![Smell helps us: ,[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Empfohlen
Weitere ähnliche Inhalte
Was ist angesagt?
Was ist angesagt? (20)
Ăhnlich wie Olfaction
Ăhnlich wie Olfaction (20)
Mehr von farhan_aq91
Mehr von farhan_aq91 (20)
KĂźrzlich hochgeladen
KĂźrzlich hochgeladen (20)
Olfaction
- 1. Olfaction The Sense of Smell
- 6. Olfaction CNGC Cl - Ca 2+ PIP 2 Ca 2+ ER OR G olf ď˘ď§ ďĄ GDP PDE AC OR i RK O BP GTP GDP cAMP ATP ďĄ GTP 5â-AMP PLC OR G q GDP PKC RK GTP GDP GTP O BP CaM (IP 3 )
- 7. Olfactory Receptors Figure 16.3a, b
- 8. Olfactory Epithelium Copyright Š 2003 Pearson Education, Inc. publishing as Benjamin Cummings
- 9. Olfaction- originates in the nasal cavity
Hinweis der Redaktion
- OR : odorant receptor O : odorant BP : binding protein G olf : G protein GDP : guanosine diphosphate GTP : guanosine triphosphate AC : adenylate cyclase ATP : adenosine triphosphate cAMP : cyclic adenosine monophosphate CNGC : cyclic nucleotide-gated channel CaM : calmodulin; decreases CNGC sensitivity PDE : phosphodiesterase 5âAMP : 5â-adenosine monophosphate RK : receptor kinase PLC : phospholipase C ER : endoplasmic reticulum PIP 2 : phosphatidylinositol-4,5-bisphosphate IP 3 : inositol-1,4,5-trisphosphate PKC : protein kinase C; increases sensitivity of AC and CNGC There appears to be a 3rd pathway that utilizes a guanylyl cyclase (cGMP) receptor. Odorant cells are one of the few cells where [Cl - ] is greater inside than outside. ď˘ -arrestin binds the phosphorylated receptor AND appears to recruit phosphodiesterase to degrade the cAMP signal Kallmann syndrome, a rare hypogonadotropic hypogonadism