"The Future of Sleep with Neurotechnology" - Anant Sachetee (Rythm) Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California. For more information including details of subsequent events, please visit http://hyperwellbeing.com The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization. WaaS newsletter sign-up http://eepurl.com/b71fdr @hyperwellbeing

1. NOVEMBER 14-16
MOUNTAIN VIEW, CA

2. 165 Jessie St, San Francisco, CA 94105, USA | 5 rue Scribe 75009 Paris, France
Brain Science for Humankind.

3. RYTHM & DREEM
At Rythm, we believe that combining
fundamental neurosciences and advanced
technologies will bring unprecedented and
powerful solutions to improve people’s
wellbeing, performance and health.
We have started with one of the biggest
modern challenge : Sleep. Dreem is the
first active sleep platform that will allow
people to improve sleep efficiently.

4. BAD SLEEP IS A MODERN SCOURGE
1/3
of the global population is suffering
from poor sleep quality, leading to
disastrous effects on health, cognitive
and physical performances.
Stress Work Environment Pathologies
13M People using
benzodiazepine in FR $100b Annual cost of bad
sleep in the USA.

5. …AND A COMPLEX PROBLEM WITH NO SOLUTION
Sleep Centers and Drugs.
MEDICAL CONSUMER
Wearables, Apps, Smarthome.
For Sleep Centers: lack of resources,
very low attending, and expensive.
For Drugs: addictive, side effects and
non individualized.
Consumer devices lack of accuracy and
are not active which lead to very low
results on improvement and usage drops
of these devices.
There is a need for an individualized and active solution
to answer efficiently the various sleep challenges.

6. BRAIN IS KEY
The last decades of research in neurosciences bring
powerful solutions to understand and improve sleep.
DEEPENING SLEEP BY HYPNOTIC SUGGESTION
Deepening Sleep by Hypnotic Suggestion
Maren J. Cordi, Dipl Psych1
; Angelika A. Schlarb, PhD2
; Björn Rasch, PhD1,3,4
1
University of Zurich, Institute of Psychology, Division of Biopsychology, Zurich, Switzerland, Binzmüh
Tübingen, Department of Psychology, Division of Clinical Psychology and Psychotherapy, Tübingen, G
Sleep Research (ZiS), University of Zurich, Zurich, Switzerland; 4
University of Fribourg, Department o
Biopsychology and Methods, Fribourg, Switzerland
Study Objectives: Slow wave sleep (SWS) plays a critical role in body restoration and promotes
across the lifespan. Despite its importance, effective tools to increase SWS are rare. Here we te
deeper” extends the amount of SWS.
Design: Within-subject, placebo-controlled crossover design.
Setting: Sleep laboratory at the University of Zurich, Switzerland.
Participants: Seventy healthy females 23.27 ± 3.17 y.
Industrial Health, 1993, 31, 35-38
35
Sleep Induction Effects of Steady 60 dB (A)
Pink Noise
Abstract : The effects of 60 dB (A) steady pink noise on sleep induction were studied. Two
experiments were conducted. First, 10 night-sleep polygrams of a young male subject were
recorded consecutively as controls. Five night polygrams of the same subject were then
recorded with exposure to steady 60 dB (A) pink noise. Second, polygrams of four students
were recorded using the same noise exposure as in the first experiment. Polygrams for the
control night were also recorded. Noise exposure tended to shorten sleep latency, i.e., the
values were 4.2 and 9.5 min in the first and second experiment, respectively. The steady 60
dB (A) noise made sleep induction easier.
Key words: Steady pink noise—-Sleep latency—-Insomnia
Environmental noise is a major cause of sleep disturbance, though passengers
in trains or airplanes often sleep well in noisy environments. Eberhardt et al.1)
made a comparison of steady and intermittent road traffic noise on sleep. They
found that 45 dB (A) steady noise caused a REM sleep deficit, while 45 dB (A)
intermittent noise caused sleep stage 3 and 4 deficits, and that 55 dB (A) noise
led to awakening. We have already reported the sleep induction effects of steady
pink noise in a case study2). This article focuses on the effects of the same 60
dB (A) pink noise on the shortening of sleep latency, adding four other young
subjects.
MATERIAL AND METHODS
Reduction in Time-to-Sleep through EEG Based
Brain State Detection and Audio Stimulation
Zhuo Zhang1
, Cuntai Guan1
, Ti Eu Chan1
, Juanhong Yu1
, Aung Aung Phyo Wai1
, Chuanchu Wang1
, Haihong Zhang1
ABSTRACT
We developed an EEG- and audio-based sleep sens-
ing and enhancing system, called iSleep (interactive Sleep
enhancement apparatus). The system adopts a closed-loop
approach which optimizes the audio recording selection
based on user’s sleep status detected through our online EEG
computing algorithm. The iSleep prototype comprises two
major parts: 1) a sleeping mask integrated with a single chan-
nel EEG electrode and amplifier, a pair of stereo earphones
and a microcontroller with wireless circuit for control and
data streaming; 2) a mobile app to receive EEG signals for
online sleep monitoring and audio playback control. In this
study we attempt to validate our hypothesis that appropriate
audio stimulation in relation to brain state can induce faster
onset of sleep and improve the quality of a nap. We conduct
experiments on 28 healthy subjects, each undergoing two
nap sessions - one with a quiet background and one with
our audio-stimulation. We compare the time-to-sleep in both
sessions between two groups of subjects, e.g., fast and slow
sleep onset groups. The p-value obtained from Wilcoxon
Signed Rank Test is 1.22e − 04 for slow onset group, which
demonstrates that iSleep can significantly reduce the time-
to-sleep for people with difficulty in falling sleep.
I. BACKGROUND
In recent years, a number of sleep enhancing products
or systems have been developed. They can be categorized
into three different groups. The first group deals with sleep
tracking and provides recommendations for improving sleep.
An example of such a product in this group is Sleep Tracker,
which was developed by Zeo (Boston, 2003). This applica-
tion helps to track users’ sleep cycles, providing them with
information on their sleep patterns, and recommendations
on how to improve their sleep quality. The second group
provides assistance in waking up users in the appropriate
stage of their sleep. Example products are Wakemate (Perfect
Third Inc. San Francisco), Lark(Lark Technologies, CA)
and Renew Sleepclock (Gear4, Hong Kong). These products
track the users’ sleep patterns and wake them up gently by
using either sounds or vibrations from a wristband when the
users are in light sleep stage. The third group consists of
sleep induction systems, an example of which is Nightwave
(Coherence Resources Inc., Portland). These systems help to
induce sleep through the playback of audio, white noise or
sounds that match the frequency of the brainwaves to calm
the user down and help him fall asleep.
Existing sleep enhancement or regulation system usually
rely on an open loop approach. In this research, we de-
veloped a novel closed-loop system to help people gain
faster and better sleep. The EEG- and audio-based sleep
Author's personal copy
Biological Psychology 95 (2014) 126–134
Contents lists available at ScienceDirect
Biological Psychology
journal homepage: www.elsevier.com/locate/biopsycho
Enhancing sleep quality and memory in insomnia using instrumental
sensorimotor rhythm conditioning
Manuel Schabusa,b,∗
, Dominik P.J. Heiba
, Julia Lechingera
, Hermann Griessenbergera
,
Wolfgang Klimeschb
, Annedore Pawlizkia,c
, Alexander B. Kunzd
, Barry M. Stermane,f
,
Kerstin Hoedlmosera,b
a
Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology, University of Salzburg, Austria
b
Center for Neurocognitive Research, University of Salzburg, Austria
c
General & Experimental Psychology, Ludwig-Maximilians University of Munich, Germany
d
Department of Neurology, Paracelsus Medical University Salzburg, Austria
e
Department of Neurobiology, UCLA School of Medicine, USA
f
Department of Biobehavioral Psychiatry, UCLA School of Medicine, USA
a r t i c l e i n f o
Article history:
Received 12 October 2012
a b s t r a c t
EEG recordings over the sensorimotor cortex show a prominent oscillatory pattern in a frequency range
between 12 and 15 Hz (sensorimotor rhythm, SMR) under quiet but alert wakefulness. This frequency
ORIGINAL ARTICLE
Brainwave entrainment for better sleep and post-sleep state of young
elite soccer players ÁA pilot study
VERA ABELN1
, JENS KLEINERT2
, HEIKO K. STRU¨ DER1
, & STEFAN SCHNEIDER1,3
1
Institute of Movement and Neurosciences, German Sport University Cologne, Cologne, Germany, 2
Department of Health and
Social Psychology, Institute of Psychology, German Sport University Cologne, Cologne, Germany, 3
Faculty of Science, Health,
Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland, Australia
Abstract
The effect of sleep deprivation on psychophysical performance and well-being is comprehensively investigated. Research
investigating the effect of improved sleep is rare. Just as little exists about attempts to support athletic mental state and
performance by improving sleep quality. This study aims to investigate whether sleep quality of top athletes can be
improved by auditory brainwave entrainment and whether this leads to enhancements of post-sleep psychophysical states.
In a pilot study, 15 young elite soccer players were stimulated for eight weeks during sleep with binaural beats around
2Á8 Hz. Once a week after wake-up, participants completed three different questionnaires: a sleep diary, an adjective list for
psychophysical and motivational state, and a self-assessment questionnaire for sleep and awakening quality. Fifteen sport
students executed the same protocol sleeping on the same pillow, but without stimulation. Subjective ratings of sleep and
awakening quality, sleepiness and motivational state were significantly improved only in the intervention group, but did not
impact their perceived physical state. In summary, eight weeks of auditory stimulation with binaural beats improved
perceived sleep quality and the post-sleep state of athletes, whereas the effect on physical level is assumed to occur in a
time-delayed fashion. It seems to be worthwhile Á to further elaborate long-time effects and consequences on physical and
mental performance.
Keywords: Neurostimulation, auditory stimulation, mental state, athletic performance, sleepiness
Introduction performance are known. For instance, when a sleep
European Journal of Sport Science, 2014
Vol. 14, No. 5, 393Á402, http://dx.doi.org/10.1080/17461391.2013.819384
iversityofColoradoatColoradoSprings]at10:0613January2015
Neuron
Article
Auditory Closed-Loop Stimulation
of the Sleep Slow Oscillation Enhances Memory
Hong-Viet V. Ngo,1,2,3 Thomas Martinetz,2 Jan Born,1,4,* and Matthias Mo¨ lle1,4
1Institute of Medical Psychology and Behavioral Neurobiology, and Center for Integrative Neuroscience, University of Tu¨ bingen,
72076 Tu¨ bingen, Germany
2Institute for Neuro- and Bioinformatics
3Graduate School for Computing in Medicine and Life Sciences
4Department of Neuroendocrinology
University of Lu¨ beck, 23538 Lu¨ beck, Germany
*Correspondence: jan.born@uni-tuebingen.de
http://dx.doi.org/10.1016/j.neuron.2013.03.006
SUMMARY
Brain rhythms regulate information processing in
different states to enable learning and memory
formation. The <1 Hz sleep slow oscillation hallmarks
slow-wave sleep and is critical to memory consolida-
tion. Here we show in sleeping humans that auditory
stimulation in phase with the ongoing rhythmic
occurrence of slow oscillation up states profoundly
enhances the slow oscillation rhythm, phase-
coupled spindle activity, and, consequently, the
consolidation of declarative memory. Stimulation
The obvious functional importance has stimulated attempts to
induce synchronized cortical SO activity through external stimu-
lation, mainly by rhythmic electrical, transmagnetic, and auditory
stimulation in humans and rats (Marshall et al., 2006; Massimini
et al., 2007; Tononi et al., 2010; Vyazovskiy et al., 2009). Impor-
tantly, such studies imposed rhythms on the brain disregarding
the phase of ongoing endogenous oscillating activity, which
might explain the overall limited functional enhancement in
memory retention accompanying SO induction. Here, we utilized
the ongoing oscillatory EEG activity to apply, in a closed-loop
feedback system, auditory stimulation in synchrony with the
brain’s own rhythm, thereby enhancing and extending trains of
SOs during sleep.

7. NEUROSCIENCES BRING POWERFUL TOOLS
Awake
REM
Stage 1
Stage 2
Stage 3
Stage 4
Sleep
induction
Deep Sleep
induction
Smart
Wake Up
Naps
Sleep Coaching
EEG

8. INTRODUCING DREEM
The First Active Sleep Platform.
Dreem brings to most efficient neurosciences solutions to the consumer, and
offers the first active, efficient and individualized sleep improvement product.
Brain auditory
stimulations to fall
asleep faster and
induce deep sleep
Naps and day
personalized expert
programs to improve
sleep.
The world’s first
personalized sleep
coach (tips and
accurate analytics)
Medical-grade
brain and body
activity
measurement

10. DREEM CORE TECHNOLOGY
Proprietary dry EEG sensors allowing
brain activity acquisition similar to
laboratories acquisition devices.
Highly miniaturized powerful electronics
allowing real-time monitoring and
synchronized brain stimulations.
Bone conduction device allowing quality
audio stimulations without wearing
earphones or headset.
The smallest and the most accurate brain
and sleep wearable computer. More than 20
patents on the technology.

11. DREEM CORE TECHNOLOGY
State-of-the art analysis and storage
brain data infrastructure. Unprecedented
amount of quality brain data.
Sleek mobile application as a user
interface, allowing the user to interact with
the headband, visualize tips and analytics.
An international team of neuroscientists
and sleep experts working as expert data
scientists on our database.
The world’s first massive database of brain
and sleep data offering an unprecedented
knowledge on sleep and high personalization.

12. THE SCIENCE BEHIND DREEM
Dreem is the result of decades of neurosciences and hundreds of publications
of our neurosciences partners, on sleep and brain stimulations. All the
features have been tested rigorously internally, on thousands of nights.
French Armed Forces
Biomedical Research Institute
Pr. Stéphane Charpier, PhD
Brain and Spine Institute of Paris
Pr. Stanislas Dehaene, PhD
INSERM / CEA / Ecole Polytechnique
Pr. Alain Destexhe, PhD
CNRS / UNIC / Human Brain Project
Pr. Jan Born, PhD
Tubingen University
Manchester University &
University of Wisconsin.

13. DREEM BETA
• Beta program of 500 selected participants (US&FR)
for product and technology testing and validation.
Price: $349. Already more than 3,000 applications.
• Technology functional, first version of the product
industrialized, focusing on deep sleep and smart
alarm clock.
In 2 years, from the lab to the Dreem First Program.

14. DREEM CONSUMER LAUNCH
(currently under development)
We are currently
working on an
evolution of the
product that will be
announced in Q1 2017
for deliveries in Q2
2017.
Improved
hardware
Smaller electronics,
improved materials,
comfort optimized, new
sensors, better autonomy.
Improved
features
New features allowing
new applications and
solving new problems,
and improved efficacy.