Hucis

Antiviral Drugs: HIV treatment Zach Laucis April 17 th , 2007

Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

History ,[object Object],[object Object],[object Object]

History ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Structure and life cycle of HIV ,[object Object],[object Object],[object Object],[object Object],[object Object]

Structure and life cycle of HIV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HIV Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]

Nucleoside Reverse Transcriptase Inhibitors NRTIs ,[object Object],[object Object]

NRTIs Abacavir ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Abacavir

NRTIs Zidovudine ,[object Object],[object Object],[object Object],[object Object],Zidovudine

NRTIs Lamivudine ,[object Object],[object Object],[object Object],[object Object],Lamivudine

Non-nucleoside Reverse Transcriptase Inhibitors NNRTIs ,[object Object],[object Object],[object Object],[object Object]

NNRTIs Nevirapine ,[object Object],[object Object],[object Object],[object Object],Tyr-181 Tyr-188 Leu-100 Val-106 Val-179 Nevirapine

NNRTIs Delavirdine ,[object Object],[object Object],[object Object],Pro-236 Lys-103 Lys-103 Tyr-181 Tyr-188 Tyr -188 Trp-229

Protease inhibitors PIs ,[object Object],[object Object],[object Object],[object Object],[object Object],Tehrahedral intermediate N OH OH

PIs 4 3 Gly-48 Gly-48 Asp-29 Asp-29 Gly-48’ Gly-48’ Gly-27 Gly-27’ Asp-29’ Asp-29’ Asp-25 Asp-25’ Catalytic Region Flap Region Ile-50 Ile-50’ H-O-H 1 2 1’ 2’ 3’ 4’

PIs Saquinavir ,[object Object],[object Object],[object Object],[object Object],S3 S1 S2 S2’ S1’

PIs Nelfinavir ,[object Object],[object Object],[object Object],S3 S1 S2’ S1’ S2

PIs Ritonavir ,[object Object],[object Object],[object Object],[object Object],[object Object],P3 P2’

Statistics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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