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Warm up – On the handout provided fill in each of the structures.

                       14           1
                  13

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                                    3
                    11
                               10
                       9

                           7
    8
                                            4

                       6
                                        5
                                                                1
Neuron Structure




                   2
PowerPoint Lecture Outlines
                     to accompany

           Hole’s Human
       Anatomy and Physiology
                          Eleventh Edition
                        Modified by Mrs. Fiser

                   Shier  Butler  Lewis
                          Chapter 10 Fat Book
                         Chapter 9 Skinny Book




Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
                                                                                               3
Chapter 9
              Nervous System I


Cell Types of Neural Tissue
   • neurons
   • neuroglial cells




                                 4
Divisions of the
               Nervous System

• Central Nervous System
    • brain
    • spinal cord
• Peripheral Nervous System
    • nerves
        • cranial nerves
        • spinal nerves


                                  5
Divisions of Peripheral Nervous
              System
Sensory Division
   • picks up sensory information and delivers it to the CNS

Motor Division
  • carries information to muscles and glands

Divisions of the Motor Division
   • Somatic – carries information to skeletal muscle
   • Autonomic – carries information to smooth muscle,
   cardiac muscle, and glands

                                                          6
Divisions Nervous System




                           7
8
Functions of Nervous System
Sensory Function
   • sensory receptors gather
   information
   • information is carried to the   Motor Function
   CNS                                 • decisions are acted
                                       upon
Integrative Function                   • impulses are
    • sensory information used to      carried to effectors
    create
       • sensations
       • memory
       • thoughts
       • decisions
                                                               9
Neuron Structure




                   10
Myelination of Axons


White Matter
  • contains myelinated
  axons
Gray Matter
  • contains
  unmyelinated
  structures
  • cell bodies, dendrites



                                  11
Classification of Neurons –
          Structural Differences
Bipolar
   • two processes
   • eyes, ears, nose

Unipolar
   • one process
   • ganglia


Multipolar
  • many processes
  • most neurons of
  CNS                                 12
Classification of Neurons – Functional
                   Differences
Sensory Neurons
    • afferent
    • carry impulse to CNS
    • most are unipolar
    • some are bipolar
Interneurons
    • link neurons
    • multipolar
    • in CNS
Motor Neurons
   • multipolar
   • carry impulses away
   from CNS
   • carry impulses to
   effectors                                  13
Types of Neuroglial Cells
                in the PNS
Schwann Cells
   • produce myelin found on peripheral
   myelinated neurons
   • speed neurotransmission


Satellite Cells
   • support clusters of neuron cell bodies (ganglia)




                                                        14
Types of Neuroglial Cells
                      in the CNS

Astrocytes
   • CNS
   • scar tissue
   • mop up excess ions, etc
   • induce synapse formation
   • connect neurons to blood
   vessels
 Oligodendrocytes               Ependyma
    • CNS                          • CNS
    • myelinating cell             • ciliated
 Microglia                         • line central canal of spinal
    • CNS                          cord
    • phagocytic cell              • line ventricles of brain     15
Types of Neuroglial Cells




http://learn.genetics.utah.edu/content/addiction/reward/c
ells.html
                                                            16
Astrocytes




             17
Oligodendrocytes




                   18
Microglial Cells




                   19
Ependymal Cells




                  20
CNS Neuroglial Cells
Sketch Structure:




Microglial          Oligodendrocytes   Astrocytes          Ependymal
Function:
________________ ________________ _________________ _______________
________________ ________________ _________________ _______________
________________ ________________ _________________ _______________

________________    ________________   _________________   _______________
________________    ________________   _________________   _______________
________________    ________________   _________________   _______________
                                                                       21
________________    ________________   _________________   _______________
PNS Neuroglial Cells
Sketch Structure:




Schwann
Function:
________________ ________________ _________________ _______________
________________ ________________ _________________ _______________
________________ ________________ _________________ _______________

________________    ________________   _________________   _______________
________________    ________________   _________________   _______________
________________    ________________   _________________   _______________
                                                                       22
________________    ________________   _________________   _______________
NEUROGLIAL CELL ADVERTISEMENT

   You are an ad executive for a major marketing firm. You must create
a billboard that will “sell” the type of neuroglial cell that you have been
assigned. Your “billboard” will be constructed on a piece of poster
board. It must include the following information about your neuroglial
cell: name, part of nervous system to which it belongs, its “importance”
or what it does, and an illustration. All of this information must be
presented within the context of an advertising theme.
Your project will be scored according as follows:

CONTENT (50 POINTS)
•Name of neuroglial cell
•Part of nervous system to which it belongs
•Importance/function
•Description/illustration
CREATIVITY (30 POINTS) (unique, slogan, artwork)
NEATNESS (10 POINTS)
TEAMWORK (10 POINTS)

                                                                      23
Schwann

Oliogodendrocyte

Microglial

Astrocytes

Ependymal
                   24
The Synapse



Nerve impulses pass
from neuron to
neuron at synapses




                              25
Synaptic Transmission



Neurotransmitters are
released when impulse
reaches synaptic knob




                                  26
Resting Membrane Potential


• inside is negative
relative to the outside
• polarized membrane
• due to distribution of
ions
• Na+/K+ pump




                                   27
Local Potential Changes




                          28
Action Potentials
• at rest membrane is
polarized

• threshold stimulus
reached

• sodium channels
open and membrane
depolarizes

• potassium leaves
cytoplasm and
membrane repolarizes


                                       29
Action Potentials




                    30
Action Potentials




                    31
Animations

• http://highered.mcgraw-
  hill.com/sites/0072437316/student_view0/chapter
  45/animations.html

http://www.blackwellpublishing.com/matthews/actio
  np.html



                                              32
All-or-None Response

• if a neuron responds at all, it responds completely

• a nerve impulse is conducted whenever a stimulus of
threshold intensity or above is applied to an axon

• all impulses carried on an axon are the same strength




                                                          33
Impulse Conduction




                     34
Neurotransmitters




                    35
Neurotransmitters




                    36
Impulse Processing
• way the NS processes nerve impulses and acts upon them

•Neuronal Pools

•Convergence

•Divergence




                                                           37
Neuronal Pools

•groups of interneurons that make synaptic connections
with each other

• interneurons work together to perform a common
function

• each pool receives input from other neurons

• each pool generates output to other neurons


                                                         38
Convergence
• neuron receives input from
several neurons

• incoming impulses represent
information from different
types of sensory receptors

• allows nervous system to
collect, process, and respond to
information

• makes it possible for a neuron
to sum impulses from different
sources                            39
Divergence
• one neuron sends
impulses to several
neurons

• can amplify an
impulse

• impulse from a single
neuron in CNS may be
amplified to activate
enough motor units
needed for muscle
contraction
                                   40
Clinical Application
                    Drug Addiction
• occurs because of the complex interaction of neurons,
drugs, and individual behaviors
• understanding how neurotransmitters fit receptors
can help explain the actions of certain drugs
• drugs have different mechanisms of action
• several questions remain about the biological effects
of addiction, such as why some individuals become
addicted and others do not
•http://learn.genetics.utah.edu/content/addiction/drugs/
mouse.html
                                                           41

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A & p holes' nervous i

  • 1. Warm up – On the handout provided fill in each of the structures. 14 1 13 12 2 3 11 10 9 7 8 4 6 5 1
  • 3. PowerPoint Lecture Outlines to accompany Hole’s Human Anatomy and Physiology Eleventh Edition Modified by Mrs. Fiser Shier  Butler  Lewis Chapter 10 Fat Book Chapter 9 Skinny Book Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 3
  • 4. Chapter 9 Nervous System I Cell Types of Neural Tissue • neurons • neuroglial cells 4
  • 5. Divisions of the Nervous System • Central Nervous System • brain • spinal cord • Peripheral Nervous System • nerves • cranial nerves • spinal nerves 5
  • 6. Divisions of Peripheral Nervous System Sensory Division • picks up sensory information and delivers it to the CNS Motor Division • carries information to muscles and glands Divisions of the Motor Division • Somatic – carries information to skeletal muscle • Autonomic – carries information to smooth muscle, cardiac muscle, and glands 6
  • 8. 8
  • 9. Functions of Nervous System Sensory Function • sensory receptors gather information • information is carried to the Motor Function CNS • decisions are acted upon Integrative Function • impulses are • sensory information used to carried to effectors create • sensations • memory • thoughts • decisions 9
  • 11. Myelination of Axons White Matter • contains myelinated axons Gray Matter • contains unmyelinated structures • cell bodies, dendrites 11
  • 12. Classification of Neurons – Structural Differences Bipolar • two processes • eyes, ears, nose Unipolar • one process • ganglia Multipolar • many processes • most neurons of CNS 12
  • 13. Classification of Neurons – Functional Differences Sensory Neurons • afferent • carry impulse to CNS • most are unipolar • some are bipolar Interneurons • link neurons • multipolar • in CNS Motor Neurons • multipolar • carry impulses away from CNS • carry impulses to effectors 13
  • 14. Types of Neuroglial Cells in the PNS Schwann Cells • produce myelin found on peripheral myelinated neurons • speed neurotransmission Satellite Cells • support clusters of neuron cell bodies (ganglia) 14
  • 15. Types of Neuroglial Cells in the CNS Astrocytes • CNS • scar tissue • mop up excess ions, etc • induce synapse formation • connect neurons to blood vessels Oligodendrocytes Ependyma • CNS • CNS • myelinating cell • ciliated Microglia • line central canal of spinal • CNS cord • phagocytic cell • line ventricles of brain 15
  • 16. Types of Neuroglial Cells http://learn.genetics.utah.edu/content/addiction/reward/c ells.html 16
  • 21. CNS Neuroglial Cells Sketch Structure: Microglial Oligodendrocytes Astrocytes Ependymal Function: ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ 21 ________________ ________________ _________________ _______________
  • 22. PNS Neuroglial Cells Sketch Structure: Schwann Function: ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ ________________ ________________ _________________ _______________ 22 ________________ ________________ _________________ _______________
  • 23. NEUROGLIAL CELL ADVERTISEMENT You are an ad executive for a major marketing firm. You must create a billboard that will “sell” the type of neuroglial cell that you have been assigned. Your “billboard” will be constructed on a piece of poster board. It must include the following information about your neuroglial cell: name, part of nervous system to which it belongs, its “importance” or what it does, and an illustration. All of this information must be presented within the context of an advertising theme. Your project will be scored according as follows: CONTENT (50 POINTS) •Name of neuroglial cell •Part of nervous system to which it belongs •Importance/function •Description/illustration CREATIVITY (30 POINTS) (unique, slogan, artwork) NEATNESS (10 POINTS) TEAMWORK (10 POINTS) 23
  • 25. The Synapse Nerve impulses pass from neuron to neuron at synapses 25
  • 26. Synaptic Transmission Neurotransmitters are released when impulse reaches synaptic knob 26
  • 27. Resting Membrane Potential • inside is negative relative to the outside • polarized membrane • due to distribution of ions • Na+/K+ pump 27
  • 29. Action Potentials • at rest membrane is polarized • threshold stimulus reached • sodium channels open and membrane depolarizes • potassium leaves cytoplasm and membrane repolarizes 29
  • 32. Animations • http://highered.mcgraw- hill.com/sites/0072437316/student_view0/chapter 45/animations.html http://www.blackwellpublishing.com/matthews/actio np.html 32
  • 33. All-or-None Response • if a neuron responds at all, it responds completely • a nerve impulse is conducted whenever a stimulus of threshold intensity or above is applied to an axon • all impulses carried on an axon are the same strength 33
  • 37. Impulse Processing • way the NS processes nerve impulses and acts upon them •Neuronal Pools •Convergence •Divergence 37
  • 38. Neuronal Pools •groups of interneurons that make synaptic connections with each other • interneurons work together to perform a common function • each pool receives input from other neurons • each pool generates output to other neurons 38
  • 39. Convergence • neuron receives input from several neurons • incoming impulses represent information from different types of sensory receptors • allows nervous system to collect, process, and respond to information • makes it possible for a neuron to sum impulses from different sources 39
  • 40. Divergence • one neuron sends impulses to several neurons • can amplify an impulse • impulse from a single neuron in CNS may be amplified to activate enough motor units needed for muscle contraction 40
  • 41. Clinical Application Drug Addiction • occurs because of the complex interaction of neurons, drugs, and individual behaviors • understanding how neurotransmitters fit receptors can help explain the actions of certain drugs • drugs have different mechanisms of action • several questions remain about the biological effects of addiction, such as why some individuals become addicted and others do not •http://learn.genetics.utah.edu/content/addiction/drugs/ mouse.html 41