Bioscience in Ohio: Facts and Stats, Sept 17 for ODOD Global Markets

1. Ohio’s Bioscience Industry Why Ohio? John F. Lewis Jr. September 17th, 2010 An Ohio Thomas Edison Center

4. Be Proud…Be Strategic “ Ohio is one of the best places in the world to optimize the profitable growth of your bioscience company because we can imbed you in an asset base, 1,253 companies and growing. We are a partner that allows you to maximize any or all phases of your business strategy”

5. The Original Biotechnologies

17. Bioscience companies and organizations can be found in 73 of Ohio’s 88 counties! Source: The Ohio Bioscience Resource Directory, May 5, 2010. www.bioohio.com/directory It’s not just the 3 C’s, Bio in Ohio is statewide!

21. 3 cities in the top 40 Biotech locations in USA In the top 10 nationally for Biotechnology Industry strength All three cities rank higher than the 100 city average in Research grant awards in Bio- Sciences $769 Million in NIH Awards in 2009! State City Rank OH Cleveland-Akron 20 Columbus 22 Cincinnati 28

24. Total Bioscience Funding 2004-2009 >$9 Billion 2009 2008 2007 2006 2005 2004 Funding In $Millions VC/Angels 96 $189 $296 $114 $98 $91 IPO 0 $0 $188 $12 $49 $0 SBIR/STTR* 24 $21 $19 $27 $29 $22 State Biomedical Partnerships (Third Frontier) 40 $98 $135 $155 $75 $51 Matching Corporate Funds for Biomedical Partnerships 47 $105 $92 $273 $112 $111 NSF Bioscience Grants 24 $13 $12 $10 $15 $36 NIH Institutional Grants 769 $637 $698 $689 $725 $695 Other Healthcare Equity Financing $0 $0 $13 $0 $112 $12 Acquisitions 59 $473 $1,089 $75 $279 $0 Total Bioscience Funding $1,059 $1,536 $2,542 $1,355 $1,494 $1,018

46. Top Employers

47. Top Employers

48. Top Employers

49. NAICS The North American Industry Classification System

50. Ohio is ranked 8 th nationally in total patents issued and has more than every country in the world except for Japan, Germany, and the UK

53. 17% of all clinical trials in the US are conducted in Ohio

54. 17% of all clinical trials in the US are conducted in Ohio Source: ClinicalTrials.gov, data 2/19/2010

60. Tax Reform

62. Ohio is ranked in the top 10 in biotechnology strength by Business Facilities magazine.

63. Ohio – National Top 10 AdvaMed

64. Ohio claims its 4th consecutive Governor's Cup, 2006-09, for the most new or expanded capital projects, thanks to the Strickland Administration's focus on taking steps necessary to be competitive, even in a challenging economic environment

65. BioOhio’s Balanced Strategy industry growth, resource optimization, community building Company & Capital Formation Company Attraction & Expansion Member / Trade Association Industry Function Bioscience Workforce & Education

67. By-The-Numbers, then & now Year 1991 2001 2008 – Today Number of Ohio bio entities 170 352 1,253 (2009, 3.6X ‘01 ) University R&D expenditures $285 million $481 million $1.1 billion (2.3X ‘01) New Company starts ≈ 12 12 80 per year 2004-09 (6.6X ‘01) Private capital raised for new starts Unknown $14 million $96 million in 2009 (6.8X ’01) Bioscience Capital sources (in State) 4 8 86 in 2010 (10.7X ‘01) BioOhio (EBTC) membership 52 86 383 in 2010 (4.4X ‘01)

69. Ohio Bioscience Growth Report 2009 Accelerating Excellence Magazine

77. Ohio’s Agricultural Output $79.6 Billion Ohio’s Chemicals, Plastics, Rubber Materials Output $49 Billion Ohio BioProducts Innovation Center

79. Technology Innovation Cycle ADVANCED RESEARCH (8-15 years) PRODUCT CYCLE (1-3 years) BREAKTHROUGH (5-8 years) v: Discovery Development Application Product Development Involves the “Application” of Technology t e r C r o s s I n d u s t r y S o u r c e s F e d e r a l R e s e a r c h C o l l a b o r a t i v e R e s e a r c h R e s e a r c h U n i v e r s i t i e s G l o b a l S o u r c i n g C o r p o r a t e L a b s I n t e r n a t i o n a l S o u r c e s I n t e g r a t i o n S e n s e & L o c a t e G a p A s s e s s m e n t A s s e s s P r o d u c t P l a t f o r m P r o d u c C u s t o m D r i v e s U n m e t N e e d s Develop

80. Medical Device Commercialization Pathway Concept Development and Initial Research Company Formation / Project Team Secure IP Portfolio Product Engineering and Prototype Development Pre-Clinical and Clinical Studies Manufacturing Development/ expansion for clinical trials Clinical Trials/Outcomes FDA Approval and Market Launch Expansion/ Investment in Working Capital $ A B

81. Typical Product Development Process Source: PTRM

85. Medical Product Development each step has defined Work Processes

86. Let me know how we can help you! John F. Lewis Jr. Vice President [email_address] 614-675-3686 x7 An Ohio Thomas Edison Center