Christina Wang, MD “Overview of CTSI Resources” Associate Director, UCLA Clinical and Translational Science Institute Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center Professor of Medicine, David Geffen School of Medicine at UCLA Division of Endocrinology, Department of Medicine

1. UCLA CTSI
Clinical and Translational Science Institute
K Award Workshop
January 10, 2012
Los Angeles Biomedical Research
Institute at Harbor-UCLA Medical
Center
Christina Wang, MD
Associate Director,
UCLA Clinical and Translational Science Institute
Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute
www.ctsi.ucla.edu

2. Purpose of the
National CTSA Program
Providing an infrastructure for clinical and translational research
Past Present and Future
Inpatient
GCRC Outpatient & community based research
Individual
investigators Transdisciplinary team science
Traditional Training in clinical and translational
training
team science
Individual
academic
Regional and national consortia
medical centers linked for collaboration 2

3. What is translational research?
UCLA CTSI translational investigation
extends from molecules to society
Translating knowledge gained from laboratory science
into clinical practice to improve health.
The aim of translational research is to produce new:
• therapeutics
• medical devices
• tools for diagnosing disease
• avenues for community engagement research

4. Overview of Pilot Grant Programs
Pilots
Pilots TeamTeam Building
Building Proposal Development
Proposal Development Proof-of-Concept
Proof-of-Concept
Catalyst Grants
Team Science Awards Prototype Grants
CTSI Scholars Novel Methods
Awards & Technologies Award
Rapid Response Team

5. Early Career Awards
Opportunity Funds Grant Amount Duration of Award Cycle Application
Award (Years) Due Date
Pilots Team Building Proposal Development Proof-of-Concept
KL2 Awards: to pursue Up to $125,000 1 year at 75% July 1 Late February
interdisciplinary, mentored research in salary and effort 2013
with training research support (renewable for
up to 3 years)
TL1 Summer Program for Summer stipend The summer June 1 Late March 2013
Professional Students: provides plus funding for between
professional students (medical, training-related student’s first
nursing and dental) early exposure to expenses and second year
interdisciplinary, community- (8 weeks)
partnered translational or health
services research
Scholar Awards: for junior faculty in Up to $30,000 Up to 1 year Annual Fall 2013
any series within their first three
years of appointment to support
mentored training in translational
research in all areas of investigation.

6. KL2 Year 1 Awardees
Amira Brown, MS, PhD
Assistant Professor, CDU
“ Effects of Varenicline on Alcohol and Nicotine Consumption and
changes in Dopamine D2-like Receptor Availability in High-Alcohol
Preferring Mice”
Joshua Zaritsky, MD, PhD
Assistant Professor, Pediatric Nephrology, UCLA
“ Hepcidin and the Anemia of Chronic Kidney Disease”
Gelareh Gabayan, MD, MSHS
Assistant Professor of Medicine, UCLA/VA
“ Patterns and Predictors of Poor Outcomes Following Emergency
Department Discharge in Older Adults”

7. KL2 Year 2 Awardees
James McKinnell, MD
Assistant Professor, LA-BioMed/Harbor-UCLA
“Using Research in Vancomycin-Resistant Enterococcus to Validate an
Efficient System of Quantifying Antibiotic Utilization”
Mary Sehl, MD, PhD
Assistant Professor, UCLA
“Modeling of EMT/MET transitions in breast cancer stem cells”
David Shackelford, PhD
Assistant Professor, UCLA
“Development of novel therapeutic strategies to target LKB1/STK11
deficient non-small cell lung cancer” 7

8. Early Career Awards
CTSI Scholar Awards
For junior faculty in any series within their first three years of
appointment to support mentored training in translational
research.
In 2012 12 CTSI scholars: 2 form Cedars, 2 from LA BioMed
and 8 from UCLA
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9. Funding Opportunities
for All Investigators
Pilots Team Building Proposal Development Proof-of-Concept
Opportunity Funds Grant Duration Award Application
Amount of Award Cycle Due Date
(Years)
Vouchers: Up to 1 Biannual/ Feb 2013
for core services at CTSI $10,000 Annual
institutions
Seed Grants: to support $1,000 to Up to 1 year Annual Fall 2013
research projects encouraging $30,000
translational science

10. Center for Translational Technology
Voucher Awards
Vouchers of up to $10,000 to utilize core services
• RFAs for Voucher Awards will be issued twice a year
• Next Voucher RFA will be cross-institutional and
announced early 2013 with an award date of March 1,
2013
Awardees
• Awards prioritized for innovation, translational, and
samples and core ready
•Junior investigators are ranked separately from established
investigators 10

11. Other Collaborative
Funding Opportunities
Opportunity Funds Grant Duration Award Application
Pilots Team Building Amount ofDevelopment Cycle
Proposal Award Proof-of-Concept
Due Date
(Years)
Team Science Awards: Up to 1-2 years Annual Rolling
multidisciplinary, cross- $200,000
institutional, translational
science leading to a proposal
under such team-science
mechanisms as P01, U54, and
center grants
Catalyst Awards: to support $1,000 to Up to 1 Quarterly RFA to be
seminar series, team-building $5,000 year released
activities and pilot studies and August 15,
other activities to encourage 2012
translational team science

12. Collaborative
Funding Opportunities
Catalyst Awards
Support team-building activities that advance translational
science and promote collaborations across disciplines and
CTSI institutions ($100 - $5,000)
Cedars Awardees
Jonathan Kaye, PhD, for the 2nd Annual Immunology LA
conference at the Skirball Center on May 24, 2012.
►The meeting provided a unique opportunity for interactions
between immunologists at all partner institutions.
12

13. Collaborative
Funding Opportunities
Team Science Awards
Support multidisciplinary, cross-institutional, team-based
research addressing major health problems (up to $200,000).
Partner with other funding organizations to leverage
resources. Co-funding is required.
2012 Awardee
Project: Clinical and Translational Science Institute Prospective
Longitudinal Assessment of Co-infected Subjects with HIV/Hepatitis
C for endothelial function study (CTSI-PLACE Study).
UCLA: Kara Chew and Debika Bhattacharya
LA BioMed/Harbor-UCLA: Eric Daar
Cedars-Sinai: David Hardy
Charles Drew: Wilbert Jordan
13

14. Upcoming Team Science Award
with LA DHS
Major focus: How can we improve health care
without increasing costs?
Anticipated release date: January 2013
The UCLA CTSI seeks to expand translational research involving the Los Angeles
Department of Health Services (LA DHS) delivery system, leading to:
(1) system solutions that improve health care, health behaviors, and/or health
status of Los Angeles residents without increasing costs
(2) submission of extramural grants involving the CTSI and DHS
Award: up to $30,000 for a period of one year
• Awards are non-renewable
• NIH guidelines for annual and end-of-project reporting will apply
• Co-funding is required
14

15. Clinical and Translational Research
Centers (CTRC)
Ambulatory Clinical Research Facilities at
Cedars, Drew, LA BioMed-Harbor, and
UCLA-CHS
• Private rooms, infusion rooms, procedure rooms
• Sleep Research Facilities at LA Biomed-Harbor
• Interview and conference rooms
• Investigational pharmacy and sample processing
• 23 hour capacity at UCLA
Inpatient Clinical Research Centers at LA
Biomed/Harbor and UCLA-Ronald
Reagan Medical Center
 “First in man” clinical pharmacology studies
 Metabolic Balance Studies
 Human Physiological Phenotyping Studies

16. Office of Investigator Services
Research Facilitation Contact a Facilitator
Provides across-the-board Cedars-Sinai Medical Center
assistance: (310) 423-2475
Jerlyn Tolentino
• research project/grant Charles Drew University of Medicine and
proposal development Sciences
(323) 357-3645
Hema Ramamurthi
• navigating and accessing
Los Angeles Biomedical Research Institute at
CTSI research support Harbor-UCLA Medical Center
resources and services (310) 222-2503
Alla Victoroff and Terry Doherty
• expert consultation on all University of California, Los Angeles
aspects - from study (310) 794-CTSI
concept through regulatory (310) 825-0791
Marisa Briones
approval and oversight
General Questions
Telephone: (310) 794-CTSI (2874)
E-mail: ois@ctsi.ucla.edu
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17. CTSA Regional Consortia
University of California,
Los Angeles

18. UC Biomedical Research Acceleration Integration and Development
(UC-BRAID)