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Whereas arteries bring blood to the
extremities and organs, veins are
vessels that return the blood to the heart.
The human body has surface (superfi-
cial) veins that are connected to deep
veins by bridging (perforator) veins.
Unlike arteries, which have thick mus-
cular walls designed to withstand higher
pressures, veins have thin, less muscular
walls and are prone to dilate in response
to persistently increased pressures. The
calf muscles act as pumps to keep blood
flowing through the legs back to the
heart. Veins have delicate valves that
keep blood flowing toward the heart and
prevent backflow of blood into the legs.
What Are Varicose Veins?
Varicose veins are superficial veins that
have become abnormally enlarged and
cause symptoms or are cosmetically dis-
tressing. Types of varicose veins include
spider veins, which are reddish-bluish
and thread-like; reticular veins, which are
bluish and string-like; and true varicose
veins, which are large rope- or worm-like
veins that feel spongy to the touch and
bulge out from the skin surface (Figure).
Symptoms of varicose veins vary
according to their size and extent and
include aching or throbbing discomfort,
burning, itching, and dry irritated skin.
Leg heaviness and fatigue, cramping,
brownish discoloration around the
ankles, swelling, hardening of the skin,
and skin breakdown (ulceration) are
more advanced symptoms that suggest
leakiness of the venous valves (called
chronic venous insufficiency).
What Causes Varicose Veins?
Risk factors for varicose veins can be
grouped as hormonal, lifestyle-related,
acquired, and inherited (Table 1). The
majority of patients with varicose veins
have multiple risk factors. High pressures
in the veins, leakiness of venous valves,
weakness of the vein wall, and inflam-
mation are the key mechanisms that
lead to varicose veins. High pressures in
the veins are caused by leakiness of the
venous valves, obstruction of the veins,
and failure of the calf muscle pump.
Leakiness of venous valves is caused
by tearing, thinning, or deformation of
the valve leaflets and can develop in the
deep, perforator, or superficial veins.
How Do Varicose Veins
Impact My Health?
Varicose veins can be cosmetically dis-
tressing and can cause symptoms that
decrease quality of life and impair the
ability to carry out activities of daily
life. If contributing factors are not
corrected and treatment is not provided,
varicose veins can progress in severity.
More advanced forms of chronic venous
insufficiency, such as ulceration, may
further decrease quality of life and result
in disability. Varicose veins can develop
blood clots or may rupture and bleed.
Varicose veins may increase the risk
of more serious blood clots in the deep
veins (called deep vein thrombosis).
How Are Varicose
Veins Diagnosed?
Varicose veins are detected on physi-
cal examination. Health care pro-
viders should evaluate patients with
varicose veins for more advanced signs
of chronic venous insufficiency, such
as swelling and ulceration. If the cause
of the varicose veins is not clear from
the physical examination, an ultrasound
study of the veins is often done to assess
for leakiness of venous valves and
blood clots. Additional testing may be
required if blockage of the large veins
in the abdomen or groin is suspected.
How Are Varicose
Veins Treated?
Treatment of varicose veins depends
on the severity of symptoms, location,
and cause. Treatment options include
(Circulation. 2014;130:e59-e61.)
© 2014 American Heart Association, Inc.
Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIRCULATIONAHA.113.008333
The information contained in this Circulation Cardiology Patient Page is not a substitute for medical advice, and the American Heart Association
recommends consultation with your doctor or healthcare professional.
From the Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.
Correspondence to Gregory Piazza, MD, MS, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115. E-mail
gpiazza@partners.org
Varicose Veins
Gregory Piazza, MD, MS
Cardiology Patient Page
byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom
e60  Circulation  August 12, 2014
lifestyle changes, compression stock-
ings, nonsurgical office-based pro-
cedures, and surgery (Table 2). Most
patients will require a combination of
treatments to achieve the best results.
Regardless of whether a nonsurgical pro-
cedure or surgery is necessary for vari-
cose vein treatment, lifestyle changes
are crucial to ensure as complete and
durable a response to treatment as pos-
sible. Most insurance companies will
not cover the costs of nonsurgical pro-
cedures or surgery for cosmetic reasons.
Compression stockings are frequently
prescribed as the first step in varicose
vein treatment and are effective for treat-
ing discomfort and swelling. Consistent
compression stocking use decreases the
leakiness of venous valves and the pres-
sure in the veins. To be effective, com-
pression stockings should be placed on
in the morning with the legs elevated at
least to waist height and worn until bed-
time. A variety of strengths and lengths
are prescribed, depending on the severity
and extent of varicose veins. To ensure
comfort, compression stockings should
be sized according to the patient’s legs.
Devices are available to help patients
apply compression stockings.
Nonsurgical procedures for varicose
veinsincludelocalveintherapiesandvein
ablation. Local vein therapies, such as
injection (sclerotherapy) or laser therapy,
are used to treat spider veins and reticular
veins. Sclerotherapy involves injection of
a chemical that causes the small veins to
seal shut. Most patients will require mul-
tiple treatments for the best results.
Vein ablation (also called endovenous
ablation) uses either radiofrequency
energy or laser to close large veins with
leaky valves. Vein ablation is usually
performed in an office-based procedure
room with local anesthesia. Popularity
of vein ablation has increased because it
is less invasive than surgery, has a faster
recovery time, and can be performed by
a variety of physicians.
Surgery for varicose veins includes
vein removal through small incisions
(called microincision phlebectomy)
Figure. Types of varicose veins. Spider veins are reddish-bluish and thread-like (A).
Reticular veins are bluish and string-like (B). True varicose veins are large rope- or worm-
like veins that bulge out from the skin surface (C).
Table 1.  Risk Factors for Varicose Veins
Category Risk Factor Effect
Hormonal Female sex High hormone levels
Lifestyle Prolonged standing/sitting High pressures in the veins
Smoking Injury to the veins
Acquired Obesity High pressures in the veins
Pregnancy High hormone levels
High pressures in the veins
Blood clots in the legs Obstruction of the veins
Leakiness of the venous valves
Age Leakiness of the venous valves
Inherited Family history of
varicose veins
Leakiness of the venous valves
Tall height High pressures in the veins
Syndromes with venous
abnormalities
Leakiness of the venous valves
High pressures in the veins
Obstruction of the veins
Table 2.  Treatments for Varicose
Veins
Treatment
Type of
Varicose Vein
Relative
Cost*
Lifestyle changes
Weight loss
Exercise
Elevation
Avoid prolonged
standing/sitting
Smoking
cessation
All types $
Compression
stockings
All types $$
Non-surgical
procedures
Local vein
therapies
Vein ablation
Spider veins,
reticular veins
Large varicose veins
$$$
$$$$
Surgery
Small-incision
vein removal
Large vein
stripping
Small varicose veins
Large varicose veins
$$$
$$$$
*Insurance companies may require a 3- to
6-month trial of compression stockings before
paying for vein treatments and may not cover
treatments performed for cosmetic reasons.
Table 3.  Tips for Preventing Varicose
Veins
•  Lose weight if overweight or obese
•  Exercise regularly
•  Avoid prolonged standing and sitting
•  Quit smoking
•  Wear compression stockings consistently
if prescribed them
byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom
Piazza  Varicose Veins  e61
and large varicose vein stripping.
Microincision phlebectomy is per-
formed under local anesthesia and is
most useful for small varicose veins.
Large varicose vein surgical stripping
has been largely replaced by less inva-
sive vein ablation procedures.
What Can I Do to Prevent
Varicose Veins?
Because varicose veins are associ-
ated with obesity, weight loss is an
important step in prevention and
treatment (Table 3). Regular physi-
cal activity such as walking may
help to improve calf muscle function.
Avoiding prolonged standing and sit-
ting encourages venous flow from the
legs. Smoking cessation is also an
important preventive measure.
Further Information
For additional information, please con-
sult the following resources:
•	 American Venous Forum
( w w w . v e i n f o r u m . o r g /
p a t i e n t s / v e i n - h a n d b o o k /
chapter-3-clotting-disorders)
•	 National Heart, Lung, and Blood
Institute (www.nhlbi.nih.gov/
health/health-topics/topics/ebc/)
•	 Rethink Varicose Veins (www.
rethinkvaricoseveins.com)
Disclosures
None.
byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom
Gregory Piazza
Varicose Veins
Print ISSN: 0009-7322. Online ISSN: 1524-4539
Copyright © 2014 American Heart Association, Inc. All rights reserved.
is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231Circulation
doi: 10.1161/CIRCULATIONAHA.113.008333
2014;130:e59-e61Circulation.
http://circ.ahajournals.org/content/130/7/e59
World Wide Web at:
The online version of this article, along with updated information and services, is located on the
http://circ.ahajournals.org//subscriptions/
is online at:CirculationInformation about subscribing toSubscriptions:
http://www.lww.com/reprints
Information about reprints can be found online at:Reprints:
document.Permissions and Rights Question and Answerthis process is available in the
click Request Permissions in the middle column of the Web page under Services. Further information about
Office. Once the online version of the published article for which permission is being requested is located,
can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialCirculationin
Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions:
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E59.full

  • 1. e59 Whereas arteries bring blood to the extremities and organs, veins are vessels that return the blood to the heart. The human body has surface (superfi- cial) veins that are connected to deep veins by bridging (perforator) veins. Unlike arteries, which have thick mus- cular walls designed to withstand higher pressures, veins have thin, less muscular walls and are prone to dilate in response to persistently increased pressures. The calf muscles act as pumps to keep blood flowing through the legs back to the heart. Veins have delicate valves that keep blood flowing toward the heart and prevent backflow of blood into the legs. What Are Varicose Veins? Varicose veins are superficial veins that have become abnormally enlarged and cause symptoms or are cosmetically dis- tressing. Types of varicose veins include spider veins, which are reddish-bluish and thread-like; reticular veins, which are bluish and string-like; and true varicose veins, which are large rope- or worm-like veins that feel spongy to the touch and bulge out from the skin surface (Figure). Symptoms of varicose veins vary according to their size and extent and include aching or throbbing discomfort, burning, itching, and dry irritated skin. Leg heaviness and fatigue, cramping, brownish discoloration around the ankles, swelling, hardening of the skin, and skin breakdown (ulceration) are more advanced symptoms that suggest leakiness of the venous valves (called chronic venous insufficiency). What Causes Varicose Veins? Risk factors for varicose veins can be grouped as hormonal, lifestyle-related, acquired, and inherited (Table 1). The majority of patients with varicose veins have multiple risk factors. High pressures in the veins, leakiness of venous valves, weakness of the vein wall, and inflam- mation are the key mechanisms that lead to varicose veins. High pressures in the veins are caused by leakiness of the venous valves, obstruction of the veins, and failure of the calf muscle pump. Leakiness of venous valves is caused by tearing, thinning, or deformation of the valve leaflets and can develop in the deep, perforator, or superficial veins. How Do Varicose Veins Impact My Health? Varicose veins can be cosmetically dis- tressing and can cause symptoms that decrease quality of life and impair the ability to carry out activities of daily life. If contributing factors are not corrected and treatment is not provided, varicose veins can progress in severity. More advanced forms of chronic venous insufficiency, such as ulceration, may further decrease quality of life and result in disability. Varicose veins can develop blood clots or may rupture and bleed. Varicose veins may increase the risk of more serious blood clots in the deep veins (called deep vein thrombosis). How Are Varicose Veins Diagnosed? Varicose veins are detected on physi- cal examination. Health care pro- viders should evaluate patients with varicose veins for more advanced signs of chronic venous insufficiency, such as swelling and ulceration. If the cause of the varicose veins is not clear from the physical examination, an ultrasound study of the veins is often done to assess for leakiness of venous valves and blood clots. Additional testing may be required if blockage of the large veins in the abdomen or groin is suspected. How Are Varicose Veins Treated? Treatment of varicose veins depends on the severity of symptoms, location, and cause. Treatment options include (Circulation. 2014;130:e59-e61.) © 2014 American Heart Association, Inc. Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIRCULATIONAHA.113.008333 The information contained in this Circulation Cardiology Patient Page is not a substitute for medical advice, and the American Heart Association recommends consultation with your doctor or healthcare professional. From the Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Correspondence to Gregory Piazza, MD, MS, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115. E-mail gpiazza@partners.org Varicose Veins Gregory Piazza, MD, MS Cardiology Patient Page byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom
  • 2. e60  Circulation  August 12, 2014 lifestyle changes, compression stock- ings, nonsurgical office-based pro- cedures, and surgery (Table 2). Most patients will require a combination of treatments to achieve the best results. Regardless of whether a nonsurgical pro- cedure or surgery is necessary for vari- cose vein treatment, lifestyle changes are crucial to ensure as complete and durable a response to treatment as pos- sible. Most insurance companies will not cover the costs of nonsurgical pro- cedures or surgery for cosmetic reasons. Compression stockings are frequently prescribed as the first step in varicose vein treatment and are effective for treat- ing discomfort and swelling. Consistent compression stocking use decreases the leakiness of venous valves and the pres- sure in the veins. To be effective, com- pression stockings should be placed on in the morning with the legs elevated at least to waist height and worn until bed- time. A variety of strengths and lengths are prescribed, depending on the severity and extent of varicose veins. To ensure comfort, compression stockings should be sized according to the patient’s legs. Devices are available to help patients apply compression stockings. Nonsurgical procedures for varicose veinsincludelocalveintherapiesandvein ablation. Local vein therapies, such as injection (sclerotherapy) or laser therapy, are used to treat spider veins and reticular veins. Sclerotherapy involves injection of a chemical that causes the small veins to seal shut. Most patients will require mul- tiple treatments for the best results. Vein ablation (also called endovenous ablation) uses either radiofrequency energy or laser to close large veins with leaky valves. Vein ablation is usually performed in an office-based procedure room with local anesthesia. Popularity of vein ablation has increased because it is less invasive than surgery, has a faster recovery time, and can be performed by a variety of physicians. Surgery for varicose veins includes vein removal through small incisions (called microincision phlebectomy) Figure. Types of varicose veins. Spider veins are reddish-bluish and thread-like (A). Reticular veins are bluish and string-like (B). True varicose veins are large rope- or worm- like veins that bulge out from the skin surface (C). Table 1.  Risk Factors for Varicose Veins Category Risk Factor Effect Hormonal Female sex High hormone levels Lifestyle Prolonged standing/sitting High pressures in the veins Smoking Injury to the veins Acquired Obesity High pressures in the veins Pregnancy High hormone levels High pressures in the veins Blood clots in the legs Obstruction of the veins Leakiness of the venous valves Age Leakiness of the venous valves Inherited Family history of varicose veins Leakiness of the venous valves Tall height High pressures in the veins Syndromes with venous abnormalities Leakiness of the venous valves High pressures in the veins Obstruction of the veins Table 2.  Treatments for Varicose Veins Treatment Type of Varicose Vein Relative Cost* Lifestyle changes Weight loss Exercise Elevation Avoid prolonged standing/sitting Smoking cessation All types $ Compression stockings All types $$ Non-surgical procedures Local vein therapies Vein ablation Spider veins, reticular veins Large varicose veins $$$ $$$$ Surgery Small-incision vein removal Large vein stripping Small varicose veins Large varicose veins $$$ $$$$ *Insurance companies may require a 3- to 6-month trial of compression stockings before paying for vein treatments and may not cover treatments performed for cosmetic reasons. Table 3.  Tips for Preventing Varicose Veins •  Lose weight if overweight or obese •  Exercise regularly •  Avoid prolonged standing and sitting •  Quit smoking •  Wear compression stockings consistently if prescribed them byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom
  • 3. Piazza  Varicose Veins  e61 and large varicose vein stripping. Microincision phlebectomy is per- formed under local anesthesia and is most useful for small varicose veins. Large varicose vein surgical stripping has been largely replaced by less inva- sive vein ablation procedures. What Can I Do to Prevent Varicose Veins? Because varicose veins are associ- ated with obesity, weight loss is an important step in prevention and treatment (Table 3). Regular physi- cal activity such as walking may help to improve calf muscle function. Avoiding prolonged standing and sit- ting encourages venous flow from the legs. Smoking cessation is also an important preventive measure. Further Information For additional information, please con- sult the following resources: • American Venous Forum ( w w w . v e i n f o r u m . o r g / p a t i e n t s / v e i n - h a n d b o o k / chapter-3-clotting-disorders) • National Heart, Lung, and Blood Institute (www.nhlbi.nih.gov/ health/health-topics/topics/ebc/) • Rethink Varicose Veins (www. rethinkvaricoseveins.com) Disclosures None. byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom
  • 4. Gregory Piazza Varicose Veins Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231Circulation doi: 10.1161/CIRCULATIONAHA.113.008333 2014;130:e59-e61Circulation. http://circ.ahajournals.org/content/130/7/e59 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals.org//subscriptions/ is online at:CirculationInformation about subscribing toSubscriptions: http://www.lww.com/reprints Information about reprints can be found online at:Reprints: document.Permissions and Rights Question and Answerthis process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published article for which permission is being requested is located, can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialCirculationin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions: byguestonMarch23,2017http://circ.ahajournals.org/Downloadedfrom