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Pathology of Demyelinating Disease
- 1. “ Demyelinating” diseases Mark L Cohen, M.D. Department of Pathology University Hospitals Case Medical Center January 6 th , 2009
- 10. Rosenthal fibers Cytoskeletal Alexander disease Perivascular inflammation Peroxisomal Adreno- leukodystrophy Globoid (multinucleated) microglia Lysosomal Krabbe Disease Metachromatic sulfatides within macrophages Lysosomal Metachromatic Leukodystrophy Pathologic features Cellular defect Disease
- 23. 1868 Nystagmus, intention tremor, scanning speech Barber Chair phenomenon Worsening of vision with exercise in optic neuritis 1890 1920
- 24. Site Symptoms Signs Cerebrum Cognitive impairment Attention deficit, dementia (late) Optic Nerve Unilateral painful visual loss Scotoma, afferent pupillary defect Cerebellum Tremor Clumsiness Intention tremor Ataxia, dysarthria Brainstem Diplopia, vertigo, emotional lability Nystagmus, INO, ophthalmoplegias Spinal cord Spasms; bowel, bladder, erectile dysfunction Spasticity
- 29. 2 steps to neuroinflammation 1 2 Glia limitans perivascularis Post-capillary venule