The document compares the commonly used inhalational anesthetics nitrous oxide, isoflurane, sevoflurane, halothane, and desflurane. It discusses their physical and chemical properties, effects on organ systems like cardiovascular, respiratory, central nervous system, hepatic, renal, and skeletal muscle. Nitrous oxide is also described in detail regarding its history of use, pharmacokinetics, and clinical applications.
51. HEPATOTOXICITY -- depends on the quantity of drug getting metabolised TFA (Trifluoro acetic acid) HALOTHANE Large amounts ISOFLURANE/ ENFLURANE/ DESFLURANE Minute quantities SEVOFLURANE Nil
75. SECOND GAS EFFECT 19% oxygen 80% nitrous oxide 19% oxygen 40% nitrous oxide 32% nitrous oxide 1% second gas 7.6% oxygen 0.4% second gas 1% second gas Uptake of half of nitrous oxide Absorbed gases replaced by added ventilation