1. The document describes research from the l’institut du thorax on proprotein convertase subtilisin/kexin type 9 (PCSK9) and its role in cholesterol regulation. 2. Gain-of-function mutations in PCSK9 are associated with hypercholesterolemia, while loss-of-function mutations are linked to lower cholesterol levels and potential cardioprotective effects. This has led to the development of a new class of cholesterol-lowering drugs. 3. The researchers generated induced pluripotent stem cells from patients with PCSK9 gain-of-function and loss-of-function mutations. Differentiating these into hepatocyte-like cells