.

1. Tooth abnormality in
systemic disease

2. CONTENTS
Syndromes
Developmental
disturbance in
tooth structure
Systemic cause
of intrinsic
staining
Abnormality
related to
medication
Medical causes
Psychological
causes
Bone pathology

3. Syndromes
Ectodermal dysplasia
Down syndrome
Ehlers Danlo syndrome
Syndromic craniosynstoses
Tricho-Dento-Oseus syndrome

5. Syndromes

6. Developmental
disturbance in tooth
structure

7. Inherited and acquired
chronic diseases
• Epidermolysis bullosa
• Coeliac disease

8. Inherited and acquired
chronic diseases
•Rickets
Bone disease of children
demineralization and defective bone growth

9. Inherited and acquired
chronic diseases
• X-linked hypophosphatemia
(PHEX)

10. Inherited and acquired
chronic diseases
• X-linked hypophosphatasia
(TNSALP)

11. Systemic cause of
intrinsic staining

12. Systemic cause of intrinsic
staining
• Neonatal jaundice
• Porphyria
• Alkaptonuria

13. Abnormality related to
medication

14. Abnormality
related to
medication
• Tetracycline
• Minocycline hydrochloride
• Cytotoxic chemotherapy

16. Medical causes

17. Other Medical
causes
• Diabetes
• Gastroesophageal reflux

18. Gastro-
esophageal
reflux

19. Psychological causes

20. Psychological
causes
• Bulimia and anorexia
• Drugs abuse

21. Bulimia and
anorexia

22. Bone pathology

23. Bone
pathology
• Ewing's sarcoma
• Histiocytosis X
• pseudotumor of haemophilia

24. References
• Burgess, J. (2015) ‘Oral Manifestations of Systemic
Disease’, Ada Cerp, pp. 1–12.
• Hunter, K. D. and Brierley, D. (2017) ‘Pathology of
the teeth: an update’, Diagnostic Histopathology.
Elsevier Ltd, 23(6), pp. 275–283. doi:
10.1016/j.mpdhp.2017.04.005.
• Sharma, U. and Bhalla, S. (2010) ‘Oral
manifestations of a systemic disease.’, American
Family Physician, 82, pp. 1381–1388. doi:
10.1016/S0733-8635(02)00066-9.
• Regezi, J., 2012. Oral Pathology clinical pathological
correlation. 6th ed. Missoury: Elsevier.