Chemistry of proteins

Chemistry of Proteins Lecture No. 4

What are proteins? ,[object Object],[object Object],[object Object],[object Object],[object Object]

General Characteristics of Proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of Proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Globular Proteins ,[object Object],[object Object]

Fibrous Proteins ,[object Object],[object Object]

Based on Biologic Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Amino Acids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

General Structure of Amino Acids ,[object Object],[object Object],[object Object]

Amino Acids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Amino Acids found in Proteins His H Histidine Gly G Glycine Glu E Glutamic acid Gln Q Glutamine Cys C Cysteine Asp D Aspartic acid Asn N Asparagine Arg R Arginine Ala A Alanine 3-letter Abbreviation 1-Letter Abbreviation Amino acids

Amino Acids found in Proteins Tyr Y Tyrosine Val V Valine Trp W Tryptophan Thr T Threonine Ser S Serine Pro P Proline Phe F Phenylalanine Met M Methionine Lys K Lysine Leu L Leucine Ile I Isoleucine

Neutral Amino Acids ,[object Object],[object Object]

Streoisomers of Alanine ,[object Object],[object Object],[object Object]

Amino Acids with Hydroxyl ,[object Object],[object Object]

Sulfur-containing Amino Acids ,[object Object],[object Object],[object Object]

Secondary Amino Acids ,[object Object],[object Object]

Acid Amino Acids ,[object Object],[object Object]

[object Object],[object Object],[object Object]

Aromatic Amino Acids ,[object Object],[object Object]

Basic Amino Acids ,[object Object],[object Object],[object Object]

How many types of proteins are in our body? ,[object Object],[object Object],[object Object],[object Object]

Biochemical Importance of Amino Acids ,[object Object],[object Object],[object Object],α -amino propanoic acid Alanine ,[object Object],[object Object],Aminoetha- noic acid Glycine Importance Systematic name Amino Acids

[object Object],[object Object],α -amino 3-methylpentanoic acid Isoleucine ,[object Object],[object Object],[object Object],α -amino 4-methyl pentanoic acid Leucine ,[object Object],[object Object],α -amino 3-methylbutanoic acid Valine

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],α - amino 3-indole propanoic acid Tryptophan ,[object Object],α -amino 3-(4-hydroxyphenyl)propanoic acid Tyrosine ,[object Object],[object Object],[object Object],[object Object],[object Object],α -amino 3-phenylpropanoic acid Phenylalanine

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],α -amino 4-methyl thiol butanoic acid Methionine

[object Object],[object Object],[object Object],[object Object],[object Object],2-amino 3 hydroxy butanoic acid Threonine ,[object Object],[object Object],[object Object],2-amino 3 hydroxy propanoic acid Serine ,[object Object],[object Object],[object Object],[object Object],2-amino 3-mercaptopropanoic acid Cysteine

[object Object],[object Object],[object Object],[object Object],α -amino 5-guanidino pentanoic acid Arginine ,[object Object],[object Object],[object Object],[object Object],2,6 diamino hexanoic acid Lysine ,[object Object],[object Object],[object Object],α -amino 3 (1H-imidazol-4-yl) propanoic acid Histidine

[object Object],α -amino 3 carbamoyl propanoic acid Asparagine ,[object Object],[object Object],[object Object],α -amino pentanedioic acid Glutamic acid ,[object Object],[object Object],[object Object],[object Object],α -amino butanedioic acid Aspartic Acid

[object Object],[object Object],Hydroxy hexanoic acid Hydroxy lysine ,[object Object],[object Object],[object Object],[object Object],Pyrrolidine-2-carboxylic acid Proline ,[object Object],[object Object],α -amino 4 carbamoyl butanoic acid Glutamine

Biologically Important Proteins Muscle action 6100 Myosin Part of immune system in blood 1320 Gamma globulin Enzyme for glycolysis 730 Hexokinase Oxygen transport in blood 574 Hemoglobin Used as anti-aging treatment 191 Growth hormone Enzyme for cell respiration 104 Cytochrome C Enzyme for sugar metabolism 51 Insulin Function No. of AA Protein

Blood Proteins Regulation of gene expression Regulatory proteins Neutralize trypsin that has leaked from the digestive system Alpha-1-Antitrypsin Blood coagulation Fibrinogens Participate in immune system Immunoglobulins Create osmotic pressure and transport other molecules Albumins

Four Levels of Architectural Organization of Proteins ,[object Object],[object Object],[object Object]

Secondary Structure of Proteins ,[object Object],[object Object],[object Object],[object Object]

3D Structure of Myoglobin ,[object Object],[object Object],[object Object],[object Object]

Quaternary Structure ,[object Object],[object Object],[object Object],[object Object]

Vasopressin ,[object Object],[object Object],[object Object]

Thyroxine ,[object Object],[object Object]

Separation of Amino Acids and Proteins ,[object Object],[object Object],[object Object],[object Object],[object Object]

Chromatography ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chemical Reaction in the Biuret test

Proteomics ,[object Object],[object Object]

Procedures of the Proteomics ,[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object]

Next meeting ,[object Object],[object Object]

Chemistry of proteins

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Chemistry of proteins