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(Psychoactive Toad)
1. Review Article
Colorado River Toad
(Psychoactive Toad)
By Mahdy Ali Ahmad Osman ,B.Pharm.,
Pharm.D., PGDPhV
Email:mahady_333@yahoo.com
The Colorado River toad (Incilius
alvarius), also known as the Sonoran
Desert toad, is a psychoactive toad found
in northern Mexico and the southwestern
United States. Its toxin, as an exudates of
glands within the skin, contains 5-MeO-
DMT and bufotenin.
Bufotenin, (5-HO-DMT,N,N
dimethylserotonin, bufotenine) is a
tryptamine related to the
neurotransmitter serotonin. It is an
alkaloid . Bufotenin is similar in chemical
structure to the psychedelics psilocin (4-
HO-DMT), 5-MeO-DMT, and DMT,
chemicals which also occur in some of the
same fungus, plant, and animal species as
bufotenin.
The psychoactivity of bufotenin has been
disputed, though recent studies suggest it
is similar in nature to 5-MeO-DMT.
The Colorado River toad can grow to
about 190 millimetres (7.5 in) long, it has
a smooth, leathery skin and is olive green
or mottled brown in color. Just behind the
large golden eye with horizontal pupil is a
bulging kidney-shaped parotoid gland.
Toads in the family bufonidae have a
region of skin known as "the seat patch",
which extends from mid abdomen to the
hind legs and is specialized for rapid
rehydration. Most of the rehydration is
done through absorption of water from
small pools or wet objects.
History
Bufotenin was first isolated from toad
skin, and named by the Austrian chemist
Handovsky at the University of Prague
during World War I. The structure of
bufotenine was first confirmed in 1934 by
Heinrich Wieland’s laboratory in Munich,
and the first reported synthesis of
bufotenine was by Toshio Hoshino and
Kenya Shimodaira in 1935.
Breeding
The breeding season starts in May, when
the rainy season begins, and can last up to
August.
Drug use of poison
The toad's primary defense system are
glands that produce a poison that may be
potent enough to kill a grown dog. These
2. parotoid glands also produce the 5-MeO-
DMT and bufotenin for which the toad is
known; both of these chemicals belong to
the family of hallucinogenic tryptamines.
5-MeO-DMT may be smoked and is
powerfully psychoactive. After inhalation,
the user usually experiences a warm
sensation, euphoria, and strong visual and
auditory hallucinations. No long-lasting
effects have been reported.
Pharmacokinetic
In rats, subcutaneously administered
bufotenin (1–100 μg/kg) distributes
mainly to the lungs, heart, and blood, and
to a much lesser extent, the brain
(hypothalamus, brain stem, striatum, and
cerebral cortex) and liver. It reaches peak
concentrations at 1 hour and is nearly
completely eliminated within 8 hours. In
humans, intravenous administration of
bufotenin results in excretion of (70%) of
injected drug in the form of 5-HIAA, an
endogenous metabolite of serotonin,
while roughly 4% is eliminated
unmetabolized in the urine. Orally
administered bufotenine undergoes
extensive first-pass metabolism by the
enzyme monoamine oxidase.
Lethal dose
The acute toxicity (LD50) of bufotenin in
rodents has been estimated at 200 to
300 mg/kg. Death occurs by respiratory
arrest. In April 2017 a South Korean man
died of bufotenin poisoning after
consuming toads that had been mistaken
as edible Asian bullfrogs.
Legal status
Australia
Bufotenin is classified as a Schedule I
controlled substance according to the
Criminal Code Regulations of the
Government of the Commonwealth of
Australia.
United Kingdom
In the UK, bufotenin is a Class A drug
under the 1971 Misuse of Drugs Act.
United States
Bufotenine (DEA Drug Code 7403) is
regulated as a Schedule I drug by the Drug
Enforcement Administration at the
federal level in the United States and is
therefore illegal to buy, possess, and sell.
Association with schizophrenia and
other mental disorders
A study conducted in the late 1960s
reported the detection of bufotenin in the
urine of schizophrenic subjects; however,
subsequent research has failed to confirm
these findings.
Studies have detected endogenous
bufotenin in urine specimens from
individuals with other psychiatric
disorders, such as infant autistic patients.
Another study indicated that paranoid
violent offenders or those who committed
violent behaviour towards family
members have higher bufotenin levels in
their urine than other violent offenders.
A 2010 study utilized a mass
spectrometry approach to detect levels of
bufotenin in the urine of individuals with
severe autism spectrum disorder (ASD),
schizophrenia, and asymptomatic
3. subjects. Their results indicate
significantly higher levels of bufotenin in
the urine of the ASD and schizophrenic
groups when compared to asymptomatic
individuals.
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