taxonomy Management - Blend taxonomies from different sources including versioning,
de-duplication, & matching

15. ©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case
Clinical Trial Site Intelligence (CTSI)
Objective
Integrate external curated global clinical trial subscription data, such as Citeline, Cortellis, PubMED,
& CT.gov with internal operational site data to support site & Principal Investigators (PIs) selection
and management. Provide a solution to capture site & PI operational experience data for wider
company use. Provide high-value, reusable & controlled analytics for many users
Potential users: Power users: Site Selection (Clin Ops), Data Management, Clinical Study Teams
Casual users: Clinical Operations, PV / Safety, Medical Affairs
Features Benefits
Discover – Explore related Citeline, Cortellis,
PubMED, & CT.gov content to identify PIs, Sites
and Trials of interest
Access a single, unified source for global clinical
trial data
Manage – Flexibly manage internal content of
investigators and sites operational experience,
capture Sponsor/CRO user feedback, curate
(annotate) these data
Better site & PI selection & management using a
single, unified source of industry & company
operational clinical trial data
Analyze – Interactively analyze PIs and Site lists
at all levels including Country, Site and TA.
Rapid answers to ‘what-if’ questions and data
exploration: hours / days versus weeks / months

16. ©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case
Clinical Trial Site Intelligence (CTSI)
Roll-up, traverse, filter and visualize data across CTSI and Citeline
Trial
Investigator
Site
Status
Disease
Address
Patient
Segment
TA
Country
Organization
Phase
TrialtroveSitetroveCTSI
List Entry
Site List
Entry Site
User
Site
Status
Status
Feedback
Tier
Category
…
Specialty

17. ©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case
Clinical Trial Site Intelligence (CTSI)
Demo

18. ©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case
Clinical Trial Site Intelligence (CTSI)
Anzo Unstructured (AU) Pipeline Orchestrator & Monitor

20. ©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case
Clinical Trial Site Intelligence (CTSI)
Demo