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ALL ABOUT OXYGEN AND CO2 DISSOCIATION CURVE
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It is a lipoprotein mixture present in thin layer of fluid lining the alveoli at the air fluid interface. COMPOSITION It is composed of Apoprotein Calcium ions Phospholipids i.e. dipalmitoyl lecithin Surfactant is secreted by 1. Mainly type II alveolar cells in the lungs. 2. Clara cells, which are situated in the bronchioles. It lowers the surface tension of fluid lining the alveoli. Surface tension is inversely proportional to surfactant concentration. During inspiration surfactant molecules move apart as lungs are expanded and during expiration surfactant molecules become concentrated as lungs shorten. When there is no surfactant, Surface Tension is 50 dynes/cm. when surfactant is present it is 5-30 dynes/cm depending upon the concentration Prevents collapse of lungs Stabilize size of alveoli Surfactant helps to keep lungs expanded. If there is deficiency of surfactant then the pressure of -20 to -30 mm of Hg will be required to keep the lungs expanded Surfactant also helps to keep the alveoli dry and prevent development of pulmonary edema. Surfactant is also helpful in lung expansion at birth. If there is deficiency then there is Respiratory Distress Syndrome. LAW OF LAPLACE: pressure required to keep a hollow viscous distended = 2 T/R Where T is tension and R is radius. During expiration, size of alveoli decreases so R is decreased and if T does not decrease, much higher pressure will be required to keep the alveoli distended. When adequate amount of surfactant is there T also decreases so increased pressure is not required. This prevents the collapse of lungs and also stabilizes the equal size of alveoli Definition: “Compliance is the measure of expansibility or distensibility of the lungs. It indicates with how much ease lungs can be expanded”. Work of Breathing In certain diseases there is increased work of breathing and depending upon the nature of breath there will be specific increase in work of breathing. In asthma there is increase in work of breathing to overcome airway resistance In restrictive lung diseases there is increase work of breathing in both tissue resistance and elastic recoil.
Surfactant & compliance, LAW OF LAPLACE, Work of Breathing (the guyton and ha...
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Ventilation perfusion ratio is : “The ratio of alveolar ventilation and the amount of blood that perfuse the alveoli”. FORMULA It is expressed as VA/Q. VA is alveolar ventilation Q is the blood flow (perfusion) Normal value of ventilation perfusion ratio is about 0.8 VA is 4.2 L /min Q is 5.5 L/min (Same as Cardiac output) So VA/Q = 4.2/5.5 = 0.8 If VA becomes zero ratio becomes zero If Q becomes zero ratio becomes infinite. If ratio becomes zero or infinite then there is no gaseous exchange. So this ratio indicates the efficiency of gaseous exchange in lungs. In standing or sitting position this ratio is not uniform in all parts of the lungs. In standing position, in upper parts of lungs there is almost no blood flow so normally in upper parts of lungs the ratio is higher may be near 3. In lower part of lungs, there is more blood flow so the ratio is decreased may be 0.6. In certain diseases the VA/Q ratio is higher which means perfusion is inadequate i.e. in some parts of lungs the alveoli are non functional or partially functional. This is seen in cases of pulmonary thrombosis or embolism. When there is higher VA/Q ratio, PO2 and PCO2 in the alveolar air resembles the values in the inspired air. When exchange is not occurring because of lack of perfusion, inspired air goes to alveoli, as there is no exchange occurring so the same values of PCO2 and PO2 as in inspired air.
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It is a lipoprotein mixture present in thin layer of fluid lining the alveoli at the air fluid interface. COMPOSITION It is composed of Apoprotein Calcium ions Phospholipids i.e. dipalmitoyl lecithin Surfactant is secreted by 1. Mainly type II alveolar cells in the lungs. 2. Clara cells, which are situated in the bronchioles. It lowers the surface tension of fluid lining the alveoli. Surface tension is inversely proportional to surfactant concentration. During inspiration surfactant molecules move apart as lungs are expanded and during expiration surfactant molecules become concentrated as lungs shorten. When there is no surfactant, Surface Tension is 50 dynes/cm. when surfactant is present it is 5-30 dynes/cm depending upon the concentration Prevents collapse of lungs Stabilize size of alveoli Surfactant helps to keep lungs expanded. If there is deficiency of surfactant then the pressure of -20 to -30 mm of Hg will be required to keep the lungs expanded Surfactant also helps to keep the alveoli dry and prevent development of pulmonary edema. Surfactant is also helpful in lung expansion at birth. If there is deficiency then there is Respiratory Distress Syndrome. LAW OF LAPLACE: pressure required to keep a hollow viscous distended = 2 T/R Where T is tension and R is radius. During expiration, size of alveoli decreases so R is decreased and if T does not decrease, much higher pressure will be required to keep the alveoli distended. When adequate amount of surfactant is there T also decreases so increased pressure is not required. This prevents the collapse of lungs and also stabilizes the equal size of alveoli Definition: “Compliance is the measure of expansibility or distensibility of the lungs. It indicates with how much ease lungs can be expanded”. Work of Breathing In certain diseases there is increased work of breathing and depending upon the nature of breath there will be specific increase in work of breathing. In asthma there is increase in work of breathing to overcome airway resistance In restrictive lung diseases there is increase work of breathing in both tissue resistance and elastic recoil.
Surfactant & compliance, LAW OF LAPLACE, Work of Breathing (the guyton and ha...
Surfactant & compliance, LAW OF LAPLACE, Work of Breathing (the guyton and ha...
Maryam Fida
Ventilation perfusion ratio is : “The ratio of alveolar ventilation and the amount of blood that perfuse the alveoli”. FORMULA It is expressed as VA/Q. VA is alveolar ventilation Q is the blood flow (perfusion) Normal value of ventilation perfusion ratio is about 0.8 VA is 4.2 L /min Q is 5.5 L/min (Same as Cardiac output) So VA/Q = 4.2/5.5 = 0.8 If VA becomes zero ratio becomes zero If Q becomes zero ratio becomes infinite. If ratio becomes zero or infinite then there is no gaseous exchange. So this ratio indicates the efficiency of gaseous exchange in lungs. In standing or sitting position this ratio is not uniform in all parts of the lungs. In standing position, in upper parts of lungs there is almost no blood flow so normally in upper parts of lungs the ratio is higher may be near 3. In lower part of lungs, there is more blood flow so the ratio is decreased may be 0.6. In certain diseases the VA/Q ratio is higher which means perfusion is inadequate i.e. in some parts of lungs the alveoli are non functional or partially functional. This is seen in cases of pulmonary thrombosis or embolism. When there is higher VA/Q ratio, PO2 and PCO2 in the alveolar air resembles the values in the inspired air. When exchange is not occurring because of lack of perfusion, inspired air goes to alveoli, as there is no exchange occurring so the same values of PCO2 and PO2 as in inspired air.
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lecture 5: it's good for as to take a breif about how does atmospheric air will pass to our lungs then to blood, for transportation and utilization of oxygen and excretion of carbon dioxide. Many issue are related when gas exchange is performed.
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Gas exchange between the alveoli and the pulmonary capillary blood occurs by diffusion, as will be discussed in the next chapter. Diffusion of oxygen and carbon dioxide occurs passively, according to their concentration differences across the alveolar-capillary barrier. These concentration differences must be maintained by ventilation of the alveoli and perfusion of the pulmonary capillaries. Alveolar ventilation brings oxygen into the lung and removes carbon dioxide from it. Similarly, the mixed venous blood brings carbon dioxide into the lung and takes up alveolar oxygen. The alveolar Image not available. and Image not available. are thus determined by the relationship between alveolar ventilation and pulmonary capillary perfusion. Alterations in the ratio of ventilation to perfusion, called the Image not available., will result in changes in the alveolar Image not available. and Image not available., as well as in gas delivery to or removal from the lung. Alveolar ventilation is normally about 4 to 6 L/min and pulmonary blood flow (which is equal to cardiac output) has a similar range, and so the Image not available. for the whole lung is in the range of 0.8 to 1.2. Image not available. However, ventilation and perfusion must be matched on the alveolar-capillary level, and the Image not available. for the whole lung is really of interest only as an approximation of the situation in all the alveolar-capillary units of the lung. For instance, suppose that all 5 L/min of the cardiac output went to the left lung and all 5 L/min of alveolar ventilation went to the right lung. The whole lung Image not available. would be 1.0, but there would be no gas exchange because there could be no gas diffusion between the ventilated alveoli and the perfused pulmonary capillaries. Oxygen is delivered to the alveolus by alveolar ventilation, is removed from the alveolus as it diffuses into the pulmonary capillary blood, and is carried away by blood flow. Similarly, carbon dioxide is delivered to the alveolus in the mixed venous blood and diffuses into the alveolus in the pulmonary capillary. The carbon dioxide is removed from the alveolus by alveolar ventilation. As will be discussed in Chapter 6, at resting cardiac outputs the diffusion of both oxygen and carbon dioxide is normally limited by pulmonary perfusion. Thus, the alveolar partial pressures of both oxygen and carbon dioxide are determined by the Image not available. If the Image not available. in an alveolar-capillary unit increases, the delivery of oxygen relative to its removal will increase, as will the removal ...
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Gas exchange between the alveoli and the pulmonary capillary blood occurs by diffusion, as will be discussed in the next chapter. Diffusion of oxygen and carbon dioxide occurs passively, according to their concentration differences across the alveolar-capillary barrier. These concentration differences must be maintained by ventilation of the alveoli and perfusion of the pulmonary capillaries. Alveolar ventilation brings oxygen into the lung and removes carbon dioxide from it. Similarly, the mixed venous blood brings carbon dioxide into the lung and takes up alveolar oxygen. The alveolar Image not available. and Image not available. are thus determined by the relationship between alveolar ventilation and pulmonary capillary perfusion. Alterations in the ratio of ventilation to perfusion, called the Image not available., will result in changes in the alveolar Image not available. and Image not available., as well as in gas delivery to or removal from the lung. Alveolar ventilation is normally about 4 to 6 L/min and pulmonary blood flow (which is equal to cardiac output) has a similar range, and so the Image not available. for the whole lung is in the range of 0.8 to 1.2. Image not available. However, ventilation and perfusion must be matched on the alveolar-capillary level, and the Image not available. for the whole lung is really of interest only as an approximation of the situation in all the alveolar-capillary units of the lung. For instance, suppose that all 5 L/min of the cardiac output went to the left lung and all 5 L/min of alveolar ventilation went to the right lung. The whole lung Image not available. would be 1.0, but there would be no gas exchange because there could be no gas diffusion between the ventilated alveoli and the perfused pulmonary capillaries. Oxygen is delivered to the alveolus by alveolar ventilation, is removed from the alveolus as it diffuses into the pulmonary capillary blood, and is carried away by blood flow. Similarly, carbon dioxide is delivered to the alveolus in the mixed venous blood and diffuses into the alveolus in the pulmonary capillary. The carbon dioxide is removed from the alveolus by alveolar ventilation. As will be discussed in Chapter 6, at resting cardiac outputs the diffusion of both oxygen and carbon dioxide is normally limited by pulmonary perfusion. Thus, the alveolar partial pressures of both oxygen and carbon dioxide are determined by the Image not available. If the Image not available. in an alveolar-capillary unit increases, the delivery of oxygen relative to its removal will increase, as will the removal ...
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Respiratory Physiology
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Chapter 16 Respiratory
Physiology
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Respiratory Zone
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Respiratory Zone
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Pleura
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Surface tension Insert
fig. 16.12
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Blood gases Insert
fig. 16.20
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Blood gases
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chemoreceptors
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Hemoglobin
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Oxyhemoglobin Dissociation Curve
Insert fig.16.34
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Disorders
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C0 2
Transport Carbonic anhydrase in RBC promotes useful changes in blood PC0 2 H 2 0 + C0 2 <- H 2 C0 3 <- HC0 3 - low P C0 2 CA H 2 0 + C0 2 -> H 2 C0 3 -> HC0 3 - high P C0 2 CA
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