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Drug excretion lecture 10

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DRUG EXCRETION ,[object Object],[object Object],[object Object],[object Object]
Renal excretion ,[object Object],[object Object]
One Nephron of the Kidney
Major Excretory Processes in the Nephron ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Glomerular filtration ,[object Object],[object Object],[object Object],[object Object]
Glomerular filtration (Cont) ,[object Object],[object Object],[object Object],[object Object]
Tubular secretion ,[object Object],[object Object],[object Object],[object Object]
Tubular re-absorption ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tubular re-absorption ,[object Object],[object Object],[object Object],[object Object]
Effect of Urine pH on tubular re-absorption ,[object Object],[object Object],[object Object]
Alteration of Urine pH ,[object Object],[object Object],[object Object],[object Object]
1.0 0.0 1.0 0.0 1.32 24.0 V.Weak 4.0 F 0.83 76.0 10.26 98.0 635.2 99.9 Weak 8.0 E 0.79 99.99 12.6 100.0 794.3 100.0 Strong 12.0 D BASES 1.0 0.3 0.99 0.02 0.99 0.0 V.Weak 10.0 C 1.25 97.0 0.115 66.6 0.04 3.0 Weak 6.0 B 1.26 100.0 0.8 99.99 0.001 99.7 Strong 2.0 A Acids Urine pH Valves 7.5 Cl R Urine pH Valves 7.5 % Ionized Urine pH Valves 6.3 Cl R Urine pH Valves 6.3 % Ionized Urine pH Valves 4.5 Cl R Urine pH Valaes 4.5 % Ionized Nature pK a Drugs
Effect of Drug pka on renal clearance ,[object Object],[object Object],[object Object],[object Object]
Effect of Drug pka on renal clearance ,[object Object],[object Object],[object Object]
Effect of Drug pka on renal clearance ,[object Object],[object Object]
Effect of Drug pka on renal clearance ,[object Object]
Renal clearance ,[object Object],[object Object],[object Object],[object Object]
Renal clearance (Cont.) ,[object Object],[object Object],[object Object]
Renal clearance (Cont.)
Renal clearance (Cont.) ,[object Object],[object Object],[object Object]
Renal clearance ,[object Object]
Hemodialysis ,[object Object],[object Object],[object Object]
Applicability of Hemodialysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biliary excretion ,[object Object],[object Object],[object Object]
Biliary excretion (Cont.) ,[object Object],[object Object],[object Object]
Enterohepatic Recycling
Cp versus Time showing a Second Peak
Enterohepatic Recycling (Cont.) ,[object Object],[object Object],[object Object],[object Object]
Pulmonary excretion ,[object Object],[object Object],[object Object]
Salivary excretion ,[object Object],[object Object],[object Object],[object Object]
Renal disease considerations ,[object Object],[object Object],[object Object]
Dose adjustment ,[object Object],[object Object],[object Object],[object Object],[object Object]
Creatinine clearance (Cont.) ,[object Object],[object Object],[object Object],[object Object]
Determination of creatinine clearance ,[object Object]
Determination of creatinine clearance (Cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Calculation of creatinine clearance ,[object Object],[object Object],[object Object]

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Drug excretion lecture 10

  • 1.
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  • 3. One Nephron of the Kidney
  • 4.
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  • 12. 1.0 0.0 1.0 0.0 1.32 24.0 V.Weak 4.0 F 0.83 76.0 10.26 98.0 635.2 99.9 Weak 8.0 E 0.79 99.99 12.6 100.0 794.3 100.0 Strong 12.0 D BASES 1.0 0.3 0.99 0.02 0.99 0.0 V.Weak 10.0 C 1.25 97.0 0.115 66.6 0.04 3.0 Weak 6.0 B 1.26 100.0 0.8 99.99 0.001 99.7 Strong 2.0 A Acids Urine pH Valves 7.5 Cl R Urine pH Valves 7.5 % Ionized Urine pH Valves 6.3 Cl R Urine pH Valves 6.3 % Ionized Urine pH Valves 4.5 Cl R Urine pH Valaes 4.5 % Ionized Nature pK a Drugs
  • 13.
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  • 22.
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  • 24.
  • 25.
  • 27. Cp versus Time showing a Second Peak
  • 28.
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  • 30.
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  • 35.
  • 36.