This document contains summaries of various blood disorders and diseases as seen under the microscope on blood and bone marrow samples: - Hereditary spherocytosis results in spherical red blood cells due to a genetic defect impacting membrane structure. - Sickle cell anemia samples show misshapen red blood cells called sickle cells and other abnormal red blood cell shapes. - Leukemia samples show immature white blood cells called blasts that indicate either acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) depending on the type of blast. - Chronic myeloid leukemia displays mature and immature white blood cells in the blood while chronic lymphocytic leukemia shows an overabund

1. By the Name of Allah,
The Most Gracious, The Most Merciful

2. Hereditary spherocytosis blood smear.

3. Sphere shape allow a much smaller surface area to volume
ratio than biconcave shape
Scanning electron micrograph of a
normal biconcave erythrocyte
Scanning electron micrograph of a
spherocyte. The spherocyte is smaller,
round, and lacks concavities

4. Sickle RBCs

5. A.Peripheral blood smear from a patient with sickle cell anemia.showing sickle cells,
anisocytosis, poikilocytosis, & target cells .B ,Higher magnification shows an
irreversibly sickled cell

6. Target cells

7. Target cells(arrows)
anisocytosis poikilocytosis.

8. Peripheral blood smear (Heinz bodies) revealed by supravital
staining.
"bite cells".

9. PCV

10. Polycythemia –blood film

11. PCV-bone marrow

12. ALL-Lymphoblasts have fewer nucleoli than do myeloblasts, and the nuclear
chromatin is more condensed.
Cytoplasmic granules are absent

13. AML-Myeloblasts have delicate nuclear chromatin, prominent nucleoli, and
fine azurophilic granules in the cytoplasm (arrows).

14. Acute lymphoblastic leukemia (ALL) blood
smear.

15. ALL-L3

16. ALL- bone marrow aspirate.

17. AML-Auer rods

18. AML-bone marrow

19. Acute promyelocytic leukemia (FAB AML-M3) blood smear.
Note the
cytoplasmic granules in the cell at the top and the multiple Auer rods in the cell at the
bottom.

20. AML-M3
bone marrow

21. CML-Peripheral blood smear shows many mature neutrophils, some
metamyelocytes, and a myelocyte and a myeloblast.

22. CLL-blood smear Lymphocytosis of small
mature-appearing lymphocytes. Numerous “smudge” cells are present.

23. .
CLL
Condensed “soccer
ball” nuclear chromatin; one “smudge cell” is present.

24. Diffuse large B-cell lymphoma, medium power.

25. Diffuse large B-cell lymphoma, high power.

26. Diffuse large B-cell lymphoma, high power.

27. Follicular lymphoma

28. Follicular lymphoma

29. Small Lymphocytic Lymphoma

30. MALT lymphoma

31. Burkitt’s Lymphoma
“starry sky” appearance.

32. Hodgkin’s lymphoma
RS cell

33. Hodgkin disease, lymphocyte-predominance type. Numerous mature-
looking lymphocytes surround scattered, large, pale-staining lymphocytic
and histiocytic variants ("popcorn" cells).

34. Hodgkin lymphoma, nodular sclerosis type. A low-power view shows well-defined
bands of pink, acellular collagen that have subdivided the tumor cells into nodules

35. Hodgkin lymphoma, nodular sclerosis type. A distinctive "lacunar cell" with multilobed nucleus
containing many small nucleoli is seen lying within a clear space created by retraction of its
cytoplasm. It is surrounded by lymphocytes.

36. Hodgkin disease, mixed-cellularity type. A diagnostic, binucleate Reed-Sternberg cell is
surrounded by multiple cell types, including eosinophils (bright-red cytoplasm), lymphocytes,
and histiocytes.

37. Multiple Myeloma

38. Multiple myeloma blood smear.
Rouleaux formation.

39. Multiple myeloma bone marrow aspirate.
Numerous plasma cells, many of
which have prominent nucleoli (normal plasma cells lack nucleoli), are present