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My Horse University and eXtension’s HorseQuest
              welcome you to this live Webcast.



 Gastric Ulcers in Horses:
 How to Tell if Your Horse
Has One, and What do Do if
          it Does

      Dr. Jenifer Nadeau
       University of Connecticut
Meet our presenter:
        Dr. Jenifer Nadeau
        Associate Professor &
           Equine Extension
           Specialist
        University of Connecticut
Prevalence of Equine Gastric Ulcer
          Syndrome (EGUS)
• 60% to 93% in                                   • 11% in lesson horses
  performance horses                              • 66.6% in pregnant
• 40% to 58% of show                                broodmares
  horses                                          • 75.9% in non pregnant
• 25% to 50% in foals                               broodmares
                                                  • 37-53% pleasure horses




Murray et al, Equine Vet J, 1996; Murray, JAVMA, 1989; Murray,
AAEP, 1997; Bertone 2000; McClure et al. 1999.
Stomach Anatomy
• Non-glandular region
• Margo plicatus
• Glandular region
Types of ulcers
• Primary squamous ulceration
• Primary glandular ulceration
• Secondary squamous ulceration
Squamous Ulcers
Glandular Ulcers
Causes
• Diet especially hydrochloric acid and volatile
  fatty acids
• Bile acids
• Bacterial contamination, including H. pylori
• Non-steroidal anti-inflammatory drugs
  (NSAIDs)
• Exercise
Causes of EGUS
• Damage occurs when aggressive
  factors overpower defenses of
  gastric mucosa
• Squamous mucosal lesions (80%)
  result from increased acids
• Glandular mucosal lesions (20%)
  result from impaired mucosal protection
Previous Study (Dietary Factors)
                         (Nadeau, Andrews, Mathew et al, AJVR, 2000)
                  1.5
                                  Gastric Lesion Number and Severity
                    1
                                  b
                  0.5
                                                           b
Change in score




                    0
                         NG Lesion#   G Lesion#   NG Severity   G Severity   Alfalfa/grain
                  -0.5
                                                                             Bromegrass
                   -1
                                                       a
                  -1.5
                             a
                   -2

                  -2.5
Conclusions
High lipid solubility            Ability to remain
                                undissociated at low pH

       Cell Acidification, Damage to Sodium
                                Transport

                         Cell Swelling

                         Necrosis and Ulceration
Risk Factors
•   Age, breed, gender
•   Exercise
•   Fasting
•   Pasture turnout
•   Starch intake
•   Forage feeding and type of forage
•   Water intake
•   NSAIDs
Clinical Signs
•   Acute and recurrent colic
•   Poor body condition
•   Poor appetite
•   Grinding of teeth
Clinical Signs
•   Poor performance
•   Attitude changes
•   Diarrhea
•   Dorsal recumbency in foals
Diagnosis
• Endoscopy
• Clinical signs & response to
  treatment
Medical Management
• Antacids
• Histamine type 2 receptor antagonists
  – Ranitidine/Cimetidine
• Omeprazole – Gastrogard
• Coating or binding agents
  – Sucralfate/bismuth subsalicylate
Prevention and Management
• Roughage – as much as possible
   – at least 1-1.5 kg/100 kg BW
   – at least 75% roughage
   – Give high protein (17-20% CP) or
     high calcium (6-14 mg/g feed) forage
• Avoid feeding sweet feeds
   – <1 g/kg BW starch meal
   – <2 g/kg BW starch/day
• If giving concentrates, feed more
  frequently
• Provide pasture turnout whenever
  possible or frequent forage (4-6 meals/day)
Prevention and Management
• Provide fresh, clean water continuously
• Whenever possible, avoid stressful situations
   – Long distance travel
   – Changing environments
   – Long periods of confinement
   – Avoid leaving horses >6 hours without forage during
     transport
   – Consider giving antiulcer medicine before transport
• Use minimal effective dose for NSAIDs, treat with
  antiulcer medicine simultaneously
Prevention and Management
• Racehorses
  – Prior to racing, give normal ration
  – Give forage up to 3 hrs prior to workout or race
  – Do not feed hay or concentrates within 3 hrs of workout or
    race
  – After the workout or race, forages can again be offered
  – Do not feed concentrates until at least 2 hrs after exercise
  – Water can be offered free choice after exercise but should
    initially drink slowly
Summary
• Multifactorial, many causes
• Long list of potential risk factors
• Important to evaluate horse’s diet and daily
  management to prevent them
• By following these recommendations, may be
  possible to prevent or reduce the risk of
  gastric ulceration
• Feeding and management practices must
  change to prevent recurrence!
Resources
• Nadeau, Jenifer & Luthersson, Nanna. Effect
  of Nutrition on Gastric Ulceration. In:Equine
  Applied and Clinical Nutrition Book Editor(s):
  Ray Geor, Pat Harris and Manfred Coenen

• Hepburn, Richard. Gastric ulceration in horses.
  March 2011. Equine Practice. 33:116-124.
Acknowledgments
• Nanna Luthersson
• Dr. Frank Andrews
• Dr. Richard Hepburn
Upcoming Events at UConn

• Spring Clinic: Trailer Driving 9-12 at UConn, March
  26
• Spring Clinic: Natural Horsemanship 1-4 at UConn,
  March 26
• Spring Clinic: Dressage with Deb Moynihan at
  UConn, March 27
Upcoming Events at UConn

• Sigma Alpha Open Horse Show – April 3
• Horseplay Lecture at UConn for the CT Museum of
  Natural History - April 3, 3 PM
• Eastern CT Draft Horse Plow Match, UConn – April 16
• Spring Horse Auction of UConn and CT Dept of Ag.
  Horses – April 23
• 4-H Hippology Contest – April 30
• 4-H Horse Judging Contest – May 1
Upcoming Events at UConn

• Riding Camp Safety Certification Clinic – June 11
• Summer Riding Program – UConn – open to public
  – Trail Sessions
  – Session I May 3, 5, 10, 12, 24, 26
  – Session II June 20, 22, July 5, 7, 19, 21
  – Session III August 2,4,9,11,16,18
Questions?
• For questions or more information
   about this and other horse-related
  topics:
  jenifer.nadeau@uconn.edu
• Website:
  http://animalscience.uconn.edu/equine/extension/extensio

• The University of Connecticut supports all state and
  federal laws that promote equal opportunity and
  prohibit discrimination.
  An equal opportunity employer and program provider.
Give us your feedback!
• You will receive a survey by email in 1-2 days.
  Please take a few minutes to give us your
  feedback on this webcast. It will help us to
  better serve you!
Upcoming Webcasts
• Understanding and Evaluating the Gaited
  Horse
  April 19, 2011
  7PM EDT
Thank you for attending this live web presentation!




                For more information about
            My Horse University please visit us at:
               www.myhorseuniversity.com




info@myhorseuniversity.com | www.myhorseuniversity.com | 517-353-3123

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Gastric Ulcers: How to Tell if Your Horse Has One, and What to Do if it Does

  • 1. My Horse University and eXtension’s HorseQuest welcome you to this live Webcast. Gastric Ulcers in Horses: How to Tell if Your Horse Has One, and What do Do if it Does Dr. Jenifer Nadeau University of Connecticut
  • 2. Meet our presenter: Dr. Jenifer Nadeau Associate Professor & Equine Extension Specialist University of Connecticut
  • 3. Prevalence of Equine Gastric Ulcer Syndrome (EGUS) • 60% to 93% in • 11% in lesson horses performance horses • 66.6% in pregnant • 40% to 58% of show broodmares horses • 75.9% in non pregnant • 25% to 50% in foals broodmares • 37-53% pleasure horses Murray et al, Equine Vet J, 1996; Murray, JAVMA, 1989; Murray, AAEP, 1997; Bertone 2000; McClure et al. 1999.
  • 4. Stomach Anatomy • Non-glandular region • Margo plicatus • Glandular region
  • 5. Types of ulcers • Primary squamous ulceration • Primary glandular ulceration • Secondary squamous ulceration
  • 8. Causes • Diet especially hydrochloric acid and volatile fatty acids • Bile acids • Bacterial contamination, including H. pylori • Non-steroidal anti-inflammatory drugs (NSAIDs) • Exercise
  • 9. Causes of EGUS • Damage occurs when aggressive factors overpower defenses of gastric mucosa • Squamous mucosal lesions (80%) result from increased acids • Glandular mucosal lesions (20%) result from impaired mucosal protection
  • 10. Previous Study (Dietary Factors) (Nadeau, Andrews, Mathew et al, AJVR, 2000) 1.5 Gastric Lesion Number and Severity 1 b 0.5 b Change in score 0 NG Lesion# G Lesion# NG Severity G Severity Alfalfa/grain -0.5 Bromegrass -1 a -1.5 a -2 -2.5
  • 11. Conclusions High lipid solubility Ability to remain undissociated at low pH Cell Acidification, Damage to Sodium Transport Cell Swelling Necrosis and Ulceration
  • 12. Risk Factors • Age, breed, gender • Exercise • Fasting • Pasture turnout • Starch intake • Forage feeding and type of forage • Water intake • NSAIDs
  • 13. Clinical Signs • Acute and recurrent colic • Poor body condition • Poor appetite • Grinding of teeth
  • 14. Clinical Signs • Poor performance • Attitude changes • Diarrhea • Dorsal recumbency in foals
  • 15. Diagnosis • Endoscopy • Clinical signs & response to treatment
  • 16. Medical Management • Antacids • Histamine type 2 receptor antagonists – Ranitidine/Cimetidine • Omeprazole – Gastrogard • Coating or binding agents – Sucralfate/bismuth subsalicylate
  • 17. Prevention and Management • Roughage – as much as possible – at least 1-1.5 kg/100 kg BW – at least 75% roughage – Give high protein (17-20% CP) or high calcium (6-14 mg/g feed) forage • Avoid feeding sweet feeds – <1 g/kg BW starch meal – <2 g/kg BW starch/day • If giving concentrates, feed more frequently • Provide pasture turnout whenever possible or frequent forage (4-6 meals/day)
  • 18. Prevention and Management • Provide fresh, clean water continuously • Whenever possible, avoid stressful situations – Long distance travel – Changing environments – Long periods of confinement – Avoid leaving horses >6 hours without forage during transport – Consider giving antiulcer medicine before transport • Use minimal effective dose for NSAIDs, treat with antiulcer medicine simultaneously
  • 19. Prevention and Management • Racehorses – Prior to racing, give normal ration – Give forage up to 3 hrs prior to workout or race – Do not feed hay or concentrates within 3 hrs of workout or race – After the workout or race, forages can again be offered – Do not feed concentrates until at least 2 hrs after exercise – Water can be offered free choice after exercise but should initially drink slowly
  • 20. Summary • Multifactorial, many causes • Long list of potential risk factors • Important to evaluate horse’s diet and daily management to prevent them • By following these recommendations, may be possible to prevent or reduce the risk of gastric ulceration • Feeding and management practices must change to prevent recurrence!
  • 21. Resources • Nadeau, Jenifer & Luthersson, Nanna. Effect of Nutrition on Gastric Ulceration. In:Equine Applied and Clinical Nutrition Book Editor(s): Ray Geor, Pat Harris and Manfred Coenen • Hepburn, Richard. Gastric ulceration in horses. March 2011. Equine Practice. 33:116-124.
  • 22. Acknowledgments • Nanna Luthersson • Dr. Frank Andrews • Dr. Richard Hepburn
  • 23. Upcoming Events at UConn • Spring Clinic: Trailer Driving 9-12 at UConn, March 26 • Spring Clinic: Natural Horsemanship 1-4 at UConn, March 26 • Spring Clinic: Dressage with Deb Moynihan at UConn, March 27
  • 24. Upcoming Events at UConn • Sigma Alpha Open Horse Show – April 3 • Horseplay Lecture at UConn for the CT Museum of Natural History - April 3, 3 PM • Eastern CT Draft Horse Plow Match, UConn – April 16 • Spring Horse Auction of UConn and CT Dept of Ag. Horses – April 23 • 4-H Hippology Contest – April 30 • 4-H Horse Judging Contest – May 1
  • 25. Upcoming Events at UConn • Riding Camp Safety Certification Clinic – June 11 • Summer Riding Program – UConn – open to public – Trail Sessions – Session I May 3, 5, 10, 12, 24, 26 – Session II June 20, 22, July 5, 7, 19, 21 – Session III August 2,4,9,11,16,18
  • 26. Questions? • For questions or more information about this and other horse-related topics: jenifer.nadeau@uconn.edu • Website: http://animalscience.uconn.edu/equine/extension/extensio • The University of Connecticut supports all state and federal laws that promote equal opportunity and prohibit discrimination. An equal opportunity employer and program provider.
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  • 28. Upcoming Webcasts • Understanding and Evaluating the Gaited Horse April 19, 2011 7PM EDT
  • 29. Thank you for attending this live web presentation! For more information about My Horse University please visit us at: www.myhorseuniversity.com info@myhorseuniversity.com | www.myhorseuniversity.com | 517-353-3123