The beneficial effects of propolis on human health and neurological diseases. Table describes the neuroprotective properties and biological activity of propolis and select flavonoids commonly found in propolis.
Neuroprotective responses of propolis and select flavonoids
1. Beneficial effects of propolis on human health and neurological diseases
Tahira Farooqui1, Akhlaq A. Farooqui2
1Department of Entomology, 2Department of Molecular and Cellular Biochemistry,
The Ohio State University, Columbus, OH, 43210, USA
Table 1.Neuroprotective responses of propolis and its selected flavonoid constituents
Propolis and its Biological activity
constituents
Propolis
Anti-oxidative
WSDP
Anti-oxidative,
CAPE
anti-inflammatory
Anti-oxidative
CAPE
CAPE
Anti-oxidative
Anti-oxidative
Apigenin
Anti-inflammatory
CAPE
Anti-inflammatory
Chrysin
Quercetin
Anti-inflammatory
Anti-inflammatory
Luteolin
Anti-inflammatory,
Kaempferol
anti-oxidative
Anti-oxidative,
Kaempferol
anti-apoptotic
Anti-oxidative,
Quercetin
anti-apoptotic
Anti-oxidative
Pinocembrin
Propolis
Anti-oxidative
Immunomodulatory
Apigenin and
Anti-inflammatory,
Luteolin
immunomodulatory
CAPE, Chrysin Anti-inflammatory,
anti-oxidative,
immunomodulatory
Pharmacological response
Reference
Attenuates KA-induced seizures
Mitigates scopolamine-induced learning and
memory impairment
(60)
(53)
Neuroprotection against I/R injury (focal cerebral
ischemia and permanent focal ischemia)
Blocks 6-OHDA-induced neurotoxicity
Protects CGNs against glutamate-induced
neurotoxicity by inhibiting phosphorylation of p38
and caspase-3 activation
Inhibits NO and PGE2 synthesis by suppressing the
expression of iNOS and COX-2 in microglia
Prevents inflammatory stress in organotypic
hippocampal slice cultures
Blocks NF-кB and JNK activations in microglia
Decreases iNOS gene expression by inhibiting IκB
kinase, NF-кB and STAT1
Attenuates PS-induced dopaminergic neuronal loss
by blocking NO generation in cultured rat microglia
(49, 50, 51)
Protects from striatal glutamatergic response in
rat brain slices by autophagy
(58)
(48)
(18)
(52)
(55, 69)
(54)
(68)
(60)
Protects from rotenone-induced acute toxicity in
(58)
SH-SY5Y cells and primary neurons by autophagy
Improves memory impairment by inhibiting the
oxidative damage in hippocampus
Protects brain against oxidation and apoptosis
Modulates innate immunity by upregulating the
expression of TLRs and producing proinflammatory cytokines
CD40 immunomodulators and suppress TRIFdependent signaling pathway of TLRs
Specific inhibitor of activation of NF-кB
(59)
(57)
(65)
(66,67)
(13, 36, 37)