10. Repellent Attractant Results in clockwise rotation (Tumbling) Binding to MCP Low level CheA-P&CheY-P Less stimulation of the pathway CheY-P interact with Flagellar motor Che W CheA-P CheA CheY CheY-P Binding to MCP Counterclockwise rotation (Smooth Run)
15. CheW CheY CheY CheY CheA Che Z CheA CheR Che B Che B Met Met Binding of attractant
16. CheW CheY CheY CheY CheA Che Z CheA CheR Che B Che B Met Met Change in conformation of MCP Less CheA-P Smooth motion Less CheB-P Methylation occurs
17. CheW CheY CheY CheY CheA Che Z CheA CheR Che B Che B Met Met Change in conformation of MCP Less CheA-P Smooth motion Less CheB-P Methylation occurs MCP returns to its original form CheA-P & Che Y-P starts increasing Tumbling occurs More CheB-P synthesised Demethylation occurs
18. Adaptation Binding of attractant or In absence of attractant Decreased activity of MCP Low Che Y-P smooth run High methylation of MCP by Che R MCP returns to original confirmation Tumblig occurs At the same time Che B—P level increases and it demethylates MCP Increase level of Che Y-P