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- 1. Where Life and Science Mean Business Israel – Hungary Innovation Day Israel Medical Technology 3 October 2013 Jeff Dykan SCP Vitalife Managing Director
- 2. Where Life and Science Mean Business Life Science Industry 2 Main Categories Biotechnology Medical Devices
- 3. Where Life and Science Mean Business Life Science Industry 2 Main Categories Biotechnology Medical Devices
- 4. Where Life and Science Mean $100M to $150 investedBusinessCapital by Venture annually in Life Sciences approximately 80% to Medical Devices ILSI Database 2013 PWC Kesselman & Kesselman
- 5. Where Life and Science Mean Business Focus on MedTech Israel’s Life Sciences Industry - Sectors Source: ILSI Database – 2013
- 6. Where Life and Science Mean Business Focus on Largest Markets Medical Devices - Main Medical Fields Source: ILSI Database – 2013
- 7. Where Life and Science Mean Business Focus on Disposables, Implantables, Diagnostics and Imaging Israel’s Medical Device Companies - Subsectors Source: ILSI Database – 2013
- 8. Where Life and Science Mean Business Young Industry 65% of active companies founded in last decade The Israeli Life Science Industry Number of Companies Founded 2010– Incomplete data ILSI Database 2013
- 9. Where Life and Science Mean Business While the industry is young, 45% have revenues Companies Developmental Stage Source: ILSI Database – 2013
- 10. Where Life and Science Mean Business Trivia Which country has the largest number of medical device patents in the world per capita ?
- 11. Where Life and Science Mean Business Trivia Which country has the largest number of medical device patents in the world per capita ? ISRAEL
- 12. Where Life and Science Mean Business Israel is #1 Medical Devices Patents per Million Capita Source: www.uspto.gov, Analysis: ILSI ©
- 13. Where Life and Science Mean Business Medtech Startups Criteria for Success • • • • Large market Strong IP Clinical evidence > superiority and value Platform technology • Path to Widespread Commercial Use
- 14. Where Life and Science Mean Business History of Israeli Medical Device Exits ILSI database 2013
- 15. Where Life and Science Mean Business SCP Vitalife • Medical Technology VC • Total $ Under Management: $230M- Vitalife I & SCP Vitalife II • Offices: Tel Aviv and Philadelphia • Primary focus on investments sourced in Israel (65%) and U.S. (35%) • Partners: Dr. Avi Ludomirski, Jeff Dykan, Wayne Weisman, Win Churchill Major Exits • ColBar: Acquired by a division of J&J • Sightline: Acquired by Stryker • MediGuide: Acquired by St. Jude •CanFite: IPO on TASE Fund’s Investment Focus & Portfolio • Medical Devices for Therapeutic Uses Avedro, NovoGI,, Endospan, Sightline, BetaO 2, Fluidnet, Spine21 • Novel Diagnostic Methods, especially Imaging Sensible, Deep Breeze, Denx, Trig, D.I.R., Pocared, MediGuid e • Biomaterials and Cell Therapies Regentis, GeneGrafts, Garnet, ColBar • Specialty Pharmaceuticals and Drug Delivery Recro, TransPharma, CanFite • Other Argo, Procognia SCP Vitalife II, L.P. 1
- 16. Where Life and Science Mean Business Active Portfolio Companies
- 17. Where Life and Science Mean DIR Technologies Business Description • DIR Technologies was formed by SCP Vitalife II via a spin-out from SCD, a leading Israeli developer and manufacturer of infrared detectors and laser diodes for defense and military purposes • DIR applies infrared technology in a variety of non-contact pharmacological tests, such as identification of counterfeit drugs through the original package, and rigorous in-line quality assurance for the manufacture and packaging of drugs by the leading pharma companies • Company is working with leading global pharma companies on both QA and anti-counterfeiting application
- 18. Where Life and Science Beta-O2 TechnologiesMean Business • • • Beta-O2 has developed a bio-artificial substitute pancreas for diabetic patients 10 9 The ß-Air is an implantable device that contains islets of Langerhans (insulin and glucagon producing cells). The cells are protected from the host’s immune system and supplied with oxygen Following extensive pre-clinical testing, BetaO2 performed its first-in-human implantation in a leading diabetes center in Germany during 2012 Following seven months of implantation: “For the first time it has been shown that allogeneic islets integrated into an oxygenated macrochamber can survive and function after transplantation in man without any immunosuppressive therapy ….... This finding is outstanding and a case sui generis.” Report by the German physicians HbA1c (%) • Initial Results of First-in-Human Implantation Hemoglobin A1c After the First 90 Days 8 7 6 5 -400 Normal Range -300 -200 -100 0 0 30 Days relative to Tx 60 90
- 19. Sensible Where Life and Science Mean Medical Innovations Business Description • Founded in May 2007, Sensible is developing the SafePatchCHF, a non-invasive system for continuous monitoring of Congestive Heart Failure patients • SafePatch is based on Remote Dielectric Sensing (ReDS) technology, which employs electromagnetic reflectometry using ultra-wide-band frequencies transmitted at very low intensities • Technology was adapted from military application utilized by Sensible’s founders during their service in special technology units of the Israeli Defense Forces • The SafePatch measures lung fluid content, respiratory rate and heart rate which, combined, provide an early indicator of heart failure de-compensation • The market potential for CHF monitoring is estimated at hundreds of millions of dollars per year
- 20. Where Life and Science Mean Pocared Diagnostics Business Description • Pocared Diagnostics has developed an innovative diagnostic system that provides physicians with realtime detection and identification of pathogens • The standard (culture-based) testing process typically requires 30 hours to identify the infectious agent; Pocared’s solution will be able to provide bacterial identification within 1-2 hours • Pathogen identification is made possible using the proprietary Pocared Optical Signature™ and Pocared Optical Fingerprint™ • The high-throughput system is compact, user-friendly and does not require the use of reagents • Has become well-known to potential acquirers, who are awaiting results of clinical trials in first half of 2013
- 21. Where Life and Science Mean Argo Medical Business • Argo Medical aims to fundamentally change the health and life experiences of individuals with spinal cord injury.