2. Definition
Multisystem disease of unknown etiology
characterized by
⢠Granulomatous necrotizing small vessel
vasculitis of the upper & lower respiratory
tract &
⢠Glomerulonephritis.
3.
4. Wegnerâs granulomatosis involves the
⢠upper respiratory tract in 100% of cases,
⢠lower respiratory tract in 90% of cases &
⢠kidneys in 80% of cases, &
⢠Tracheo-bronchial tree in 60% of cases.
9. Rare manifestations of WG
⢠Interstitial abnormalities (thickening of
interlobular sepat).
⢠Hilar lymphadenopathy.
⢠Pleural thickening or effusion.
10. Nodules
⢠Single or multiple.
⢠Small or large (few mm to 10 cm).
⢠Cavitating or non cavitating.
⢠Thin walled (1-3 mm) or thick walled (> 3
mm) cavities.
⢠Halo sign (due to surrounding alveolar
hemorrhage).
⢠Reversed halo sign.
22. Case
27-year-old woman involved in a severe motor
vehicle collision years ago with a prolonged
hospital course now presents with a several
months history of progressive dyspnea.
⢠What is the pertinent radiologic finding?
⢠What is your differential diagnosis?
⢠What is your favorite diagnosis?