Physiologyof Coagulation

The Physiology of coagulation How to clot But not too much

Basis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Haemostasis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Platelet shape change ,[object Object],[object Object],[object Object]

Platelet adhesion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Platelet release reaction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Platelet Phospholipid Arachadonic acid Endoperoxidases Thromboxane A2 Calcium flux Phospholipase A2 Cyclooxygenase Thromboxane synthase Phosphodiesterase

Platelet aggregation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Coagulation forms fibrin mesh ,[object Object],[object Object],[object Object]

General concepts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cascade effect -> amplification 2x10 8 mol Fibrin mesh 1 mol

Coagulation cascade XII XI IX X VIII Prothrombin (II) thrombin fibrinogen fibrin STABILISED FIBRIN V, Ca, P/L VII Intrinsic pathway Extrinsic pathway XIII APTT PT

X Xa II (Prothrombin) IIa (Thrombin) INITIATION VIIa TF Va VIIIa Va XIa

AMPLIFICATION IXa Xa-Va-II Prothrombinase Platelet IXa- VIIa-X “ tenase” TF IX VIIa THROMBIN (IIa) FIBRIN

Fibrinogen -> fibrin ,[object Object],[object Object],[object Object],[object Object],[object Object]

Inhibitors: ANTI-coagulants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticoagulants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fibrinolysis ,[object Object],[object Object],[object Object]

Components: fibrinolysis ,[object Object],[object Object],[object Object],[object Object]

Effect of plasmin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Blood Vessel: endothelium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Haemostatic response ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Haemostatic response ,[object Object],[object Object],[object Object],[object Object]

Haemostasis reaction ,[object Object],[object Object],[object Object],[object Object]

A test tube is not a person ,[object Object],[object Object],[object Object],[object Object],[object Object]

Physiologyof Coagulation

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