Atp Teach Intro

ATP Making energy! The point is to make ATP !

The energy needs of life ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Where do we get the energy from? ,[object Object],[object Object],+ + energy + energy + digestion synthesis

Living economy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ATP Whoa ! Hot stuff !

ATP ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],How efficient! Build once, use many ways high energy bonds

How does ATP store energy? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Instability of its P bonds makes ATP an excellent energy donor I think he’s a bit unstable… don’t you? AMP ADP ATP P O – O – O – O P O – O – O – O P O – O – O – O P O – O – O – O P O – O – O – O P O – O – O – O P O – O – O – O P O – O – O – O

How does ATP transfer energy? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],7.3 energy + ADP ATP P O – O – O – O P O – O – O – O P O – O – O – O P O – O – O – O

An example of Phosphorylation… ,[object Object],[object Object],[object Object],It’s never that simple ! +4.2 kcal/mol “ kinase” enzyme -7.3 kcal/mol -3.1 kcal/mol synthesis C H OH H H O C C H O H C + H 2 O + C H OH C H P + ATP + ADP H H O C + C H O H C C H P + P i enzyme H OH C H H O C

Another example of Phosphorylation… ,[object Object],[object Object],glucose C-C-C-C-C-C fructose-1,6bP P- C-C-C-C-C-C -P DHAP P- C-C-C G3P C-C-C -P Those phosphates sure make it uncomfortable around here ! activation energy hexo kinase phosphofructo kinase C H P C P C ATP 2 ADP 2

ATP / ADP cycle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],A working muscle recycles over 10 million ATPs per second Whoa ! Pass me the glucose (and O 2 ) ! ATP ADP 7.3 kcal/mole cellular respiration P i +

[object Object],What’s the point? The point is to make ATP !

ATP synthase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ATP But… How is the proton (H + ) gradient formed? ADP H + catalytic head rod rotor H + H + H + H + H + H + H + H + P +

That’s the rest of my story ! Any Questions?

Atp Teach Intro

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