The Insight eNO System has five main components – a compact desktop monitor, an accurate eNO sensor, disposable breath tubes, smart patient cards, and a dedicated printer. In addition, it comes with quality control kits and carbon dioxide filters. The Insight eNO System’s biosensor is a novel, porous matrix embedded with a protein that selectively binds to nitric oxide. When a patient exhales into the device, nitric oxide in the patient’s breath sample binds with a highly selective heme-protein inside the matrix. An optical measurement of this binding gives a highly accurate nitric oxide measurement in less than a minute.
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Insight eNO System to Assist Physcians with Patient Asthma Management
1. !
EW
N
Quantify Airway Inflammation.
Precisely!
Managing asthma is a
2. The Insight™ eNO System measures exhaled nitric oxide
(eNO) which offers:
• Accurate measure of your patient’s degree of airway inflammation1, 2, 3
• Definitive method to titrate and optimize asthma medication4
COMPREHENSIVE
• Clinical approach to identify lack of compliance5, 6
ASTHMA MANAGEMENT
• Safe monitoring and prediction of asthma control5, 7, 8
With an accurate measure
of your patient’s airway
The Insight eNO System utilizes patented biosensor technology to make safe, accurate
inflammation and customized and non-invasive measurement of nitric oxide. The Insight system’s unique, simple
reports for each patient, you design features:
can significantly improve the • A product designed exclusively for physician’s practice
precision of your therapy • A hygienic approach that is safe for use in a multi-patient clinic setting
• A long-lasting, reliable system proven for 18,000 test cycles between service intervals
• Comprehensive data management and analysis for customized patient therapy
• Accurate measurement of nitric oxide suitable for a broad population of asthma patients
The Insight eNO System has five main components – a compact desktop monitor, an ac-
curate eNO sensor, disposable breath tubes, smart patient cards, and a dedicated printer.
In addition, it comes with quality control kits and carbon dioxide filters. The Insight eNO
System’s biosensor is a novel, porous matrix embedded with a protein that selectively
binds to nitric oxide. When a patient exhales into the device, nitric oxide in the patient’s
breath sample binds with a highly selective heme-protein inside the matrix. An optical
measurement of this binding gives a highly accurate nitric oxide measurement in less
than a minute.
1. Frank TL, Adisesh A, Pickering AC, et al. Relationship between Exhaled Nitric Oxide and Childhood Asthma. Am
J Respir Crit Care Med. 1998;158:1032-1036
2. Sergei A, Kharitonov SA, Yates DH, Barnes PJ. Inhaled Glucocorticoids Decrease Nitric Oxide in Exhaled Air of
Asthmatic Patients. Am J Respir Crit Care Med. 1996;153:454-457
3. Holgate S. Mediator and Cytokine Mechanisms in Asthma. Thorax. 1993;48:103-109
4. Smith AD, Cowan JO, Brassett KP , Herbison GP, Taylor DR. Use of Exhaled Nitric Oxide Measurements to Guide
Treatment in Chronic Asthma. N Engl J Med. 2005;352(21):2163-73.
5. Delgado-Corcoran C, Kissoon N, Murphy SP , Duckworth LJ. Exhaled Nitric Oxide Reflects Asthma Severity and
Asthma Control. Pediatr Crit Care Med. 2004;5(1):48-52
6. Beck-Ripp J, Griese M, Arenz S, et al. Changes of Exhaled Nitric Oxide During Steroid Treatment of Childhood
Asthma. Eur. Respir. J. 2002;19:1015-1019
7 Jones SL, Kittelson J, Cowan JO et al. The Predictive Value of Exhaled Nitric Oxide Measurements In
.
Assessing Changes In Asthma Control. Am J Respir Crit Care Med. 2001;164:738-743
8. Harkins MS, Fiato KL, Iwamoto GK. Exhaled Nitric Oxide Predicts Asthma Exacerbation. Journal of Asthma.
2004;41(4):471-476
3. Insight™ Monitor
The Insight monitor is an easy-to-use, versatile desktop system that enables both the
physician and the patient to view and interpret the results.
Features Benefits
Long-lasting, reliable device that can be used for Accurate, reliable measurements over time – confidence
18,000 test cycles between service intervals without the inconvenience of changing monitors regularly
Easy to read and use – both the healthcare professional and
the patient can see critical information simultaneously – no
Large, color LCD screen with a friendly user- room for errors or confusion
interface
Tailored for in-clinic application; ability to interact with data
and optimize analysis for efficient output
Patients can get comfortable and confident before doing a real
Practice mode enabled
measurement - no wasted tests
Precise customization of medication and therapy to individual
Powerful data management and analysis, and a
patients – immediate access to patient eNO history and patient-
dedicated printer
specific trend reports and charts
Insight™ Sensor
The Insight sensor is based on patented biosensor technology that uses a novel, porous
matrix embedded with a protein that selectively binds to nitric oxide.
Features Benefits
Highly sensitive and selective to nitric oxide Accurate, reliable measurements for optimal decision-making
Prevents using sensors that have already been used
Smart chip coded
No calibration of sensors necessary
The Insight™ Breath Tube
The Insight breath tube is custom designed using biocompatible material and an
anti-bacterial filter to ensure patient safety and to prevent patient contamination.
Features Benefits
Disposable, patient-specific
Custom designed using biocompatible material and
an anti-bacterial filter
Prevents cross-contamination between patients, promotes
Patient exhales only, no patient inhalation of safety and hygiene
sample required
Patient handles breath tube only, no patient
handling of monitor required
The Insight™ Patient Card
The Insight patient card provides a convenient and safe way to store and manage individual
patient information.
Features Benefits
Patient-specific card to record and store patient Prevents mixing of patient information and enables therapy
eNO information (up to 300 individual test results) customized for each patient