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Energizing Change through Network Leadership ----- Uppsala BIO – The Life Science Initiative  Dr. Robin Teigland Stockholm School of Economics, CiND [email_address] www.knowledgenetworking.org
Uppsala – One of the world’s most biotech-concentrated cities? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Areas of Expertise www.uppsalabio.com
IgE Phadia 230 MUSD Dextran ,[object Object],[object Object],[object Object],[object Object],Solvay Pharma (NeoPharma), 3 MUSD Electrophoresis Function of  Hyaluronic acid 2000 Duodopa 1960 1940 Personal Chemistry Microwave synthesis Pyrosequencing Pyrosequencing SPR Biosensors Biacore  (Part of GE Healthcare) Q-Med  147 MUSD Biotage  33 MUSD 1980 Turnover (2006) AMO Uppsala 77 MUSD Heparin Fragmin™ Padlock Probes Olink 1,5 MUSD Neuropeptides effect on ocular blood flow  Xalatan ™ 1,3 BUSD An impressive record of research turned into innovations and growth Research
But significant challenges in an increasingly competitive world ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],A local initiative from life science industry, universities, and regional development bodies Uppsala BIO  –   the life science initiative
Uppsala BIO and Uppsala University ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Looking at the Uppsala Biotech Cluster as a network of interacting actors Government is quite distant from all commercial actors Government Academic/research Biotech companies Service companies Finance companies Institutes for collaboration 2004 survey
Building bridges between the different worlds “ I have been to several meetings organized by Uppsala BIO, but as a university professor, I feel really out of place among all those young businessmen in suits.  As a natural scientist, who am I supposed to speak with?”  Survey 2006 respondent comment
What is Uppsala BIO really working to achieve? Consulting Company Licensing Research Trade sale Start-up Commercialization path Changes in attitudes and behaviors – “ Weaving competitiveness into everyday life”  Collaboration between academia and industry for competitive commercialization
Adapted from Kotter 1996 2. Build a powerful guiding coalition 1. Establish a sense of urgency 3. Create and communicate a compelling vision 8. Consolidate improvements and produce more change 4. Develop an effective activity plan 5. Choose a change specialist as a project leader 6. Ensure commitment and empower others 7. Plan for and create short-term wins Uppsala BIO: An agent of change? Eight steps to successful change (from Business Administration)
1. Establish a sense of urgency Forces for change Forces for stability The status quo Kotter 1996, Burnes 2004 “ Well over 50% of organizations fail in this phase.”
UB created a sense of urgency through the decline of Pharmacia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Challenge: Individuals experience sense of urgency at different levels Completely disagree Completely agree The Stockholm-Uppsala region is one of the world’s five leading life science regions. Neutral Average 2008 survey
2. Build a powerful guiding coalition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Beer 2002, Kotter 1996 The   team  that will   lead   the change But look out for people with big egos or “snakes”
County Admin.  Swedish Univ. of Agriculture Chamber of Comm.  County Council Uppsala  Municipality STUNS CEO Vinnova Swedish Univ of Agric  Uppsala Municipality Industry Uppsala BIO Steering  Committee Visibility Innovation Competence Uppsala BIO-X Uppsala Univ   CIND Uppsala University Uppsala BIO Management Uppsala BIO -  A complex project organization University Hospital Scientific Advisory Board Uppsala University  Coordinating Committee
Uppsala BIO ”Owners” - Financers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Industry, academic, and government sectors all  represented!
Challenge: Ensure diversity across sectors and organizational size Teigland 2003 Avoid a closed “old boys network”
3. Create and communicate a compelling vision ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],But listen as well!! Adapted from Kotter 1996
[object Object],[object Object],A local initiative from life science industry, universities, and regional development bodies Uppsala BIO  –   the life science initiative
Communication strategy ,[object Object]
Challenge: Uppsala BIO’s vision appears to be clear, but the business sector is less sure. Strongly disagree Strongly agree Neutral 2006 survey
4. Develop an effective activity plan ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Adapted from Kotter 1996
The Action Plan Uppsala BIO:  A  facilitator,  not an operator  ! ,[object Object],[object Object],[object Object],[object Object]
All Uppsala BIO activities are seen as valuable  Extremely unvaluable Extremely valuable Neutral 2006 survey
Challenge: Relative  value  of activities varies greatly by sector and by involvement in UB +++ 1st valuable,  ++ 2nd valuable,  + 3rd valuable,  –  Least valuable Some columns have several activities with same value ranking due to equal values 2006 survey Academia Industry Government   Activity Pers inv Inv org Uninv org  Pers inv Inv org Uninv org  Pers inv Inv org Uninv org  Bio-Pubs     – ++ +++ ++     – Uppsala BIO website +   +++   – + ++     Uppsala BIO newsletter   – ++     +++     + BIO-X projects   +++   ++       ++ –   UIC programs + ++ +++     +++ ++ – Advice on patent/IP ++ +++   + ++   ++   +++ Career Days – ++   – – – +   External visitors’ activities     ++     +   ++ +++ ++
Challenge: Different underlying objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Uppsala BIO
5. Choose a change specialist as project leader ,[object Object],[object Object],[object Object],[object Object],[object Object],University Industry Uppsala BIO Project Leader Academia Challenge: Skills required change over time
6. Ensure commitment and empower others to act on the vision Do people have the  resources  to act? Do people have the appropriate  skills  to act? Do the  structures & systems  align with the vision? Adapted from Kotter 1996
Challenge: Uppsala BIO – A modest budget  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Innovation support  – together with Uppsala Innovation Centre ,[object Object],[object Object],[object Object],[object Object],Business Start Business Lab Business Accelerator Alumni Growth www.uic.se
Long-term supply of competence ,[object Object],[object Object],[object Object],[object Object],[object Object]
7. Plan for and create short-term wins 1. Create obtainable targets 2. Encourage & convince people that targets can be reached 3. Recognize and reward “winners” Communicate the wins Adapted from Kotter 1996
Uppsala BIO-X fills the research gap - approximately 50% of UB’s resources Basic research Publication Explorative research Product development Academia Industry ,[object Object],[object Object],[object Object],[object Object],RESOURCE GAP Uppsala BIO-X
Some results from Uppsala BIO-X ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Challenge: Different underlying objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Uppsala BIO
8.Consolidate improvements and produce more change Change  Project 1 Change  Project 2 Change  Project 3 Time Scope of change Adapted from Kotter 1996
Results to date for Uppsala BIO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Creation of greater regional initiative Stockholm-Uppsala Life Science shall promote the development of the life-science sector in the region, and promote the region itself on the international arena to attract new resources and investment. (www.suls.se)
[object Object],Challenge: How to evaluate progress? Impact of Uppsala BIO on the Cluster’s development Continuous external evaluation Local  rivalry Demand conditions Factor conditions Related industries
Adapted from Kotter 1996 How well does your development initiative fulfill the steps of successful change? 2. Build a powerful guiding coalition 1. Establish a sense of urgency 3. Create and communicate a compelling vision 8. Consolidate improvements and produce more change 4. Develop an effective activity plan 5. Choose a change specialist as a process leader 6. Ensure commitment and empower others 7. Plan for and create short-term wins
Leading and learning Leadership and learning are indispensable to each other.” - John F. Kennedy Leadership, teaching, and learning are inextricably interlinked. - Jack Welch
Interested in learning more? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Appendix
Sweden’s leading life science region
Life Science subsectors Source: VINNOVA, 2007 Sweden Uppsala N=4 400 N=36 500
Perceptions of competitiveness differ significantly among cluster actors Teigland & Lindqvist 2007
GROWTH Scouting ,[object Object],[object Object],[object Object],[object Object],[object Object],Red = Innovation System Green = Uppsala BIO-X Blue = Competence Black  = Marketing ,[object Object],[object Object],From idea to sustainable growth? ? $ Business BIO-X ,[object Object],[object Object],Competence Chain Universities Schools Entrepreneurs Innovators Company  Employees Value Marketing of Biotech in Uppsala ,[object Object],[object Object],[object Object],[object Object]
Most see Uppsala BIO as a good use of resources while business is less positive Big waste of resources In general, what is your opinion of Uppsala BIO? Average Neutral Excellent use of resources 2006 survey
Respondents appear satisfied with the leadership of Uppsala BIO Strongly disagree Strongly agree Neutral The leadership of Uppsala BIO… 2008 survey
Strong primary level impact, yet weak secondary level impact Strongly disagree Strongly agree Neutral In general, during the past two years Uppsala BIO has contributed to an increase in ... UB’s primary objectives Secondary effects 2006 survey
Uppsala BIO has made an impact in its four focus areas ,[object Object],[object Object],[object Object],[object Object],Yes Yes Yes Yes 2006 survey
However, Government rates UB as having more impact than Academia and Business In general, during the past two years Uppsala BIO has contributed to an increase in ... Strongly disagree Strongly agree Neutral 2006 survey
Participation  in UB activities by respondents  involved directly or indirectly  through their organization in UB Never heard of  Very frequently 2006 survey
Participation  in UB activities by respondents whose organization is  not involved  in UB N=60 Never heard of  Very frequently 2006 survey
Value  of UB activities by respondents  involved directly or indirectly  through their organization in UB  N=99 Extremely valuable Extremely unvaluable  2006 survey
Value of UB activities by respondents whose organization is  not involved  in UB Extremely unvaluable  Extremely valuable N=49 2006 survey
Nanoporous bioceramics for safe drug release - for safe, slow release of potent drugs  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Micro dosing with Accelerator Mass Spectrometry, AMS -  For long term drug development studies ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CAMDIA -  cancer marker diagnostics -   high precision technique for ultra-sensitive identification of tumor leakage biomarkers in blood
Earlier projects in Uppsala BIO-X  ,[object Object],[object Object],[object Object],[object Object]
Respondents view insufficient financing and potential company exits as biggest threats What are the biggest threats to Uppsala Biotech Cluster within the next 5 years? (% responses) Total responses = 241 2006 survey
Can Uppsala BIO make a difference? ,[object Object],[object Object],[object Object],[object Object]
Questions to ponder….. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Uppsala BIO - An agent of change

  • 1. Energizing Change through Network Leadership ----- Uppsala BIO – The Life Science Initiative Dr. Robin Teigland Stockholm School of Economics, CiND [email_address] www.knowledgenetworking.org
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. Looking at the Uppsala Biotech Cluster as a network of interacting actors Government is quite distant from all commercial actors Government Academic/research Biotech companies Service companies Finance companies Institutes for collaboration 2004 survey
  • 8. Building bridges between the different worlds “ I have been to several meetings organized by Uppsala BIO, but as a university professor, I feel really out of place among all those young businessmen in suits. As a natural scientist, who am I supposed to speak with?” Survey 2006 respondent comment
  • 9. What is Uppsala BIO really working to achieve? Consulting Company Licensing Research Trade sale Start-up Commercialization path Changes in attitudes and behaviors – “ Weaving competitiveness into everyday life” Collaboration between academia and industry for competitive commercialization
  • 10. Adapted from Kotter 1996 2. Build a powerful guiding coalition 1. Establish a sense of urgency 3. Create and communicate a compelling vision 8. Consolidate improvements and produce more change 4. Develop an effective activity plan 5. Choose a change specialist as a project leader 6. Ensure commitment and empower others 7. Plan for and create short-term wins Uppsala BIO: An agent of change? Eight steps to successful change (from Business Administration)
  • 11. 1. Establish a sense of urgency Forces for change Forces for stability The status quo Kotter 1996, Burnes 2004 “ Well over 50% of organizations fail in this phase.”
  • 12.
  • 13. Challenge: Individuals experience sense of urgency at different levels Completely disagree Completely agree The Stockholm-Uppsala region is one of the world’s five leading life science regions. Neutral Average 2008 survey
  • 14.
  • 15. County Admin. Swedish Univ. of Agriculture Chamber of Comm. County Council Uppsala Municipality STUNS CEO Vinnova Swedish Univ of Agric Uppsala Municipality Industry Uppsala BIO Steering Committee Visibility Innovation Competence Uppsala BIO-X Uppsala Univ CIND Uppsala University Uppsala BIO Management Uppsala BIO - A complex project organization University Hospital Scientific Advisory Board Uppsala University Coordinating Committee
  • 16.
  • 17. Challenge: Ensure diversity across sectors and organizational size Teigland 2003 Avoid a closed “old boys network”
  • 18.
  • 19.
  • 20.
  • 21. Challenge: Uppsala BIO’s vision appears to be clear, but the business sector is less sure. Strongly disagree Strongly agree Neutral 2006 survey
  • 22.
  • 23.
  • 24. All Uppsala BIO activities are seen as valuable Extremely unvaluable Extremely valuable Neutral 2006 survey
  • 25. Challenge: Relative value of activities varies greatly by sector and by involvement in UB +++ 1st valuable, ++ 2nd valuable, + 3rd valuable, – Least valuable Some columns have several activities with same value ranking due to equal values 2006 survey Academia Industry Government   Activity Pers inv Inv org Uninv org Pers inv Inv org Uninv org Pers inv Inv org Uninv org Bio-Pubs     – ++ +++ ++     – Uppsala BIO website +   +++   – + ++     Uppsala BIO newsletter   – ++     +++     + BIO-X projects   +++   ++       ++ –   UIC programs + ++ +++     +++ ++ – Advice on patent/IP ++ +++   + ++   ++   +++ Career Days – ++   – – – +   External visitors’ activities     ++     +   ++ +++ ++
  • 26.
  • 27.
  • 28. 6. Ensure commitment and empower others to act on the vision Do people have the resources to act? Do people have the appropriate skills to act? Do the structures & systems align with the vision? Adapted from Kotter 1996
  • 29.
  • 30.
  • 31.
  • 32. 7. Plan for and create short-term wins 1. Create obtainable targets 2. Encourage & convince people that targets can be reached 3. Recognize and reward “winners” Communicate the wins Adapted from Kotter 1996
  • 33.
  • 34.
  • 35.
  • 36. 8.Consolidate improvements and produce more change Change Project 1 Change Project 2 Change Project 3 Time Scope of change Adapted from Kotter 1996
  • 37.
  • 38. Creation of greater regional initiative Stockholm-Uppsala Life Science shall promote the development of the life-science sector in the region, and promote the region itself on the international arena to attract new resources and investment. (www.suls.se)
  • 39.
  • 40. Adapted from Kotter 1996 How well does your development initiative fulfill the steps of successful change? 2. Build a powerful guiding coalition 1. Establish a sense of urgency 3. Create and communicate a compelling vision 8. Consolidate improvements and produce more change 4. Develop an effective activity plan 5. Choose a change specialist as a process leader 6. Ensure commitment and empower others 7. Plan for and create short-term wins
  • 41. Leading and learning Leadership and learning are indispensable to each other.” - John F. Kennedy Leadership, teaching, and learning are inextricably interlinked. - Jack Welch
  • 42.
  • 44. Sweden’s leading life science region
  • 45. Life Science subsectors Source: VINNOVA, 2007 Sweden Uppsala N=4 400 N=36 500
  • 46. Perceptions of competitiveness differ significantly among cluster actors Teigland & Lindqvist 2007
  • 47.
  • 48. Most see Uppsala BIO as a good use of resources while business is less positive Big waste of resources In general, what is your opinion of Uppsala BIO? Average Neutral Excellent use of resources 2006 survey
  • 49. Respondents appear satisfied with the leadership of Uppsala BIO Strongly disagree Strongly agree Neutral The leadership of Uppsala BIO… 2008 survey
  • 50. Strong primary level impact, yet weak secondary level impact Strongly disagree Strongly agree Neutral In general, during the past two years Uppsala BIO has contributed to an increase in ... UB’s primary objectives Secondary effects 2006 survey
  • 51.
  • 52. However, Government rates UB as having more impact than Academia and Business In general, during the past two years Uppsala BIO has contributed to an increase in ... Strongly disagree Strongly agree Neutral 2006 survey
  • 53. Participation in UB activities by respondents involved directly or indirectly through their organization in UB Never heard of Very frequently 2006 survey
  • 54. Participation in UB activities by respondents whose organization is not involved in UB N=60 Never heard of Very frequently 2006 survey
  • 55. Value of UB activities by respondents involved directly or indirectly through their organization in UB N=99 Extremely valuable Extremely unvaluable 2006 survey
  • 56. Value of UB activities by respondents whose organization is not involved in UB Extremely unvaluable Extremely valuable N=49 2006 survey
  • 57.
  • 58.
  • 59.
  • 60.
  • 61. Respondents view insufficient financing and potential company exits as biggest threats What are the biggest threats to Uppsala Biotech Cluster within the next 5 years? (% responses) Total responses = 241 2006 survey
  • 62.
  • 63.