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2012 IVG Symposium
  This session sponsored by:
The itchy patient:
interactive cases

Michaela Austel, Dr. med. vet., DACVD
Never forget to round up the
„usual suspects‟: *

- Demodicosis
- Cheyletiella
- Dermatophytosis
- Pyoderma

* diseases that may or may not be pruritic
- Bacterial infections/overgrowths
- Fungal infections/overgrowths
- Parasites
- Allergies


Allergy tests are RARELY the first
diagnostic procedure performed in pruritic patients
“Eike” German Shepherd, m, 3 y


Owner noticed dog scratching/biting
around the base of the tail and the hind legs
six weeks ago.
Owner detected several fleas, treated Eike
immediately with FrontlineÂŽ.
Pruritus decreased a lot at first, but then it
returned plus problem “spread”.
Diagnostic tests:

- Flea comb (+ “water test”):   negative
- Wood‟s lamp exam:             negative
What is the next, most “reasonable”
(considering the history) diagnostic step?

1. Skin scrapes
2. Fungal culture
3. Trial treatment for
   Sarcoptes
4. Bacterial culture
5. Cytology
6. 1 & 2
7. 3 & 4
8. Other
What is the next, most “reasonable”
(considering the history) diagnostic step?

1. Skin scrapes
2. Fungal culture
3. Trial treatment for
   Sarcoptes
4. Bacterial culture
5. Cytology
6. 1 & 2
7. 3 & 4
8. Other
Treatment options
- shampoos
- conditioners
- oral antibiotics      Cephalexin
                       Cefpodoxime
                   Cefovecin inj.
                 Enrofloxacin
               Ciprofloxacin
              Marbofloxacin
            Orbifloxacin
          Clindamycin, Chloramphenicol, Rifampin
        Amoxicillin/Clavulanic Acid
      Trimethoprim/Sulfadiazine
     Ormethoprim/Sulfadimethoxime and more…
How long do you want to treat???
-> at least 3 weeks
-> one week past resolution of
   clinical signs


Baseline: patient needs to be
rechecked!
“Max” Labrador Retr., mn, 5 y



Started with facial pruritus 3 years ago. Problem got
progressively worse plus spread to entire body. Any
treatment resulted in temporary improvement but no
resolution. RDVM treated mainly with oral antibiotics (for 3-
4 weeks) and steroid shots (once monthly) -> „some‟
improvement.
No other animals in the household. Owner has no lesions.
Owner mentions that dog has sometimes soft stool, but is
not sure whether this is due to the previous treatment
(antibiotics) or the fact that Max gets a lot of people
food/treats on a regular basis.
Diagnostic tests:
- Flea comb/‟water test‟:   negative
- Wood‟s lamp exam:         negative
- Fungal culture:           negative
- Cytology:                 no microorganisms
- Skin scrapes:             negative
- Trial treatment for
  Sarcoptes:                negative

- Food switched to „100% allergen free diet‟
  (Pinnacle duck, OTC diet),
   no treats, bones, etc.: no change
- IDAT:                      no positive reactions
What would you do next?

1. Specific IgE test („blood
   allergy test)
2. Strict elimination diet for
   10 weeks with
   hydrolyzed soy
   prescription diet
3. Start all over/repeat all
   tests, something was
   missed
4. Give oral cyclosporine
   A/Atopica
5. Switch to grain-free diet
6. Other
What would you do next?

1. Specific IgE test („blood
   allergy test)
2. Strict elimination diet for
   10 weeks with
   hydrolyzed soy
   prescription diet
3. Start all over/repeat all
   tests, something was
   missed
4. Give oral cyclosporine
   A/Atopica
5. Switch to grain-free diet
6. Other
Treatment options
- Symptomatic ?
- Immunotherapy ?
- Strict (!!!) elimination diet for a minimum of
  8-12 weeks

      a) dry prescription diets
         (novel protein or hydrolyzed) +
      b) canned prescription diets     ++
      c) home cooked diets*            +++

* may be necessary in up to 20% of food allergic patients
„Beware of‟
- uninformed household members, neighbors
- flavored heartworm preventatives
- vitamin or mineral supplements, fish oil
- flavored tooth paste
- flavored nylabones
- cat litter boxes
- empty food bowls of other dogs/cats
- bones, raw hides, treats, pill pockets, etc.
- medications in capsules

--> nothing in the mouth but the diet
Compliance approx. 20%   
The owner is very unhappy about your
  suggestion and rather wants to pursue
  expensive symptomatic treatment instead.
  Your answer is
1. Sure, let‟s give
   cyclosporine A; it is
   expensive but
   convenient and
   works for most dogs
2. This is most likely not
   going to work in Max‟
   case, because……
3. Other
The owner is very unhappy about your
  suggestion and rather wants to pursue
  expensive symptomatic treatment instead.
  Your answer is
1. Sure, let‟s give cyclosporine A;
   it is expensive but convenient
   and works for most dogs
2. This is most likely not going to
   work in Max
   case, because……symptomatic
   treatment does not work in the
   majority of food allergic patients
3. Other
It can take several weeks of „dieting‟ until
symptoms improve……….
“Jimmy” from NY
 DSH, mn, 3.5 y

• Only cat in the household
• Indoors/outdoor
• “Fur mowing” for 2 ½ years
• Nonseasonal problem
• Advantage + Revolution
  every 3 weeks
• Responds to injectable
  steroids (nearly 100%, owner
 concerned because cat needs
 more shots with larger dose)
Diagnostic tests:

- Flea comb/
  paper towel test:                  negative
- Wood‟s lamp exam:                  negative
- Fungal culture:                    negative
- Cytology:                          negative
- Skin scrapes:                      negative
- Elimination diet
 (RC rabbit for 10 weeks, strict):   negative
- IDAT:                              positive*

                                      * several pollen
What would you do now?

1. Desensitization
2. Oral cyclosporine
   A/Atopica
3. 1) & 2)
4. 1) & oral steroids
5. Another food trial
   with different brand
6. Home-cooked food
   trial
7. Other
What would you do now?

1. Desensitization
2. Oral cyclosporine A/Atopica
3. 1) & 2)
4. 1) & oral steroids
5. Another food trial with
   different brand
6. Home-cooked food trial
   (pollen are
   seasonal, Jimmy‟s problem
   is non-seasonal!)
7. Other
Never forget to use common
sense when you look at either
IDAT or specific IgE level results
What if………….

Jimmy is not any better after a
correct home-cooked elimination
diet trial???
Up to 5% of atopic individuals do
not show positive allergy test
results (IDAT or specific IgE)



   (Avoidance)
   Symptomatic treatment
   (Immunotherapy)
“Prince”
 Labrador Retriever, mn, 5 y

Nonseasonal pruritus for almost 4 years
(initially seasonal). He responded well to
steroids in the past (not any more). Prince
underwent extensive diagnostics and
immunotherapy based on IDAT for 1.5
years without improvement. Most recent
treatment consisted of raw chicken
carcasses and herbal supplements for 4
months (no improvement). His level of
itchiness right now is 10/10.
Diagnostic tests:
- Flea comb/‟water test‟:         20x negative
- Wood‟s lamp exam:               5x negative
- Fungal culture:                 2x negative
- Cytology:                       25x various infections
- Skin scrapes:                   25x negative
- Scabies trial treatment
 (inj. ivermectin, lime sulfur
 dip, still on Revolution):       3x negative
- Elimination diets
 (hydrolyzed prescription diet,
 home-cooked pork diet,
 raw chicken diet):          3x negative
- Blood allergy test/IgE:    HDM I+II, beef, eggs
- IDAT:                   HDM I+II & several pollen
No diagnostic tests (except for raw
chicken elimination diet) during the past
               3 months
What would you do?

1. Vegetarian elimination diet
2. Hydrolyzed elimination diet
3. Repeat IDAT
4. Injectable steroids
5. Oral cyclosporine/Atopica
6. Start from scratch (repeat
   ALL tests)
7. Check for infections
8. Other
What would you do?

1. Vegetarian elimination diet
2. Hydrolyzed elimination diet
3. Repeat IDAT
4. Injectable steroids
5. Oral cyclosporine/Atopica
6. Start from scratch (repeat
   ALL tests)
7. Check for infections
8. Other
Staphylococcus
                 Malassezia



                    Trichophyton


    Atopy
Immunotherapy:
Desensitization, Hyposensitization

  Goal:
- increase the patients tolerance
- reduce the patients sensitivity

- Success rate approx. 75%
 (final evaluation after 12 months)
What was missing in Prince‟s case???
desensitization
 concentration


                         Symptomatic
                         Therapy
                         Desensitization




                  time
• No “universal” pruritus
  treatment

• Diagnostics are key

• “Banana” technique
Surgeons are sprinters…..

Dermatologists are
marathon runners………

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3 the itchy patient cases- austel finalwithpolls

  • 1. 2012 IVG Symposium This session sponsored by:
  • 2. The itchy patient: interactive cases Michaela Austel, Dr. med. vet., DACVD
  • 3. Never forget to round up the „usual suspects‟: * - Demodicosis - Cheyletiella - Dermatophytosis - Pyoderma * diseases that may or may not be pruritic
  • 4. - Bacterial infections/overgrowths - Fungal infections/overgrowths - Parasites - Allergies Allergy tests are RARELY the first diagnostic procedure performed in pruritic patients
  • 5. “Eike” German Shepherd, m, 3 y Owner noticed dog scratching/biting around the base of the tail and the hind legs six weeks ago. Owner detected several fleas, treated Eike immediately with FrontlineÂŽ. Pruritus decreased a lot at first, but then it returned plus problem “spread”.
  • 6.
  • 7.
  • 8.
  • 9. Diagnostic tests: - Flea comb (+ “water test”): negative - Wood‟s lamp exam: negative
  • 10. What is the next, most “reasonable” (considering the history) diagnostic step? 1. Skin scrapes 2. Fungal culture 3. Trial treatment for Sarcoptes 4. Bacterial culture 5. Cytology 6. 1 & 2 7. 3 & 4 8. Other
  • 11.
  • 12. What is the next, most “reasonable” (considering the history) diagnostic step? 1. Skin scrapes 2. Fungal culture 3. Trial treatment for Sarcoptes 4. Bacterial culture 5. Cytology 6. 1 & 2 7. 3 & 4 8. Other
  • 13.
  • 14. Treatment options - shampoos - conditioners - oral antibiotics Cephalexin Cefpodoxime Cefovecin inj. Enrofloxacin Ciprofloxacin Marbofloxacin Orbifloxacin Clindamycin, Chloramphenicol, Rifampin Amoxicillin/Clavulanic Acid Trimethoprim/Sulfadiazine Ormethoprim/Sulfadimethoxime and more…
  • 15. How long do you want to treat??? -> at least 3 weeks -> one week past resolution of clinical signs Baseline: patient needs to be rechecked!
  • 16. “Max” Labrador Retr., mn, 5 y Started with facial pruritus 3 years ago. Problem got progressively worse plus spread to entire body. Any treatment resulted in temporary improvement but no resolution. RDVM treated mainly with oral antibiotics (for 3- 4 weeks) and steroid shots (once monthly) -> „some‟ improvement. No other animals in the household. Owner has no lesions. Owner mentions that dog has sometimes soft stool, but is not sure whether this is due to the previous treatment (antibiotics) or the fact that Max gets a lot of people food/treats on a regular basis.
  • 17.
  • 18.
  • 19. Diagnostic tests: - Flea comb/‟water test‟: negative - Wood‟s lamp exam: negative - Fungal culture: negative - Cytology: no microorganisms - Skin scrapes: negative - Trial treatment for Sarcoptes: negative - Food switched to „100% allergen free diet‟ (Pinnacle duck, OTC diet), no treats, bones, etc.: no change - IDAT: no positive reactions
  • 20. What would you do next? 1. Specific IgE test („blood allergy test) 2. Strict elimination diet for 10 weeks with hydrolyzed soy prescription diet 3. Start all over/repeat all tests, something was missed 4. Give oral cyclosporine A/Atopica 5. Switch to grain-free diet 6. Other
  • 21.
  • 22. What would you do next? 1. Specific IgE test („blood allergy test) 2. Strict elimination diet for 10 weeks with hydrolyzed soy prescription diet 3. Start all over/repeat all tests, something was missed 4. Give oral cyclosporine A/Atopica 5. Switch to grain-free diet 6. Other
  • 23. Treatment options - Symptomatic ? - Immunotherapy ? - Strict (!!!) elimination diet for a minimum of 8-12 weeks a) dry prescription diets (novel protein or hydrolyzed) + b) canned prescription diets ++ c) home cooked diets* +++ * may be necessary in up to 20% of food allergic patients
  • 24. „Beware of‟ - uninformed household members, neighbors - flavored heartworm preventatives - vitamin or mineral supplements, fish oil - flavored tooth paste - flavored nylabones - cat litter boxes - empty food bowls of other dogs/cats - bones, raw hides, treats, pill pockets, etc. - medications in capsules --> nothing in the mouth but the diet
  • 26. The owner is very unhappy about your suggestion and rather wants to pursue expensive symptomatic treatment instead. Your answer is 1. Sure, let‟s give cyclosporine A; it is expensive but convenient and works for most dogs 2. This is most likely not going to work in Max‟ case, because…… 3. Other
  • 27.
  • 28. The owner is very unhappy about your suggestion and rather wants to pursue expensive symptomatic treatment instead. Your answer is 1. Sure, let‟s give cyclosporine A; it is expensive but convenient and works for most dogs 2. This is most likely not going to work in Max case, because……symptomatic treatment does not work in the majority of food allergic patients 3. Other
  • 29. It can take several weeks of „dieting‟ until symptoms improve……….
  • 30. “Jimmy” from NY DSH, mn, 3.5 y • Only cat in the household • Indoors/outdoor • “Fur mowing” for 2 ½ years • Nonseasonal problem • Advantage + Revolution every 3 weeks • Responds to injectable steroids (nearly 100%, owner concerned because cat needs more shots with larger dose)
  • 31.
  • 32. Diagnostic tests: - Flea comb/ paper towel test: negative - Wood‟s lamp exam: negative - Fungal culture: negative - Cytology: negative - Skin scrapes: negative - Elimination diet (RC rabbit for 10 weeks, strict): negative - IDAT: positive* * several pollen
  • 33. What would you do now? 1. Desensitization 2. Oral cyclosporine A/Atopica 3. 1) & 2) 4. 1) & oral steroids 5. Another food trial with different brand 6. Home-cooked food trial 7. Other
  • 34.
  • 35. What would you do now? 1. Desensitization 2. Oral cyclosporine A/Atopica 3. 1) & 2) 4. 1) & oral steroids 5. Another food trial with different brand 6. Home-cooked food trial (pollen are seasonal, Jimmy‟s problem is non-seasonal!) 7. Other
  • 36. Never forget to use common sense when you look at either IDAT or specific IgE level results
  • 37. What if…………. Jimmy is not any better after a correct home-cooked elimination diet trial???
  • 38. Up to 5% of atopic individuals do not show positive allergy test results (IDAT or specific IgE) (Avoidance) Symptomatic treatment (Immunotherapy)
  • 39. “Prince” Labrador Retriever, mn, 5 y Nonseasonal pruritus for almost 4 years (initially seasonal). He responded well to steroids in the past (not any more). Prince underwent extensive diagnostics and immunotherapy based on IDAT for 1.5 years without improvement. Most recent treatment consisted of raw chicken carcasses and herbal supplements for 4 months (no improvement). His level of itchiness right now is 10/10.
  • 40.
  • 41.
  • 42.
  • 43. Diagnostic tests: - Flea comb/‟water test‟: 20x negative - Wood‟s lamp exam: 5x negative - Fungal culture: 2x negative - Cytology: 25x various infections - Skin scrapes: 25x negative - Scabies trial treatment (inj. ivermectin, lime sulfur dip, still on Revolution): 3x negative - Elimination diets (hydrolyzed prescription diet, home-cooked pork diet, raw chicken diet): 3x negative - Blood allergy test/IgE: HDM I+II, beef, eggs - IDAT: HDM I+II & several pollen
  • 44. No diagnostic tests (except for raw chicken elimination diet) during the past 3 months
  • 45. What would you do? 1. Vegetarian elimination diet 2. Hydrolyzed elimination diet 3. Repeat IDAT 4. Injectable steroids 5. Oral cyclosporine/Atopica 6. Start from scratch (repeat ALL tests) 7. Check for infections 8. Other
  • 46.
  • 47. What would you do? 1. Vegetarian elimination diet 2. Hydrolyzed elimination diet 3. Repeat IDAT 4. Injectable steroids 5. Oral cyclosporine/Atopica 6. Start from scratch (repeat ALL tests) 7. Check for infections 8. Other
  • 48. Staphylococcus Malassezia Trichophyton Atopy
  • 49. Immunotherapy: Desensitization, Hyposensitization Goal: - increase the patients tolerance - reduce the patients sensitivity - Success rate approx. 75% (final evaluation after 12 months)
  • 50. What was missing in Prince‟s case???
  • 51. desensitization concentration Symptomatic Therapy Desensitization time
  • 52.
  • 53.
  • 54. • No “universal” pruritus treatment • Diagnostics are key • “Banana” technique
  • 55. Surgeons are sprinters….. Dermatologists are marathon runners………