Aflp

Acute Fatty Liver With Pregnancy Dr. Mohammed Abdalla Egypt, Domiat General Hospital

Historical points ,[object Object],[object Object],[object Object]

Incidence and Characteristics ,[object Object]

[object Object],Incidence and Characteristics Riely CA. Hepatic disease in pregnancy. Am J Med 1994;96(1A):18S-22S. 3. Samuels P, Cohen AW. Pregnancies complicated by liver disease and liver dysfunction. Obstet Gynecol Clin North Am 1992;19:745-63

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Incidence and Characteristics

Liver Function Tests ,[object Object],No single liver function test is available to quantify liver disease

[object Object],[object Object],Liver Function Tests ,[object Object],[object Object]

[object Object],Liver Function Tests ,[object Object],[object Object]

[object Object],[object Object],[object Object],Liver function tests In normal pregnancies, alkaline phosphatase levels may be elevated three- to fourfold, secondary to placental alkaline phosphatase levels evaluate Cholestasis and biliary obstruction

Pathogenesis ,[object Object]

Pathogenesis ,[object Object],[object Object],[object Object]

CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Symptoms/Signs %

[object Object],[object Object],[object Object],polydipsia,

[object Object],Lethargy and encephalopathy

[object Object],But marked deterioration after delivery has been observed

LABORATORY FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Histopathology ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],Histopathology Vigil-De Gracia P, Lavergne JA. Acute fatty liver of pregnancy. Int J Gynaecol Obstet 2001;72:193-5.

Complications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

[object Object],( a mild proteinuria ,mild edema and a mild increase in blood urea nitrogen and creatinine ).

[object Object],Diagnosis and managment next

[object Object],Riely CA, Latham PS, Romero R, Duffy TP. Acute fatty liver of pregnancy. A reassessment based on observations in nine patients. Ann Intern Med 1987;106:703-6.

[object Object],[object Object]

[object Object],[object Object],against the diagnosis of. fulminant hepatitis (viral or toxic).

[object Object],uncommon in fulminant hepatitis . and they favor the diagnosis of acute fatty liver of pregnancy.

[object Object],[object Object],next

[object Object],TREATMENT next

But also that no patient has yet been reported with a recovery before delivery. TREATMENT next

[object Object],[object Object],[object Object],[object Object],SO ,a prompt delivery is preferable.

[object Object],[object Object],the emergency therapeutic decisions usually are made without waiting for a histologically proven diagnosis.

Thank You Dr. Mohammed Abdalla EGYPT, Domiat general hospital

Aflp

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