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GE Healthcare
Discovery* CT750 HD
Great care by design
At GE Healthcare, imag in
lie at the heart of every th
than 30 years, we’ve d e
that enhance the ways c
and treat disease. Bett e
us to render the inner w
greater fidelity and det a
than before.
2  GE Healthcare Discovery CT750 HD
g ination and knowledge
y thing we do. For more
d esigned CT systems
s clinicians diagnose
t er tools have enabled
r world of the body with
et ail — and at lower dose
g ination and knowledge
y thing we do. For more
d esigned CT systems
s clinicians diagnose
t er tools have enabled
r world of the body with
et ail — and at lower dose
 GE Healthcare Discovery CT750 HD 3
Filtered Back Projection (FBP)
The Discovery*
 CT750 HD is designed
to deliver up to 50%1
lower dose,
helping assure patients with faster,
more confident diagnoses.
1. In clinical practice, the use of ASiR may reduce CT patient dose
depending on the clinical task, patient size, anatomical location
and clinical practice. A consultation with a radiologist and a
physicist should be made to determine the appropriate dose to
obtain diagnostic image quality for the particular clinical task.
ASiR dose reduction was measured on a standard 20cm water
phantom. The test involved maintaining constant pixel standard
deviation as the mA was reduced at 120 kVp.
4  GE Healthcare Discovery CT750 HD
ASiR* (Adaptive Statistical Iterative Reconstruction)
 GE Healthcare Discovery CT750 HD 5
The Discovery CT750 HD offers the
highest available cardiac spatial
resolution in the industry at1
18.2 lp/cm.
1. Based upon internal test data comparing Discovery CT750 HD
cardiac half-scan spatial resolution to data from “Advanced CT
Scanners for Coronary Angiography”, ImPACT Report CEP10043,
March, 2010, available at http://www.impactscan.org
6 GE Healthcare Discovery CT750 HD
Standard Resolution
HD Resolution
 GE Healthcare Discovery CT750 HD 7
Conventional 140 kVp Spectral 50 keV
Powered by our proprietary CT scintillator
material, the Discovery CT750 HD features
Gemstone*
Spectral Imaging. At temporal
registrations speeds of up to 165 times
faster than the nearest competitor,
GSI is the first quantitative dual energy
on the market.
8  GE Healthcare Discovery CT750 HD
Grayscale quantitative MD iodine image Colored quantitative MD iodine image
In the arterial phase images, you can visualize an early contrast
uptake, especially on iodine and low keV images.
 GE Healthcare Discovery CT750 HD 9
In addition to its specialized applications,
the Discovery CT750 HD makes an
excellent scanner for routine imaging by
improving the clarity of the image while
lowering patients’ dose.
10  GE Healthcare Discovery CT750 HD
GE Healthcare Discovery CT750 HD 11
And with our breakthrough Veo
image reconstruction technology,
the Discovery CT750 HD can
acquire images at under 1 mSv
with profound clarity.
FBP
In clinical practice the use of Veo may reduce CT patient dose
depending on the clinical task, patient size, anatomical location
and clinical practice. A consultation with a radiologist and a
physician should be made to determine the appropriate dose to
obtain diagnostic image quality for the particular clinical task.
12  GE Healthcare Discovery CT750 HD
Veo image, 0.61 mSv, DLP 36.02
Obtained by EUR-16262 EN, using an abdomen factor
of 0.015*DLP and a pelvis factor of 0.019*DLP
 GE Healthcare Discovery CT750 HD 13
You and your patients continue to
demand lower dose — but not
at the expense of image quality.
The Discovery CT750 HD delivers
on both imperatives — precise
imaging for a confident diagnosis
and enhanced patient care.
14  GE Healthcare Discovery CT750 HD
GE Healthcare Discovery CT750 HD 15
“We decided to implement ASiR on 100% of our exams
and achieved excellent results. As such, ASiR has become
a key component in our campaign for low dose CT.
The community response from both our patients and
physicians was greater than we ever expected, and
UW is now viewed as the go-to place for low dose CT”
William P. Shuman, M.D.
University of Washington Medical Center
“With the Discovery CT750 HD, we have been able to
significantly reduce radiation dose while, at the same
time, improving image quality. Our patients are
benefiting from the dose reduction in every exam we
perform, all without compromising diagnostic quality.
With this dramatic dose reduction our practice has
grown our referral base, and patients are asking to be
scanned on the Discovery CT750 HD.”
David A. Dowe, M.D.
Atlantic Medical Imaging
“With the Discovery CT750 HD we have been able to
reduce drastically the dose in coronary CTA, while
improving image quality. We routinely scan patients at
less than 1 mSv and still achieve high diagnostic quality.”
Jean-Nicolas Dacher, M.D., Ph.D.
Rouen University Hospital
16 GE Healthcare Discovery CT750 HD
ASiR may reduce dose by
up to 50%1
by allowing the
use of lower mA protocols — 
and with high definition
image quality across all
anatomies — the Discovery
CT750 HD can reach any
part of the body, any age
patient, and any application
that demands the leading
edge of CT clarity.
1. In clinical practice, the use of ASiR may reduce CT patient dose
depending on the clinical task, patient size, anatomical location
and clinical practice. A consultation with a radiologist and a
physicist should be made to determine the appropriate dose to
obtain diagnostic image quality for the particular clinical task.
ASiR dose reduction was measured on a standard 20cm water
phantom. The test involved maintaining constant pixel standard
deviation as the mA was reduced at 120 kVp.
 GE Healthcare Discovery CT750 HD 17
A better path forward
Incremental reductions in dose can
go a long way toward supporting
improved care, but the highest
standard can only be achieved
through breakthrough innovation
in image reconstruction.
Leading the way with image reconstruction
Typically, lowering dose has increased noise and image
artifacts, creating an unfortunate trade-off between
higher image quality and lower dose. In order to over-
come this obstacle, GE developed an industry exclusive
high definition approach to image reconstruction — 
Adaptive Statistical Iterative Reconstruction (ASiR).
Low dose kidney stone protocol at 83 mAs
18  GE Healthcare Discovery CT750 HD
ASiR provides exceptional image quality by improving low
contrast detectability (LCD) and suppressing noise without
degrading anatomical integrity. It overcomes the limitations
of the conventional CT reconstruction approach known
as filtered back projection and arrives at an optimal image
using an advanced iterative computation. As a result, the
Discovery CT750 HD is capable of significant dose reduction
with no loss of diagnostic image quality. Since its introduction
in 2008, ASiR has earned positive mention from clinicians
in peer-reviewed journals, in dozens of abstracts, and at
multiple conferences. Millions of patients’ exams make ASiR
the proven choice for image reconstruction.
 GE Healthcare Discovery CT750 HD 19
The Discovery CT750 HD has the
industry leading Cardiac CT spatial
resolution. At 18.2 lp/cm, the system
provides up to 66% greater spatial
resolution than comparable systems.
20  GE Healthcare Discovery CT750 HD
GE Healthcare Discovery CT750 HD 21
The improved resolution of the
Discovery CT750 HD displays
reduction in calcium blooming
compared to standard resolution,
enabling an accurate diagnosis.
Standard Resolution HD Resolution
22  GE Healthcare Discovery CT750 HD
”Utilizing the Discovery CT750 HD has increased
my confidence in evaluating calcified segments,
thereby decreasing the need for additional
downstream testing. The improvement in spatial
resolution is real and impacts my practice on
a daily basis.”
Jonathan Leipsic, M.D.
FRCPC, University of British Columbia,
Providence Healthcare
The Discovery CT750 HD
delivers improvements
in spatial resolution that
can help you accurately
quantify stenosis in
coronary vessels.
 GE Healthcare Discovery CT750 HD 23
Low dose cardiac imaging
with excellent IQ
at less than 1mSv
SnapShot Pulse and ASiR*
enable
low dose not only for Coronary CT
but across cardiovascular exams,
enabling cardiac CT of less than
1mSv.
Using SnapShot Pulse imaging
and ASiR, the Discovery CT750 HD
achieves a dose reduction of
greater than 83% compared to
gated helical acquisition.3,4,5
Acquisition protocols are easily
adapted to the clinical needs of
the individual patient for optimal
diagnostic results at low dose.
Intelligent system design helps to
manage high and unstable heart
rates in prospective and
retrospective modes.
1. Estimated Radiation Dose Reduction
Using Adaptive Statistical Iterative
Reconstruction in Coronary CT Angiography:
The ERASIR Study, AJR:195, 2010 Sept;
195(3):655-60
2. Effect of Standardized Quality-
Improvement Protocol on Radiation Dose
in Coronary Computed Tomographic
Angiography, Am J Cardiol, 2010 Dec 1;
106(11):1663-7
“In the multicenter ERASIR study1
of more than 500 patients that
examined the effect of ASiR on
radiation dose, we noted a 27%
reduction in dose for patients
undergoing coronary CT angiography.
In the second independent study,2
using a combination of SnapShot
imaging, reduced tube voltage and
ASiR, we have observed in 449
patients an average dose of 1.3 mSv
in unselected patients undergoing
CT angiography.”
James Min, M.D.
Co-director of Cardiac Imaging
Director of Cardiac Imaging Research
Cedars Sinai Heart Institute
3. In clinical practice, the use of ASiR may reduce CT patient dose depending on the
clinical task, patient size, anatomical location and clinical practice. A consultation
with a radiologist and a physicist should be made to determine the appropriate dose
to obtain diagnostic image quality for the particular clinical task.
4. Dose reduction was measured on a standard 20cm water phantom comparing a
SnapShot Pulse prospective gated axial acquisition at 120kV/300mA and 50% ASiR to
a cardiac helical acquisition 120kV/500mA without ASiR both with a 224mm scan
coverage.
5. In clinical practice, the use of SnapShot Pulse may reduce cardiac CT patient dose
depending on the clinical task and patient heart rate. A consultation with a radiologist
should be made to determine the appropriate acquisition mode and scan settings to
obtain diagnostic image quality for the particular clinical task.
24  GE Healthcare Discovery CT750 HD
6 Obtained by ICRP using a chest factor of
0.014* DLP
7 May J et.al. Low-risk chest pain patients
in the emergency department: Negative
64-channel cardiac CT angiography may
reduce length of stay and hospital charges.
AJR 2009; 192(S5): A1.
5 hours
vs.
25.4 hours
Assessing chest pain in the ER
with the Discovery CT750 HD.
A traditional cardiac diagnostic
pathway can take between 12 and
36 hours, utilizing a significant
amount of hospital time, personnel,
and resources. With the Discovery
CT750 HD system, unless the
scan indicates an occlusion with
greater than 75 percent stenosis,
patients may avoid additional
diagnostic cardiac procedures — 
all while decreasing the time to
diagnosis and increasing through­
put and efficiency in your care
environment.
GE’s Discovery CT750 HD produces
remarkably clear, quality cardiac
images that have the potential to
streamline the care process, freeing
clinical staff to care for more patients.
A recent study has reported that a
diagnostic work up of a single set
of enzymes and an ECG along with
a cardiac CT angiography (CCTA)
takes an average of only 5 hours to
rule out coronary artery disease,
compared to an average of 25.4
hours with standard care workup.7
That means your hospital can save
both time and resources.
0.57 mSv6
Cardiac CTA is achievable
utilizing ASiR image reconstruction
on the Discovery CT750 HD.
Even at this ultra-low dose level, the
Discovery CT750 HD can visualize
vessels as small as 1mm in coronary
CTA exams.
 GE Healthcare Discovery CT750 HD 25
26  GE Healthcare Discovery CT750 HD
Gemstone Spectral Imaging is a revolutionary feature
exclusive to the Discovery CT750 HD. Today, it is expanding
the information available for clinical diagnosis and
workflow in the following key areas: characterization of
small lesions, beam hardening reduction, kidney stone
characterization, optimization of contrast and virtual
non-contrast like imaging. Tomorrow, its broad applications
and unprecedented level of detail have the potential to
completely re-define diagnostic imaging.
 GE Healthcare Discovery CT750 HD 27
Gemstone
Spectral Imaging
Gemstone Spectral
Imaging (GSI) is a unique
dual energy technique that
uses rapid kV switching
and Gemstone Detector
technology to acquire and
generate material density
data. This data can be
used to separate materials
and derive monochromatic
spectral images using
a projection-space
reconstruction algorithm.
Virtual noncontrast-like imaging
Gemstone Spectral Imaging can subtract iodine from
images to generate a virtual noncontrast-like image.
Note the kidney stone is obscured in the IV contrast
image, but visualized in the water density image.
70 keV Spectral
MD Water
Material Separation
GSI provides information about the chemical composi-
tion of body materials. This capability enables the user
to easily separate calcium, iodine and water to aid in
the characterization of pathology.
28  GE Healthcare Discovery CT750 HD
Quantitative Lesion Characterization
at 50cm FOV
Spectral Imaging’s potential to enhance lesion charac-
terization is seen here with the two lesions displayed
on the images. Utilizing GSI and viewing the images at
lower spectral energy, the lesion is more conspicuous,
and the differentiation of the non-enhancing cyst
and enhancing lesion is well depicted on the spectral
curves, normalized to the liver parenchyma.
70 keV Spectral 70 keV Spectral color
Spectral Hounsfield unit curve Normalized Spectral Hounsfield unit curve
 GE Healthcare Discovery CT750 HD 29
“Traditionally, CT provided an excellent depiction of the
pulmonary vessels, thrombi and emboli. However, it
could not give us information on the severity of
pulmonary embolism obstruction or perfusion deficit
defects. With the GSI-generated iodine maps, I can
clearly see the severity of perfusion deficit. GSI is a
very effective technique that eliminates the need for
additional scans to gather functional information on
lung perfusion.”
Valentin Sinitsyn, M.D., Ph.D.
Moscow Federal Center of Medicine
“About 40% of our routine spine exams involve metal
instrumentation. Reducing artifact for these exams is
an important benefit that GSI provides. Spectral CT
generates virtually pristine images in these most
challenging circumstances where traditional techniques
often fail.”
Lawrence N. Tanenbaum, MD, FACR
Mount Sinai School of Medicine
“With Gemstone Spectral Imaging we can more easily
obtain high quality images on the femoral arteries in
patients with metallic hip prostheses. This capability is
particularly important when planning a transcatheter
aortic valve implantation (TAVI).”
Jean-Nicolas Dacher, M.D., Ph.D.
Rouen University Hospital
30  GE Healthcare Discovery CT750 HD
Gemstone Spectral Imaging
is delivering real diagnostic
results today. Tomorrow
it has the potential to be
used as a routine scan
acquisition mode, taking the
possibilities even further.
 GE Healthcare Discovery CT750 HD 31
Enhancing image quality with monochromatic spectral image
Exclusive to the Discovery CT750 HD, the spectral image is created as though
it comes from a single energy (keV) source. Individual spectral images can
be derived from 101 user-selectable energy levels. This approach enables
image contrast optimization, accurate CT numbers and up to a 50% reduction
in common beam hardening artifacts — features that together aid in a fast,
confident diagnosis.
Utilizing lower energy spectral images allows for better contrast differen-
tiation, thereby accentuating subtle contrast differences.
In the study below, due to the patient’s impaired renal function only 60cc
of contrast was utilized. With GSI’s capability to review different levels of
monochromatic energy levels for better iodine conspicuity, the endoleak
was visualized.
VR images VR images demonstrating
thrombus
Conventional CT 93 keV Spectral image 93 keV VR Spectral image
Curved view demonstrating
endoleak visualization
Beam hardening reduction
Reducing visually obstructive beam hardening artifacts will reveal impor-
tant underlying anatomical information for a complete diagnosis.
32  GE Healthcare Discovery CT750 HD
How it works
Central to spectral image acquisition is the Gemstone
detector’s ability to differentiate between two different
energy levels from view to view (as illustrated by the
blue and green data sets below). Both high and low
energy data sets are acquired simultaneously to improve
image registration for material separation throughout
the full 50cm field of view.
Using known attenuation curves, the material specific
difference in attenuation enables an easy classification
of the elementary chemical composition of the scanned
tissue. This creates the ability to generate material
density images.
Spectral images are derived from the material density
images and depict how the object would look if the
X-ray source produced only photons at a single energy.
Quicker
Diagnosis
equals
Reduced
Hospital
Cost
Painful episodes of renal-related
conditions result in more than one
million patient visits to emergency
departments annually.1
Reducing
the time spent on imaging,
additional testing, and waiting for
results has the potential to
decrease both length of stay and
overall costs to the hospital. This is
critical, as hospitals are paid a fixed
amount per admission regardless
of the number of services provided.
Using GE’s Discovery CT750 HD
with Gemstone Spectral Imaging
(GSI), a single contrast-enhanced
CT may provide information to
evaluate the presence or absence
of a renal lesion. With the same
exam data, GSI can create a “virtual
non-contrast like image” that can
provide information to assess for
kidney stones. GSI also has the
ability to help characterize renal
stones without a urinalysis — 
meaning treatment can start
earlier, minimizing in-patient stay
time. GSI can also help physicians
characterize lesions, reducing
the need for additional testing in
patients with symptoms whose
CT results indicate a renal mass.
80 kVp raw data140 kVp raw data
1,968 views reconstruction
+
1. Brown J. Diagnostic and treatment
patterns for renal colic in US Emergency
Departments. International Urology and
Nephrology 2006; 38: 87-92.
 GE Healthcare Discovery CT750 HD 33
34  GE Healthcare Discovery CT750 HD
Leading edge clarity requires innovation
throughout the image chain — and across
every variable of image development.
The Discovery CT750 HD introduces significant
enhancements to four areas that define CT
image quality: resolution, low contrast
detectability, noise reduction and artifact
reduction. Combined, they set a new standard
in diagnostic imaging; enabling greater degrees
of insight, broader applications and new
benchmarks of care.
 GE Healthcare Discovery CT750 HD 35
The leading
edge of care
For more than 20 years,
GE’s scintillator material
has been the industry
standard — the foundation
for CT imaging excellence.
Now, with the introduction
of the Discovery CT750 HD,
an even higher standard
has been set.
– Definition, clarity and confidence at a much
lower dose
– Extended coverage with Volume Helical Shuttle
– Gemstone Spectral Imaging — an entirely new path for
diagnostic imaging
– Cardiac imaging— the highest spatial resolution in the
industry at 18.2 lp/cm
The Discovery CT750 HD is capable of extending the
boundaries of detectability and driving breakthrough
diagnostic applications. With technologies and features
that set new benchmarks for image clarity, high-definition
CT opens the door to new non-invasive diagnostic
capabilities and innovative techniques for challenging
conditions.
The Detector
The Gemstone detector sets new benchmarks for CT
speed, recovery and performance.
Primary Speed,
100X FASTER
The exclusive garnet
structure enables high
definition imaging during
sub-second scanning
and fast kV switching.
Afterglow performance,
4X FASTER
Gemstone’s recovery time
is 4-times faster, delivering
increased spatial resolution
and significant artifact
reduction
GE Gemstone 0.03μs GE Gemstone 0.001%
GOS 3.0μs GOS 0.004%
Gemstone is the essential
innovation that drives the
high definition breakthrough.
36  GE Healthcare Discovery CT750 HD
The Data Acquisition System (DAS)
Volara* DAS technology delivers improved signal
performance and image quality.
A dramatic reduction in
electronic noise
– Low noise, for outstand-
ing image quality in high
and low signal areas of
the anatomy
Improved spatial
resolution across entire field
of view
– 2.5X more views per
rotation to improve x  y
resolution, and reduce
artifacts
– 7.1 kHz sampling rate
The Tube
The Performix* HD Tube enables the visualization of
more detail with dynamic focal spot control.
Power at your fingertips
– Increased data sampling
– Ultra-fast kVp switching
– Up to 570mA on the small focal spot
The reconstruction
Critical to limiting dose, ASiR1
on the Discovery CT750 HD,
may also aid in delivering clarity via an increase in low
contrast detectability of up to 40% and further artifact
suppression. And with Veo, clinicians can achieve
previously unheard of image quality at doses lower
than ever before—a bold step into the future of high-
definition CT imaging.
Non-HD CT
Less than 1,000 views
per rotation
Discovery CT750 HD
2,496 views per rotation
1. In clinical practice, the use of ASiR and Veo may reduce CT
patient dose depending on the clinical task, patient size,
anatomical location and clinical practice. A consultation with a
radiologist and a physicist should be made to determine the
appropriate dose to obtain diagnostic image quality for the
particular clinical task.
LCD was measured using the Statistical LCD technique, which is
based on an analysis of the pixel standard deviation on the
uniform section of the CatPhan (R) 600 phantom. The
improvement is demonstrated at 120kVp, when comparing ASiR
images acquired with 40% lower mAs to full dose FBP images.
GE Healthcare Discovery CT750 HD 37
Highly-detailed spatial resolution
Increasing spatial resolution by up to 33% across
the entire body provides you with a clarity and
range of vision you’ve never had before. With
unprecedented detail, the Discovery CT750 HD
delivers imaging enhancements that advance the
way caregivers diagnose illness and disease.
38  GE Healthcare Discovery CT750 HD
Excellent Routine Imaging with 128-Slice mode
GE Healthcare utilizes a unique combination of conjugate ray acquisition and overlapped reconstruction
technology to acquire 128 individual samples, resulting in 128 overlapped images.
This series of overlapped images may enable improved visibility of small objects. Combining higher sampling
density and information from 128 samples of projection, the conjugate reconstruction technique improves
small object visualization.
The high definition standard
In making a confident diagnosis, image clarity is every-
thing. That’s why high definition CT represents such
a significant diagnostic breakthrough. In picturing the
fine anatomical details, it supports deep insight, certain
decisions and an accelerated path to diagnosis and
treatment. In delivering improved image quality across
the entire body, it supports broad clinical applications
and precise treatment paths for diverse patient needs.
Chest CT in 2.2 seconds
 GE Healthcare Discovery CT750 HD 39
VolumeShuttle —
twice the coverage with less dose
VolumeShuttle helps make the most challenging
neuro CT perfusion and angiographic studies possible.
It doubles the acquisition coverage to 80mm, with less
dose. As a result, practitioners can perform studies
such as 4D CTA and CT perfusion in a single scan and
with a single contrast injection. For Neuro imaging it
ensures ample coverage to perform “whole territory
perfusion” (from the basal ganglia to the top of the
lateral ventricles).
Extending coverage for
functional assessment
The Discovery CT750 HD allows for extended coverage
for both 4D CT Angiography (CTA) and perfusion studies
with two innovative features: VolumeShuttle*
and
Volume Helical Shuttle combined with CT Perfusion 4D,
which provides volumetric functional analysis using a
new Smart Map that creates noise reduced maps while
preserving functional detail. They both extend coverage
and overcome today’s challenge of coverage limited
by detector width.
Perfusion coverage1
up to 140mm
4D CTA coverage up to 312.5mm
40  GE Healthcare Discovery CT750 HD
Blood flow
Mean transit time
Blood volume
Tissue classification
T Max
1. Up to 120mm for brain perfusion.
Volume Helical Shuttle —
further extending the range
The Discovery CT750 HD introduces an innovative
approach to further extend coverage for studies such
as 4D CTA and large internal organ physiological
assessments. Volume Helical Shuttle is a continuous
bi-directional scan mode that extends z-coverage and
improves temporal sampling. GE’s unique Dynamic
Pitch reconstruction method utilizes acquired scan data
during table acceleration and deceleration rather than
only during constant table speed. The result is more
than 300mm of high-resolution volume coverage for
4D CTA studies.
Volume Helical Shuttle may enable anatomical assess-
ment that surpasses the coverage of today’s widest
detectors and enables you to set the coverage to exactly
the range you need. For example you can perform a
4D CTA study to characterize the inflow and outflow of
contrast in the arterial and venous system over a length
of 312.5mm, equivalent to a 500-slice image. In addition,
Volume Helical Shuttle allows you to perform perfusion1
studies for the brain and body organs.
three-series
scan
time-saving
results
On average, someone in the United
States has a stroke every 40 seconds.2
Discovery CT750 HD’s ability to
acquire whole brain coverage
perfusion in addition to the other
stroke workup exams provides the
information physicians need to
make a diagnosis. Hospitals receive
a fixed payment for admitted
patients, so reducing the amount of
resources used translates directly
to cost saving for the hospital.
With GE’s Discovery CT750 HD, a
single three-series scan can provide
the results of a non-contrast CT, a
4D dynamic CT angiography, and
12 cm of whole brain perfusion
coverage at once. Discovery CT750
HD’s Volume Helical Shuttle (VHS)
with 12 cm of full coverage allows
for whole brain imaging, which can
potentially eliminate the need for
follow-up MR and reduce the cost
of a patient’s hospital stay.
3
1
2. Lloyd-Jones D et.al. Heart disease and
stroke statistics 2009 updated. A report
from the American Heart Association
statistics committee and stroke statistic
subcommittee. Circulation 2008
(ePub ahead of print); DOI: 10.1161/
CIRCULATIONAHA.108.191261.
 GE Healthcare Discovery CT750 HD 41
What if radiologists and clinicians could have
the enhanced image quality at a radiation
dose never before thought possible?
Introducing Veo*
— the breakthrough that’s
rewriting the rules of CT imaging.
42  GE Healthcare Discovery CT750 HD
GE Healthcare Discovery CT750 HD 43
The latest advance in
CT image reconstruction
technology
Veo is the world’s first model-based iterative recon-
struction product. This breakthrough is changing
the way physicians use CT imaging. It may deliver a
combination of high-quality images and low dose
that was previously unthinkable.
GE Healthcare has solved this challenge in partnership
with leading healthcare partners and hardware
manufacturers, combining sophisticated algorithms
and advanced computing power. As a result, a CT
reconstruction technique that was once only theoretical
has now been put into practice.
So radiologists and clinicians can now operate
under a new set of rules. Lower pixel noise standard
deviation and higher resolution may be achieved
within a single image. Veo may help clinicians achieve
confident diagnosis with lower dose, opening up
new possibilities for challenging cases and sensitive
patients.1
“Veo may reduce dose but also increase image quality:
In oncology studies, we can increase the conspicuity
of the tumor for tissue characterization — In vascular
studies, it is possible to differentiate stenosis from
occlusion and reduce the blooming effect that result
from the presence of a stent or calcified plaque. There
are instances where a higher quality study is more
important, and Veo enables us to increase spatial and
contrast resolution to visualize very small lesions.”
Dr. Jean Louis Sablayrolles
Centre Cardiologique du Nord, Saint Denis, France
1. In clinical practice, the use of Veo may reduce CT patient dose
depending on the clinical task, patient size, anatomical location
and clinical practice. A consultation with a radiologist and a
physicist should be made to determine the appropriate dose to
obtain diagnostic image quality for the particular clinical task.
44  GE Healthcare Discovery CT750 HD
New levels of
image quality
Veo provides a new benchmark
for CT image quality. Its powerful
modeling techniques may result in
better images, delivering previously
unattainable levels of combined
pixel noise standard deviation
reduction, resolution gain,
improved contrast, and artifact
suppression.1
In traditional approaches, higher
spatial resolution is accompanied
by higher image noise. But Veo
challenges this common trade-off.
Veo may improve resolution and
may reduce pixel noise standard
deviation.1
FBP
Veo
Images courtesy of Dr. Sablayrolles,
CCN, France
1. In clinical practice, the actual level of low signal artifact, LCD and resolution
improvement may vary. Consult with a radiologist and a physicist.
 GE Healthcare Discovery CT750 HD 45
Imaging under 1mSv
The benefits of dose reduction are significant, especially
for the most radiosensitive patients — including pediatric
cases and young women. Veo may also provide the
opportunity to dramatically reduce cumulative dose in
patients who require regular follow-up exams.1
“Veo allowed us to scan a chest CT at 0.06 mSv with
readable images where pathology could be analyzed.
With Veo, we can conduct lower dose CT scans in
children, and this is particularly important in groups
that require continued follow-up, such as those with
cystic fibrosis or lymphoma.”
Professor Johan de Mey, M.D.
Chair of Radiology Department,
University Hospital, Brussels
DLP of 5.02 mGy.cm, 0.02 mSv, obtained by EUR-162662 EN, using a pediatric head factor of 0.004*DLP
46  GE Healthcare Discovery CT750 HD
Veo is the next step in GE’s commitment to lower-dose
CT. Our ASiR technology, introduced with the launch of
the Discovery CT750 HD, offers fast reconstructions and
may allow for low-dose imaging without compromise — 
an ideal approach for routine, robust imaging. By push-
ing the possibilities even further, Veo represents added
capability for the most sensitive cases. By changing
the rules, these potential dose-reduction capabilities
open up exciting new possibilities in CT.
Veo establishes new rules in the relationship between
image quality and dose reduction. Veo can give the
clinicians the diagnostic information they need and
may allow for it to be done at a previously unthinkable
low dose.1
So at an equivalent dose, Veo may deliver
dramatically better aspects of image quality.
The rules have changed. But the goal hasn’t.
Radiologists and clinicians have another powerful new
tool to deliver more informed, confident diagnoses. And
above all else, Veo can help achieve what has always
been the ultimate goal — the best patient care available.
DLP 3.16 mGy.cm, 0.05 mSv, obtained by EUR-16262 EN, using a chest factor of 0.017*DLP
1. In clinical practice, the use of Veo may reduce CT patient dose depending on the clinical task, patient size, anatomical location and
clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic
image quality for the particular clinical task.
 GE Healthcare Discovery CT750 HD 47
GE Healthcare Services
With GE CT you’re backed by the largest, most experi-
enced service team in the industry.
Maximizing uptime
The ground-breaking Discovery CT750 HD incorporates
fault tolerant design and InSite* OnWatch proactive
service to help eliminate surprises and keep your
scanner performing so you can stay on schedule.
Simplify your access to service
Have a question about performance or a Discovery
CT750 HD process? Thanks to iLinq* instant help, your
staff can quickly connect to our service team. Rest
assured, when you have questions about support or
training, we’ll help you get the answers — fast.
Enabling better asset management
To help ensure maximum scanner efficiency and
productivity, GE also provides iCenter* asset manage-
ment tools for accurate reporting and analysis.
More from your network
A wide range of learning tools teaches your imaging
professionals how to use the advanced imaging
capabilities of the Discovery CT750 HD with skill and
finesse.
Physician and Technologist instructed
CT Masters series
A comprehensive range of courses, in Advanced CT
Applications, taught by experts in the latest technologies.
GE Healthcare Institute
A hands-on institute with offerings that include: clinical,
technical, service, patient, and leadership education.
On-site training
Detailed on-site training and consulting to help you
grow your clinical performance, referral power and
your bottom line.
TiP*
Virtual Assistant
For application support, the TiP Virtual Assistant provides
your staff with interactive real-time training and support
right on the console from a dedicated and experienced
team of application specialists.
Invest in a Discovery CT750 HD and experience
all of the benefits of being a Discovery
customer, including field service paired with
education and consulting.
48  GE Healthcare Discovery CT750 HD
GE Healthcare
Discovery* CT750 HD
Great care by design
Discovery*CT750HDTheleadingedgeofCTclarity
©2011 General Electric Company.
GE, and GE Monogram are trademarks of General Electric Company.
*Trademark of General Electric Company.
About GE Healthcare
GE Healthcare provides transformational medical
technologies and services that are shaping a new age
of patient care. Our broad expertise in medical imaging
and information technologies, medical diagnostics,
patient monitoring systems, drug discovery, biopharma-
ceutical manufacturing technologies, performance
improvement and performance solutions services help
our customers to deliver better care to more people
around the world at a lower cost. In addition, we partner
with healthcare leaders, striving to leverage the global
policy change necessary to implement a successful
shift to sustainable healthcare systems.
Our “healthymagination” vision for the future invites the
world to join us on our journey as we continuously
develop innovations focused on reducing costs, increas-
ing access and improving quality around the world.
Headquartered in the United Kingdom, GE Healthcare is
a unit of General Electric Company (NYSE: GE). Worldwide,
GE Healthcare employees are committed to serving
healthcare professionals and their patients in more than
100 countries. For more information about GE Healthcare,
visit our website at www.gehealthcare.com.
GE Healthcare
3200 N. Grandview Blvd.
Waukesha, WI 53188
U.S.A.
CT-0480-08.11-EN-US
DOC1026296

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Cardiac Output, Venous Return, and Their Regulation
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Discovery ct750 hd book

  • 1. GE Healthcare Discovery* CT750 HD Great care by design
  • 2. At GE Healthcare, imag in lie at the heart of every th than 30 years, we’ve d e that enhance the ways c and treat disease. Bett e us to render the inner w greater fidelity and det a than before. 2  GE Healthcare Discovery CT750 HD
  • 3. g ination and knowledge y thing we do. For more d esigned CT systems s clinicians diagnose t er tools have enabled r world of the body with et ail — and at lower dose g ination and knowledge y thing we do. For more d esigned CT systems s clinicians diagnose t er tools have enabled r world of the body with et ail — and at lower dose GE Healthcare Discovery CT750 HD 3
  • 4. Filtered Back Projection (FBP) The Discovery*  CT750 HD is designed to deliver up to 50%1 lower dose, helping assure patients with faster, more confident diagnoses. 1. In clinical practice, the use of ASiR may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. ASiR dose reduction was measured on a standard 20cm water phantom. The test involved maintaining constant pixel standard deviation as the mA was reduced at 120 kVp. 4  GE Healthcare Discovery CT750 HD
  • 5. ASiR* (Adaptive Statistical Iterative Reconstruction) GE Healthcare Discovery CT750 HD 5
  • 6. The Discovery CT750 HD offers the highest available cardiac spatial resolution in the industry at1 18.2 lp/cm. 1. Based upon internal test data comparing Discovery CT750 HD cardiac half-scan spatial resolution to data from “Advanced CT Scanners for Coronary Angiography”, ImPACT Report CEP10043, March, 2010, available at http://www.impactscan.org 6 GE Healthcare Discovery CT750 HD
  • 7. Standard Resolution HD Resolution GE Healthcare Discovery CT750 HD 7
  • 8. Conventional 140 kVp Spectral 50 keV Powered by our proprietary CT scintillator material, the Discovery CT750 HD features Gemstone* Spectral Imaging. At temporal registrations speeds of up to 165 times faster than the nearest competitor, GSI is the first quantitative dual energy on the market. 8  GE Healthcare Discovery CT750 HD
  • 9. Grayscale quantitative MD iodine image Colored quantitative MD iodine image In the arterial phase images, you can visualize an early contrast uptake, especially on iodine and low keV images. GE Healthcare Discovery CT750 HD 9
  • 10. In addition to its specialized applications, the Discovery CT750 HD makes an excellent scanner for routine imaging by improving the clarity of the image while lowering patients’ dose. 10  GE Healthcare Discovery CT750 HD
  • 11. GE Healthcare Discovery CT750 HD 11
  • 12. And with our breakthrough Veo image reconstruction technology, the Discovery CT750 HD can acquire images at under 1 mSv with profound clarity. FBP In clinical practice the use of Veo may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physician should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. 12  GE Healthcare Discovery CT750 HD
  • 13. Veo image, 0.61 mSv, DLP 36.02 Obtained by EUR-16262 EN, using an abdomen factor of 0.015*DLP and a pelvis factor of 0.019*DLP GE Healthcare Discovery CT750 HD 13
  • 14. You and your patients continue to demand lower dose — but not at the expense of image quality. The Discovery CT750 HD delivers on both imperatives — precise imaging for a confident diagnosis and enhanced patient care. 14  GE Healthcare Discovery CT750 HD
  • 15. GE Healthcare Discovery CT750 HD 15
  • 16. “We decided to implement ASiR on 100% of our exams and achieved excellent results. As such, ASiR has become a key component in our campaign for low dose CT. The community response from both our patients and physicians was greater than we ever expected, and UW is now viewed as the go-to place for low dose CT” William P. Shuman, M.D. University of Washington Medical Center “With the Discovery CT750 HD, we have been able to significantly reduce radiation dose while, at the same time, improving image quality. Our patients are benefiting from the dose reduction in every exam we perform, all without compromising diagnostic quality. With this dramatic dose reduction our practice has grown our referral base, and patients are asking to be scanned on the Discovery CT750 HD.” David A. Dowe, M.D. Atlantic Medical Imaging “With the Discovery CT750 HD we have been able to reduce drastically the dose in coronary CTA, while improving image quality. We routinely scan patients at less than 1 mSv and still achieve high diagnostic quality.” Jean-Nicolas Dacher, M.D., Ph.D. Rouen University Hospital 16 GE Healthcare Discovery CT750 HD
  • 17. ASiR may reduce dose by up to 50%1 by allowing the use of lower mA protocols —  and with high definition image quality across all anatomies — the Discovery CT750 HD can reach any part of the body, any age patient, and any application that demands the leading edge of CT clarity. 1. In clinical practice, the use of ASiR may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. ASiR dose reduction was measured on a standard 20cm water phantom. The test involved maintaining constant pixel standard deviation as the mA was reduced at 120 kVp. GE Healthcare Discovery CT750 HD 17
  • 18. A better path forward Incremental reductions in dose can go a long way toward supporting improved care, but the highest standard can only be achieved through breakthrough innovation in image reconstruction. Leading the way with image reconstruction Typically, lowering dose has increased noise and image artifacts, creating an unfortunate trade-off between higher image quality and lower dose. In order to over- come this obstacle, GE developed an industry exclusive high definition approach to image reconstruction —  Adaptive Statistical Iterative Reconstruction (ASiR). Low dose kidney stone protocol at 83 mAs 18  GE Healthcare Discovery CT750 HD
  • 19. ASiR provides exceptional image quality by improving low contrast detectability (LCD) and suppressing noise without degrading anatomical integrity. It overcomes the limitations of the conventional CT reconstruction approach known as filtered back projection and arrives at an optimal image using an advanced iterative computation. As a result, the Discovery CT750 HD is capable of significant dose reduction with no loss of diagnostic image quality. Since its introduction in 2008, ASiR has earned positive mention from clinicians in peer-reviewed journals, in dozens of abstracts, and at multiple conferences. Millions of patients’ exams make ASiR the proven choice for image reconstruction. GE Healthcare Discovery CT750 HD 19
  • 20. The Discovery CT750 HD has the industry leading Cardiac CT spatial resolution. At 18.2 lp/cm, the system provides up to 66% greater spatial resolution than comparable systems. 20  GE Healthcare Discovery CT750 HD
  • 21. GE Healthcare Discovery CT750 HD 21
  • 22. The improved resolution of the Discovery CT750 HD displays reduction in calcium blooming compared to standard resolution, enabling an accurate diagnosis. Standard Resolution HD Resolution 22  GE Healthcare Discovery CT750 HD
  • 23. ”Utilizing the Discovery CT750 HD has increased my confidence in evaluating calcified segments, thereby decreasing the need for additional downstream testing. The improvement in spatial resolution is real and impacts my practice on a daily basis.” Jonathan Leipsic, M.D. FRCPC, University of British Columbia, Providence Healthcare The Discovery CT750 HD delivers improvements in spatial resolution that can help you accurately quantify stenosis in coronary vessels. GE Healthcare Discovery CT750 HD 23
  • 24. Low dose cardiac imaging with excellent IQ at less than 1mSv SnapShot Pulse and ASiR* enable low dose not only for Coronary CT but across cardiovascular exams, enabling cardiac CT of less than 1mSv. Using SnapShot Pulse imaging and ASiR, the Discovery CT750 HD achieves a dose reduction of greater than 83% compared to gated helical acquisition.3,4,5 Acquisition protocols are easily adapted to the clinical needs of the individual patient for optimal diagnostic results at low dose. Intelligent system design helps to manage high and unstable heart rates in prospective and retrospective modes. 1. Estimated Radiation Dose Reduction Using Adaptive Statistical Iterative Reconstruction in Coronary CT Angiography: The ERASIR Study, AJR:195, 2010 Sept; 195(3):655-60 2. Effect of Standardized Quality- Improvement Protocol on Radiation Dose in Coronary Computed Tomographic Angiography, Am J Cardiol, 2010 Dec 1; 106(11):1663-7 “In the multicenter ERASIR study1 of more than 500 patients that examined the effect of ASiR on radiation dose, we noted a 27% reduction in dose for patients undergoing coronary CT angiography. In the second independent study,2 using a combination of SnapShot imaging, reduced tube voltage and ASiR, we have observed in 449 patients an average dose of 1.3 mSv in unselected patients undergoing CT angiography.” James Min, M.D. Co-director of Cardiac Imaging Director of Cardiac Imaging Research Cedars Sinai Heart Institute 3. In clinical practice, the use of ASiR may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. 4. Dose reduction was measured on a standard 20cm water phantom comparing a SnapShot Pulse prospective gated axial acquisition at 120kV/300mA and 50% ASiR to a cardiac helical acquisition 120kV/500mA without ASiR both with a 224mm scan coverage. 5. In clinical practice, the use of SnapShot Pulse may reduce cardiac CT patient dose depending on the clinical task and patient heart rate. A consultation with a radiologist should be made to determine the appropriate acquisition mode and scan settings to obtain diagnostic image quality for the particular clinical task. 24  GE Healthcare Discovery CT750 HD
  • 25. 6 Obtained by ICRP using a chest factor of 0.014* DLP 7 May J et.al. Low-risk chest pain patients in the emergency department: Negative 64-channel cardiac CT angiography may reduce length of stay and hospital charges. AJR 2009; 192(S5): A1. 5 hours vs. 25.4 hours Assessing chest pain in the ER with the Discovery CT750 HD. A traditional cardiac diagnostic pathway can take between 12 and 36 hours, utilizing a significant amount of hospital time, personnel, and resources. With the Discovery CT750 HD system, unless the scan indicates an occlusion with greater than 75 percent stenosis, patients may avoid additional diagnostic cardiac procedures —  all while decreasing the time to diagnosis and increasing through­ put and efficiency in your care environment. GE’s Discovery CT750 HD produces remarkably clear, quality cardiac images that have the potential to streamline the care process, freeing clinical staff to care for more patients. A recent study has reported that a diagnostic work up of a single set of enzymes and an ECG along with a cardiac CT angiography (CCTA) takes an average of only 5 hours to rule out coronary artery disease, compared to an average of 25.4 hours with standard care workup.7 That means your hospital can save both time and resources. 0.57 mSv6 Cardiac CTA is achievable utilizing ASiR image reconstruction on the Discovery CT750 HD. Even at this ultra-low dose level, the Discovery CT750 HD can visualize vessels as small as 1mm in coronary CTA exams. GE Healthcare Discovery CT750 HD 25
  • 26. 26  GE Healthcare Discovery CT750 HD
  • 27. Gemstone Spectral Imaging is a revolutionary feature exclusive to the Discovery CT750 HD. Today, it is expanding the information available for clinical diagnosis and workflow in the following key areas: characterization of small lesions, beam hardening reduction, kidney stone characterization, optimization of contrast and virtual non-contrast like imaging. Tomorrow, its broad applications and unprecedented level of detail have the potential to completely re-define diagnostic imaging. GE Healthcare Discovery CT750 HD 27
  • 28. Gemstone Spectral Imaging Gemstone Spectral Imaging (GSI) is a unique dual energy technique that uses rapid kV switching and Gemstone Detector technology to acquire and generate material density data. This data can be used to separate materials and derive monochromatic spectral images using a projection-space reconstruction algorithm. Virtual noncontrast-like imaging Gemstone Spectral Imaging can subtract iodine from images to generate a virtual noncontrast-like image. Note the kidney stone is obscured in the IV contrast image, but visualized in the water density image. 70 keV Spectral MD Water Material Separation GSI provides information about the chemical composi- tion of body materials. This capability enables the user to easily separate calcium, iodine and water to aid in the characterization of pathology. 28  GE Healthcare Discovery CT750 HD
  • 29. Quantitative Lesion Characterization at 50cm FOV Spectral Imaging’s potential to enhance lesion charac- terization is seen here with the two lesions displayed on the images. Utilizing GSI and viewing the images at lower spectral energy, the lesion is more conspicuous, and the differentiation of the non-enhancing cyst and enhancing lesion is well depicted on the spectral curves, normalized to the liver parenchyma. 70 keV Spectral 70 keV Spectral color Spectral Hounsfield unit curve Normalized Spectral Hounsfield unit curve GE Healthcare Discovery CT750 HD 29
  • 30. “Traditionally, CT provided an excellent depiction of the pulmonary vessels, thrombi and emboli. However, it could not give us information on the severity of pulmonary embolism obstruction or perfusion deficit defects. With the GSI-generated iodine maps, I can clearly see the severity of perfusion deficit. GSI is a very effective technique that eliminates the need for additional scans to gather functional information on lung perfusion.” Valentin Sinitsyn, M.D., Ph.D. Moscow Federal Center of Medicine “About 40% of our routine spine exams involve metal instrumentation. Reducing artifact for these exams is an important benefit that GSI provides. Spectral CT generates virtually pristine images in these most challenging circumstances where traditional techniques often fail.” Lawrence N. Tanenbaum, MD, FACR Mount Sinai School of Medicine “With Gemstone Spectral Imaging we can more easily obtain high quality images on the femoral arteries in patients with metallic hip prostheses. This capability is particularly important when planning a transcatheter aortic valve implantation (TAVI).” Jean-Nicolas Dacher, M.D., Ph.D. Rouen University Hospital 30  GE Healthcare Discovery CT750 HD
  • 31. Gemstone Spectral Imaging is delivering real diagnostic results today. Tomorrow it has the potential to be used as a routine scan acquisition mode, taking the possibilities even further. GE Healthcare Discovery CT750 HD 31
  • 32. Enhancing image quality with monochromatic spectral image Exclusive to the Discovery CT750 HD, the spectral image is created as though it comes from a single energy (keV) source. Individual spectral images can be derived from 101 user-selectable energy levels. This approach enables image contrast optimization, accurate CT numbers and up to a 50% reduction in common beam hardening artifacts — features that together aid in a fast, confident diagnosis. Utilizing lower energy spectral images allows for better contrast differen- tiation, thereby accentuating subtle contrast differences. In the study below, due to the patient’s impaired renal function only 60cc of contrast was utilized. With GSI’s capability to review different levels of monochromatic energy levels for better iodine conspicuity, the endoleak was visualized. VR images VR images demonstrating thrombus Conventional CT 93 keV Spectral image 93 keV VR Spectral image Curved view demonstrating endoleak visualization Beam hardening reduction Reducing visually obstructive beam hardening artifacts will reveal impor- tant underlying anatomical information for a complete diagnosis. 32  GE Healthcare Discovery CT750 HD
  • 33. How it works Central to spectral image acquisition is the Gemstone detector’s ability to differentiate between two different energy levels from view to view (as illustrated by the blue and green data sets below). Both high and low energy data sets are acquired simultaneously to improve image registration for material separation throughout the full 50cm field of view. Using known attenuation curves, the material specific difference in attenuation enables an easy classification of the elementary chemical composition of the scanned tissue. This creates the ability to generate material density images. Spectral images are derived from the material density images and depict how the object would look if the X-ray source produced only photons at a single energy. Quicker Diagnosis equals Reduced Hospital Cost Painful episodes of renal-related conditions result in more than one million patient visits to emergency departments annually.1 Reducing the time spent on imaging, additional testing, and waiting for results has the potential to decrease both length of stay and overall costs to the hospital. This is critical, as hospitals are paid a fixed amount per admission regardless of the number of services provided. Using GE’s Discovery CT750 HD with Gemstone Spectral Imaging (GSI), a single contrast-enhanced CT may provide information to evaluate the presence or absence of a renal lesion. With the same exam data, GSI can create a “virtual non-contrast like image” that can provide information to assess for kidney stones. GSI also has the ability to help characterize renal stones without a urinalysis —  meaning treatment can start earlier, minimizing in-patient stay time. GSI can also help physicians characterize lesions, reducing the need for additional testing in patients with symptoms whose CT results indicate a renal mass. 80 kVp raw data140 kVp raw data 1,968 views reconstruction + 1. Brown J. Diagnostic and treatment patterns for renal colic in US Emergency Departments. International Urology and Nephrology 2006; 38: 87-92. GE Healthcare Discovery CT750 HD 33
  • 34. 34  GE Healthcare Discovery CT750 HD
  • 35. Leading edge clarity requires innovation throughout the image chain — and across every variable of image development. The Discovery CT750 HD introduces significant enhancements to four areas that define CT image quality: resolution, low contrast detectability, noise reduction and artifact reduction. Combined, they set a new standard in diagnostic imaging; enabling greater degrees of insight, broader applications and new benchmarks of care. GE Healthcare Discovery CT750 HD 35
  • 36. The leading edge of care For more than 20 years, GE’s scintillator material has been the industry standard — the foundation for CT imaging excellence. Now, with the introduction of the Discovery CT750 HD, an even higher standard has been set. – Definition, clarity and confidence at a much lower dose – Extended coverage with Volume Helical Shuttle – Gemstone Spectral Imaging — an entirely new path for diagnostic imaging – Cardiac imaging— the highest spatial resolution in the industry at 18.2 lp/cm The Discovery CT750 HD is capable of extending the boundaries of detectability and driving breakthrough diagnostic applications. With technologies and features that set new benchmarks for image clarity, high-definition CT opens the door to new non-invasive diagnostic capabilities and innovative techniques for challenging conditions. The Detector The Gemstone detector sets new benchmarks for CT speed, recovery and performance. Primary Speed, 100X FASTER The exclusive garnet structure enables high definition imaging during sub-second scanning and fast kV switching. Afterglow performance, 4X FASTER Gemstone’s recovery time is 4-times faster, delivering increased spatial resolution and significant artifact reduction GE Gemstone 0.03μs GE Gemstone 0.001% GOS 3.0μs GOS 0.004% Gemstone is the essential innovation that drives the high definition breakthrough. 36  GE Healthcare Discovery CT750 HD
  • 37. The Data Acquisition System (DAS) Volara* DAS technology delivers improved signal performance and image quality. A dramatic reduction in electronic noise – Low noise, for outstand- ing image quality in high and low signal areas of the anatomy Improved spatial resolution across entire field of view – 2.5X more views per rotation to improve x y resolution, and reduce artifacts – 7.1 kHz sampling rate The Tube The Performix* HD Tube enables the visualization of more detail with dynamic focal spot control. Power at your fingertips – Increased data sampling – Ultra-fast kVp switching – Up to 570mA on the small focal spot The reconstruction Critical to limiting dose, ASiR1 on the Discovery CT750 HD, may also aid in delivering clarity via an increase in low contrast detectability of up to 40% and further artifact suppression. And with Veo, clinicians can achieve previously unheard of image quality at doses lower than ever before—a bold step into the future of high- definition CT imaging. Non-HD CT Less than 1,000 views per rotation Discovery CT750 HD 2,496 views per rotation 1. In clinical practice, the use of ASiR and Veo may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. LCD was measured using the Statistical LCD technique, which is based on an analysis of the pixel standard deviation on the uniform section of the CatPhan (R) 600 phantom. The improvement is demonstrated at 120kVp, when comparing ASiR images acquired with 40% lower mAs to full dose FBP images. GE Healthcare Discovery CT750 HD 37
  • 38. Highly-detailed spatial resolution Increasing spatial resolution by up to 33% across the entire body provides you with a clarity and range of vision you’ve never had before. With unprecedented detail, the Discovery CT750 HD delivers imaging enhancements that advance the way caregivers diagnose illness and disease. 38  GE Healthcare Discovery CT750 HD
  • 39. Excellent Routine Imaging with 128-Slice mode GE Healthcare utilizes a unique combination of conjugate ray acquisition and overlapped reconstruction technology to acquire 128 individual samples, resulting in 128 overlapped images. This series of overlapped images may enable improved visibility of small objects. Combining higher sampling density and information from 128 samples of projection, the conjugate reconstruction technique improves small object visualization. The high definition standard In making a confident diagnosis, image clarity is every- thing. That’s why high definition CT represents such a significant diagnostic breakthrough. In picturing the fine anatomical details, it supports deep insight, certain decisions and an accelerated path to diagnosis and treatment. In delivering improved image quality across the entire body, it supports broad clinical applications and precise treatment paths for diverse patient needs. Chest CT in 2.2 seconds GE Healthcare Discovery CT750 HD 39
  • 40. VolumeShuttle — twice the coverage with less dose VolumeShuttle helps make the most challenging neuro CT perfusion and angiographic studies possible. It doubles the acquisition coverage to 80mm, with less dose. As a result, practitioners can perform studies such as 4D CTA and CT perfusion in a single scan and with a single contrast injection. For Neuro imaging it ensures ample coverage to perform “whole territory perfusion” (from the basal ganglia to the top of the lateral ventricles). Extending coverage for functional assessment The Discovery CT750 HD allows for extended coverage for both 4D CT Angiography (CTA) and perfusion studies with two innovative features: VolumeShuttle* and Volume Helical Shuttle combined with CT Perfusion 4D, which provides volumetric functional analysis using a new Smart Map that creates noise reduced maps while preserving functional detail. They both extend coverage and overcome today’s challenge of coverage limited by detector width. Perfusion coverage1 up to 140mm 4D CTA coverage up to 312.5mm 40  GE Healthcare Discovery CT750 HD
  • 41. Blood flow Mean transit time Blood volume Tissue classification T Max 1. Up to 120mm for brain perfusion. Volume Helical Shuttle — further extending the range The Discovery CT750 HD introduces an innovative approach to further extend coverage for studies such as 4D CTA and large internal organ physiological assessments. Volume Helical Shuttle is a continuous bi-directional scan mode that extends z-coverage and improves temporal sampling. GE’s unique Dynamic Pitch reconstruction method utilizes acquired scan data during table acceleration and deceleration rather than only during constant table speed. The result is more than 300mm of high-resolution volume coverage for 4D CTA studies. Volume Helical Shuttle may enable anatomical assess- ment that surpasses the coverage of today’s widest detectors and enables you to set the coverage to exactly the range you need. For example you can perform a 4D CTA study to characterize the inflow and outflow of contrast in the arterial and venous system over a length of 312.5mm, equivalent to a 500-slice image. In addition, Volume Helical Shuttle allows you to perform perfusion1 studies for the brain and body organs. three-series scan time-saving results On average, someone in the United States has a stroke every 40 seconds.2 Discovery CT750 HD’s ability to acquire whole brain coverage perfusion in addition to the other stroke workup exams provides the information physicians need to make a diagnosis. Hospitals receive a fixed payment for admitted patients, so reducing the amount of resources used translates directly to cost saving for the hospital. With GE’s Discovery CT750 HD, a single three-series scan can provide the results of a non-contrast CT, a 4D dynamic CT angiography, and 12 cm of whole brain perfusion coverage at once. Discovery CT750 HD’s Volume Helical Shuttle (VHS) with 12 cm of full coverage allows for whole brain imaging, which can potentially eliminate the need for follow-up MR and reduce the cost of a patient’s hospital stay. 3 1 2. Lloyd-Jones D et.al. Heart disease and stroke statistics 2009 updated. A report from the American Heart Association statistics committee and stroke statistic subcommittee. Circulation 2008 (ePub ahead of print); DOI: 10.1161/ CIRCULATIONAHA.108.191261. GE Healthcare Discovery CT750 HD 41
  • 42. What if radiologists and clinicians could have the enhanced image quality at a radiation dose never before thought possible? Introducing Veo* — the breakthrough that’s rewriting the rules of CT imaging. 42  GE Healthcare Discovery CT750 HD
  • 43. GE Healthcare Discovery CT750 HD 43
  • 44. The latest advance in CT image reconstruction technology Veo is the world’s first model-based iterative recon- struction product. This breakthrough is changing the way physicians use CT imaging. It may deliver a combination of high-quality images and low dose that was previously unthinkable. GE Healthcare has solved this challenge in partnership with leading healthcare partners and hardware manufacturers, combining sophisticated algorithms and advanced computing power. As a result, a CT reconstruction technique that was once only theoretical has now been put into practice. So radiologists and clinicians can now operate under a new set of rules. Lower pixel noise standard deviation and higher resolution may be achieved within a single image. Veo may help clinicians achieve confident diagnosis with lower dose, opening up new possibilities for challenging cases and sensitive patients.1 “Veo may reduce dose but also increase image quality: In oncology studies, we can increase the conspicuity of the tumor for tissue characterization — In vascular studies, it is possible to differentiate stenosis from occlusion and reduce the blooming effect that result from the presence of a stent or calcified plaque. There are instances where a higher quality study is more important, and Veo enables us to increase spatial and contrast resolution to visualize very small lesions.” Dr. Jean Louis Sablayrolles Centre Cardiologique du Nord, Saint Denis, France 1. In clinical practice, the use of Veo may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. 44  GE Healthcare Discovery CT750 HD
  • 45. New levels of image quality Veo provides a new benchmark for CT image quality. Its powerful modeling techniques may result in better images, delivering previously unattainable levels of combined pixel noise standard deviation reduction, resolution gain, improved contrast, and artifact suppression.1 In traditional approaches, higher spatial resolution is accompanied by higher image noise. But Veo challenges this common trade-off. Veo may improve resolution and may reduce pixel noise standard deviation.1 FBP Veo Images courtesy of Dr. Sablayrolles, CCN, France 1. In clinical practice, the actual level of low signal artifact, LCD and resolution improvement may vary. Consult with a radiologist and a physicist. GE Healthcare Discovery CT750 HD 45
  • 46. Imaging under 1mSv The benefits of dose reduction are significant, especially for the most radiosensitive patients — including pediatric cases and young women. Veo may also provide the opportunity to dramatically reduce cumulative dose in patients who require regular follow-up exams.1 “Veo allowed us to scan a chest CT at 0.06 mSv with readable images where pathology could be analyzed. With Veo, we can conduct lower dose CT scans in children, and this is particularly important in groups that require continued follow-up, such as those with cystic fibrosis or lymphoma.” Professor Johan de Mey, M.D. Chair of Radiology Department, University Hospital, Brussels DLP of 5.02 mGy.cm, 0.02 mSv, obtained by EUR-162662 EN, using a pediatric head factor of 0.004*DLP 46  GE Healthcare Discovery CT750 HD
  • 47. Veo is the next step in GE’s commitment to lower-dose CT. Our ASiR technology, introduced with the launch of the Discovery CT750 HD, offers fast reconstructions and may allow for low-dose imaging without compromise —  an ideal approach for routine, robust imaging. By push- ing the possibilities even further, Veo represents added capability for the most sensitive cases. By changing the rules, these potential dose-reduction capabilities open up exciting new possibilities in CT. Veo establishes new rules in the relationship between image quality and dose reduction. Veo can give the clinicians the diagnostic information they need and may allow for it to be done at a previously unthinkable low dose.1 So at an equivalent dose, Veo may deliver dramatically better aspects of image quality. The rules have changed. But the goal hasn’t. Radiologists and clinicians have another powerful new tool to deliver more informed, confident diagnoses. And above all else, Veo can help achieve what has always been the ultimate goal — the best patient care available. DLP 3.16 mGy.cm, 0.05 mSv, obtained by EUR-16262 EN, using a chest factor of 0.017*DLP 1. In clinical practice, the use of Veo may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. GE Healthcare Discovery CT750 HD 47
  • 48. GE Healthcare Services With GE CT you’re backed by the largest, most experi- enced service team in the industry. Maximizing uptime The ground-breaking Discovery CT750 HD incorporates fault tolerant design and InSite* OnWatch proactive service to help eliminate surprises and keep your scanner performing so you can stay on schedule. Simplify your access to service Have a question about performance or a Discovery CT750 HD process? Thanks to iLinq* instant help, your staff can quickly connect to our service team. Rest assured, when you have questions about support or training, we’ll help you get the answers — fast. Enabling better asset management To help ensure maximum scanner efficiency and productivity, GE also provides iCenter* asset manage- ment tools for accurate reporting and analysis. More from your network A wide range of learning tools teaches your imaging professionals how to use the advanced imaging capabilities of the Discovery CT750 HD with skill and finesse. Physician and Technologist instructed CT Masters series A comprehensive range of courses, in Advanced CT Applications, taught by experts in the latest technologies. GE Healthcare Institute A hands-on institute with offerings that include: clinical, technical, service, patient, and leadership education. On-site training Detailed on-site training and consulting to help you grow your clinical performance, referral power and your bottom line. TiP* Virtual Assistant For application support, the TiP Virtual Assistant provides your staff with interactive real-time training and support right on the console from a dedicated and experienced team of application specialists. Invest in a Discovery CT750 HD and experience all of the benefits of being a Discovery customer, including field service paired with education and consulting. 48  GE Healthcare Discovery CT750 HD
  • 49. GE Healthcare Discovery* CT750 HD Great care by design Discovery*CT750HDTheleadingedgeofCTclarity ©2011 General Electric Company. GE, and GE Monogram are trademarks of General Electric Company. *Trademark of General Electric Company. About GE Healthcare GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our broad expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, drug discovery, biopharma- ceutical manufacturing technologies, performance improvement and performance solutions services help our customers to deliver better care to more people around the world at a lower cost. In addition, we partner with healthcare leaders, striving to leverage the global policy change necessary to implement a successful shift to sustainable healthcare systems. Our “healthymagination” vision for the future invites the world to join us on our journey as we continuously develop innovations focused on reducing costs, increas- ing access and improving quality around the world. Headquartered in the United Kingdom, GE Healthcare is a unit of General Electric Company (NYSE: GE). Worldwide, GE Healthcare employees are committed to serving healthcare professionals and their patients in more than 100 countries. For more information about GE Healthcare, visit our website at www.gehealthcare.com. GE Healthcare 3200 N. Grandview Blvd. Waukesha, WI 53188 U.S.A. CT-0480-08.11-EN-US DOC1026296