Glucocorticoid potency

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This document compares the potency and properties of various glucocorticosteroids. It lists cortisone, hydrocortisone, prednisone, prednisolone, and methylprednisolone as intermediate acting steroids with anti-inflammatory potencies ranging from 0.8 to 5 times that of hydrocortisone and sodium retaining effects from 0.6 to 1. Dexamethasone is categorized as long acting with the highest potency of 25 times hydrocortisone and lowest sodium retaining effect of 0.75. The document also notes that physiological cortisol secretion is equivalent to 7.5mg of prednisone per day.

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Glucocorticosteroid potency
Drug 抗炎效力相等劑量留鈉效力 Biologic half life
Short cortisone 0.8 25 1 <12hrs
Hydrocortisone(SoluCortef) 1 20 1
Intermedi
ate
Prednisone 4 5 0.6 12-48 hrs
Prednisolone(口服) 4 5 0.6
Methylprednisolone(SoluMedrol) 5 4 0.5
Long Dexamethasone(Decardron) 25 0.75 0 >48hrs
生理cortisol 分泌量= 7.5mg prednisone/day

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