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RBC Disorders ,[object Object],[object Object],[object Object]
Anemia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of Anemia
[object Object],[object Object]
Morphological ,[object Object],[object Object],[object Object],[object Object]
Etiological ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Microcytic Hypochromic Anemia Iron deficiency Anemia
Iron metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IRON ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IRON Body Compartments - 75 kg man 3 mg Absorption < 1 mg/day Excretion < 1 mg/day Stores 1000mg Tissue 500 mg Red Cells 2300 mg
IRON   CYCLE Fe Fe Fe Fe Fe Ferritin Hemosiderin slow Fe Fe Fe Fe Fe Fe Fe Fe Fe Ferritin Ferritin Transferrin Receptor RBC PRECURSOR CIRCULATING RBCs Fe Fe TRANSFERRIN MONONUCLEAR PHAGOCYTES
Iron absorption ,[object Object],[object Object],[object Object]
Factors affecting Iron Absoption ,[object Object],[object Object],[object Object],[object Object]
Iron balance ,[object Object],[object Object]
 
GI ABSORPTION OF IRON Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Ferritin Fe Fe Fe Fe Fe Fe Fe TRANSFERRIN
IRON Causes of Iron Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IRON STORES Iron Deficiency Anemia Stores 0 mg 3 mg Absorption 2-10 mg/day Excretion Dependent on Cause Tissue 500 mg Red Cells 1500 mg
IRON DEFICIENCY Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Laboratory Findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differential Diagnosis ,[object Object],[object Object],[object Object]
N HB A 2  increase N N HB electro Ring form present absent absent Blast iron present present Present Absent BM Iron I N N D Ferritin  Normal Normal D I TIBC Inc Normal D D Serum Iron D D D decrease MCHC D D  D “ MCH Decrease Decreas e Low/N decrease MCV Sidero Thal ACD Fe Def Investigation
Treatment ,[object Object],[object Object],[object Object],[object Object]
Plummer Vinson Syndrome   (Patterson Kelly Syndrome) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Iron overload  ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Classification Of Anaemia & Ida

  • 1.
  • 2.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10. Microcytic Hypochromic Anemia Iron deficiency Anemia
  • 11.
  • 12.
  • 13.
  • 14. IRON Body Compartments - 75 kg man 3 mg Absorption < 1 mg/day Excretion < 1 mg/day Stores 1000mg Tissue 500 mg Red Cells 2300 mg
  • 15. IRON CYCLE Fe Fe Fe Fe Fe Ferritin Hemosiderin slow Fe Fe Fe Fe Fe Fe Fe Fe Fe Ferritin Ferritin Transferrin Receptor RBC PRECURSOR CIRCULATING RBCs Fe Fe TRANSFERRIN MONONUCLEAR PHAGOCYTES
  • 16.
  • 17.
  • 18.
  • 19.  
  • 20. GI ABSORPTION OF IRON Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Fe Ferritin Fe Fe Fe Fe Fe Fe Fe TRANSFERRIN
  • 21.
  • 22. IRON STORES Iron Deficiency Anemia Stores 0 mg 3 mg Absorption 2-10 mg/day Excretion Dependent on Cause Tissue 500 mg Red Cells 1500 mg
  • 23.
  • 24.  
  • 25.  
  • 26.
  • 27.
  • 28.
  • 29.
  • 30. N HB A 2 increase N N HB electro Ring form present absent absent Blast iron present present Present Absent BM Iron I N N D Ferritin Normal Normal D I TIBC Inc Normal D D Serum Iron D D D decrease MCHC D D D “ MCH Decrease Decreas e Low/N decrease MCV Sidero Thal ACD Fe Def Investigation
  • 31.
  • 32.
  • 33.